| Definition | Anaeromyxobacter dehalogenans 2CP-1 chromosome, complete genome. |
|---|---|
| Accession | NC_011891 |
| Length | 5,029,329 |
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The map label for this gene is yvgN [H]
Identifier: 220917039
GI number: 220917039
Start: 2188362
End: 2189195
Strand: Reverse
Name: yvgN [H]
Synonym: A2cp1_1935
Alternate gene names: 220917039
Gene position: 2189195-2188362 (Counterclockwise)
Preceding gene: 220917041
Following gene: 220917037
Centisome position: 43.53
GC content: 71.7
Gene sequence:
>834_bases ATGGCCGGCGCCTGGACGATCCGATCGACCGTCGAGCTTCGCGGCGGCGTGCGCATGCCGATCCTCGGCCTGGGGGTGTG GCAGTCTCCGCCCGGGGACGAGACGCGCAACGCGGTGCTCGCGGCGCTGCGGCTGGGGTACCGGCTGGTGGACACCGCCC GCGCCTACCGGAACGAGGAGGACGTGGGCGCGGCCATCCGCGAGAGCGGCGTGCCGCGCGACGAGGTCTTCGTCACCACC AAGCTCTGGAACTCCGATCACGGCTACGACTCGACGCTGCGCGCCTGCGACGAGAGCCTGCGGCGGCTCGGGCTCGACCG GCTCGACCTATACCTCGTCCACTGGCCGGTGCCGAAGCTGCGCGGCGAGACCTGGCGCGCCATGGAGCGGATCCTGGCCG AGGGGAAGGCGCGGGCCATCGGCGTGTCGAACTACACCATCCGTCACCTGGACGAGCTGCTCGCGTCGGCGAACGAGCCG CCCTCGGTGAACCAGGTCGAGCTGCACCCGTTCCTGGTCCAGCGCGGGCTGGTGGACCACTGCCAGGCGAACGGCATCCA GGTCGAGGCGTACGGACCGCTGGTCCGCGGGCACAAGATGGAGAACCCGGTGCTGCAGCGGATCGCGCACCGGGTCGAGC GCACGCCCGCGCAGGTGCTCATCCGCTGGGGCATCGAGCACGGCCTGGTGACCATCCCGAAGTCGGTGCACGAGCACCGC ATCCGCGAGAACGCCGACGTGTTCGGGTTCTCGCTCTCGCCCGCGGACCTGGCCGCGCTCGACGCGCTCGACGAGGGCTA CCGGACGAGCTGGGATCCCACCGACGCGCCCTAG
Upstream 100 bases:
>100_bases CGCCCACGCGAAACGCGGGCGGTGCGCGGCGGCCCGGCCTGCGTCATTATGTCGTCTCGACCCTCGGTTCGCCGTTCCGC CGCGAGGGGGAGGAGACGTC
Downstream 100 bases:
>100_bases ATCGCGTTCCGCGGCGGCGGGCCGGCTCACGCGCGCAGCGCCGCGGCCACGATCGCCCTCGCCTCCCCCAGGATGCGATC CAGGTGGGCCGCGTCGCGGA
Product: 2,5-didehydrogluconate reductase
Products: NA
Alternate protein names: GR; Methylglyoxal reductase [H]
Number of amino acids: Translated: 277; Mature: 276
Protein sequence:
>277_residues MAGAWTIRSTVELRGGVRMPILGLGVWQSPPGDETRNAVLAALRLGYRLVDTARAYRNEEDVGAAIRESGVPRDEVFVTT KLWNSDHGYDSTLRACDESLRRLGLDRLDLYLVHWPVPKLRGETWRAMERILAEGKARAIGVSNYTIRHLDELLASANEP PSVNQVELHPFLVQRGLVDHCQANGIQVEAYGPLVRGHKMENPVLQRIAHRVERTPAQVLIRWGIEHGLVTIPKSVHEHR IRENADVFGFSLSPADLAALDALDEGYRTSWDPTDAP
Sequences:
>Translated_277_residues MAGAWTIRSTVELRGGVRMPILGLGVWQSPPGDETRNAVLAALRLGYRLVDTARAYRNEEDVGAAIRESGVPRDEVFVTT KLWNSDHGYDSTLRACDESLRRLGLDRLDLYLVHWPVPKLRGETWRAMERILAEGKARAIGVSNYTIRHLDELLASANEP PSVNQVELHPFLVQRGLVDHCQANGIQVEAYGPLVRGHKMENPVLQRIAHRVERTPAQVLIRWGIEHGLVTIPKSVHEHR IRENADVFGFSLSPADLAALDALDEGYRTSWDPTDAP >Mature_276_residues AGAWTIRSTVELRGGVRMPILGLGVWQSPPGDETRNAVLAALRLGYRLVDTARAYRNEEDVGAAIRESGVPRDEVFVTTK LWNSDHGYDSTLRACDESLRRLGLDRLDLYLVHWPVPKLRGETWRAMERILAEGKARAIGVSNYTIRHLDELLASANEPP SVNQVELHPFLVQRGLVDHCQANGIQVEAYGPLVRGHKMENPVLQRIAHRVERTPAQVLIRWGIEHGLVTIPKSVHEHRI RENADVFGFSLSPADLAALDALDEGYRTSWDPTDAP
Specific function: Reduces glyoxal and methylglyoxal. Is not involved in the vitamin B6 biosynthesis [H]
COG id: COG0656
COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the aldo/keto reductase family [H]
Homologues:
Organism=Homo sapiens, GI24497577, Length=295, Percent_Identity=39.3220338983051, Blast_Score=221, Evalue=4e-58, Organism=Homo sapiens, GI5174391, Length=295, Percent_Identity=39.3220338983051, Blast_Score=221, Evalue=4e-58, Organism=Homo sapiens, GI223468663, Length=301, Percent_Identity=35.8803986710963, Blast_Score=189, Evalue=3e-48, Organism=Homo sapiens, GI4502049, Length=297, Percent_Identity=40.0673400673401, Blast_Score=187, Evalue=1e-47, Organism=Homo sapiens, GI24497585, Length=300, Percent_Identity=36, Blast_Score=179, Evalue=3e-45, Organism=Homo sapiens, GI310109922, Length=282, Percent_Identity=36.8794326241135, Blast_Score=178, Evalue=4e-45, Organism=Homo sapiens, GI310109920, Length=302, Percent_Identity=35.7615894039735, Blast_Score=178, Evalue=5e-45, Organism=Homo sapiens, GI45446745, Length=302, Percent_Identity=35.7615894039735, Blast_Score=178, Evalue=5e-45, Organism=Homo sapiens, GI4503285, Length=302, Percent_Identity=35.7615894039735, Blast_Score=178, Evalue=5e-45, Organism=Homo sapiens, GI5453543, Length=303, Percent_Identity=35.3135313531353, Blast_Score=177, Evalue=1e-44, Organism=Homo sapiens, GI93277124, Length=307, Percent_Identity=34.5276872964169, Blast_Score=176, Evalue=3e-44, Organism=Homo sapiens, GI24497583, Length=297, Percent_Identity=35.016835016835, Blast_Score=173, Evalue=1e-43, Organism=Homo sapiens, GI5174695, Length=301, Percent_Identity=32.2259136212625, Blast_Score=159, Evalue=4e-39, Organism=Homo sapiens, GI291291012, Length=274, Percent_Identity=33.5766423357664, Blast_Score=152, Evalue=2e-37, Organism=Homo sapiens, GI300116273, Length=280, Percent_Identity=32.5, Blast_Score=144, Evalue=1e-34, Organism=Homo sapiens, GI300116271, Length=276, Percent_Identity=30.4347826086957, Blast_Score=130, Evalue=9e-31, Organism=Homo sapiens, GI310109924, Length=158, Percent_Identity=36.7088607594937, Blast_Score=102, Evalue=6e-22, Organism=Homo sapiens, GI207028673, Length=114, Percent_Identity=39.4736842105263, Blast_Score=86, Evalue=5e-17, Organism=Homo sapiens, GI310109926, Length=114, Percent_Identity=39.4736842105263, Blast_Score=85, Evalue=6e-17, Organism=Escherichia coli, GI87082198, Length=269, Percent_Identity=43.8661710037175, Blast_Score=223, Evalue=8e-60, Organism=Escherichia coli, GI1786400, Length=266, Percent_Identity=36.0902255639098, Blast_Score=169, Evalue=2e-43, Organism=Escherichia coli, GI1788081, Length=273, Percent_Identity=37.3626373626374, Blast_Score=141, Evalue=6e-35, Organism=Escherichia coli, GI1788070, Length=210, Percent_Identity=30.4761904761905, Blast_Score=72, Evalue=4e-14, Organism=Escherichia coli, GI1789375, Length=213, Percent_Identity=29.5774647887324, Blast_Score=72, Evalue=4e-14, Organism=Escherichia coli, GI87081735, Length=183, Percent_Identity=30.0546448087432, Blast_Score=64, Evalue=8e-12, Organism=Caenorhabditis elegans, GI71998625, Length=272, Percent_Identity=39.7058823529412, Blast_Score=205, Evalue=2e-53, Organism=Caenorhabditis elegans, GI17550248, Length=286, Percent_Identity=35.6643356643357, Blast_Score=179, Evalue=1e-45, Organism=Caenorhabditis elegans, GI17537075, Length=300, Percent_Identity=35.3333333333333, Blast_Score=176, Evalue=1e-44, Organism=Caenorhabditis elegans, GI17537077, Length=294, Percent_Identity=34.6938775510204, Blast_Score=176, Evalue=1e-44, Organism=Caenorhabditis elegans, GI17564128, Length=298, Percent_Identity=34.5637583892617, Blast_Score=175, Evalue=2e-44, Organism=Caenorhabditis elegans, GI17552492, Length=273, Percent_Identity=33.3333333333333, Blast_Score=174, Evalue=3e-44, Organism=Caenorhabditis elegans, GI17561298, Length=273, Percent_Identity=34.7985347985348, Blast_Score=167, Evalue=7e-42, Organism=Caenorhabditis elegans, GI17537079, Length=302, Percent_Identity=31.7880794701987, Blast_Score=158, Evalue=3e-39, Organism=Caenorhabditis elegans, GI17566692, Length=285, Percent_Identity=31.9298245614035, Blast_Score=152, Evalue=2e-37, Organism=Caenorhabditis elegans, GI17538386, Length=274, Percent_Identity=33.5766423357664, Blast_Score=152, Evalue=2e-37, Organism=Caenorhabditis elegans, GI17561300, Length=253, Percent_Identity=32.0158102766798, Blast_Score=143, Evalue=1e-34, Organism=Caenorhabditis elegans, GI17562292, Length=278, Percent_Identity=30.2158273381295, Blast_Score=134, Evalue=6e-32, Organism=Saccharomyces cerevisiae, GI6324694, Length=287, Percent_Identity=41.1149825783972, Blast_Score=212, Evalue=6e-56, Organism=Saccharomyces cerevisiae, GI6322556, Length=277, Percent_Identity=40.072202166065, Blast_Score=206, Evalue=3e-54, Organism=Saccharomyces cerevisiae, GI6320576, Length=299, Percent_Identity=38.1270903010033, Blast_Score=192, Evalue=5e-50, Organism=Saccharomyces cerevisiae, GI6321896, Length=317, Percent_Identity=31.8611987381703, Blast_Score=154, Evalue=2e-38, Organism=Saccharomyces cerevisiae, GI6319625, Length=304, Percent_Identity=34.5394736842105, Blast_Score=145, Evalue=8e-36, Organism=Saccharomyces cerevisiae, GI6320079, Length=278, Percent_Identity=30.5755395683453, Blast_Score=128, Evalue=8e-31, Organism=Drosophila melanogaster, GI24662789, Length=289, Percent_Identity=39.4463667820069, Blast_Score=201, Evalue=6e-52, Organism=Drosophila melanogaster, GI24657054, Length=288, Percent_Identity=39.2361111111111, Blast_Score=191, Evalue=3e-49, Organism=Drosophila melanogaster, GI20129731, Length=288, Percent_Identity=39.9305555555556, Blast_Score=181, Evalue=5e-46, Organism=Drosophila melanogaster, GI24663317, Length=293, Percent_Identity=36.1774744027304, Blast_Score=178, Evalue=3e-45, Organism=Drosophila melanogaster, GI21356425, Length=291, Percent_Identity=36.426116838488, Blast_Score=178, Evalue=4e-45, Organism=Drosophila melanogaster, GI24662781, Length=279, Percent_Identity=38.3512544802867, Blast_Score=175, Evalue=3e-44, Organism=Drosophila melanogaster, GI45553081, Length=292, Percent_Identity=36.3013698630137, Blast_Score=173, Evalue=1e-43, Organism=Drosophila melanogaster, GI24662785, Length=273, Percent_Identity=38.0952380952381, Blast_Score=170, Evalue=8e-43, Organism=Drosophila melanogaster, GI24644950, Length=303, Percent_Identity=35.973597359736, Blast_Score=169, Evalue=1e-42, Organism=Drosophila melanogaster, GI221378297, Length=323, Percent_Identity=33.1269349845201, Blast_Score=161, Evalue=5e-40, Organism=Drosophila melanogaster, GI281366140, Length=257, Percent_Identity=35.408560311284, Blast_Score=150, Evalue=6e-37,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR001395 - InterPro: IPR018170 - InterPro: IPR020471 - InterPro: IPR023210 [H]
Pfam domain/function: PF00248 Aldo_ket_red [H]
EC number: =1.1.1.283 [H]
Molecular weight: Translated: 30981; Mature: 30849
Theoretical pI: Translated: 6.68; Mature: 6.68
Prosite motif: PS00798 ALDOKETO_REDUCTASE_1 ; PS00062 ALDOKETO_REDUCTASE_2 ; PS00063 ALDOKETO_REDUCTASE_3
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.7 %Cys (Translated Protein) 1.4 %Met (Translated Protein) 2.2 %Cys+Met (Translated Protein) 0.7 %Cys (Mature Protein) 1.1 %Met (Mature Protein) 1.8 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MAGAWTIRSTVELRGGVRMPILGLGVWQSPPGDETRNAVLAALRLGYRLVDTARAYRNEE CCCCEEHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHH DVGAAIRESGVPRDEVFVTTKLWNSDHGYDSTLRACDESLRRLGLDRLDLYLVHWPVPKL HHHHHHHHCCCCCHHEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHH RGETWRAMERILAEGKARAIGVSNYTIRHLDELLASANEPPSVNQVELHPFLVQRGLVDH CCHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHH CQANGIQVEAYGPLVRGHKMENPVLQRIAHRVERTPAQVLIRWGIEHGLVTIPKSVHEHR HCCCCEEEEECCCHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCEEECCHHHHHHH IRENADVFGFSLSPADLAALDALDEGYRTSWDPTDAP HHCCCCEEEEECCHHHHHHHHHHHCCCCCCCCCCCCC >Mature Secondary Structure AGAWTIRSTVELRGGVRMPILGLGVWQSPPGDETRNAVLAALRLGYRLVDTARAYRNEE CCCEEHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHH DVGAAIRESGVPRDEVFVTTKLWNSDHGYDSTLRACDESLRRLGLDRLDLYLVHWPVPKL HHHHHHHHCCCCCHHEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHH RGETWRAMERILAEGKARAIGVSNYTIRHLDELLASANEPPSVNQVELHPFLVQRGLVDH CCHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHH CQANGIQVEAYGPLVRGHKMENPVLQRIAHRVERTPAQVLIRWGIEHGLVTIPKSVHEHR HCCCCEEEEECCCHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCEEECCHHHHHHH IRENADVFGFSLSPADLAALDALDEGYRTSWDPTDAP HHCCCCEEEEECCHHHHHHHHHHHCCCCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 9639930; 9384377 [H]