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The map label for this gene is aceE [H]

Identifier: 220916931

GI number: 220916931

Start: 2041611

End: 2044268

Strand: Reverse

Name: aceE [H]

Synonym: A2cp1_1827

Alternate gene names: 220916931

Gene position: 2044268-2041611 (Counterclockwise)

Preceding gene: 220916935

Following gene: 220916930

Centisome position: 40.65

GC content: 69.9

Gene sequence:

>2658_bases
ATGGACAAGCTCCCCGACCTCGATCCGCAGGAGACGCGCGAGTGGCTGGACGCCCTCGAGGGCGTGCTCCAGCGCGAGGG
CACGGACCGCGCGCACTTCCTCATCGAGCAGCTCATCGACCGCGCCCGCCGCTCCGGCGCGTACCTGCCGTTCTCGGCCA
ACACCGCCTACGTGAACACCATCCCGGTGGAGAAGCAGCCGCGCTACCCGGGCGACTTCGCCATCGAGCAGACCATCCGC
CACTACCTCCGCTGGAACGCGATGGCGATGGTGGTGCGGGCGAACAAGCACACCAACGTCGGCGGCCACATCGCCAGCTT
CGCCTCGGCCGCGACGCTCTACGACGTCGGCTACAACCACTTCTGGCGGGCCTGGACCCCGGACCGCGGCGGCGACCTCG
TCTACATCCAGGGCCACTCCGCGCCCGGCATCTACGCGCGCGCGTTCCTGCTCGGCCTGCTCAGCGAGGAGCAGCTCCAG
AACTTCCGCCAGGAGGTGGACGGCAAGGGCCTGTCCTCGTACCCGCACCCCTGGCTCATGCCGGACTTCTGGCAGTTCCC
CACCGTGTCGATGGGCCTCGGGCCGCACATGGCCATCTACCAGGCCCGCTTCATGCGGTACCTGCACGACCGCGGCATCG
CCGACACCGCCGACCGCAAGGTCTGGGCGTTCTGCGGCGACGGCGAGATGGACGAGCCGGAGGCCATGGGCGCCATCGAC
CGCGCCGGCCGCGAGAAGCTCGACAACCTCATCTTCGTGGTGAACTGCAACCTGCAGCGGCTCGACGGGCCGGTCCGCGG
CAACGGCAAGATCATCCAGGAGCTGGAGGGCACGTTCCGCGGCGCCGGCTGGAACGTCATCAAGGTGATCTGGGGCCGCC
ACTGGGATCCGCTGTTCGCGAAGGACTCGGAGGGGATCCTGCGCCGCCGGATGATGGAGGTGGTGGACGGCGAGTACCAG
CTCTACAAGTCGCGCAACGGCGCGTTCGTCCGCGAGCACTTCTTCAACTCGCCCGAGCTGAAGGCCATGGTCTCCGAGCT
GTCCGACGAGGACGTCTGGCGGCTGAACCGCGGCGGGCACGATCCGTTCAAGGTCTACGCGGCCTACGACGCGGCGGTGA
AGCACACCGGCCAGCCCACCGTGATCCTCGCGAAGACCATCAAGGGCTACGGCATGGGCGAGGCCGGCGAGGCCATGAAC
ATCGCGCACCAGCAGAAGAAGATCGCGGTGGACGCCATCCGGCGCTTCCGCGACCGCTTCGACCTGCCGGTGCCGGACGA
CCAGCTCGAGAAGGTGCCGTTCCTGAAGCTGCCGGAGGGCTCGAAGGAGCTCGAGTACCTGAAGGCGCGCCGGCAGGACC
TCGGCGGCGACCGGCCGCGGCGCCGCGCCAAGGCGAAGCCGCTGGAGGTACCGCCGCTCTCCGCGTTCGACCGGCTCCTG
AAGAGCAGCGAGGACCGCGAGCTGTCCACCACCATGGCGCTCGTGCAGATCATGACGCTCCTCGCGCGCGACAAGGCCAT
CGGGAAGCGCGTGGTGCCCATCGTGCCGGACGAGGGGCGCACGTTCGGCATGGAGGGCATGTACCGGCAGCTCGGGATCT
GGAGCCACGTCGGCCAGCTCTACACGCCCGAGGACGCGGACAAGCTCGCCTACTACCGCGAGGACAAGCAGGGGCAGGTG
CTGCAGGAGGGCATCACCGAGGCCGGCGCGATGTGCGACTGGATCGCCGCCGCGTCCGCGTACGCCACGCACGGCGAGCC
GATGATCCCGTTCTACCTGTTCTATTCGATGTTCGGCTTCCAGCGCGTCGGCGACTTCGCCTGGGCGGCCGGCGACATGC
GCTGCCGCGGCTTCCTCGTCGGCGGCACCTCCGGGCGCACCACGCTGAACGGCGAGGGGCTCCAGCACGAGGACGGGCAC
TCGCACGTGCTCTCGTCGGTGATCCCGAACTGCCGCTCCTACGATCCGACGTTCTCGTACGAGGTGGCGGTGATCGTGCA
CGACGGCCTGCGCCGCATGCTGGCGGAGCAGGAGGACGCGTACTGGTACGTCACCGTCCTCAACGAGAACTACGCGCACC
CGGGCATGCCGGAGGGCGCGGAGCAGGACATCGTGAAGGGCATGTACCTGTTCAAGCAGGGCGCGAAGGCGAAGGGCAAG
GCGCCGCGGGTGCAGCTCCTCGGCTCCGGGGCCATCCTCCGCGAGGTGATCGCCGCGGCCGACCTGCTGAAGAGCCAGTG
GGGCGTGGACGCGGACGTGTGGAGCTGCCCGAGCTTCACCGAGCTGGCGCGCGACGGCATGGCGGTGTCGCGCCACAACC
GGCTCCACCCCGAGGACGCGCCCCGCCGCTCGCACGTGGAGACCTGCCTCGGCGGCACGCAGGGGCCGGTCGTCGCCGCG
ACCGACTACGTCCGCACCTTCGCCGAGCAGATCCGCCCGTGGGTGCCGCGCGCCTACCACGTGCTCGGCACCGACGGCTT
CGGCCGCTCCGACACGCGCGAGAAGCTGCGCGGCTTCTTCGAGGTGGACCGGCACCACGTGGCGATCGCCGCGCTGAAGG
CGCTCGCCGACGAGGGCACCGTGCCCGCCGCGAAGGTCGCCGAGGCGCTGAAGAAGTACGGCATCGACCCCGCGAAGCCC
GCCCCCTGGACCGTCTAG

Upstream 100 bases:

>100_bases
GCGCGCCGGTGCGCACCGTCCTCTCGGGGTCCAAGGGTTCGTTTGAATCCGGGACCCCTCCCCAGTAGGAGTAGCGCGCA
ACCAACGCCCAGGGACCGAC

Downstream 100 bases:

>100_bases
ACCGCGAGAACGAGGACATGCGCACCATCGAGGTCAAGGTCCCGAACATCGGCGACTACAAGGACGTCCCGGTCATCGAC
GTGCTGGTGAAGCCCGGCGA

Product: pyruvate dehydrogenase subunit E1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 885; Mature: 885

Protein sequence:

>885_residues
MDKLPDLDPQETREWLDALEGVLQREGTDRAHFLIEQLIDRARRSGAYLPFSANTAYVNTIPVEKQPRYPGDFAIEQTIR
HYLRWNAMAMVVRANKHTNVGGHIASFASAATLYDVGYNHFWRAWTPDRGGDLVYIQGHSAPGIYARAFLLGLLSEEQLQ
NFRQEVDGKGLSSYPHPWLMPDFWQFPTVSMGLGPHMAIYQARFMRYLHDRGIADTADRKVWAFCGDGEMDEPEAMGAID
RAGREKLDNLIFVVNCNLQRLDGPVRGNGKIIQELEGTFRGAGWNVIKVIWGRHWDPLFAKDSEGILRRRMMEVVDGEYQ
LYKSRNGAFVREHFFNSPELKAMVSELSDEDVWRLNRGGHDPFKVYAAYDAAVKHTGQPTVILAKTIKGYGMGEAGEAMN
IAHQQKKIAVDAIRRFRDRFDLPVPDDQLEKVPFLKLPEGSKELEYLKARRQDLGGDRPRRRAKAKPLEVPPLSAFDRLL
KSSEDRELSTTMALVQIMTLLARDKAIGKRVVPIVPDEGRTFGMEGMYRQLGIWSHVGQLYTPEDADKLAYYREDKQGQV
LQEGITEAGAMCDWIAAASAYATHGEPMIPFYLFYSMFGFQRVGDFAWAAGDMRCRGFLVGGTSGRTTLNGEGLQHEDGH
SHVLSSVIPNCRSYDPTFSYEVAVIVHDGLRRMLAEQEDAYWYVTVLNENYAHPGMPEGAEQDIVKGMYLFKQGAKAKGK
APRVQLLGSGAILREVIAAADLLKSQWGVDADVWSCPSFTELARDGMAVSRHNRLHPEDAPRRSHVETCLGGTQGPVVAA
TDYVRTFAEQIRPWVPRAYHVLGTDGFGRSDTREKLRGFFEVDRHHVAIAALKALADEGTVPAAKVAEALKKYGIDPAKP
APWTV

Sequences:

>Translated_885_residues
MDKLPDLDPQETREWLDALEGVLQREGTDRAHFLIEQLIDRARRSGAYLPFSANTAYVNTIPVEKQPRYPGDFAIEQTIR
HYLRWNAMAMVVRANKHTNVGGHIASFASAATLYDVGYNHFWRAWTPDRGGDLVYIQGHSAPGIYARAFLLGLLSEEQLQ
NFRQEVDGKGLSSYPHPWLMPDFWQFPTVSMGLGPHMAIYQARFMRYLHDRGIADTADRKVWAFCGDGEMDEPEAMGAID
RAGREKLDNLIFVVNCNLQRLDGPVRGNGKIIQELEGTFRGAGWNVIKVIWGRHWDPLFAKDSEGILRRRMMEVVDGEYQ
LYKSRNGAFVREHFFNSPELKAMVSELSDEDVWRLNRGGHDPFKVYAAYDAAVKHTGQPTVILAKTIKGYGMGEAGEAMN
IAHQQKKIAVDAIRRFRDRFDLPVPDDQLEKVPFLKLPEGSKELEYLKARRQDLGGDRPRRRAKAKPLEVPPLSAFDRLL
KSSEDRELSTTMALVQIMTLLARDKAIGKRVVPIVPDEGRTFGMEGMYRQLGIWSHVGQLYTPEDADKLAYYREDKQGQV
LQEGITEAGAMCDWIAAASAYATHGEPMIPFYLFYSMFGFQRVGDFAWAAGDMRCRGFLVGGTSGRTTLNGEGLQHEDGH
SHVLSSVIPNCRSYDPTFSYEVAVIVHDGLRRMLAEQEDAYWYVTVLNENYAHPGMPEGAEQDIVKGMYLFKQGAKAKGK
APRVQLLGSGAILREVIAAADLLKSQWGVDADVWSCPSFTELARDGMAVSRHNRLHPEDAPRRSHVETCLGGTQGPVVAA
TDYVRTFAEQIRPWVPRAYHVLGTDGFGRSDTREKLRGFFEVDRHHVAIAALKALADEGTVPAAKVAEALKKYGIDPAKP
APWTV
>Mature_885_residues
MDKLPDLDPQETREWLDALEGVLQREGTDRAHFLIEQLIDRARRSGAYLPFSANTAYVNTIPVEKQPRYPGDFAIEQTIR
HYLRWNAMAMVVRANKHTNVGGHIASFASAATLYDVGYNHFWRAWTPDRGGDLVYIQGHSAPGIYARAFLLGLLSEEQLQ
NFRQEVDGKGLSSYPHPWLMPDFWQFPTVSMGLGPHMAIYQARFMRYLHDRGIADTADRKVWAFCGDGEMDEPEAMGAID
RAGREKLDNLIFVVNCNLQRLDGPVRGNGKIIQELEGTFRGAGWNVIKVIWGRHWDPLFAKDSEGILRRRMMEVVDGEYQ
LYKSRNGAFVREHFFNSPELKAMVSELSDEDVWRLNRGGHDPFKVYAAYDAAVKHTGQPTVILAKTIKGYGMGEAGEAMN
IAHQQKKIAVDAIRRFRDRFDLPVPDDQLEKVPFLKLPEGSKELEYLKARRQDLGGDRPRRRAKAKPLEVPPLSAFDRLL
KSSEDRELSTTMALVQIMTLLARDKAIGKRVVPIVPDEGRTFGMEGMYRQLGIWSHVGQLYTPEDADKLAYYREDKQGQV
LQEGITEAGAMCDWIAAASAYATHGEPMIPFYLFYSMFGFQRVGDFAWAAGDMRCRGFLVGGTSGRTTLNGEGLQHEDGH
SHVLSSVIPNCRSYDPTFSYEVAVIVHDGLRRMLAEQEDAYWYVTVLNENYAHPGMPEGAEQDIVKGMYLFKQGAKAKGK
APRVQLLGSGAILREVIAAADLLKSQWGVDADVWSCPSFTELARDGMAVSRHNRLHPEDAPRRSHVETCLGGTQGPVVAA
TDYVRTFAEQIRPWVPRAYHVLGTDGFGRSDTREKLRGFFEVDRHHVAIAALKALADEGTVPAAKVAEALKKYGIDPAKP
APWTV

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG2609

COG function: function code C; Pyruvate dehydrogenase complex, dehydrogenase (E1) component

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786304, Length=883, Percent_Identity=58.3238958097395, Blast_Score=1065, Evalue=0.0,

Paralogues:

None

Copy number: 1140 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 400 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004660
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005474 [H]

Pfam domain/function: PF00456 Transketolase_N [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 99376; Mature: 99376

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKLPDLDPQETREWLDALEGVLQREGTDRAHFLIEQLIDRARRSGAYLPFSANTAYVNT
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEECCCCEEEEE
IPVEKQPRYPGDFAIEQTIRHYLRWNAMAMVVRANKHTNVGGHIASFASAATLYDVGYNH
ECCCCCCCCCCCHHHHHHHHHHHHHHHEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCC
FWRAWTPDRGGDLVYIQGHSAPGIYARAFLLGLLSEEQLQNFRQEVDGKGLSSYPHPWLM
CEECCCCCCCCCEEEEECCCCCCHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCCCC
PDFWQFPTVSMGLGPHMAIYQARFMRYLHDRGIADTADRKVWAFCGDGEMDEPEAMGAID
CCCCCCCCEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCHHHHHHHH
RAGREKLDNLIFVVNCNLQRLDGPVRGNGKIIQELEGTFRGAGWNVIKVIWGRHWDPLFA
HHHHHHHCCEEEEEECCHHHCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCC
KDSEGILRRRMMEVVDGEYQLYKSRNGAFVREHFFNSPELKAMVSELSDEDVWRLNRGGH
CCCHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHCCCHHHHHHHHHCCCCCHHHHCCCCC
DPFKVYAAYDAAVKHTGQPTVILAKTIKGYGMGEAGEAMNIAHQQKKIAVDAIRRFRDRF
CCEEEEEEHHHHHHCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
DLPVPDDQLEKVPFLKLPEGSKELEYLKARRQDLGGDRPRRRAKAKPLEVPPLSAFDRLL
CCCCCCHHHHCCCEEECCCCCHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCHHHHHHHH
KSSEDRELSTTMALVQIMTLLARDKAIGKRVVPIVPDEGRTFGMEGMYRQLGIWSHVGQL
HCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCEECHHHHHHHHHHHHHHCCC
YTPEDADKLAYYREDKQGQVLQEGITEAGAMCDWIAAASAYATHGEPMIPFYLFYSMFGF
CCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
QRVGDFAWAAGDMRCRGFLVGGTSGRTTLNGEGLQHEDGHSHVLSSVIPNCRSYDPTFSY
HHHHHHHHCCCCCEEEEEEEECCCCCEEECCCCCCCCCCHHHHHHHHCCCCCCCCCCCCE
EVAVIVHDGLRRMLAEQEDAYWYVTVLNENYAHPGMPEGAEQDIVKGMYLFKQGAKAKGK
EEEEEEHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCC
APRVQLLGSGAILREVIAAADLLKSQWGVDADVWSCPSFTELARDGMAVSRHNRLHPEDA
CCEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCEEHHCCCCCCCCC
PRRSHVETCLGGTQGPVVAATDYVRTFAEQIRPWVPRAYHVLGTDGFGRSDTREKLRGFF
CCHHHHHHHHCCCCCCEEEHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHHH
EVDRHHVAIAALKALADEGTVPAAKVAEALKKYGIDPAKPAPWTV
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MDKLPDLDPQETREWLDALEGVLQREGTDRAHFLIEQLIDRARRSGAYLPFSANTAYVNT
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEECCCCEEEEE
IPVEKQPRYPGDFAIEQTIRHYLRWNAMAMVVRANKHTNVGGHIASFASAATLYDVGYNH
ECCCCCCCCCCCHHHHHHHHHHHHHHHEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCC
FWRAWTPDRGGDLVYIQGHSAPGIYARAFLLGLLSEEQLQNFRQEVDGKGLSSYPHPWLM
CEECCCCCCCCCEEEEECCCCCCHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCCCC
PDFWQFPTVSMGLGPHMAIYQARFMRYLHDRGIADTADRKVWAFCGDGEMDEPEAMGAID
CCCCCCCCEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCHHHHHHHH
RAGREKLDNLIFVVNCNLQRLDGPVRGNGKIIQELEGTFRGAGWNVIKVIWGRHWDPLFA
HHHHHHHCCEEEEEECCHHHCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCC
KDSEGILRRRMMEVVDGEYQLYKSRNGAFVREHFFNSPELKAMVSELSDEDVWRLNRGGH
CCCHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHCCCHHHHHHHHHCCCCCHHHHCCCCC
DPFKVYAAYDAAVKHTGQPTVILAKTIKGYGMGEAGEAMNIAHQQKKIAVDAIRRFRDRF
CCEEEEEEHHHHHHCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
DLPVPDDQLEKVPFLKLPEGSKELEYLKARRQDLGGDRPRRRAKAKPLEVPPLSAFDRLL
CCCCCCHHHHCCCEEECCCCCHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCHHHHHHHH
KSSEDRELSTTMALVQIMTLLARDKAIGKRVVPIVPDEGRTFGMEGMYRQLGIWSHVGQL
HCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCEECHHHHHHHHHHHHHHCCC
YTPEDADKLAYYREDKQGQVLQEGITEAGAMCDWIAAASAYATHGEPMIPFYLFYSMFGF
CCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
QRVGDFAWAAGDMRCRGFLVGGTSGRTTLNGEGLQHEDGHSHVLSSVIPNCRSYDPTFSY
HHHHHHHHCCCCCEEEEEEEECCCCCEEECCCCCCCCCCHHHHHHHHCCCCCCCCCCCCE
EVAVIVHDGLRRMLAEQEDAYWYVTVLNENYAHPGMPEGAEQDIVKGMYLFKQGAKAKGK
EEEEEEHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCC
APRVQLLGSGAILREVIAAADLLKSQWGVDADVWSCPSFTELARDGMAVSRHNRLHPEDA
CCEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCEEHHCCCCCCCCC
PRRSHVETCLGGTQGPVVAATDYVRTFAEQIRPWVPRAYHVLGTDGFGRSDTREKLRGFF
CCHHHHHHHHCCCCCCEEEHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHHH
EVDRHHVAIAALKALADEGTVPAAKVAEALKKYGIDPAKPAPWTV
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8021225 [H]