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The map label for this gene is dmsA [H]

Identifier: 220916751

GI number: 220916751

Start: 1838138

End: 1840561

Strand: Reverse

Name: dmsA [H]

Synonym: A2cp1_1646

Alternate gene names: 220916751

Gene position: 1840561-1838138 (Counterclockwise)

Preceding gene: 220916752

Following gene: 220916750

Centisome position: 36.6

GC content: 73.35

Gene sequence:

>2424_bases
ATGCCGGCCGCCAAGGCGACCTCGGAGCGCATCCCCATATACTGCGCGCTGTGCGTCTCGCGCTGCGGCGCCATCGCGAC
GATCGAGGATGGCCGGTTCGTCCGGCTCGATCCCGACCCGTCACATCCCACCGGCCAGGCGCTCTGCGCGAAGGGCCGGG
CGGGGCCGGAGCTCGTCTACCACCCTGGCCGTCTCGAGTTCCCGTTGCTGCGCACGCGCCCGAAGGGCGATCCCGAACCC
GGCTGGAAGCGGATCGGCTGGGACGAAGCGCTGTCGATCACCGCGTCGCGGCTCCGCCAGCTCGCCACGGAGTCCGGGCC
CGAGAGCGTCGCGTTCAGCCTGGTGTCACCGTCCACCTCGGCCTCGGACGACTCGATGGCCTGGGTCGAGCGGCTGACGC
GCACGTTCGGCAGCCCGAACCTCGTCGTCGCCATGGAGCTGTGCGGCTGGGGACGGCACTTCGCGACGACGTTCACCTTC
GGTGCGCCGGTTCCCGGACGCTACCTGCCCGACCTCGAGCACGCCGGCTGCATCCTGTTCTGGGGCTACAACCCCAACCA
CGCGCGGCTCGCCCACGCGACCGCCACGATCGCCGCGCAGAAGCGCGGGGCGCGCCTCGTCGTGGTCGATCCCCGGCGCA
CCGAGCCCGCCCGGCGCGCCGACGCGTGGCTGCGGGTGCGCCCGGGGACGGACGGCGCGCTCGCGCTCGGGATCGCCGGC
GTGATGATCGAGCGCGGGTGGTTCGACGAGCCGTTCGTGCGTGAGTGGACGAACGGCCCGCTGCTCGTCCGCTCCGACAC
GGGCCGCCTCCTGACGGGCGCGGACCTCGAGGGCGGCGACCCGGGATCCTTCGTGGCCTGGGACCGGACCTCTGACCGCC
CCGTGCTCTACGACCCCCGGTGCGTGCGGTACGAGACCGGCGCGGTCGACCTCGCCCTGTTCGGCGAGCACACGCTGGAG
ACGCCGAAGGGAAGCGTGCACTGCCAGACCGCCTTCGAGCTCGCCGCCGCGCGCTGCCGGGCGTACTCGCCGGAGCGCGT
GGAGGCGATCACCGGCGTCCCGCGGGGCGAGGTCGAGCGCGCCGCGCGGCTCCTGTGGGAGGCGAGGCCCCTCGCCTACT
ACGCGTGGAGCGGGGTCGAGATGCAGACCAGCTCGACGCAGATCGCGCGAGCGATCGCGCAGCTCTCCGTGCTGACGGGC
AGCTTCGATGCACGGGGCGGCAACGTGCTCTTCCCCTCGGTCCCTTCCCCCGCCGTCGGCACCGAGGTGCCACCGCGGCC
GGAGCACTCCGCCGTCGGGCTCGGCGTCGCCGACCGTCCGCTCGGCCCGGCGCGGTGGGGGTTCGCGACCACCGACGAGC
TGTACCGCGCCATCCTCGAACGAAGGCCGTACGCGGTCCGCGGTCTCGTCGGCTTCGGCTCCAACCTCCTGCTGTCGCAC
GGCGACGTCCCGCGCGGGCGCGAGGCGCTCCGCGCGCTCGACTTCTACGTCCACGCGGACCTCTTCATGAACCCCACCGC
GGAGCTCGCCGACCTGGTCCTGCCGGTGGCGAGCGGCTTCGAGCGCGAGGCGCTCAAGCTCGGCTTCGAGGTGAGCCCCG
AGGCGCAGTCGCTCGTGCAGCTGCGGCGGCCCGTGGCCGCGCCCCCTGGCGAGGCGCGCTCCGACACCGAGCTCGTCTTC
GGCCTCGCCGTCGCGCTCGGGCTCGGGGAGCACTTCTGGAACGGGGACGTCGACGCCGCCTATCGCCACCAGCTCGGGCC
CTCGGGGCTCTCGCTCGAGTGGCTGCGCGAGCACCCCGCGGGTGCGCGCGTCGCGCTCGAGACGCGCTACCGCAAGTTCG
CGGAGGAGGCCGGCGGGATCCCGCGAGGCTTCGACACGCCCACGCGCAAGATCGAGCTGTACTCCGAGACGCTGCTCGCC
CACGGCCACCCGCCGCTGCCCGAGTACCAGGAGCCACTCGTCGGTCCGGTCTCCCGCCCCGACCTCGCGGAGCGCTATCC
GCTCGTCCTCACGTGCACGAAGCACACCCTCTTCTGCGAGACCCAGCACCGCGCGCTCCCCAGCCTGCGGCGGAAGGCGA
TGGACCCCGAGGTCGAGCTGCACCCCGCGGCTGCGGCGGAACGCGGCATCGCGACGGGCGACTGGGTCCGCATCGAGACG
CCCGACGGCAGCGTGCGCGCGCGGGCGCGGCTGAACGACACGTTGCAGCCGGACGTGGTCTCCGGGCAGCACGGGTGGTG
GCAGCCGTGCCCGGAGGTTGGAGCACCCGGCTACGATCCGTTCGGCCCTGACGGCGCGAACTTCAACCTCCTGATCGGGA
ACGCCGCGATCGATCCGATCAGCGGGTCCGTGCCTCACCGGGCATATCTCTGTGAGATCCGGCGGATCCAAGAGGTTGTG
GCCGCGGCCTCACGCCGCGCCTAG

Upstream 100 bases:

>100_bases
GCCGGGCCATTGAGCGACCGCACGTCCGTCCCAATCCGTTCGGGGCTCGGGCCCAAGATGGATCGGCCACCGCCGCCATG
GCGCCCCAACGGCACGGAGC

Downstream 100 bases:

>100_bases
AGCCTGGTTTTCGAGGGGGGCGAACCATGGAACACCCGCATGCGATGGAACCCGCGCGAGCGGCTCCGAACGCCGACGCG
GTGGATGCGTTCGGGAACCG

Product: molybdopterin oxidoreductase

Products: Reduced form of N-Oxide compounds [C]

Alternate protein names: DMSO reductase [H]

Number of amino acids: Translated: 807; Mature: 806

Protein sequence:

>807_residues
MPAAKATSERIPIYCALCVSRCGAIATIEDGRFVRLDPDPSHPTGQALCAKGRAGPELVYHPGRLEFPLLRTRPKGDPEP
GWKRIGWDEALSITASRLRQLATESGPESVAFSLVSPSTSASDDSMAWVERLTRTFGSPNLVVAMELCGWGRHFATTFTF
GAPVPGRYLPDLEHAGCILFWGYNPNHARLAHATATIAAQKRGARLVVVDPRRTEPARRADAWLRVRPGTDGALALGIAG
VMIERGWFDEPFVREWTNGPLLVRSDTGRLLTGADLEGGDPGSFVAWDRTSDRPVLYDPRCVRYETGAVDLALFGEHTLE
TPKGSVHCQTAFELAAARCRAYSPERVEAITGVPRGEVERAARLLWEARPLAYYAWSGVEMQTSSTQIARAIAQLSVLTG
SFDARGGNVLFPSVPSPAVGTEVPPRPEHSAVGLGVADRPLGPARWGFATTDELYRAILERRPYAVRGLVGFGSNLLLSH
GDVPRGREALRALDFYVHADLFMNPTAELADLVLPVASGFEREALKLGFEVSPEAQSLVQLRRPVAAPPGEARSDTELVF
GLAVALGLGEHFWNGDVDAAYRHQLGPSGLSLEWLREHPAGARVALETRYRKFAEEAGGIPRGFDTPTRKIELYSETLLA
HGHPPLPEYQEPLVGPVSRPDLAERYPLVLTCTKHTLFCETQHRALPSLRRKAMDPEVELHPAAAAERGIATGDWVRIET
PDGSVRARARLNDTLQPDVVSGQHGWWQPCPEVGAPGYDPFGPDGANFNLLIGNAAIDPISGSVPHRAYLCEIRRIQEVV
AAASRRA

Sequences:

>Translated_807_residues
MPAAKATSERIPIYCALCVSRCGAIATIEDGRFVRLDPDPSHPTGQALCAKGRAGPELVYHPGRLEFPLLRTRPKGDPEP
GWKRIGWDEALSITASRLRQLATESGPESVAFSLVSPSTSASDDSMAWVERLTRTFGSPNLVVAMELCGWGRHFATTFTF
GAPVPGRYLPDLEHAGCILFWGYNPNHARLAHATATIAAQKRGARLVVVDPRRTEPARRADAWLRVRPGTDGALALGIAG
VMIERGWFDEPFVREWTNGPLLVRSDTGRLLTGADLEGGDPGSFVAWDRTSDRPVLYDPRCVRYETGAVDLALFGEHTLE
TPKGSVHCQTAFELAAARCRAYSPERVEAITGVPRGEVERAARLLWEARPLAYYAWSGVEMQTSSTQIARAIAQLSVLTG
SFDARGGNVLFPSVPSPAVGTEVPPRPEHSAVGLGVADRPLGPARWGFATTDELYRAILERRPYAVRGLVGFGSNLLLSH
GDVPRGREALRALDFYVHADLFMNPTAELADLVLPVASGFEREALKLGFEVSPEAQSLVQLRRPVAAPPGEARSDTELVF
GLAVALGLGEHFWNGDVDAAYRHQLGPSGLSLEWLREHPAGARVALETRYRKFAEEAGGIPRGFDTPTRKIELYSETLLA
HGHPPLPEYQEPLVGPVSRPDLAERYPLVLTCTKHTLFCETQHRALPSLRRKAMDPEVELHPAAAAERGIATGDWVRIET
PDGSVRARARLNDTLQPDVVSGQHGWWQPCPEVGAPGYDPFGPDGANFNLLIGNAAIDPISGSVPHRAYLCEIRRIQEVV
AAASRRA
>Mature_806_residues
PAAKATSERIPIYCALCVSRCGAIATIEDGRFVRLDPDPSHPTGQALCAKGRAGPELVYHPGRLEFPLLRTRPKGDPEPG
WKRIGWDEALSITASRLRQLATESGPESVAFSLVSPSTSASDDSMAWVERLTRTFGSPNLVVAMELCGWGRHFATTFTFG
APVPGRYLPDLEHAGCILFWGYNPNHARLAHATATIAAQKRGARLVVVDPRRTEPARRADAWLRVRPGTDGALALGIAGV
MIERGWFDEPFVREWTNGPLLVRSDTGRLLTGADLEGGDPGSFVAWDRTSDRPVLYDPRCVRYETGAVDLALFGEHTLET
PKGSVHCQTAFELAAARCRAYSPERVEAITGVPRGEVERAARLLWEARPLAYYAWSGVEMQTSSTQIARAIAQLSVLTGS
FDARGGNVLFPSVPSPAVGTEVPPRPEHSAVGLGVADRPLGPARWGFATTDELYRAILERRPYAVRGLVGFGSNLLLSHG
DVPRGREALRALDFYVHADLFMNPTAELADLVLPVASGFEREALKLGFEVSPEAQSLVQLRRPVAAPPGEARSDTELVFG
LAVALGLGEHFWNGDVDAAYRHQLGPSGLSLEWLREHPAGARVALETRYRKFAEEAGGIPRGFDTPTRKIELYSETLLAH
GHPPLPEYQEPLVGPVSRPDLAERYPLVLTCTKHTLFCETQHRALPSLRRKAMDPEVELHPAAAAERGIATGDWVRIETP
DGSVRARARLNDTLQPDVVSGQHGWWQPCPEVGAPGYDPFGPDGANFNLLIGNAAIDPISGSVPHRAYLCEIRRIQEVVA
AASRRA

Specific function: Terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds. Allows E.coli to grow anaerobically on Me(2)SO as respiratory oxidant [H]

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI87081797, Length=798, Percent_Identity=25.9398496240602, Blast_Score=180, Evalue=4e-46,
Organism=Escherichia coli, GI1787870, Length=846, Percent_Identity=25.2955082742317, Blast_Score=166, Evalue=8e-42,
Organism=Escherichia coli, GI171474008, Length=839, Percent_Identity=24.7914183551847, Blast_Score=154, Evalue=2e-38,
Organism=Escherichia coli, GI3868721, Length=256, Percent_Identity=25.78125, Blast_Score=102, Evalue=1e-22,
Organism=Escherichia coli, GI3868719, Length=421, Percent_Identity=25.1781472684086, Blast_Score=100, Evalue=7e-22,
Organism=Escherichia coli, GI3868720, Length=421, Percent_Identity=23.9904988123515, Blast_Score=99, Evalue=9e-22,
Organism=Escherichia coli, GI1788534, Length=573, Percent_Identity=22.1640488656195, Blast_Score=87, Evalue=4e-18,
Organism=Escherichia coli, GI1787231, Length=362, Percent_Identity=25.6906077348066, Blast_Score=72, Evalue=2e-13,
Organism=Escherichia coli, GI145693196, Length=302, Percent_Identity=25.1655629139073, Blast_Score=66, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011888
- InterPro:   IPR009010
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006963
- InterPro:   IPR006655
- InterPro:   IPR006311 [H]

Pfam domain/function: PF04879 Molybdop_Fe4S4; PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: 1.8.99.- [C]

Molecular weight: Translated: 87862; Mature: 87731

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAAKATSERIPIYCALCVSRCGAIATIEDGRFVRLDPDPSHPTGQALCAKGRAGPELVY
CCCCCCCCCCCCCHHHHHHHHCCCEEEECCCEEEEECCCCCCCCCHHHHHCCCCCCCEEE
HPGRLEFPLLRTRPKGDPEPGWKRIGWDEALSITASRLRQLATESGPESVAFSLVSPSTS
CCCCCCCCCEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCC
ASDDSMAWVERLTRTFGSPNLVVAMELCGWGRHFATTFTFGAPVPGRYLPDLEHAGCILF
CCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHEEEEECCCCCCCCCCCCCCCCEEEE
WGYNPNHARLAHATATIAAQKRGARLVVVDPRRTEPARRADAWLRVRPGTDGALALGIAG
ECCCCCCCEEHHHHHHHHHHCCCCEEEEECCCCCCCHHHCCCEEEEECCCCCHHHHHHHH
VMIERGWFDEPFVREWTNGPLLVRSDTGRLLTGADLEGGDPGSFVAWDRTSDRPVLYDPR
HHHCCCCCCCCHHHHCCCCCEEEECCCCCEEECCCCCCCCCCCEEEECCCCCCCEEECCE
CVRYETGAVDLALFGEHTLETPKGSVHCQTAFELAAARCRAYSPERVEAITGVPRGEVER
EEEEECCCEEEEEECCCCCCCCCCCEEEHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHH
AARLLWEARPLAYYAWSGVEMQTSSTQIARAIAQLSVLTGSFDARGGNVLFPSVPSPAVG
HHHHHHHCCCCEEEEECCEEEECCHHHHHHHHHHHHHHCCCCCCCCCCEECCCCCCCCCC
TEVPPRPEHSAVGLGVADRPLGPARWGFATTDELYRAILERRPYAVRGLVGFGSNLLLSH
CCCCCCCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCEEEEC
GDVPRGREALRALDFYVHADLFMNPTAELADLVLPVASGFEREALKLGFEVSPEAQSLVQ
CCCCCHHHHHHHHHHHEEEHHHCCCHHHHHHHHHHHHCCCCHHHHHCCCCCCCHHHHHHH
LRRPVAAPPGEARSDTELVFGLAVALGLGEHFWNGDVDAAYRHQLGPSGLSLEWLREHPA
HHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCHHHHHCCCC
GARVALETRYRKFAEEAGGIPRGFDTPTRKIELYSETLLAHGHPPLPEYQEPLVGPVSRP
CCEEEHHHHHHHHHHHHCCCCCCCCCCCCEEEHHHHHHHHCCCCCCCCHHCCCCCCCCCC
DLAERYPLVLTCTKHTLFCETQHRALPSLRRKAMDPEVELHPAAAAERGIATGDWVRIET
CHHHCCCEEEEECCCEEEECCHHHHHHHHHHHHCCCCCEECCCHHHHCCCCCCCEEEEEC
PDGSVRARARLNDTLQPDVVSGQHGWWQPCPEVGAPGYDPFGPDGANFNLLIGNAAIDPI
CCCCEEEEECCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCEEEEEECCCCCCC
SGSVPHRAYLCEIRRIQEVVAAASRRA
CCCCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PAAKATSERIPIYCALCVSRCGAIATIEDGRFVRLDPDPSHPTGQALCAKGRAGPELVY
CCCCCCCCCCCCHHHHHHHHCCCEEEECCCEEEEECCCCCCCCCHHHHHCCCCCCCEEE
HPGRLEFPLLRTRPKGDPEPGWKRIGWDEALSITASRLRQLATESGPESVAFSLVSPSTS
CCCCCCCCCEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCC
ASDDSMAWVERLTRTFGSPNLVVAMELCGWGRHFATTFTFGAPVPGRYLPDLEHAGCILF
CCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHEEEEECCCCCCCCCCCCCCCCEEEE
WGYNPNHARLAHATATIAAQKRGARLVVVDPRRTEPARRADAWLRVRPGTDGALALGIAG
ECCCCCCCEEHHHHHHHHHHCCCCEEEEECCCCCCCHHHCCCEEEEECCCCCHHHHHHHH
VMIERGWFDEPFVREWTNGPLLVRSDTGRLLTGADLEGGDPGSFVAWDRTSDRPVLYDPR
HHHCCCCCCCCHHHHCCCCCEEEECCCCCEEECCCCCCCCCCCEEEECCCCCCCEEECCE
CVRYETGAVDLALFGEHTLETPKGSVHCQTAFELAAARCRAYSPERVEAITGVPRGEVER
EEEEECCCEEEEEECCCCCCCCCCCEEEHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHH
AARLLWEARPLAYYAWSGVEMQTSSTQIARAIAQLSVLTGSFDARGGNVLFPSVPSPAVG
HHHHHHHCCCCEEEEECCEEEECCHHHHHHHHHHHHHHCCCCCCCCCCEECCCCCCCCCC
TEVPPRPEHSAVGLGVADRPLGPARWGFATTDELYRAILERRPYAVRGLVGFGSNLLLSH
CCCCCCCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCEEEEC
GDVPRGREALRALDFYVHADLFMNPTAELADLVLPVASGFEREALKLGFEVSPEAQSLVQ
CCCCCHHHHHHHHHHHEEEHHHCCCHHHHHHHHHHHHCCCCHHHHHCCCCCCCHHHHHHH
LRRPVAAPPGEARSDTELVFGLAVALGLGEHFWNGDVDAAYRHQLGPSGLSLEWLREHPA
HHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCHHHHHCCCC
GARVALETRYRKFAEEAGGIPRGFDTPTRKIELYSETLLAHGHPPLPEYQEPLVGPVSRP
CCEEEHHHHHHHHHHHHCCCCCCCCCCCCEEEHHHHHHHHCCCCCCCCHHCCCCCCCCCC
DLAERYPLVLTCTKHTLFCETQHRALPSLRRKAMDPEVELHPAAAAERGIATGDWVRIET
CHHHCCCEEEEECCCEEEECCHHHHHHHHHHHHCCCCCEECCCHHHHCCCCCCCEEEEEC
PDGSVRARARLNDTLQPDVVSGQHGWWQPCPEVGAPGYDPFGPDGANFNLLIGNAAIDPI
CCCCEEEEECCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCEEEEEECCCCCCC
SGSVPHRAYLCEIRRIQEVVAAASRRA
CCCCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: May Bind 4Fe-4S Cluster. [C]

Metal ions: Fe; Mo [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N-Oxide; Sulfoxide Compounds Including Trimethylamine N-Oxide. [C]

Specific reaction: Reduces Various N-Oxide And Sulfoxide Compounds Including Trimethylamine N-Oxide. [C]

General reaction: Oxidoreductases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3062312; 8905232; 9278503; 2170332; 8125918; 10801884 [H]