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The map label for this gene is bkdA1 [H]

Identifier: 220916623

GI number: 220916623

Start: 1696767

End: 1697999

Strand: Direct

Name: bkdA1 [H]

Synonym: A2cp1_1517

Alternate gene names: 220916623

Gene position: 1696767-1697999 (Clockwise)

Preceding gene: 220916619

Following gene: 220916624

Centisome position: 33.74

GC content: 77.62

Gene sequence:

>1233_bases
GTGCGTTCCACCCTGCGTCCCGACAAGGTCGAGCCCTCCCGCCGCCCGCGCAGCGCTCGCGTCCACGCCGTCCCCGCGCC
GTCGTCGGAGCCCGCCGGGCGGGCCGACGGCGGACTGGCCGCGGACGCCGGGCGAGGGTGGGAGGCGGCGTTCCCGATCT
TCCGCGTGCTCGACGACGACGGCGTGGCGGACCCGCGCCACGCCACCCTCACGCCCGCGGAGGCGCTGGCGCTGCACCGG
CACCTGGTGCGCGCGCGCGCGCTCGACGCGCGGATGACCGCGCTCCAGCGCCAGGGCCGCATCGGCTTCTACGTGGGCGC
GGAGGGTGAGGAGGCGTGTGTGGTGGGCGCGGCCGCCGCGATGGCCCCGCAGGACTGGCTCTTCCCGTGCTACCGCGAGC
ACGCCGCGGCGCTCCTGCGCGGGCTCCCGCTGGACGCGTTCCTCTGCAACCTGTTCGGCAACTCGGGCGATCTCGCCCGC
GGCCGCCAGATGCCGTGCCACGAGACCTGGCGCGCTGGCCACTACGCCTCGGTGAGCGCGCCGCTCGGCACCCAGCTCCC
GCACGCGGTCGGCGCCGCCTGGGCGGCCCGCCTGAAGGGCGAGGACATGGTGTCGCTCACCTGGTTCGGCGACGGCGCCA
CCAGCACGCACGACTTCCACACCGCGCTCGGCTTCGCGGGCGTGCACCGGGTGCCGGTGGTGTTCCTGTGCCGGGCCAAC
GGCTGGGCCATCAGCACGCCCACCGCGATGCAGACGGCCGCCGAGACCATCGCGCAGAAGGGCATCGCCTACGGCGTCCG
CGGCGAGCGGGTGGATGGCAACGACCTGCTCGCGGTGCACGCGGCCACCCGCCGGGCCCGGGCGCGGGCGGCGGCGGGGG
AGGGGCCGACGCTGCTCGAGTGCGTCACCTACCGCGTCGGCCCGCACACCACCTCCGACGACCCGCGCGGCTACCGCGAC
GAGGCCGAGGTGGCGCCCTGGCGCGCGCGGGATCCGATCGAGCGGCTGCGGGTGCACCTGGAGCGGATCGGCGCGCTCGC
GCCGGGCGCGCACGCAGCCCTGCTGCGCGAGGCCGACGAGGAGATCCGCGCCGCGGTGGCGCGCGTCGAGGCGCTCCCGC
CGCCGGCGCGCGAGAGCCTGTTCGACGACGTCTACGCGGAGCCCCTCCGGCAGCAGCGCGAGCAGCGCGACGAGTGCCTG
GCCGCGCCGGCGGGCCCGGCGCGCGATCGCTGA

Upstream 100 bases:

>100_bases
GTCCTCCGGGGGGCGGGCGCGCGAGCATATCAACACACGTGATACTTACATCACCACAATCACTTGGACTTATGCGGCCG
CGCGTCGCTAGGGTCGGACC

Downstream 100 bases:

>100_bases
CGCGGGGGGGGCGCCGGCGCGAGGGACGCGCACCGGGGAAAGGCAGCGCTCCGCGCGGTCCGCCGGTTGCCCGCGCGCCG
CGACTGCCGCATAACCTCCG

Product: Pyruvate dehydrogenase

Products: NA

Alternate protein names: Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain; BCKDH E1-alpha [H]

Number of amino acids: Translated: 410; Mature: 410

Protein sequence:

>410_residues
MRSTLRPDKVEPSRRPRSARVHAVPAPSSEPAGRADGGLAADAGRGWEAAFPIFRVLDDDGVADPRHATLTPAEALALHR
HLVRARALDARMTALQRQGRIGFYVGAEGEEACVVGAAAAMAPQDWLFPCYREHAAALLRGLPLDAFLCNLFGNSGDLAR
GRQMPCHETWRAGHYASVSAPLGTQLPHAVGAAWAARLKGEDMVSLTWFGDGATSTHDFHTALGFAGVHRVPVVFLCRAN
GWAISTPTAMQTAAETIAQKGIAYGVRGERVDGNDLLAVHAATRRARARAAAGEGPTLLECVTYRVGPHTTSDDPRGYRD
EAEVAPWRARDPIERLRVHLERIGALAPGAHAALLREADEEIRAAVARVEALPPPARESLFDDVYAEPLRQQREQRDECL
AAPAGPARDR

Sequences:

>Translated_410_residues
MRSTLRPDKVEPSRRPRSARVHAVPAPSSEPAGRADGGLAADAGRGWEAAFPIFRVLDDDGVADPRHATLTPAEALALHR
HLVRARALDARMTALQRQGRIGFYVGAEGEEACVVGAAAAMAPQDWLFPCYREHAAALLRGLPLDAFLCNLFGNSGDLAR
GRQMPCHETWRAGHYASVSAPLGTQLPHAVGAAWAARLKGEDMVSLTWFGDGATSTHDFHTALGFAGVHRVPVVFLCRAN
GWAISTPTAMQTAAETIAQKGIAYGVRGERVDGNDLLAVHAATRRARARAAAGEGPTLLECVTYRVGPHTTSDDPRGYRD
EAEVAPWRARDPIERLRVHLERIGALAPGAHAALLREADEEIRAAVARVEALPPPARESLFDDVYAEPLRQQREQRDECL
AAPAGPARDR
>Mature_410_residues
MRSTLRPDKVEPSRRPRSARVHAVPAPSSEPAGRADGGLAADAGRGWEAAFPIFRVLDDDGVADPRHATLTPAEALALHR
HLVRARALDARMTALQRQGRIGFYVGAEGEEACVVGAAAAMAPQDWLFPCYREHAAALLRGLPLDAFLCNLFGNSGDLAR
GRQMPCHETWRAGHYASVSAPLGTQLPHAVGAAWAARLKGEDMVSLTWFGDGATSTHDFHTALGFAGVHRVPVVFLCRAN
GWAISTPTAMQTAAETIAQKGIAYGVRGERVDGNDLLAVHAATRRARARAAAGEGPTLLECVTYRVGPHTTSDDPRGYRD
EAEVAPWRARDPIERLRVHLERIGALAPGAHAALLREADEEIRAAVARVEALPPPARESLFDDVYAEPLRQQREQRDECL
AAPAGPARDR

Specific function: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components:branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltran

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the BCKDHA family [H]

Homologues:

Organism=Homo sapiens, GI11386135, Length=352, Percent_Identity=40.625, Blast_Score=260, Evalue=1e-69,
Organism=Homo sapiens, GI258645172, Length=352, Percent_Identity=40.625, Blast_Score=257, Evalue=2e-68,
Organism=Homo sapiens, GI4885543, Length=324, Percent_Identity=30.8641975308642, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI4505685, Length=376, Percent_Identity=30.0531914893617, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI291084742, Length=324, Percent_Identity=31.1728395061728, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI291084744, Length=383, Percent_Identity=29.5039164490862, Blast_Score=132, Evalue=8e-31,
Organism=Homo sapiens, GI291084757, Length=377, Percent_Identity=26.790450928382, Blast_Score=99, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI86563355, Length=355, Percent_Identity=40.2816901408451, Blast_Score=263, Evalue=9e-71,
Organism=Caenorhabditis elegans, GI86563357, Length=355, Percent_Identity=40.2816901408451, Blast_Score=263, Evalue=1e-70,
Organism=Caenorhabditis elegans, GI17536047, Length=357, Percent_Identity=29.9719887955182, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI32564172, Length=357, Percent_Identity=29.9719887955182, Blast_Score=126, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6321026, Length=344, Percent_Identity=30.5232558139535, Blast_Score=150, Evalue=4e-37,
Organism=Drosophila melanogaster, GI21355903, Length=355, Percent_Identity=36.6197183098592, Blast_Score=234, Evalue=6e-62,
Organism=Drosophila melanogaster, GI24639744, Length=322, Percent_Identity=29.1925465838509, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI28571106, Length=322, Percent_Identity=29.1925465838509, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24639740, Length=322, Percent_Identity=29.1925465838509, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24639746, Length=289, Percent_Identity=29.757785467128, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24639748, Length=326, Percent_Identity=27.9141104294479, Blast_Score=108, Evalue=8e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR022593 [H]

Pfam domain/function: PF00676 E1_dh; PF12573 OxoDH_E1alpha_N [H]

EC number: =1.2.4.4 [H]

Molecular weight: Translated: 44171; Mature: 44171

Theoretical pI: Translated: 7.42; Mature: 7.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSTLRPDKVEPSRRPRSARVHAVPAPSSEPAGRADGGLAADAGRGWEAAFPIFRVLDDD
CCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCEECCCCCCCHHHHHHHHEECCC
GVADPRHATLTPAEALALHRHLVRARALDARMTALQRQGRIGFYVGAEGEEACVVGAAAA
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEEHHHH
MAPQDWLFPCYREHAAALLRGLPLDAFLCNLFGNSGDLARGRQMPCHETWRAGHYASVSA
HCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHCCCCCEEECC
PLGTQLPHAVGAAWAARLKGEDMVSLTWFGDGATSTHDFHTALGFAGVHRVPVVFLCRAN
CCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEEECC
GWAISTPTAMQTAAETIAQKGIAYGVRGERVDGNDLLAVHAATRRARARAAAGEGPTLLE
CEEECCCHHHHHHHHHHHHCCCEECCCCCEECCCCEEEEHHHHHHHHHHHCCCCCCHHHH
CVTYRVGPHTTSDDPRGYRDEAEVAPWRARDPIERLRVHLERIGALAPGAHAALLREADE
HHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
EIRAAVARVEALPPPARESLFDDVYAEPLRQQREQRDECLAAPAGPARDR
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MRSTLRPDKVEPSRRPRSARVHAVPAPSSEPAGRADGGLAADAGRGWEAAFPIFRVLDDD
CCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCEECCCCCCCHHHHHHHHEECCC
GVADPRHATLTPAEALALHRHLVRARALDARMTALQRQGRIGFYVGAEGEEACVVGAAAA
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEEHHHH
MAPQDWLFPCYREHAAALLRGLPLDAFLCNLFGNSGDLARGRQMPCHETWRAGHYASVSA
HCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHCCCCCEEECC
PLGTQLPHAVGAAWAARLKGEDMVSLTWFGDGATSTHDFHTALGFAGVHRVPVVFLCRAN
CCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEEECC
GWAISTPTAMQTAAETIAQKGIAYGVRGERVDGNDLLAVHAATRRARARAAAGEGPTLLE
CEEECCCHHHHHHHHHHHHCCCEECCCCCEECCCCEEEEHHHHHHHHHHHCCCCCCHHHH
CVTYRVGPHTTSDDPRGYRDEAEVAPWRARDPIERLRVHLERIGALAPGAHAALLREADE
HHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
EIRAAVARVEALPPPARESLFDDVYAEPLRQQREQRDECLAAPAGPARDR
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]