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The map label for this gene is relA [H]

Identifier: 220916506

GI number: 220916506

Start: 1564901

End: 1567141

Strand: Direct

Name: relA [H]

Synonym: A2cp1_1400

Alternate gene names: 220916506

Gene position: 1564901-1567141 (Clockwise)

Preceding gene: 220916503

Following gene: 220916507

Centisome position: 31.12

GC content: 68.59

Gene sequence:

>2241_bases
ATGATGGGCAGGCTCACAGGCTTGCCGCACTCCGACGCGACCCGTTACGCTGGCCCTTCGACCTTGCTCAGGCTCAACGA
CATCCTGGACCGGGTATCCGGCTACCACCCCGATCCCGATCTCGACCTGATCAAGAAGGCCTACGTCTACAGCGCCAAGG
TCCACCAGGGGCAGATCCGCAAATCGGGCGAGCCGTACCTGGTGCATCCGCTGGAGGTCGCGGGCATCCTCGCCGAGCTG
AAGCTGGACGAGTCGTCGGTGGTGACCGGGCTGCTGCACGACACCATCGAGGACACCCTCGCCACGAAGAAGGAGATCTC
CGAGCTGTTCGGCCCGGAGATCGCCGACCTGGTGGACGGGGTCACCAAGCTCTCGCAGTTCACCGCCGCCAACACCCAGG
AGGAGAAGCAGGCGGAGAACTTCCGCAAGATGGTGGTGGCGATGGCGAAGGACATCCGCGTGCTGCTGGTGAAGCTCGCG
GACCGCACCCACAACATGCGGACGCTCGACGCGATGAAGCCGGAGTCGCAGGAGCGCATCGCCCGCGAGACGCTGGACAT
CTACGCGCCGCTCGCGAACCGGCTCGGCATCCAGTGGATCAAGACCGAGCTGGAGGAGCTGTCGTTCAAGTACCTGCGCC
CGGGCGACTACTCCGAGCTGAACGAGAAGGTCTCGGTGCGCGCCCGCGAGAAGGAGCGGTTCGTCGCGGAGGTGGTGGAG
ATCATCCGCCGCCGGCTGGCCGAGGCCGGCATGCAGGCCGACGTCTCCGGGCGCGTGAAGCACGTCTACTCGATCTACCG
GAAGATGCGGCAGCTCGACGTGGACTTCGAGCAGATCCAGGACGTGGTCGGGTTCCGCGTCATCGTGGACACGGTGGCGG
AGTGCTACGAGTCGCTCGGGTTCGTGCACTCGCTGTGGAAGCCGGTGCCGGGCCGCTTCAAGGACTACATCGCCATCCCG
AAGCCCAACCTGTACCAGTCGCTCCACACCACCGTGGTCGGCCCGGCGGGCGAGCGCATCGAGGTGCAGATCCGCACCCG
CGAGATGCACCGCATCGCCGAGGAGGGCGTGGCGGCGCACTGGGCCTACAAGGAGAAGGGGCGCGACGGGAAGGGCGCGG
AGCTGTCGCGCAAGGACGCGGCGTCGTTCGGCTGGCTCCGCCAGCTGGTGGAGTTCCAGCGCGACCTCGCCGACCCGCGC
GAGTTCCTGGAGACCGTCAAGGTCGACCTGTTCTCCGACGAGGTGTTCGTCTTCACGCCGAAGGGCGCGGTGAAGAGCCT
GCCGCGCGGCGCCACGCCGGTGGACTTCGCCTACACCATCCACTCGGAGATCGGCGAGCACACCGTCGGCGCCAAGGTGA
ACGGCAAGCTCGTCCCGCTCCGCTACACGCTCAAGAACGGCGACACGATCGAGATCCTCACCAGCCCGAACGCGCACCCG
TCCAAGGACTGGCTCACCTTCGTCAAGACCAGCCGCGCCCAGGCCCGCATCCGCCAGTTCATCCGGCAGGCCGAGCACCG
GCGCTCGGTGGAGATCGGGCGCGACATCGCCGAGCGCGAGCTGCGCCGCTTCGGCGTCACGCTCAACAAGCTGCAGAAGG
GCGGCGAGCTGGAGAAGGCGGCGCAGGCGCTCGGGTACCGGGTGGCGGACGACGTGCTCGCCGCGGTCGGCTACGGCAAG
GTGTCGCCGGGGCAGCTCCTGCAGCAGGTGCTCCCGCCCGACCGGCTCGCCGAGCCGCCGCCGCCCGCCGAGGCGGCGCC
CACCAGCCGCATCACCGAGCTGTTCCGGAAGATGGCGCGCCGCCCGACCGAGGGCGTCCGCATCAACGGCATCGACGACG
TGCTGGTCCGCTACGGCAAGTGCTGCAACCCGGTGCCCGGCGACGCCATCGTGGGCTTCATCACCCGCGGGCGCGGCGTG
ACCGTGCACACCGCCTCGTGCGACAAGGTGCTGGGCATCGACCCGGAGCGGCGCGTGGACGTGGCCTGGGACGTGCGCGG
CGACTTCAAGCGCCCGGTCTCGCTGCGGGTCATCACCACCGATCGCCCCGGCATCCTCGCCAAGATCTCGCAGACGTTCA
GCGAGGCCGGCGTGAACATCTCGCAGGCGAGCTGCCGCACCACGCCGGGCGAGCGCGCGGTGAACGACTTCGAGGTCACC
ATCGGCGACCTGAAGCAGCTCAACTCGGTGATCCGCAGCATCGAACGGATCGAGGGCGTGCAGTCGGTCCAGCGCGTCTG
A

Upstream 100 bases:

>100_bases
CTCCCGCCGTCGCCCAGGGGGGACGCCCGCGACCCATCCCGGCGCCCGGTGCGTCCGCGGGTCATGGCACCGGGTGGCGC
GCCGCGTTACGGGATCTGAG

Downstream 100 bases:

>100_bases
GGTGGCCCCCGCCGGCGCGTTGCCGGGGCCGCCGCGCGCGGGTAGGGTGCCGCGCATGAAGACCCCCATCGCGACGGACG
GCGCCCCGAAGGCCATCGGC

Product: (p)ppGpp synthetase I SpoT/RelA

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 746; Mature: 746

Protein sequence:

>746_residues
MMGRLTGLPHSDATRYAGPSTLLRLNDILDRVSGYHPDPDLDLIKKAYVYSAKVHQGQIRKSGEPYLVHPLEVAGILAEL
KLDESSVVTGLLHDTIEDTLATKKEISELFGPEIADLVDGVTKLSQFTAANTQEEKQAENFRKMVVAMAKDIRVLLVKLA
DRTHNMRTLDAMKPESQERIARETLDIYAPLANRLGIQWIKTELEELSFKYLRPGDYSELNEKVSVRAREKERFVAEVVE
IIRRRLAEAGMQADVSGRVKHVYSIYRKMRQLDVDFEQIQDVVGFRVIVDTVAECYESLGFVHSLWKPVPGRFKDYIAIP
KPNLYQSLHTTVVGPAGERIEVQIRTREMHRIAEEGVAAHWAYKEKGRDGKGAELSRKDAASFGWLRQLVEFQRDLADPR
EFLETVKVDLFSDEVFVFTPKGAVKSLPRGATPVDFAYTIHSEIGEHTVGAKVNGKLVPLRYTLKNGDTIEILTSPNAHP
SKDWLTFVKTSRAQARIRQFIRQAEHRRSVEIGRDIAERELRRFGVTLNKLQKGGELEKAAQALGYRVADDVLAAVGYGK
VSPGQLLQQVLPPDRLAEPPPPAEAAPTSRITELFRKMARRPTEGVRINGIDDVLVRYGKCCNPVPGDAIVGFITRGRGV
TVHTASCDKVLGIDPERRVDVAWDVRGDFKRPVSLRVITTDRPGILAKISQTFSEAGVNISQASCRTTPGERAVNDFEVT
IGDLKQLNSVIRSIERIEGVQSVQRV

Sequences:

>Translated_746_residues
MMGRLTGLPHSDATRYAGPSTLLRLNDILDRVSGYHPDPDLDLIKKAYVYSAKVHQGQIRKSGEPYLVHPLEVAGILAEL
KLDESSVVTGLLHDTIEDTLATKKEISELFGPEIADLVDGVTKLSQFTAANTQEEKQAENFRKMVVAMAKDIRVLLVKLA
DRTHNMRTLDAMKPESQERIARETLDIYAPLANRLGIQWIKTELEELSFKYLRPGDYSELNEKVSVRAREKERFVAEVVE
IIRRRLAEAGMQADVSGRVKHVYSIYRKMRQLDVDFEQIQDVVGFRVIVDTVAECYESLGFVHSLWKPVPGRFKDYIAIP
KPNLYQSLHTTVVGPAGERIEVQIRTREMHRIAEEGVAAHWAYKEKGRDGKGAELSRKDAASFGWLRQLVEFQRDLADPR
EFLETVKVDLFSDEVFVFTPKGAVKSLPRGATPVDFAYTIHSEIGEHTVGAKVNGKLVPLRYTLKNGDTIEILTSPNAHP
SKDWLTFVKTSRAQARIRQFIRQAEHRRSVEIGRDIAERELRRFGVTLNKLQKGGELEKAAQALGYRVADDVLAAVGYGK
VSPGQLLQQVLPPDRLAEPPPPAEAAPTSRITELFRKMARRPTEGVRINGIDDVLVRYGKCCNPVPGDAIVGFITRGRGV
TVHTASCDKVLGIDPERRVDVAWDVRGDFKRPVSLRVITTDRPGILAKISQTFSEAGVNISQASCRTTPGERAVNDFEVT
IGDLKQLNSVIRSIERIEGVQSVQRV
>Mature_746_residues
MMGRLTGLPHSDATRYAGPSTLLRLNDILDRVSGYHPDPDLDLIKKAYVYSAKVHQGQIRKSGEPYLVHPLEVAGILAEL
KLDESSVVTGLLHDTIEDTLATKKEISELFGPEIADLVDGVTKLSQFTAANTQEEKQAENFRKMVVAMAKDIRVLLVKLA
DRTHNMRTLDAMKPESQERIARETLDIYAPLANRLGIQWIKTELEELSFKYLRPGDYSELNEKVSVRAREKERFVAEVVE
IIRRRLAEAGMQADVSGRVKHVYSIYRKMRQLDVDFEQIQDVVGFRVIVDTVAECYESLGFVHSLWKPVPGRFKDYIAIP
KPNLYQSLHTTVVGPAGERIEVQIRTREMHRIAEEGVAAHWAYKEKGRDGKGAELSRKDAASFGWLRQLVEFQRDLADPR
EFLETVKVDLFSDEVFVFTPKGAVKSLPRGATPVDFAYTIHSEIGEHTVGAKVNGKLVPLRYTLKNGDTIEILTSPNAHP
SKDWLTFVKTSRAQARIRQFIRQAEHRRSVEIGRDIAERELRRFGVTLNKLQKGGELEKAAQALGYRVADDVLAAVGYGK
VSPGQLLQQVLPPDRLAEPPPPAEAAPTSRITELFRKMARRPTEGVRINGIDDVLVRYGKCCNPVPGDAIVGFITRGRGV
TVHTASCDKVLGIDPERRVDVAWDVRGDFKRPVSLRVITTDRPGILAKISQTFSEAGVNISQASCRTTPGERAVNDFEVT
IGDLKQLNSVIRSIERIEGVQSVQRV

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

Organism=Escherichia coli, GI1790082, Length=716, Percent_Identity=41.2011173184358, Blast_Score=552, Evalue=1e-158,
Organism=Escherichia coli, GI1789147, Length=723, Percent_Identity=34.0248962655602, Blast_Score=448, Evalue=1e-127,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 83529; Mature: 83529

Theoretical pI: Translated: 9.06; Mature: 9.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMGRLTGLPHSDATRYAGPSTLLRLNDILDRVSGYHPDPDLDLIKKAYVYSAKVHQGQIR
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCHHH
KSGEPYLVHPLEVAGILAELKLDESSVVTGLLHDTIEDTLATKKEISELFGPEIADLVDG
CCCCCEEECHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
VTKLSQFTAANTQEEKQAENFRKMVVAMAKDIRVLLVKLADRTHNMRTLDAMKPESQERI
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCHHHHH
ARETLDIYAPLANRLGIQWIKTELEELSFKYLRPGDYSELNEKVSVRAREKERFVAEVVE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
IIRRRLAEAGMQADVSGRVKHVYSIYRKMRQLDVDFEQIQDVVGFRVIVDTVAECYESLG
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
FVHSLWKPVPGRFKDYIAIPKPNLYQSLHTTVVGPAGERIEVQIRTREMHRIAEEGVAAH
HHHHHHCCCCCCCCCEEECCCCHHHHHHHHHEECCCCCEEEEEEEHHHHHHHHHHCHHHH
WAYKEKGRDGKGAELSRKDAASFGWLRQLVEFQRDLADPREFLETVKVDLFSDEVFVFTP
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHEECCCEEEECC
KGAVKSLPRGATPVDFAYTIHSEIGEHTVGAKVNGKLVPLRYTLKNGDTIEILTSPNAHP
CHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCEECCEEEEEEEEECCCCEEEEEECCCCCC
SKDWLTFVKTSRAQARIRQFIRQAEHRRSVEIGRDIAERELRRFGVTLNKLQKGGELEKA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCHHHH
AQALGYRVADDVLAAVGYGKVSPGQLLQQVLPPDRLAEPPPPAEAAPTSRITELFRKMAR
HHHHCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHC
RPTEGVRINGIDDVLVRYGKCCNPVPGDAIVGFITRGRGVTVHTASCDKVLGIDPERRVD
CCCCCEEECCHHHHHHHHCCCCCCCCCHHHHHHEECCCCEEEEECCCCCCCCCCCCCCEE
VAWDVRGDFKRPVSLRVITTDRPGILAKISQTFSEAGVNISQASCRTTPGERAVNDFEVT
EEEECCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCHHHEE
IGDLKQLNSVIRSIERIEGVQSVQRV
HHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MMGRLTGLPHSDATRYAGPSTLLRLNDILDRVSGYHPDPDLDLIKKAYVYSAKVHQGQIR
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCHHH
KSGEPYLVHPLEVAGILAELKLDESSVVTGLLHDTIEDTLATKKEISELFGPEIADLVDG
CCCCCEEECHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
VTKLSQFTAANTQEEKQAENFRKMVVAMAKDIRVLLVKLADRTHNMRTLDAMKPESQERI
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCHHHHH
ARETLDIYAPLANRLGIQWIKTELEELSFKYLRPGDYSELNEKVSVRAREKERFVAEVVE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
IIRRRLAEAGMQADVSGRVKHVYSIYRKMRQLDVDFEQIQDVVGFRVIVDTVAECYESLG
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
FVHSLWKPVPGRFKDYIAIPKPNLYQSLHTTVVGPAGERIEVQIRTREMHRIAEEGVAAH
HHHHHHCCCCCCCCCEEECCCCHHHHHHHHHEECCCCCEEEEEEEHHHHHHHHHHCHHHH
WAYKEKGRDGKGAELSRKDAASFGWLRQLVEFQRDLADPREFLETVKVDLFSDEVFVFTP
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHEECCCEEEECC
KGAVKSLPRGATPVDFAYTIHSEIGEHTVGAKVNGKLVPLRYTLKNGDTIEILTSPNAHP
CHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCEECCEEEEEEEEECCCCEEEEEECCCCCC
SKDWLTFVKTSRAQARIRQFIRQAEHRRSVEIGRDIAERELRRFGVTLNKLQKGGELEKA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCHHHH
AQALGYRVADDVLAAVGYGKVSPGQLLQQVLPPDRLAEPPPPAEAAPTSRITELFRKMAR
HHHHCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHC
RPTEGVRINGIDDVLVRYGKCCNPVPGDAIVGFITRGRGVTVHTASCDKVLGIDPERRVD
CCCCCEEECCHHHHHHHHCCCCCCCCCHHHHHHEECCCCEEEEECCCCCCCCCCCCCCEE
VAWDVRGDFKRPVSLRVITTDRPGILAKISQTFSEAGVNISQASCRTTPGERAVNDFEVT
EEEECCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCHHHEE
IGDLKQLNSVIRSIERIEGVQSVQRV
HHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA