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The map label for this gene is ykuU [H]

Identifier: 220916381

GI number: 220916381

Start: 1430364

End: 1430885

Strand: Direct

Name: ykuU [H]

Synonym: A2cp1_1275

Alternate gene names: 220916381

Gene position: 1430364-1430885 (Clockwise)

Preceding gene: 220916376

Following gene: 220916383

Centisome position: 28.44

GC content: 73.56

Gene sequence:

>522_bases
GTGGCGAGGATCCTCGACAGGGCGCCGGACTTCAAGCTGCCGGCGGTGCGCGGACGGGGCGCGCCGGTGGAGGTCTCGCT
GTCGGCGCTCGCCGGTCGCTGGGCGGTGCTGCTGTTCTACCCGCGCGACTTCACCGCCGTCTGCCCGACGGAGGTGCTGG
AGCTCTCGAAGCGCATGCCGGAGCTGCGCGCGCTCGGCGCCGAGGCGATCGGCATCTCGGTGGACGACCTCGACACGCAC
CGTCGGTGGATCGAGGAGAAGCTGGGCGAGGTGGCGTTCCCGCTCGCGGCCGATCCGGACCGGGTGGTGTCGCGCGCGTA
CGGCGCGCTGCTGGAGCGGGAGGGCGTGGCGGCGCGGGCCACGTTCGTCGTCGATCCGGAGGGGGTGGTGCAGTACGCGG
CGTTCCACAACCTCAGGGTGGGCCGCTCGATCTCGGAGATCGTCCGCGTGCTCGAGGCGCTGGAGACGGGCGAGAAGGCG
CCGGCCGAGTGGAGGCCGGGCGCGCCGACGCTGGGACGTTGA

Upstream 100 bases:

>100_bases
CGAGCGCGAGCAGGGGGGCGATCACCGTGACCTCCAGGGTTGACGCGCCGCCCGGCGGGGCCGAAGGTAGCGCTCCTCGG
GACGCCGGGCGGGAGGGAAC

Downstream 100 bases:

>100_bases
GGGTCGAGCGGCGGCGCCCGCGACGAGGCGGGGAGGGATGGGCCGGGGATCGGGGTGTCGGGCGGGGCCGGGTCTAGCGC
CCGCCGAGCAGCGCGGCCGG

Product: alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen

Products: an alcohol; H2O; NAD [C]

Alternate protein names: NA

Number of amino acids: Translated: 173; Mature: 172

Protein sequence:

>173_residues
MARILDRAPDFKLPAVRGRGAPVEVSLSALAGRWAVLLFYPRDFTAVCPTEVLELSKRMPELRALGAEAIGISVDDLDTH
RRWIEEKLGEVAFPLAADPDRVVSRAYGALLEREGVAARATFVVDPEGVVQYAAFHNLRVGRSISEIVRVLEALETGEKA
PAEWRPGAPTLGR

Sequences:

>Translated_173_residues
MARILDRAPDFKLPAVRGRGAPVEVSLSALAGRWAVLLFYPRDFTAVCPTEVLELSKRMPELRALGAEAIGISVDDLDTH
RRWIEEKLGEVAFPLAADPDRVVSRAYGALLEREGVAARATFVVDPEGVVQYAAFHNLRVGRSISEIVRVLEALETGEKA
PAEWRPGAPTLGR
>Mature_172_residues
ARILDRAPDFKLPAVRGRGAPVEVSLSALAGRWAVLLFYPRDFTAVCPTEVLELSKRMPELRALGAEAIGISVDDLDTHR
RWIEEKLGEVAFPLAADPDRVVSRAYGALLEREGVAARATFVVDPEGVVQYAAFHNLRVGRSISEIVRVLEALETGEKAP
AEWRPGAPTLGR

Specific function: Directly Reduces Organic Hydroperoxides In Its Reduced Dithiol Form. [C]

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI32189392, Length=179, Percent_Identity=45.2513966480447, Blast_Score=143, Evalue=6e-35,
Organism=Homo sapiens, GI4505591, Length=179, Percent_Identity=37.9888268156425, Blast_Score=139, Evalue=2e-33,
Organism=Homo sapiens, GI32455266, Length=179, Percent_Identity=37.9888268156425, Blast_Score=139, Evalue=2e-33,
Organism=Homo sapiens, GI32455264, Length=179, Percent_Identity=37.9888268156425, Blast_Score=139, Evalue=2e-33,
Organism=Homo sapiens, GI5802974, Length=177, Percent_Identity=37.8531073446328, Blast_Score=131, Evalue=4e-31,
Organism=Homo sapiens, GI32483377, Length=174, Percent_Identity=38.5057471264368, Blast_Score=130, Evalue=5e-31,
Organism=Homo sapiens, GI5453549, Length=157, Percent_Identity=36.3057324840764, Blast_Score=119, Evalue=1e-27,
Organism=Homo sapiens, GI33188454, Length=85, Percent_Identity=51.7647058823529, Blast_Score=85, Evalue=4e-17,
Organism=Homo sapiens, GI4758638, Length=181, Percent_Identity=29.8342541436464, Blast_Score=75, Evalue=3e-14,
Organism=Escherichia coli, GI1786822, Length=178, Percent_Identity=34.8314606741573, Blast_Score=119, Evalue=9e-29,
Organism=Caenorhabditis elegans, GI193204376, Length=173, Percent_Identity=40.4624277456647, Blast_Score=134, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI32565831, Length=173, Percent_Identity=40.4624277456647, Blast_Score=134, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17554494, Length=177, Percent_Identity=35.5932203389831, Blast_Score=125, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI25153706, Length=185, Percent_Identity=28.1081081081081, Blast_Score=80, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6323613, Length=180, Percent_Identity=37.7777777777778, Blast_Score=120, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6320661, Length=180, Percent_Identity=35, Blast_Score=115, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6319407, Length=183, Percent_Identity=31.6939890710383, Blast_Score=96, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24656348, Length=179, Percent_Identity=42.4581005586592, Blast_Score=139, Evalue=8e-34,
Organism=Drosophila melanogaster, GI17864676, Length=179, Percent_Identity=42.4581005586592, Blast_Score=139, Evalue=8e-34,
Organism=Drosophila melanogaster, GI17738015, Length=175, Percent_Identity=37.7142857142857, Blast_Score=134, Evalue=3e-32,
Organism=Drosophila melanogaster, GI21357347, Length=180, Percent_Identity=39.4444444444444, Blast_Score=130, Evalue=4e-31,
Organism=Drosophila melanogaster, GI17157991, Length=180, Percent_Identity=37.2222222222222, Blast_Score=121, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24641739, Length=180, Percent_Identity=37.2222222222222, Blast_Score=121, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24581278, Length=184, Percent_Identity=28.804347826087, Blast_Score=90, Evalue=6e-19,
Organism=Drosophila melanogaster, GI17975518, Length=187, Percent_Identity=27.2727272727273, Blast_Score=90, Evalue=8e-19,
Organism=Drosophila melanogaster, GI24652436, Length=187, Percent_Identity=27.2727272727273, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24652434, Length=187, Percent_Identity=27.2727272727273, Blast_Score=89, Evalue=1e-18,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR019479
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA [H]

EC number: 1.6.4.- [C]

Molecular weight: Translated: 18927; Mature: 18796

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARILDRAPDFKLPAVRGRGAPVEVSLSALAGRWAVLLFYPRDFTAVCPTEVLELSKRMP
CCCCCCCCCCCCCCCCCCCCCCEEEEHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHCH
ELRALGAEAIGISVDDLDTHRRWIEEKLGEVAFPLAADPDRVVSRAYGALLEREGVAARA
HHHHCCCHHEECCHHCHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHCCCCEEE
TFVVDPEGVVQYAAFHNLRVGRSISEIVRVLEALETGEKAPAEWRPGAPTLGR
EEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
ARILDRAPDFKLPAVRGRGAPVEVSLSALAGRWAVLLFYPRDFTAVCPTEVLELSKRMP
CCCCCCCCCCCCCCCCCCCCCEEEEHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHCH
ELRALGAEAIGISVDDLDTHRRWIEEKLGEVAFPLAADPDRVVSRAYGALLEREGVAARA
HHHHCCCHHEECCHHCHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHCCCCEEE
TFVVDPEGVVQYAAFHNLRVGRSISEIVRVLEALETGEKAPAEWRPGAPTLGR
EEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ROOH; Proton; NADH [C]

Specific reaction: ROOH + Proton + NADH = an alcohol + H2O + NAD [C]

General reaction: Oxidoreductases; Acting on NADH or NADPH; With a disulfide as acceptor [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]