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The map label for this gene is adh [H]

Identifier: 220916297

GI number: 220916297

Start: 1333760

End: 1334719

Strand: Direct

Name: adh [H]

Synonym: A2cp1_1190

Alternate gene names: 220916297

Gene position: 1333760-1334719 (Clockwise)

Preceding gene: 220916296

Following gene: 220916298

Centisome position: 26.52

GC content: 77.5

Gene sequence:

>960_bases
ATGGCGGCGCACATGCGCGCTGCGGTGCTGGCGGGCCCGCGGCGGATCGAGCTCGCCGAGGTGGAGCGGCCCCGGCCCGG
GCCGGGCGAGGTGCTGGTGCGCCTGCACGGCTGCGGCGTGTGCGGCTCCAACCTGGCGCCGTGGCAGGGGCGGGCCTGGT
TCACCTATCCGTTCGCGCCGGGCGTGCCGGGGCACGAGGGGTGGGGCGTCGTGGAGCGGCTGGGCGCGGGCGTGGACGGG
CTGGTGGAGGGGCAGCGGGTGGCGCTGCTCTCCGGGGCCGCGTTCGCGCAGTACGACCTCGCTGCCGCGGACCGGGTCCT
GCCCATCCCGGAGGCGCTCACCGGCCCGTTCCCGGGCGAGGCGCTCGGCTGCGCGGTGAACGTCTTCCGTCGCGCCGCGA
TCGGGCAGGGCGACACGGTGGCGGTGGTGGGGGCGGGCTTCCTCGGGCTGATGGTGCTCCGGCTCGCCGCGCTGGCCGGC
GCGCGGGTCCTGGCGCTCTCGCGGCGCGAGACCTCGCTCGCGCTGGCGCGGCGGCTCGGCGCCGACGAGGCCATCCCGAC
CGGCGATCCGGGCGCCGCCGAGGCGCGGGTGCGGGATCTCACCGGCGGGCGGCTGTGCCGGGTGGTGGTCGAGGCGATCG
GCTCGCAGGAGGCGCTGGATCTCGCCTCGCGGCTGGTGGCCGAGGGCGGGCGGCTCGCCATCGCCGGCTACCACCAGGAC
GGCCCCCGCACCGTGGACATGCAGTCGTGGAACTGGCGCGGGATCGACGTCGTGAACGCCCACGAGCGCGATCCCGCGGT
GCAGCGGGAGGGGGTCCTCGCGGCGGCGCGGCTGGTGGCGGAGGGGCGGCTCGATCCCGGGCCGCTCTACCGGAGCTTCC
CGCTCGACCGGCTCGCCGACGCATTCCAGGCGATGGAGGAGCGGCCGGACGGCTTCGTGAAGGCCCTCGTCACCCCATGA

Upstream 100 bases:

>100_bases
GCGCACCGGCGTGCAGGAGGGCGTGCGGCGGCTGCACGCGTGGCTGGCGGCGGCGGCGCGGCCGCAGCGCCCGGCCACGC
TCGAGGAGGCGGCGACCTAG

Downstream 100 bases:

>100_bases
TCGCGTACCCCTCGGCCAGCCCGGCGCGCCCGCGGCTCGGCTTCCTCGGCGTCGGCTGGATCGGCCGGCACCGCCTGCGC
GCCATCCTCGAGTCCGGCGC

Product: alcohol dehydrogenase zinc-binding domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 319; Mature: 318

Protein sequence:

>319_residues
MAAHMRAAVLAGPRRIELAEVERPRPGPGEVLVRLHGCGVCGSNLAPWQGRAWFTYPFAPGVPGHEGWGVVERLGAGVDG
LVEGQRVALLSGAAFAQYDLAAADRVLPIPEALTGPFPGEALGCAVNVFRRAAIGQGDTVAVVGAGFLGLMVLRLAALAG
ARVLALSRRETSLALARRLGADEAIPTGDPGAAEARVRDLTGGRLCRVVVEAIGSQEALDLASRLVAEGGRLAIAGYHQD
GPRTVDMQSWNWRGIDVVNAHERDPAVQREGVLAAARLVAEGRLDPGPLYRSFPLDRLADAFQAMEERPDGFVKALVTP

Sequences:

>Translated_319_residues
MAAHMRAAVLAGPRRIELAEVERPRPGPGEVLVRLHGCGVCGSNLAPWQGRAWFTYPFAPGVPGHEGWGVVERLGAGVDG
LVEGQRVALLSGAAFAQYDLAAADRVLPIPEALTGPFPGEALGCAVNVFRRAAIGQGDTVAVVGAGFLGLMVLRLAALAG
ARVLALSRRETSLALARRLGADEAIPTGDPGAAEARVRDLTGGRLCRVVVEAIGSQEALDLASRLVAEGGRLAIAGYHQD
GPRTVDMQSWNWRGIDVVNAHERDPAVQREGVLAAARLVAEGRLDPGPLYRSFPLDRLADAFQAMEERPDGFVKALVTP
>Mature_318_residues
AAHMRAAVLAGPRRIELAEVERPRPGPGEVLVRLHGCGVCGSNLAPWQGRAWFTYPFAPGVPGHEGWGVVERLGAGVDGL
VEGQRVALLSGAAFAQYDLAAADRVLPIPEALTGPFPGEALGCAVNVFRRAAIGQGDTVAVVGAGFLGLMVLRLAALAGA
RVLALSRRETSLALARRLGADEAIPTGDPGAAEARVRDLTGGRLCRVVVEAIGSQEALDLASRLVAEGGRLAIAGYHQDG
PRTVDMQSWNWRGIDVVNAHERDPAVQREGVLAAARLVAEGRLDPGPLYRSFPLDRLADAFQAMEERPDGFVKALVTP

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=342, Percent_Identity=26.3157894736842, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI194239674, Length=315, Percent_Identity=24.7619047619048, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI13236495, Length=315, Percent_Identity=24.7619047619048, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI226510992, Length=352, Percent_Identity=25.8522727272727, Blast_Score=91, Evalue=7e-20,
Organism=Escherichia coli, GI1788073, Length=265, Percent_Identity=26.7924528301887, Blast_Score=65, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6319621, Length=297, Percent_Identity=25.2525252525253, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323729, Length=291, Percent_Identity=24.3986254295533, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 33558; Mature: 33427

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAHMRAAVLAGPRRIELAEVERPRPGPGEVLVRLHGCGVCGSNLAPWQGRAWFTYPFAP
CCCCHHHHHHCCCCEEEEHHCCCCCCCCHHEEEEEECCCCCCCCCCCCCCCEEEECCCCC
GVPGHEGWGVVERLGAGVDGLVEGQRVALLSGAAFAQYDLAAADRVLPIPEALTGPFPGE
CCCCCCCCCHHHHHCCCCCHHHCCCEEEEEECCHHHHHHHHHCCCCCCCCHHHCCCCCCH
ALGCAVNVFRRAAIGQGDTVAVVGAGFLGLMVLRLAALAGARVLALSRRETSLALARRLG
HHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHCC
ADEAIPTGDPGAAEARVRDLTGGRLCRVVVEAIGSQEALDLASRLVAEGGRLAIAGYHQD
CCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEEECCC
GPRTVDMQSWNWRGIDVVNAHERDPAVQREGVLAAARLVAEGRLDPGPLYRSFPLDRLAD
CCEEECCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHH
AFQAMEERPDGFVKALVTP
HHHHHHHCCCCEEEEECCC
>Mature Secondary Structure 
AAHMRAAVLAGPRRIELAEVERPRPGPGEVLVRLHGCGVCGSNLAPWQGRAWFTYPFAP
CCCHHHHHHCCCCEEEEHHCCCCCCCCHHEEEEEECCCCCCCCCCCCCCCEEEECCCCC
GVPGHEGWGVVERLGAGVDGLVEGQRVALLSGAAFAQYDLAAADRVLPIPEALTGPFPGE
CCCCCCCCCHHHHHCCCCCHHHCCCEEEEEECCHHHHHHHHHCCCCCCCCHHHCCCCCCH
ALGCAVNVFRRAAIGQGDTVAVVGAGFLGLMVLRLAALAGARVLALSRRETSLALARRLG
HHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHCC
ADEAIPTGDPGAAEARVRDLTGGRLCRVVVEAIGSQEALDLASRLVAEGGRLAIAGYHQD
CCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEEECCC
GPRTVDMQSWNWRGIDVVNAHERDPAVQREGVLAAARLVAEGRLDPGPLYRSFPLDRLAD
CCEEECCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHH
AFQAMEERPDGFVKALVTP
HHHHHHHCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2846513 [H]