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The map label for this gene is cls [H]

Identifier: 220916164

GI number: 220916164

Start: 1173787

End: 1176489

Strand: Direct

Name: cls [H]

Synonym: A2cp1_1051

Alternate gene names: 220916164

Gene position: 1173787-1176489 (Clockwise)

Preceding gene: 220916163

Following gene: 220916166

Centisome position: 23.34

GC content: 79.87

Gene sequence:

>2703_bases
ATGAGGTACCGCCGCGTGCTCGCGTTGGTGGAGCAGGGCGCCGACGCCGGCCCGGCCTTCGGCGCCGTGCGCGCGCTCGC
GCCGGACGCGGAGTCGCTGGGCGTGGTGGCCTGCCCGCCGCCGCGGCCGCACGCCTGGCTCCCAGGGGTGGCCGCGCCGG
CGCCGGCCGGCGGCGCGGGGACTGGGTGGCTCGACCGGCTGCGCGAGGAGGCTGTCCCGCTGGCGGGGCGGGTGGCGGTG
GGCGCGGTGCCGGACCTGGATCCCGAGGCGCTCGCGGCGCTCGCCGGGGACCGCGAGGTGGACCTGGTCGTCGCGGGGCC
GCTCCCGGCGGCGGCCGGCGAGGCGGTCTCCGAGCTGCGCCGCCTCCGGCCACTCGCGGTCGCGTGGGTGGCCGCCGCCG
CGGCGGCGGCGACCGCGCGCCTCCGTGAGCCGGCGCGGGAGCTGCTCTGCGTCGCGCCGGGCGACCGCGCCCGCGCGGCG
CTGGCCGGCTTCCTGCGCGATCACGGGGATCCCTCCCAGCGCGTCACGCTCCTGGCGCTCGCGTCGCCCTCGCGCGACGC
GCTCGCCGCCGCGCTGGAGGTGGCCGGCATCCGCGCCCGGGTCGAGCTGGCCGGCGGCTTCGGCTCCGGGACGTGGCGGA
CGCTGGAGACGGTCGCCCGGGAGCGACGGCTCGACCTGGTCGTTCTGTCGCGGCTGCCCGGGGCGCTGCTGCGCAGCGCA
CCCTGGCCGGCGCCGCTGCTGGTGCTGCCGCCGGCGGCGCCGAGCCGGACCGGCCTGCGGCGCCCGCTCGACGTGCCGGA
CCTCGTGGACGCCGGCGGCCCCCTCCGGCTGCGCGCCGGCTACGGTTACGGCGTCGGCCGCAACCCGCCGGTCGAGGACC
AGGAGCTGGCGCTCGTGTCGGACGGCCGCGTCGTGGCCCGCGTGCGCACGCGCGGCGGCGAGGCGGAGCTGCCGGCGGGG
CTCGCCGCCGGCTCGCTGGGCGTGTTCCGCGCGCGCGACGCCGAGGGCCTCGACCCGGTCGTCGCGGTGGAGCGGCAGGT
CGCGGTGATCCGCCCGGGCGTGCTGCCGCTCCTGCCGTTCGACGCCGAGCTGGCCCCGGAGGACCTCGCCGCCCTCGCCC
GCGTGGACGGCGCCGAGCCGCTCGCGGTGCGCCTGCGCCCGGCGCGGAGCTGCCACCTGCTGCGCGAGCGGCTGCGCGGC
GCCGGGCTCGCCGCGCGCGTGGTGGACGCGAGCGCGGTGCTGGACGAGGGCGAGGCGGCCGACGTGAGCGAGGCGCACGA
CGCCGTGCGCCTGGCGCGGGTGGGCGGCCGCCTGCGCGCGGCCGGGTTCCCGGTCGCGGCGATCGTGCATCGCGGACCGC
ACCCTCCCGCCGCGATCGGGTTCGAGGCGCTGGAGGCGCGCCAGCTCGCCGGGCGGGCCTGGCGAGCGCCACCGCTCGCG
CCCCGTCCCGACACGCTCGACGCGCGGCTCGACGCGGCCACGGCCGCGCCCGCGATCGAGGGAAACCGCGTCGAGCTGGA
GCTCGACAACGTCACCGCCCGCGGCTGGCTGCTCGAGGCGATCCGCGGCGCGCGCCGGACGCTCCACCTCCAGGTCTACC
TGGCCACCGACGACGACGCCGGCCGGCGCGTCGAGGCCGCGCTCGCCGGCGCCGGGCGCCGCGGCGTGAAGGTGCGGGTG
CTGGTGGACTCCCTGCACGGCCTGCACGGCTCCTTCGGCCTGGAGAACCCGCTCCTCGCGCGCCTCGCGACGCGGCCCGG
GGTCGAGGTGCGGGTCTCGCGGCCGGTGGCGGCGGTCCCGAGCGTGGAGGACCTGAAGCGGCGCGACCACCGCAAGCTGG
TGGTGGCCGACGGAGCGGTGGCGCTGGTGGGCGGACGGAACCTCGCGCACGAGTACTACACCGGGTTCGACGAGGTCCGG
GTCGGGCCGCGGACGCCGTGGCGCGAGGTGCCCTGGCTGGACGGCGGGGCGCGGGTGCGCGGGCCGGCGGTGGCCGCGGT
GGAGCGCGCCTTCCTGGAGGCGTGGACCGGCGCGGGCGGCGCGCCGTTCGAGGTGGCGGCGCCCGGCGTGGCCGGGGCGG
AGCGGGTGCGGGTGGTGGTGCACCAGGGCCTGCGGGACGCGAGCACGCTCGAGGCCTACCTGGCGCTCGTCGAGAGCGCG
CGCCACCGGCTGGTCGCGGTGAACGGGTTCCCGCTGCTGCTCGAGCTGGAGCACGCGCTCTCTCGCGCGCTGCGCCGCGG
CGTGCGGGTGCAGGTGCTCCTCGGCGAGGTCACGCCCACGCACGGCGGCGAGCCGTTCGAGGGGCCCTGGGCCAGCGCGC
GCACCGCGGCCACCTGGCTGGTGCACTCGCGCATCGACGCGCTGGTGGCGGCCGGGGCCGAGGCCAGGCTGCTCGGCGTG
CGCGACGTGCCGGGCTGGTCGCCCGAGCTCGGCCTGGTGCACCCGCACGTGCACGCGAAGGCGATGATCGCCGATGGGCG
CGCCTGCGCGGTGGGCAGCGCCAACCTGGACGTCACCGCGAGCTACTGGGAGGACGAGCTGCTGCTCGTCGTCGAGGACG
AGGCGGTCGCCGGCGCGTTCGAGGCGCGGGTGCAGGCGCTCCTGGCCGGCTCGACGCGCGTGGATCGCGCCGACCCGGCC
TGGCAGCGGCGCGTGCGCGCGCGGGACTGGGCGCGCCACTGGCCGGGGATCCTGTCGATCTGA

Upstream 100 bases:

>100_bases
TCAGGGACGACGGGAGCCTGGCCGCCGTCGAGGCGCACGTGGTCGCGCCCGACGGGCGCTCCGTGGAGCGCGTGGCGCTG
CCGGAGGCGGAGGCCGTCGC

Downstream 100 bases:

>100_bases
GGCAGGGCTGCGGGCGCCCGGTGGCAGCGGCCGCGCCGCGGCTATCGAAGCGCCGGCTTCAGGTCCACCACCGGCGTGCC
GTCGATCGCCTCGATGGGAC

Product: phospholipase D/Transphosphatidylase

Products: NA

Alternate protein names: CL synthase [H]

Number of amino acids: Translated: 900; Mature: 900

Protein sequence:

>900_residues
MRYRRVLALVEQGADAGPAFGAVRALAPDAESLGVVACPPPRPHAWLPGVAAPAPAGGAGTGWLDRLREEAVPLAGRVAV
GAVPDLDPEALAALAGDREVDLVVAGPLPAAAGEAVSELRRLRPLAVAWVAAAAAAATARLREPARELLCVAPGDRARAA
LAGFLRDHGDPSQRVTLLALASPSRDALAAALEVAGIRARVELAGGFGSGTWRTLETVARERRLDLVVLSRLPGALLRSA
PWPAPLLVLPPAAPSRTGLRRPLDVPDLVDAGGPLRLRAGYGYGVGRNPPVEDQELALVSDGRVVARVRTRGGEAELPAG
LAAGSLGVFRARDAEGLDPVVAVERQVAVIRPGVLPLLPFDAELAPEDLAALARVDGAEPLAVRLRPARSCHLLRERLRG
AGLAARVVDASAVLDEGEAADVSEAHDAVRLARVGGRLRAAGFPVAAIVHRGPHPPAAIGFEALEARQLAGRAWRAPPLA
PRPDTLDARLDAATAAPAIEGNRVELELDNVTARGWLLEAIRGARRTLHLQVYLATDDDAGRRVEAALAGAGRRGVKVRV
LVDSLHGLHGSFGLENPLLARLATRPGVEVRVSRPVAAVPSVEDLKRRDHRKLVVADGAVALVGGRNLAHEYYTGFDEVR
VGPRTPWREVPWLDGGARVRGPAVAAVERAFLEAWTGAGGAPFEVAAPGVAGAERVRVVVHQGLRDASTLEAYLALVESA
RHRLVAVNGFPLLLELEHALSRALRRGVRVQVLLGEVTPTHGGEPFEGPWASARTAATWLVHSRIDALVAAGAEARLLGV
RDVPGWSPELGLVHPHVHAKAMIADGRACAVGSANLDVTASYWEDELLLVVEDEAVAGAFEARVQALLAGSTRVDRADPA
WQRRVRARDWARHWPGILSI

Sequences:

>Translated_900_residues
MRYRRVLALVEQGADAGPAFGAVRALAPDAESLGVVACPPPRPHAWLPGVAAPAPAGGAGTGWLDRLREEAVPLAGRVAV
GAVPDLDPEALAALAGDREVDLVVAGPLPAAAGEAVSELRRLRPLAVAWVAAAAAAATARLREPARELLCVAPGDRARAA
LAGFLRDHGDPSQRVTLLALASPSRDALAAALEVAGIRARVELAGGFGSGTWRTLETVARERRLDLVVLSRLPGALLRSA
PWPAPLLVLPPAAPSRTGLRRPLDVPDLVDAGGPLRLRAGYGYGVGRNPPVEDQELALVSDGRVVARVRTRGGEAELPAG
LAAGSLGVFRARDAEGLDPVVAVERQVAVIRPGVLPLLPFDAELAPEDLAALARVDGAEPLAVRLRPARSCHLLRERLRG
AGLAARVVDASAVLDEGEAADVSEAHDAVRLARVGGRLRAAGFPVAAIVHRGPHPPAAIGFEALEARQLAGRAWRAPPLA
PRPDTLDARLDAATAAPAIEGNRVELELDNVTARGWLLEAIRGARRTLHLQVYLATDDDAGRRVEAALAGAGRRGVKVRV
LVDSLHGLHGSFGLENPLLARLATRPGVEVRVSRPVAAVPSVEDLKRRDHRKLVVADGAVALVGGRNLAHEYYTGFDEVR
VGPRTPWREVPWLDGGARVRGPAVAAVERAFLEAWTGAGGAPFEVAAPGVAGAERVRVVVHQGLRDASTLEAYLALVESA
RHRLVAVNGFPLLLELEHALSRALRRGVRVQVLLGEVTPTHGGEPFEGPWASARTAATWLVHSRIDALVAAGAEARLLGV
RDVPGWSPELGLVHPHVHAKAMIADGRACAVGSANLDVTASYWEDELLLVVEDEAVAGAFEARVQALLAGSTRVDRADPA
WQRRVRARDWARHWPGILSI
>Mature_900_residues
MRYRRVLALVEQGADAGPAFGAVRALAPDAESLGVVACPPPRPHAWLPGVAAPAPAGGAGTGWLDRLREEAVPLAGRVAV
GAVPDLDPEALAALAGDREVDLVVAGPLPAAAGEAVSELRRLRPLAVAWVAAAAAAATARLREPARELLCVAPGDRARAA
LAGFLRDHGDPSQRVTLLALASPSRDALAAALEVAGIRARVELAGGFGSGTWRTLETVARERRLDLVVLSRLPGALLRSA
PWPAPLLVLPPAAPSRTGLRRPLDVPDLVDAGGPLRLRAGYGYGVGRNPPVEDQELALVSDGRVVARVRTRGGEAELPAG
LAAGSLGVFRARDAEGLDPVVAVERQVAVIRPGVLPLLPFDAELAPEDLAALARVDGAEPLAVRLRPARSCHLLRERLRG
AGLAARVVDASAVLDEGEAADVSEAHDAVRLARVGGRLRAAGFPVAAIVHRGPHPPAAIGFEALEARQLAGRAWRAPPLA
PRPDTLDARLDAATAAPAIEGNRVELELDNVTARGWLLEAIRGARRTLHLQVYLATDDDAGRRVEAALAGAGRRGVKVRV
LVDSLHGLHGSFGLENPLLARLATRPGVEVRVSRPVAAVPSVEDLKRRDHRKLVVADGAVALVGGRNLAHEYYTGFDEVR
VGPRTPWREVPWLDGGARVRGPAVAAVERAFLEAWTGAGGAPFEVAAPGVAGAERVRVVVHQGLRDASTLEAYLALVESA
RHRLVAVNGFPLLLELEHALSRALRRGVRVQVLLGEVTPTHGGEPFEGPWASARTAATWLVHSRIDALVAAGAEARLLGV
RDVPGWSPELGLVHPHVHAKAMIADGRACAVGSANLDVTASYWEDELLLVVEDEAVAGAFEARVQALLAGSTRVDRADPA
WQRRVRARDWARHWPGILSI

Specific function: Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol [H]

COG id: COG1502

COG function: function code I; Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PLD phosphodiesterase domains [H]

Homologues:

Organism=Escherichia coli, GI87081826, Length=447, Percent_Identity=24.6085011185682, Blast_Score=79, Evalue=9e-16,
Organism=Escherichia coli, GI1787007, Length=418, Percent_Identity=25.8373205741627, Blast_Score=79, Evalue=2e-15,
Organism=Escherichia coli, GI1787502, Length=405, Percent_Identity=24.4444444444444, Blast_Score=77, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022924
- InterPro:   IPR001736 [H]

Pfam domain/function: PF00614 PLDc [H]

EC number: NA

Molecular weight: Translated: 94707; Mature: 94707

Theoretical pI: Translated: 8.64; Mature: 8.64

Prosite motif: PS50035 PLD ; PS00211 ABC_TRANSPORTER_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.2 %Met     (Translated Protein)
0.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.2 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYRRVLALVEQGADAGPAFGAVRALAPDAESLGVVACPPPRPHAWLPGVAAPAPAGGAG
CCHHHHHHHHHCCCCCCCHHHHHHHCCCCHHHCCEEECCCCCCCCCCCCCCCCCCCCCCC
TGWLDRLREEAVPLAGRVAVGAVPDLDPEALAALAGDREVDLVVAGPLPAAAGEAVSELR
CHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHH
RLRPLAVAWVAAAAAAATARLREPARELLCVAPGDRARAALAGFLRDHGDPSQRVTLLAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHCCCCCCEEEEEEE
ASPSRDALAAALEVAGIRARVELAGGFGSGTWRTLETVARERRLDLVVLSRLPGALLRSA
CCCCHHHHHHHHHHHCCEEEEEEECCCCCCCHHHHHHHHHHHCCCEEEEHHCCHHHHHCC
PWPAPLLVLPPAAPSRTGLRRPLDVPDLVDAGGPLRLRAGYGYGVGRNPPVEDQELALVS
CCCCCEEEECCCCCCCCCCCCCCCCCHHHCCCCCEEEEECCCCCCCCCCCCCCCCEEEEE
DGRVVARVRTRGGEAELPAGLAAGSLGVFRARDAEGLDPVVAVERQVAVIRPGVLPLLPF
CCEEEEEEECCCCCCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHEEEEECCCCCEECCC
DAELAPEDLAALARVDGAEPLAVRLRPARSCHLLRERLRGAGLAARVVDASAVLDEGEAA
CCCCCHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCC
DVSEAHDAVRLARVGGRLRAAGFPVAAIVHRGPHPPAAIGFEALEARQLAGRAWRAPPLA
CHHHHHHHHHHHHHCCEEEECCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCC
PRPDTLDARLDAATAAPAIEGNRVELELDNVTARGWLLEAIRGARRTLHLQVYLATDDDA
CCCCCCHHHHCHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCEEEEEEEEEEECCCC
GRRVEAALAGAGRRGVKVRVLVDSLHGLHGSFGLENPLLARLATRPGVEVRVSRPVAAVP
CCEEHHHHHCCCCCCCEEEEEEEHHCCCCCCCCCCCHHHHHHHCCCCCEEEECCCCCCCC
SVEDLKRRDHRKLVVADGAVALVGGRNLAHEYYTGFDEVRVGPRTPWREVPWLDGGARVR
CHHHHHHCCCCEEEEECCEEEEECCCHHHHHHHCCHHHEECCCCCCCCCCCCCCCCCEEC
GPAVAAVERAFLEAWTGAGGAPFEVAAPGVAGAERVRVVVHQGLRDASTLEAYLALVESA
CHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHC
RHRLVAVNGFPLLLELEHALSRALRRGVRVQVLLGEVTPTHGGEPFEGPWASARTAATWL
CCEEEEECCCEEEEEHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHH
VHSRIDALVAAGAEARLLGVRDVPGWSPELGLVHPHVHAKAMIADGRACAVGSANLDVTA
HHHHHHHHHHCCCCEEEEEEECCCCCCCCCCEECCCCCEEEEEECCCEEEECCCCCEEEE
SYWEDELLLVVEDEAVAGAFEARVQALLAGSTRVDRADPAWQRRVRARDWARHWPGILSI
EECCCEEEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MRYRRVLALVEQGADAGPAFGAVRALAPDAESLGVVACPPPRPHAWLPGVAAPAPAGGAG
CCHHHHHHHHHCCCCCCCHHHHHHHCCCCHHHCCEEECCCCCCCCCCCCCCCCCCCCCCC
TGWLDRLREEAVPLAGRVAVGAVPDLDPEALAALAGDREVDLVVAGPLPAAAGEAVSELR
CHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHH
RLRPLAVAWVAAAAAAATARLREPARELLCVAPGDRARAALAGFLRDHGDPSQRVTLLAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHCCCCCCEEEEEEE
ASPSRDALAAALEVAGIRARVELAGGFGSGTWRTLETVARERRLDLVVLSRLPGALLRSA
CCCCHHHHHHHHHHHCCEEEEEEECCCCCCCHHHHHHHHHHHCCCEEEEHHCCHHHHHCC
PWPAPLLVLPPAAPSRTGLRRPLDVPDLVDAGGPLRLRAGYGYGVGRNPPVEDQELALVS
CCCCCEEEECCCCCCCCCCCCCCCCCHHHCCCCCEEEEECCCCCCCCCCCCCCCCEEEEE
DGRVVARVRTRGGEAELPAGLAAGSLGVFRARDAEGLDPVVAVERQVAVIRPGVLPLLPF
CCEEEEEEECCCCCCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHEEEEECCCCCEECCC
DAELAPEDLAALARVDGAEPLAVRLRPARSCHLLRERLRGAGLAARVVDASAVLDEGEAA
CCCCCHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCC
DVSEAHDAVRLARVGGRLRAAGFPVAAIVHRGPHPPAAIGFEALEARQLAGRAWRAPPLA
CHHHHHHHHHHHHHCCEEEECCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCC
PRPDTLDARLDAATAAPAIEGNRVELELDNVTARGWLLEAIRGARRTLHLQVYLATDDDA
CCCCCCHHHHCHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCEEEEEEEEEEECCCC
GRRVEAALAGAGRRGVKVRVLVDSLHGLHGSFGLENPLLARLATRPGVEVRVSRPVAAVP
CCEEHHHHHCCCCCCCEEEEEEEHHCCCCCCCCCCCHHHHHHHCCCCCEEEECCCCCCCC
SVEDLKRRDHRKLVVADGAVALVGGRNLAHEYYTGFDEVRVGPRTPWREVPWLDGGARVR
CHHHHHHCCCCEEEEECCEEEEECCCHHHHHHHCCHHHEECCCCCCCCCCCCCCCCCEEC
GPAVAAVERAFLEAWTGAGGAPFEVAAPGVAGAERVRVVVHQGLRDASTLEAYLALVESA
CHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHC
RHRLVAVNGFPLLLELEHALSRALRRGVRVQVLLGEVTPTHGGEPFEGPWASARTAATWL
CCEEEEECCCEEEEEHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHH
VHSRIDALVAAGAEARLLGVRDVPGWSPELGLVHPHVHAKAMIADGRACAVGSANLDVTA
HHHHHHHHHHCCCCEEEEEEECCCCCCCCCCEECCCCCEEEEEECCCEEEECCCCCEEEE
SYWEDELLLVVEDEAVAGAFEARVQALLAGSTRVDRADPAWQRRVRARDWARHWPGILSI
EECCCEEEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12235376 [H]