Click here to switch to the map view.

The map label for this gene is ttcA

Identifier: 220916067

GI number: 220916067

Start: 1073661

End: 1074536

Strand: Direct

Name: ttcA

Synonym: A2cp1_0954

Alternate gene names: 220916067

Gene position: 1073661-1074536 (Clockwise)

Preceding gene: 220916061

Following gene: 220916068

Centisome position: 21.35

GC content: 73.17

Gene sequence:

>876_bases
ATGCAGCAGATCCACCGGCTGGAGCGGAAGCTCCTCCGCGCGACGGCAGAGGCCATCCGCGACTTCGACCTCGTCTCCCA
GGGCGACCGGATCATGGTCGCCGTCTCGGGGGGCAAGGACAGCTACACCCTGCTCCACCTGCTCATGCGGCTGCGCGAGC
GGGCCCCCATCGACTTCGACCTGGTGGCGGTGAACCTCGACCAGGGGCAGCCCGGCTTCCCCGCGCAGGTGGTGGAGGAT
CACCTCCGGTCGGTGGGCGTCCCCTACCGCATGCTCCAGCGCGACACGTACTCCGTGGTGCGGCGGCTCGTGCCGGAGGG
GAAGACCACCTGCCCGGTCTGCTCGCGCCTGCGGCGCGGGGTCCTCTACAACGCCGCCGTCGAGATGGGCTGCACGAAGA
TCGCGCTCGGCCACCACCGCGACGACCTCGTCGAGACGCTGCTCCTCTCGGCGCTCTACTCCGGCGCGCTGAAGAGCATG
CCGCCCAAGCTCCGCTCGCGCGACGGCCGGAACGTGGTCGTGCGGCCGCTCTGCTACGCGGCCGAGGAGGACGTGGCCGC
GTTCGCCGAGGCCATGCGCTTCCCCATCGTCCCCTGCGACCTGTGCGGCTCGCAGCCCAACCTGCGCCGCAAGCGCGTGA
AGCGGCTGCTGGCGGAGCTGTCCGCCGAGCACCCGGCGGTGAAGGGCAACCTGCTCCACGCGCTCGCGCACGTCGTCCCC
TCGCACCTGCTCGACCGCGACCTCCACCGCCAGCTCGCCGACGCGACGGGCCGCGATCCCTGGCTCGACGCCGAGGACGA
GGAGGCGGAGGACTGCGGCGAGCCGCCCGCCGGCGACGGCGTGGTGTCGCTGGGCGGCGCCCGCGGCGGGCGGTAG

Upstream 100 bases:

>100_bases
GCGGAGAAGCCGGGCCTTTATCCCAACGAAAGCGGCGGCGTCAAACGGAAATGGCGCCGCACCCTCGACCGCCGGGGCTG
GGCCGCGCTAGAACCCCGCC

Downstream 100 bases:

>100_bases
CATCCGCGCATGCGCTCCGTTCCCCCCGAGGCGATCCGCACCCCGCGCGATCTCGCGCCGTACCTCGACCACACCGTGCT
CGCGCCGGAGGCGACGCTCG

Product: PP-loop domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MQQIHRLERKLLRATAEAIRDFDLVSQGDRIMVAVSGGKDSYTLLHLLMRLRERAPIDFDLVAVNLDQGQPGFPAQVVED
HLRSVGVPYRMLQRDTYSVVRRLVPEGKTTCPVCSRLRRGVLYNAAVEMGCTKIALGHHRDDLVETLLLSALYSGALKSM
PPKLRSRDGRNVVVRPLCYAAEEDVAAFAEAMRFPIVPCDLCGSQPNLRRKRVKRLLAELSAEHPAVKGNLLHALAHVVP
SHLLDRDLHRQLADATGRDPWLDAEDEEAEDCGEPPAGDGVVSLGGARGGR

Sequences:

>Translated_291_residues
MQQIHRLERKLLRATAEAIRDFDLVSQGDRIMVAVSGGKDSYTLLHLLMRLRERAPIDFDLVAVNLDQGQPGFPAQVVED
HLRSVGVPYRMLQRDTYSVVRRLVPEGKTTCPVCSRLRRGVLYNAAVEMGCTKIALGHHRDDLVETLLLSALYSGALKSM
PPKLRSRDGRNVVVRPLCYAAEEDVAAFAEAMRFPIVPCDLCGSQPNLRRKRVKRLLAELSAEHPAVKGNLLHALAHVVP
SHLLDRDLHRQLADATGRDPWLDAEDEEAEDCGEPPAGDGVVSLGGARGGR
>Mature_291_residues
MQQIHRLERKLLRATAEAIRDFDLVSQGDRIMVAVSGGKDSYTLLHLLMRLRERAPIDFDLVAVNLDQGQPGFPAQVVED
HLRSVGVPYRMLQRDTYSVVRRLVPEGKTTCPVCSRLRRGVLYNAAVEMGCTKIALGHHRDDLVETLLLSALYSGALKSM
PPKLRSRDGRNVVVRPLCYAAEEDVAAFAEAMRFPIVPCDLCGSQPNLRRKRVKRLLAELSAEHPAVKGNLLHALAHVVP
SHLLDRDLHRQLADATGRDPWLDAEDEEAEDCGEPPAGDGVVSLGGARGGR

Specific function: Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32)

COG id: COG0037

COG function: function code D; Predicted ATPase of the PP-loop superfamily implicated in cell cycle control

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TtcA family

Homologues:

Organism=Escherichia coli, GI1787606, Length=246, Percent_Identity=52.4390243902439, Blast_Score=297, Evalue=7e-82,
Organism=Caenorhabditis elegans, GI193211090, Length=241, Percent_Identity=30.7053941908714, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17540090, Length=220, Percent_Identity=28.6363636363636, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24651972, Length=227, Percent_Identity=26.431718061674, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TTCA_ANAD2 (B8JEH9)

Other databases:

- EMBL:   CP001359
- RefSeq:   YP_002491371.1
- GeneID:   7298625
- GenomeReviews:   CP001359_GR
- KEGG:   acp:A2cp1_0954
- HOGENOM:   HBG347038
- ProtClustDB:   PRK10696
- GO:   GO:0005737
- HAMAP:   MF_01850
- InterPro:   IPR012089
- InterPro:   IPR014729
- InterPro:   IPR011063
- Gene3D:   G3DSA:3.40.50.620
- PIRSF:   PIRSF004976

Pfam domain/function: PF01171 ATP_bind_3

EC number: NA

Molecular weight: Translated: 32141; Mature: 32141

Theoretical pI: Translated: 7.84; Mature: 7.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQIHRLERKLLRATAEAIRDFDLVSQGDRIMVAVSGGKDSYTLLHLLMRLRERAPIDFD
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCCEE
LVAVNLDQGQPGFPAQVVEDHLRSVGVPYRMLQRDTYSVVRRLVPEGKTTCPVCSRLRRG
EEEEEECCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
VLYNAAVEMGCTKIALGHHRDDLVETLLLSALYSGALKSMPPKLRSRDGRNVVVRPLCYA
HHHHHHHHHCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCEEEHHHHHH
AEEDVAAFAEAMRFPIVPCDLCGSQPNLRRKRVKRLLAELSAEHPAVKGNLLHALAHVVP
HHHHHHHHHHHHHCCCCCHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
SHLLDRDLHRQLADATGRDPWLDAEDEEAEDCGEPPAGDGVVSLGGARGGR
HHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCCCCCCEEEECCCCCCC
>Mature Secondary Structure
MQQIHRLERKLLRATAEAIRDFDLVSQGDRIMVAVSGGKDSYTLLHLLMRLRERAPIDFD
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCCEE
LVAVNLDQGQPGFPAQVVEDHLRSVGVPYRMLQRDTYSVVRRLVPEGKTTCPVCSRLRRG
EEEEEECCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
VLYNAAVEMGCTKIALGHHRDDLVETLLLSALYSGALKSMPPKLRSRDGRNVVVRPLCYA
HHHHHHHHHCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCEEEHHHHHH
AEEDVAAFAEAMRFPIVPCDLCGSQPNLRRKRVKRLLAELSAEHPAVKGNLLHALAHVVP
HHHHHHHHHHHHHCCCCCHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
SHLLDRDLHRQLADATGRDPWLDAEDEEAEDCGEPPAGDGVVSLGGARGGR
HHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCCCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA