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The map label for this gene is cvrA [H]

Identifier: 220916032

GI number: 220916032

Start: 1038835

End: 1040307

Strand: Reverse

Name: cvrA [H]

Synonym: A2cp1_0919

Alternate gene names: 220916032

Gene position: 1040307-1038835 (Counterclockwise)

Preceding gene: 220916033

Following gene: 220916025

Centisome position: 20.68

GC content: 74.95

Gene sequence:

>1473_bases
GTGACCGAGCCACTCCCCACCGCGATCGCGCTCACCGCCACCGCGCTCCTGCTCGGCCTGAGCGTCCTCTCGTCCCGCAC
CTCCGGGCGGCTGGGCGTCCCGTTCGCGCTGCTGTTCCTCGCGGTGGGCATCCTGGCGGGCTCCGAGGGCATCGGCGGGA
TCGCGTTCGCCGACTACCACCTCACGTTCCGCGTGGGCACGGTGGCGCTGGTGCTGATCCTGTTCGAGGGCGGCCTCAGC
ACCGACGTGCGCGGGCTCCGCCGGATCATCGCGCCCGCCGCGCTGCTCGCCACCGCCGGCGTGGCCGGCACCGCCGCGCT
GACCGCGCTGGGCGCGCGCGCGTTCGGCCTGCCCTGGCCGGAGGCGCTGCTGCTCGGCGCCATCGTCTCCTCCACCGACG
CCGCGGCGGTGTTCTCGGCGCTGCGCAACGCCGGGGTGCGGGTGCGCCCGCGCGTGGCGCACCTGCTCGAGGTCGAGTCG
GGCGGCAACGACCCGATGGCGGTGATCCTCACCCTCGCCGTGACCCAGGTCCTCGCGTCCGGCGAGCCGGTCCGCTGGAC
CATCCTGGCGGAGATCGCGATCCAGCTCGCGGTCGGGCTGGCCGCCGGCGTGGGCATCGGCCTGGGCGGGCGCTGGCTCC
TCCGCCGCGCGCACCTCGCCGCGAGCGGCCTCTACCCGGTGCTGACCCTCTCCATCGCCCTGTTCGCGTTCGGCGCGCCC
ACGCTGCTGTGGGGCAGCGGCTTCGTGGCGGTCTACGCGGCCGGGCTCACGCTCGGCGCGGGCCAGCTCCCCTACCTGGC
CGGCCTGCGCCGCGTGCACGACGCCATGGCGTGGTTCAGCCAGGTGGCGATGTTCCTGCTCCTCGGGCTGCTGGTGTTCC
CGTCGCGCGTGGCGGCGGTCGCGGGCCCCGGGCTGGCGATCGGCCTGCTCCTCGCGTTCGTGGCGCGGCCGCTGGTGGTG
GGGCTCATGCTGCTGCCGTTCCGCATGCCGGCACGGGAGGTGATCTTCATCTCCTGGGTCGGGCTGCGCGGCGCGGTCCC
CATCATGCTCGCCACCACGCCGGTGCTGGCCGGCCTCCCGTTCGCCGAGCACGTGTTCGACCTGGTCTTCTTCGTGGTGG
TGGTGAGCACGGTGGTGCAGGGCTCGACCATCGCCTGGCTCGCGCGCAAGCTCGGCCTCGAGACCGCGGGGCCGCCCCCG
CCGCGCGCCGTGCTCGAGATCGTGTCCACCCAGCAGCTCGGCGGCGAGGTCGCCTCGTACTACGTCGAGCCGGCGAGCGC
CGTGGCCGGCTCGCGCATCTCGGAGCTGCCGTTCCCGGAGGGCTCGACCGTGATGCTGGTGGTCCGCGGCCGCGAGCTGG
TGGCGGCGCGCGGGCGCACCGTGCTCCAGCCCGGCGACCACGTCTACGTGTTCGCCCCGCCGGACGAGAAGGCGTTCGTG
CAGCTCCTGTTCGGGCGCGAGGAGGAGGGATGA

Upstream 100 bases:

>100_bases
GGGGCCCCGGCGGCGCCTGAGCGCGCGCGCCGCGCGCAGGACGCGCCCGGGGCGTACGCTCGCGGCCCCACGGCGGCGCC
GCCTCGGTTAAGGTCGGCAG

Downstream 100 bases:

>100_bases
GCCGCGCCGGGCGCCGTCAGGTCCGCGAGGCCCGGATGGCGTCCTCGAGCTCGTTCGGCGGCGGGCGGGCGGAGGGGTCG
CGCGGGAAGTGCTCGGCGAG

Product: sodium/hydrogen exchanger

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 490; Mature: 489

Protein sequence:

>490_residues
MTEPLPTAIALTATALLLGLSVLSSRTSGRLGVPFALLFLAVGILAGSEGIGGIAFADYHLTFRVGTVALVLILFEGGLS
TDVRGLRRIIAPAALLATAGVAGTAALTALGARAFGLPWPEALLLGAIVSSTDAAAVFSALRNAGVRVRPRVAHLLEVES
GGNDPMAVILTLAVTQVLASGEPVRWTILAEIAIQLAVGLAAGVGIGLGGRWLLRRAHLAASGLYPVLTLSIALFAFGAP
TLLWGSGFVAVYAAGLTLGAGQLPYLAGLRRVHDAMAWFSQVAMFLLLGLLVFPSRVAAVAGPGLAIGLLLAFVARPLVV
GLMLLPFRMPAREVIFISWVGLRGAVPIMLATTPVLAGLPFAEHVFDLVFFVVVVSTVVQGSTIAWLARKLGLETAGPPP
PRAVLEIVSTQQLGGEVASYYVEPASAVAGSRISELPFPEGSTVMLVVRGRELVAARGRTVLQPGDHVYVFAPPDEKAFV
QLLFGREEEG

Sequences:

>Translated_490_residues
MTEPLPTAIALTATALLLGLSVLSSRTSGRLGVPFALLFLAVGILAGSEGIGGIAFADYHLTFRVGTVALVLILFEGGLS
TDVRGLRRIIAPAALLATAGVAGTAALTALGARAFGLPWPEALLLGAIVSSTDAAAVFSALRNAGVRVRPRVAHLLEVES
GGNDPMAVILTLAVTQVLASGEPVRWTILAEIAIQLAVGLAAGVGIGLGGRWLLRRAHLAASGLYPVLTLSIALFAFGAP
TLLWGSGFVAVYAAGLTLGAGQLPYLAGLRRVHDAMAWFSQVAMFLLLGLLVFPSRVAAVAGPGLAIGLLLAFVARPLVV
GLMLLPFRMPAREVIFISWVGLRGAVPIMLATTPVLAGLPFAEHVFDLVFFVVVVSTVVQGSTIAWLARKLGLETAGPPP
PRAVLEIVSTQQLGGEVASYYVEPASAVAGSRISELPFPEGSTVMLVVRGRELVAARGRTVLQPGDHVYVFAPPDEKAFV
QLLFGREEEG
>Mature_489_residues
TEPLPTAIALTATALLLGLSVLSSRTSGRLGVPFALLFLAVGILAGSEGIGGIAFADYHLTFRVGTVALVLILFEGGLST
DVRGLRRIIAPAALLATAGVAGTAALTALGARAFGLPWPEALLLGAIVSSTDAAAVFSALRNAGVRVRPRVAHLLEVESG
GNDPMAVILTLAVTQVLASGEPVRWTILAEIAIQLAVGLAAGVGIGLGGRWLLRRAHLAASGLYPVLTLSIALFAFGAPT
LLWGSGFVAVYAAGLTLGAGQLPYLAGLRRVHDAMAWFSQVAMFLLLGLLVFPSRVAAVAGPGLAIGLLLAFVARPLVVG
LMLLPFRMPAREVIFISWVGLRGAVPIMLATTPVLAGLPFAEHVFDLVFFVVVVSTVVQGSTIAWLARKLGLETAGPPPP
RAVLEIVSTQQLGGEVASYYVEPASAVAGSRISELPFPEGSTVMLVVRGRELVAARGRTVLQPGDHVYVFAPPDEKAFVQ
LLFGREEEG

Specific function: Participates in control of cell volume in low-osmolarity conditions [H]

COG id: COG3263

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI87081854, Length=442, Percent_Identity=40.2714932126697, Blast_Score=262, Evalue=3e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018421
- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR016169
- InterPro:   IPR006037
- InterPro:   IPR005170 [H]

Pfam domain/function: PF03471 CorC_HlyC; PF00999 Na_H_Exchanger; PF02080 TrkA_C [H]

EC number: NA

Molecular weight: Translated: 50809; Mature: 50678

Theoretical pI: Translated: 9.67; Mature: 9.67

Prosite motif: PS00687 ALDEHYDE_DEHYDR_GLU

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEPLPTAIALTATALLLGLSVLSSRTSGRLGVPFALLFLAVGILAGSEGIGGIAFADYH
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEEE
LTFRVGTVALVLILFEGGLSTDVRGLRRIIAPAALLATAGVAGTAALTALGARAFGLPWP
EEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCH
EALLLGAIVSSTDAAAVFSALRNAGVRVRPRVAHLLEVESGGNDPMAVILTLAVTQVLAS
HHHHHHHHHCCCHHHHHHHHHHHCCCEECCHHHHHEEECCCCCCHHHHHHHHHHHHHHHC
GEPVRWTILAEIAIQLAVGLAAGVGIGLGGRWLLRRAHLAASGLYPVLTLSIALFAFGAP
CCCEEEHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCC
TLLWGSGFVAVYAAGLTLGAGQLPYLAGLRRVHDAMAWFSQVAMFLLLGLLVFPSRVAAV
HHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGPGLAIGLLLAFVARPLVVGLMLLPFRMPAREVIFISWVGLRGAVPIMLATTPVLAGLP
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCEEEHHHHHHCCC
FAEHVFDLVFFVVVVSTVVQGSTIAWLARKLGLETAGPPPPRAVLEIVSTQQLGGEVASY
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCHHHHHH
YVEPASAVAGSRISELPFPEGSTVMLVVRGRELVAARGRTVLQPGDHVYVFAPPDEKAFV
HCCCHHHHHCCCHHCCCCCCCCEEEEEEECCHHHHHCCCEEECCCCEEEEEECCCHHHHH
QLLFGREEEG
HHHHCCCCCC
>Mature Secondary Structure 
TEPLPTAIALTATALLLGLSVLSSRTSGRLGVPFALLFLAVGILAGSEGIGGIAFADYH
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEEE
LTFRVGTVALVLILFEGGLSTDVRGLRRIIAPAALLATAGVAGTAALTALGARAFGLPWP
EEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCH
EALLLGAIVSSTDAAAVFSALRNAGVRVRPRVAHLLEVESGGNDPMAVILTLAVTQVLAS
HHHHHHHHHCCCHHHHHHHHHHHCCCEECCHHHHHEEECCCCCCHHHHHHHHHHHHHHHC
GEPVRWTILAEIAIQLAVGLAAGVGIGLGGRWLLRRAHLAASGLYPVLTLSIALFAFGAP
CCCEEEHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCC
TLLWGSGFVAVYAAGLTLGAGQLPYLAGLRRVHDAMAWFSQVAMFLLLGLLVFPSRVAAV
HHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGPGLAIGLLLAFVARPLVVGLMLLPFRMPAREVIFISWVGLRGAVPIMLATTPVLAGLP
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCEEEHHHHHHCCC
FAEHVFDLVFFVVVVSTVVQGSTIAWLARKLGLETAGPPPPRAVLEIVSTQQLGGEVASY
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCHHHHHH
YVEPASAVAGSRISELPFPEGSTVMLVVRGRELVAARGRTVLQPGDHVYVFAPPDEKAFV
HCCCHHHHHCCCHHCCCCCCCCEEEEEEECCHHHHHCCCEEECCCCEEEEEECCCHHHHH
QLLFGREEEG
HHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA