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The map label for this gene is zraR [H]

Identifier: 220915978

GI number: 220915978

Start: 970884

End: 972284

Strand: Direct

Name: zraR [H]

Synonym: A2cp1_0864

Alternate gene names: 220915978

Gene position: 970884-972284 (Clockwise)

Preceding gene: 220915976

Following gene: 220915981

Centisome position: 19.3

GC content: 75.87

Gene sequence:

>1401_bases
ATGAAGCGCGACCGCATCCTCGTCATCGATGGCAACCCGCTCGACGGGGCCGGCCTCAGGGCCGCCCTGTGCGAGCGCGG
CTTCGACGCGGTCGAGGCCGCCAGCGCGGAGCGCGCGCTCGGGCTCGTCCCGAGCTTCCAGCCCGCCGCGGTGCTGGCCG
ACGTGACGCTCCCCGGCTGCGAGGCCGGCGAGCTGGTCGGCCGCCTGCGCGAGCTCGGGTCCGACGCGGCGGTGGTGGTC
GCGGCGCCGCACGACCGGCTGGAGGCGGCGGTCCAGGCGCTGCGCGCCGGGGCCGAGAGCTTCCTGGTCCGCCCGGTGGA
CGCCGGCCAGGCGCTGGTGGTGCTCCAGAAGGCGCTCGAGAAGCGCGGGCTGCGCCGCGATCGCGCCGAGCTGCGCGAGC
GCGTCCGCGCGCGCGCCGCGCTGGTGGGCACCGCGCCGGAGATGCAGGGTGTGGTCGAGCTGGTGCGCCGCGTGGCGCCC
ACCAAGGCGACGGTCCTGGTGCTGGGCGAGTCTGGCACCGGCAAGGAGCACGTCGCCCAGGCGCTGCACGAGGCCTCGCC
CCGGCGCGACCGGCCGTTCGTGCGGGTCAACTGCGCGGCGCTCTCGGAGGCGCTGCTCGAGTCCGACCTCTTCGGCCACG
AGCCGGGGGCGTTCGCCGACTCCGAGGAGCGCCACGTCGGCAAGCTGGAGCTCGCCGACGGCGGGACCCTGTACCTGCAC
GAGGTGGGGAGCCTGCCGCCGCCGGTCCAGGTGAAGCTGCTCCGGGTGCTCCAGCAGGGCGAGATGGAGCGGATGGGCGG
CCGCGAGACGCTGCGGGTGGACGTGCGCGTGGTGGCGGGCGCGCAGCACGACCTCGCCGAGGAGGTCCGCGCCGGCCGGT
TCCGCGACGACCTGTACTACCGGCTCAACGTGGTGGCGGTGGCGCTGCCCCCGCTGCGCGAGCGCAAGGGCGACATCCCC
GCGCTGGTGAACCACTTCCTCGATGTGGCGGCCCGCACGCAGGGGAGCGAGGTCGTCGGCGTGACCCCGGGGACGCTCTC
GGCGCTGTTCGCCTACGACTGGCCGGGCAACGTGCGCGAGCTGGCGAGCGTGGTCGAGCACGCGGTGTCGGTGGCGCGCG
GGCGCGAGATCACCGCGGAGGACCTCTCGCCGGTGCTGCACGGCGCCCGCCCGGAGGAGAGCGGCGCCTCCGCCCTCATC
CCCGGCGCCACGCTGTTCGAGATCGAGCGCGAGGCGATCCTGCGCACGCTCGAGCAGTGCGGCGGCTCGACCGCCCGCGC
GGCGGAGGTGCTGGGCGTCTCGGTGCGGAAGATCCAGTACCGCCTGAAGGAGTACCGGAGCGGCGTCCCCGGACGCCGGC
CCCCCGAGCTCGAGGACGCCTACGCCGAGGCGCACAAGTAG

Upstream 100 bases:

>100_bases
GACGCTGCGCACGCAGCGTGCGGGCGGGCGGCGCGCAATTCGTGCACGCAAAGGCGGTTGATTCCCGGGTACGGGAGTTG
CTATCCCCCGCCCCGGCAAG

Downstream 100 bases:

>100_bases
CGCGCCGCCGGCCCGAGCCCCGCTCCCTTCCCGCCCGCGGGCCCGAAAAAAAGACCGCCCGGCAGTGGTGTGCCGGGCGG
CCCCGAGCGCGCGGGGGCGC

Product: two component sigma-54 specific Fis family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 466; Mature: 466

Protein sequence:

>466_residues
MKRDRILVIDGNPLDGAGLRAALCERGFDAVEAASAERALGLVPSFQPAAVLADVTLPGCEAGELVGRLRELGSDAAVVV
AAPHDRLEAAVQALRAGAESFLVRPVDAGQALVVLQKALEKRGLRRDRAELRERVRARAALVGTAPEMQGVVELVRRVAP
TKATVLVLGESGTGKEHVAQALHEASPRRDRPFVRVNCAALSEALLESDLFGHEPGAFADSEERHVGKLELADGGTLYLH
EVGSLPPPVQVKLLRVLQQGEMERMGGRETLRVDVRVVAGAQHDLAEEVRAGRFRDDLYYRLNVVAVALPPLRERKGDIP
ALVNHFLDVAARTQGSEVVGVTPGTLSALFAYDWPGNVRELASVVEHAVSVARGREITAEDLSPVLHGARPEESGASALI
PGATLFEIEREAILRTLEQCGGSTARAAEVLGVSVRKIQYRLKEYRSGVPGRRPPELEDAYAEAHK

Sequences:

>Translated_466_residues
MKRDRILVIDGNPLDGAGLRAALCERGFDAVEAASAERALGLVPSFQPAAVLADVTLPGCEAGELVGRLRELGSDAAVVV
AAPHDRLEAAVQALRAGAESFLVRPVDAGQALVVLQKALEKRGLRRDRAELRERVRARAALVGTAPEMQGVVELVRRVAP
TKATVLVLGESGTGKEHVAQALHEASPRRDRPFVRVNCAALSEALLESDLFGHEPGAFADSEERHVGKLELADGGTLYLH
EVGSLPPPVQVKLLRVLQQGEMERMGGRETLRVDVRVVAGAQHDLAEEVRAGRFRDDLYYRLNVVAVALPPLRERKGDIP
ALVNHFLDVAARTQGSEVVGVTPGTLSALFAYDWPGNVRELASVVEHAVSVARGREITAEDLSPVLHGARPEESGASALI
PGATLFEIEREAILRTLEQCGGSTARAAEVLGVSVRKIQYRLKEYRSGVPGRRPPELEDAYAEAHK
>Mature_466_residues
MKRDRILVIDGNPLDGAGLRAALCERGFDAVEAASAERALGLVPSFQPAAVLADVTLPGCEAGELVGRLRELGSDAAVVV
AAPHDRLEAAVQALRAGAESFLVRPVDAGQALVVLQKALEKRGLRRDRAELRERVRARAALVGTAPEMQGVVELVRRVAP
TKATVLVLGESGTGKEHVAQALHEASPRRDRPFVRVNCAALSEALLESDLFGHEPGAFADSEERHVGKLELADGGTLYLH
EVGSLPPPVQVKLLRVLQQGEMERMGGRETLRVDVRVVAGAQHDLAEEVRAGRFRDDLYYRLNVVAVALPPLRERKGDIP
ALVNHFLDVAARTQGSEVVGVTPGTLSALFAYDWPGNVRELASVVEHAVSVARGREITAEDLSPVLHGARPEESGASALI
PGATLFEIEREAILRTLEQCGGSTARAAEVLGVSVRKIQYRLKEYRSGVPGRRPPELEDAYAEAHK

Specific function: Member of the two-component regulatory system zraS/zraR. When activated by zraS it acts in conjunction with sigma-54 to regulate the expression of zraP. Positively autoregulates the expression of the zraSR operon [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=450, Percent_Identity=36.4444444444444, Blast_Score=313, Evalue=1e-86,
Organism=Escherichia coli, GI1790437, Length=437, Percent_Identity=40.9610983981693, Blast_Score=309, Evalue=2e-85,
Organism=Escherichia coli, GI1790299, Length=484, Percent_Identity=35.5371900826446, Blast_Score=274, Evalue=8e-75,
Organism=Escherichia coli, GI1788905, Length=428, Percent_Identity=35.0467289719626, Blast_Score=249, Evalue=3e-67,
Organism=Escherichia coli, GI87082117, Length=382, Percent_Identity=38.4816753926702, Blast_Score=247, Evalue=1e-66,
Organism=Escherichia coli, GI1789087, Length=306, Percent_Identity=43.1372549019608, Blast_Score=228, Evalue=7e-61,
Organism=Escherichia coli, GI1789233, Length=317, Percent_Identity=38.1703470031546, Blast_Score=227, Evalue=1e-60,
Organism=Escherichia coli, GI87082152, Length=311, Percent_Identity=40.5144694533762, Blast_Score=214, Evalue=7e-57,
Organism=Escherichia coli, GI87081872, Length=317, Percent_Identity=40.0630914826498, Blast_Score=212, Evalue=4e-56,
Organism=Escherichia coli, GI1786524, Length=331, Percent_Identity=39.2749244712991, Blast_Score=203, Evalue=2e-53,
Organism=Escherichia coli, GI1787583, Length=316, Percent_Identity=37.3417721518987, Blast_Score=193, Evalue=2e-50,
Organism=Escherichia coli, GI87081858, Length=302, Percent_Identity=33.7748344370861, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI1789828, Length=273, Percent_Identity=31.8681318681319, Blast_Score=120, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 50075; Mature: 50075

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRDRILVIDGNPLDGAGLRAALCERGFDAVEAASAERALGLVPSFQPAAVLADVTLPGC
CCCCCEEEEECCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHHEEECCCCCC
EAGELVGRLRELGSDAAVVVAAPHDRLEAAVQALRAGAESFLVRPVDAGQALVVLQKALE
CHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHCCHHHEEECCCCCHHHHHHHHHHH
KRGLRRDRAELRERVRARAALVGTAPEMQGVVELVRRVAPTKATVLVLGESGTGKEHVAQ
HCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHH
ALHEASPRRDRPFVRVNCAALSEALLESDLFGHEPGAFADSEERHVGKLELADGGTLYLH
HHHHCCCCCCCCEEEEEHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCEEEEE
EVGSLPPPVQVKLLRVLQQGEMERMGGRETLRVDVRVVAGAQHDLAEEVRAGRFRDDLYY
ECCCCCCCHHHHHHHHHHHCCHHHCCCCCEEEEEEEEEECCHHHHHHHHHHCCCHHHHHE
RLNVVAVALPPLRERKGDIPALVNHFLDVAARTQGSEVVGVTPGTLSALFAYDWPGNVRE
EEEEEEEECCCHHHHCCCHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHEEECCCCCHHH
LASVVEHAVSVARGREITAEDLSPVLHGARPEESGASALIPGATLFEIEREAILRTLEQC
HHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHH
GGSTARAAEVLGVSVRKIQYRLKEYRSGVPGRRPPELEDAYAEAHK
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCC
>Mature Secondary Structure
MKRDRILVIDGNPLDGAGLRAALCERGFDAVEAASAERALGLVPSFQPAAVLADVTLPGC
CCCCCEEEEECCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHHEEECCCCCC
EAGELVGRLRELGSDAAVVVAAPHDRLEAAVQALRAGAESFLVRPVDAGQALVVLQKALE
CHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHCCHHHEEECCCCCHHHHHHHHHHH
KRGLRRDRAELRERVRARAALVGTAPEMQGVVELVRRVAPTKATVLVLGESGTGKEHVAQ
HCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHH
ALHEASPRRDRPFVRVNCAALSEALLESDLFGHEPGAFADSEERHVGKLELADGGTLYLH
HHHHCCCCCCCCEEEEEHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCEEEEE
EVGSLPPPVQVKLLRVLQQGEMERMGGRETLRVDVRVVAGAQHDLAEEVRAGRFRDDLYY
ECCCCCCCHHHHHHHHHHHCCHHHCCCCCEEEEEEEEEECCHHHHHHHHHHCCCHHHHHE
RLNVVAVALPPLRERKGDIPALVNHFLDVAARTQGSEVVGVTPGTLSALFAYDWPGNVRE
EEEEEEEECCCHHHHCCCHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHEEECCCCCHHH
LASVVEHAVSVARGREITAEDLSPVLHGARPEESGASALIPGATLFEIEREAILRTLEQC
HHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHH
GGSTARAAEVLGVSVRKIQYRLKEYRSGVPGRRPPELEDAYAEAHK
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]