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The map label for this gene is f1pep1 [H]

Identifier: 220915957

GI number: 220915957

Start: 946251

End: 948212

Strand: Direct

Name: f1pep1 [H]

Synonym: A2cp1_0843

Alternate gene names: 220915957

Gene position: 946251-948212 (Clockwise)

Preceding gene: 220915954

Following gene: 220915961

Centisome position: 18.81

GC content: 76.81

Gene sequence:

>1962_bases
ATGCACGCCTTCCTCCTCGCATGCCTCGTCGCGGCCGGCGCCGTGGCCGCCCCGCTCGACCTCGCCCCGGTCCCGGGCCG
CCCCAACCTGCTCCAGCTCGGCGTCCCCGAGGTCCCCCCGGAGGTGTCCGCCCGCCTCGAGCAGTACGAGAACGCGCGCG
CCGCGGTCCTCCGCGACGTGTCGCCGGACGGCCGGGCCATGCTGGTGACCACGCGGTTCGGCAGCACCGCCCAGCTCCAC
CTCGTGCTGGCGCCGCTGGGCATGCGCGAGCAGCTCACGTTCGGCGACGAGCCGGTGTCCGACGCCGCGTTCCTGCCGGG
CCGGCCGGAGCGACTGCTCTACCTGCAGGACAAGGGCGGCGGCGAGTTCTTCCAGCTCTACGGCCTGGACCGGCGCACCG
GCCGCTCGGAGCTGCTCACCGACGGCCGGAGCCGCCACTCGGACCTGGTGGTCTCGCCGGACGGCCGGCGCCTCGCGTAC
TCGGGGACGGGCCGCAACGGCAAGGACGCGGACGTGTACGTGGCCGAGGCCGACCGGCCCGGCGCCGCGCGGCGCGTGGT
GGAGGCGGAGGGGAGCTGGTCGGCGCTCGACTTCTCGCGCGACGGGCGCCGGCTGCTGGTCCGCCGGTACCGCGCCGCCT
CCGACGCCGACCTCGAGCTGGTGGACCTCGCGACCGGCGCGCGGACGCCGCTGCTCGCCGGCAAGGGCTCGGTGGGCGGG
GCCGCGTTCTCCGCGGACGGGAGGTACGCGTACGCCATCACCGACCGCGGCGCCGGGCACGCGGCGCTGGTCCGCGTGGA
CCTCGCGCAGCCGGAGGCCGCGCCGCGTCCGGTCGCGCCCGGGGTGGCCTGGGACGTCGAGCAGGTGGTGGTGGCGCGCG
ACGGCACCGTGGCCTTCACCGCCGACGCGGACGGCGTCTCGCTGCTCCACGTGGTGGACCCGCGCACCGGCCGGCTGCGC
GGCGTGGCGCTCCCGGGCCGGGGCGTCGCGACGCTCCGGTTCCCCTCCGGGCGGAGCGACCTCCTCGCGGTCGGGCTGGT
GAGCGCCACCTCGCCCTGGGACGCCTGGACGGTCGAGCTCCGCGGCGGGAAGGCGGTGCGCTGGACGCGCTCGGAGGTGG
GCGGGCTCGATCCGGCCGGGTTCGTGGAGCCGGAGCGGGTCCGCTACCCGAGCGCCGGCGGCGCGGAGGTGCCGGCGCTC
CTGTACCGGCCGCGCGGCGGCGGACGGGTCCCGGTGGTCGTGAACTGGCATGGCGGCCCCGAGAGCCAGCACCGGCCGGC
GTTCAGCCCCATGGTGCAGTTCCTGGTGGCGGAGCTGGGCGTGGCGGTGCTCCAGCCGAACGTGCGCGGCTCCGCCGGCT
ACGGGAAGGACTGGCTCGCGCTCGACGACGGGGTGCGCCGCGAGGAGGCGCTGAAGGACGTCCCGGCCACGTTCCAGTTC
ATCGCCTCGAGGCCCGACCTCGACGCCTCGCGCGCGGTGGTGTGGGGCGGCTCCTACGGCGGCTATATGGTGCTCGCGAC
GCTCACGCTGTTCCCGGGCCTGGCGAGCGCCGGCGTGGACGTGGTGGGCATCTCCTCGCTGCCGAGCTTCCTCGAGAGCA
CCCAGGCGTACCGGCGCGACCTGCGCCGCGCCGAGTACGGCGACGAGCGCGTGCCGGAGGTGCGCGCGGTCCAGGAGCGG
ATCTCGCCGCTGGGCCGGGCCGGGGCCATCCGCGTGCCGCTGCTCGTCATCCAGGGCGCGAACGACCCGCGCGTCCCGCG
CTCCGAGGCCGAGCAGATCGTCCGGGCGGTCCGCGCGAACGGGCAGGAGGTCTGGTACCTCGTCGCGCTCGACGAGGGGC
ACGGCTTCAAGAAGAAGGAGAACCGCGACCACGCCGACGCGGTCACGGTGGCGTTCCTGCAGCGGATGCTGGCCGGCGCG
CCCCCCGCCGCGCAGCAGCGCGGCGCCGCCTCGGCACGCTGA

Upstream 100 bases:

>100_bases
CGGCGCGCACCCGCAGGCCCCCTGCGCGCGGACCCGGGGCTCCCCCGCAGGACCGAGCCGGCTGCTCGCCTTCTTCCCCG
GCCTCGCCTAGAGGTGGGGA

Downstream 100 bases:

>100_bases
GGCCAACGTCCGGCGCGCCGACTAGCTCGGCGGGCCCGCTCCGCCGAGCTGCCACCGCCCGCGCAGCGTGGGCTGCTCCA
GCGCGCGGGCGAGCCGGGCC

Product: peptidase S9 prolyl oligopeptidase active site domain-containing protein

Products: NA

Alternate protein names: Post-proline cleaving enzyme; Proline-specific endopeptidase; PE; PSE [H]

Number of amino acids: Translated: 653; Mature: 653

Protein sequence:

>653_residues
MHAFLLACLVAAGAVAAPLDLAPVPGRPNLLQLGVPEVPPEVSARLEQYENARAAVLRDVSPDGRAMLVTTRFGSTAQLH
LVLAPLGMREQLTFGDEPVSDAAFLPGRPERLLYLQDKGGGEFFQLYGLDRRTGRSELLTDGRSRHSDLVVSPDGRRLAY
SGTGRNGKDADVYVAEADRPGAARRVVEAEGSWSALDFSRDGRRLLVRRYRAASDADLELVDLATGARTPLLAGKGSVGG
AAFSADGRYAYAITDRGAGHAALVRVDLAQPEAAPRPVAPGVAWDVEQVVVARDGTVAFTADADGVSLLHVVDPRTGRLR
GVALPGRGVATLRFPSGRSDLLAVGLVSATSPWDAWTVELRGGKAVRWTRSEVGGLDPAGFVEPERVRYPSAGGAEVPAL
LYRPRGGGRVPVVVNWHGGPESQHRPAFSPMVQFLVAELGVAVLQPNVRGSAGYGKDWLALDDGVRREEALKDVPATFQF
IASRPDLDASRAVVWGGSYGGYMVLATLTLFPGLASAGVDVVGISSLPSFLESTQAYRRDLRRAEYGDERVPEVRAVQER
ISPLGRAGAIRVPLLVIQGANDPRVPRSEAEQIVRAVRANGQEVWYLVALDEGHGFKKKENRDHADAVTVAFLQRMLAGA
PPAAQQRGAASAR

Sequences:

>Translated_653_residues
MHAFLLACLVAAGAVAAPLDLAPVPGRPNLLQLGVPEVPPEVSARLEQYENARAAVLRDVSPDGRAMLVTTRFGSTAQLH
LVLAPLGMREQLTFGDEPVSDAAFLPGRPERLLYLQDKGGGEFFQLYGLDRRTGRSELLTDGRSRHSDLVVSPDGRRLAY
SGTGRNGKDADVYVAEADRPGAARRVVEAEGSWSALDFSRDGRRLLVRRYRAASDADLELVDLATGARTPLLAGKGSVGG
AAFSADGRYAYAITDRGAGHAALVRVDLAQPEAAPRPVAPGVAWDVEQVVVARDGTVAFTADADGVSLLHVVDPRTGRLR
GVALPGRGVATLRFPSGRSDLLAVGLVSATSPWDAWTVELRGGKAVRWTRSEVGGLDPAGFVEPERVRYPSAGGAEVPAL
LYRPRGGGRVPVVVNWHGGPESQHRPAFSPMVQFLVAELGVAVLQPNVRGSAGYGKDWLALDDGVRREEALKDVPATFQF
IASRPDLDASRAVVWGGSYGGYMVLATLTLFPGLASAGVDVVGISSLPSFLESTQAYRRDLRRAEYGDERVPEVRAVQER
ISPLGRAGAIRVPLLVIQGANDPRVPRSEAEQIVRAVRANGQEVWYLVALDEGHGFKKKENRDHADAVTVAFLQRMLAGA
PPAAQQRGAASAR
>Mature_653_residues
MHAFLLACLVAAGAVAAPLDLAPVPGRPNLLQLGVPEVPPEVSARLEQYENARAAVLRDVSPDGRAMLVTTRFGSTAQLH
LVLAPLGMREQLTFGDEPVSDAAFLPGRPERLLYLQDKGGGEFFQLYGLDRRTGRSELLTDGRSRHSDLVVSPDGRRLAY
SGTGRNGKDADVYVAEADRPGAARRVVEAEGSWSALDFSRDGRRLLVRRYRAASDADLELVDLATGARTPLLAGKGSVGG
AAFSADGRYAYAITDRGAGHAALVRVDLAQPEAAPRPVAPGVAWDVEQVVVARDGTVAFTADADGVSLLHVVDPRTGRLR
GVALPGRGVATLRFPSGRSDLLAVGLVSATSPWDAWTVELRGGKAVRWTRSEVGGLDPAGFVEPERVRYPSAGGAEVPAL
LYRPRGGGRVPVVVNWHGGPESQHRPAFSPMVQFLVAELGVAVLQPNVRGSAGYGKDWLALDDGVRREEALKDVPATFQF
IASRPDLDASRAVVWGGSYGGYMVLATLTLFPGLASAGVDVVGISSLPSFLESTQAYRRDLRRAEYGDERVPEVRAVQER
ISPLGRAGAIRVPLLVIQGANDPRVPRSEAEQIVRAVRANGQEVWYLVALDEGHGFKKKENRDHADAVTVAFLQRMLAGA
PPAAQQRGAASAR

Specific function: Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long. Has an absolute requirement for an X-Pro bond in the trans configuration immediately preceding the Pro-Y scissible bond [H]

COG id: COG1506

COG function: function code E; Dipeptidyl aminopeptidases/acylaminoacyl-peptidases

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9A family [H]

Homologues:

Organism=Homo sapiens, GI23510451, Length=262, Percent_Identity=26.7175572519084, Blast_Score=82, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI25144540, Length=232, Percent_Identity=37.0689655172414, Blast_Score=134, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI25144537, Length=232, Percent_Identity=37.0689655172414, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17552908, Length=275, Percent_Identity=27.2727272727273, Blast_Score=96, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI25144543, Length=136, Percent_Identity=36.7647058823529, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI25149159, Length=234, Percent_Identity=28.6324786324786, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002471
- InterPro:   IPR001375
- InterPro:   IPR002470
- InterPro:   IPR004106 [H]

Pfam domain/function: PF00326 Peptidase_S9; PF02897 Peptidase_S9_N [H]

EC number: =3.4.21.26 [H]

Molecular weight: Translated: 69646; Mature: 69646

Theoretical pI: Translated: 8.77; Mature: 8.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHAFLLACLVAAGAVAAPLDLAPVPGRPNLLQLGVPEVPPEVSARLEQYENARAAVLRDV
CHHHHHHHHHHHCHHHCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCEEEEECC
SPDGRAMLVTTRFGSTAQLHLVLAPLGMREQLTFGDEPVSDAAFLPGRPERLLYLQDKGG
CCCCCEEEEEEECCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCC
GEFFQLYGLDRRTGRSELLTDGRSRHSDLVVSPDGRRLAYSGTGRNGKDADVYVAEADRP
CCEEEEECCCCCCCCHHHHCCCCCCCCCEEECCCCCEEEEECCCCCCCCCEEEEEECCCC
GAARRVVEAEGSWSALDFSRDGRRLLVRRYRAASDADLELVDLATGARTPLLAGKGSVGG
CHHHEEEECCCCEEEEECCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCEEECCCCCCC
AAFSADGRYAYAITDRGAGHAALVRVDLAQPEAAPRPVAPGVAWDVEQVVVARDGTVAFT
EEEECCCEEEEEEECCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEE
ADADGVSLLHVVDPRTGRLRGVALPGRGVATLRFPSGRSDLLAVGLVSATSPWDAWTVEL
ECCCCEEEEEEECCCCCCEEEEECCCCCEEEEECCCCCCCEEEEEEEECCCCCCEEEEEE
RGGKAVRWTRSEVGGLDPAGFVEPERVRYPSAGGAEVPALLYRPRGGGRVPVVVNWHGGP
CCCCEEEEEHHHHCCCCCCCCCCHHHEECCCCCCCCCCEEEEECCCCCEEEEEEECCCCC
ESQHRPAFSPMVQFLVAELGVAVLQPNVRGSAGYGKDWLALDDGVRREEALKDVPATFQF
CCCCCCCHHHHHHHHHHHHCCEEECCCCCCCCCCCCCEEECCCCCCHHHHHHHCCHHHHH
IASRPDLDASRAVVWGGSYGGYMVLATLTLFPGLASAGVDVVGISSLPSFLESTQAYRRD
HHCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCHHHCCCCEEEHHHHHHHHHHHHHHHHH
LRRAEYGDERVPEVRAVQERISPLGRAGAIRVPLLVIQGANDPRVPRSEAEQIVRAVRAN
HHHHHCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHCC
GQEVWYLVALDEGHGFKKKENRDHADAVTVAFLQRMLAGAPPAAQQRGAASAR
CCEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHCCCCCCC
>Mature Secondary Structure
MHAFLLACLVAAGAVAAPLDLAPVPGRPNLLQLGVPEVPPEVSARLEQYENARAAVLRDV
CHHHHHHHHHHHCHHHCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCEEEEECC
SPDGRAMLVTTRFGSTAQLHLVLAPLGMREQLTFGDEPVSDAAFLPGRPERLLYLQDKGG
CCCCCEEEEEEECCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCC
GEFFQLYGLDRRTGRSELLTDGRSRHSDLVVSPDGRRLAYSGTGRNGKDADVYVAEADRP
CCEEEEECCCCCCCCHHHHCCCCCCCCCEEECCCCCEEEEECCCCCCCCCEEEEEECCCC
GAARRVVEAEGSWSALDFSRDGRRLLVRRYRAASDADLELVDLATGARTPLLAGKGSVGG
CHHHEEEECCCCEEEEECCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCEEECCCCCCC
AAFSADGRYAYAITDRGAGHAALVRVDLAQPEAAPRPVAPGVAWDVEQVVVARDGTVAFT
EEEECCCEEEEEEECCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEE
ADADGVSLLHVVDPRTGRLRGVALPGRGVATLRFPSGRSDLLAVGLVSATSPWDAWTVEL
ECCCCEEEEEEECCCCCCEEEEECCCCCEEEEECCCCCCCEEEEEEEECCCCCCEEEEEE
RGGKAVRWTRSEVGGLDPAGFVEPERVRYPSAGGAEVPALLYRPRGGGRVPVVVNWHGGP
CCCCEEEEEHHHHCCCCCCCCCCHHHEECCCCCCCCCCEEEEECCCCCEEEEEEECCCCC
ESQHRPAFSPMVQFLVAELGVAVLQPNVRGSAGYGKDWLALDDGVRREEALKDVPATFQF
CCCCCCCHHHHHHHHHHHHCCEEECCCCCCCCCCCCCEEECCCCCCHHHHHHHCCHHHHH
IASRPDLDASRAVVWGGSYGGYMVLATLTLFPGLASAGVDVVGISSLPSFLESTQAYRRD
HHCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCHHHCCCCEEEHHHHHHHHHHHHHHHHH
LRRAEYGDERVPEVRAVQERISPLGRAGAIRVPLLVIQGANDPRVPRSEAEQIVRAVRAN
HHHHHCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHCC
GQEVWYLVALDEGHGFKKKENRDHADAVTVAFLQRMLAGAPPAAQQRGAASAR
CCEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1840588; 7764331 [H]