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The map label for this gene is pdp [H]

Identifier: 220915770

GI number: 220915770

Start: 725646

End: 726953

Strand: Direct

Name: pdp [H]

Synonym: A2cp1_0651

Alternate gene names: 220915770

Gene position: 725646-726953 (Clockwise)

Preceding gene: 220915769

Following gene: 220915771

Centisome position: 14.43

GC content: 75.69

Gene sequence:

>1308_bases
TTGCGCGCCTACGAGATCATCCACGCGAAGCGCGACGGCCGGGTCCTGCCCGCGGACGCCATCGCGGCGCTGGTGGACGG
GTTCACCCACGGCGAGGTCCCCGACTACCAGATGGCGGCGTTCTGCATGGCGGTGTTCTTCCGCGGCATGGACGACGCGG
AGGTGCGCGCGCTCACCGAGGCGATGCTCCGCTCCGGCGACGTGCTCGATCTATCGGACGTCCCGGGAGCGAAGGTGGAC
AAGCACTCCACCGGCGGCGTGGGCGACAAGGTCTCGCTCGCGCTCGCGCCGCTCGCGGCGGCCTGCGGCGTGAAGGTGCC
GATGATCTCCGGGCGCGGCCTGGGCCACACCGGCGGCACGCTCGACAAGCTGGAGGCGATCCCGGGGTTCCGGGTGGACC
TGCCGGTGGAGCGCTTTCGCGCGCAGGTGCGCGACGTGGGCGCCTGCCTGATCGGCCAGACCGCGCGCCTCGCGCCGGCG
GACCGGAAGCTCTACGCGCTGCGTGACGTGACCGCCACGGTGGAGTCGATCCCGCTGATCGCCGCCTCGATCATGTCGAA
GAAGCTGGCCGAGGGGATCGACGCGCTGGTGCTGGACGTGAAGGTCGGCTCGGGCGCGTTCATGAAGCGGCCGGAGGACG
CGCGGGCGCTGGCGCGCACGCTCGCGGCGATCGGGCGCGGGATGGGCAAGCGGGTCACCGCACTGCTCACCGGGATGGAC
CAGCCGCTCGGCCGGGCGGTGGGGAACGCGCTGGAGGTCGCGGAGGTGCTCGAGCTCCTCCGCGGCGGCGGGCCCGCGGA
CCTGCGGGCCATCACGGTCGAGCTCACGGCCGAGATGCTCCTCGCCGGCGGAGTCGCGCCGGAGCTCGCCGCGGCGCGCG
CGGCGGTGGAGCAGGCCATCGGCGACGGGCGCGGGCTCGCCAAGCTGGAGGAGATCGTGGCCGCGCAGGGCGGCGATCCG
GCCGCCATCCGCGATCCGTCGCGGCTGCCGCGCGCCGCCGGCACCTACCCCGTGCCCTCTCCCGCCGCGGGGTTCGTGCA
GGCCGTGGACACCGAGGCGGTGGGGCTCGCCGCGGTCGCGCTCGGCGCCGGGCGTGCCCGGGTGGACGACCCGGTCGACC
CGGCGGTGGGCATCCTCGTCGAGCGCAAGCTGGGCGACCGCGTCGAGCGGGGCGAGCCGCTCTGCGTCGTCCACCACGGC
CCGCGCAGCGAGCCGCGCGAGCGCATCGCCGCCCGGCTCGCGGGCGCGTACCGCATCGGCCCGGCCGCGCCCCCCGCCGC
GCCCCTGTTCCTCGAGAGGCTGACATGA

Upstream 100 bases:

>100_bases
CGCGTGAGCGCGCCGCCCCCCCCACCGCTGCCGTCGCGCGGCGCCGCGCCCTGCGCTAGGCTCGGAATACGCGCCGACGC
CGGTGCGCCGGGAGGGCCGC

Downstream 100 bases:

>100_bases
CCCGGCGCGCCGATCTCCCCACCCGGCTCTCCTACGCGCTCGCCTGGGTGCGCGGCCAGGCCGAGGCCGCGCCCGCCGCC
GGCGTCATCCTGGGCTCCGG

Product: pyrimidine-nucleoside phosphorylase

Products: NA

Alternate protein names: PYNP [H]

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MRAYEIIHAKRDGRVLPADAIAALVDGFTHGEVPDYQMAAFCMAVFFRGMDDAEVRALTEAMLRSGDVLDLSDVPGAKVD
KHSTGGVGDKVSLALAPLAAACGVKVPMISGRGLGHTGGTLDKLEAIPGFRVDLPVERFRAQVRDVGACLIGQTARLAPA
DRKLYALRDVTATVESIPLIAASIMSKKLAEGIDALVLDVKVGSGAFMKRPEDARALARTLAAIGRGMGKRVTALLTGMD
QPLGRAVGNALEVAEVLELLRGGGPADLRAITVELTAEMLLAGGVAPELAAARAAVEQAIGDGRGLAKLEEIVAAQGGDP
AAIRDPSRLPRAAGTYPVPSPAAGFVQAVDTEAVGLAAVALGAGRARVDDPVDPAVGILVERKLGDRVERGEPLCVVHHG
PRSEPRERIAARLAGAYRIGPAAPPAAPLFLERLT

Sequences:

>Translated_435_residues
MRAYEIIHAKRDGRVLPADAIAALVDGFTHGEVPDYQMAAFCMAVFFRGMDDAEVRALTEAMLRSGDVLDLSDVPGAKVD
KHSTGGVGDKVSLALAPLAAACGVKVPMISGRGLGHTGGTLDKLEAIPGFRVDLPVERFRAQVRDVGACLIGQTARLAPA
DRKLYALRDVTATVESIPLIAASIMSKKLAEGIDALVLDVKVGSGAFMKRPEDARALARTLAAIGRGMGKRVTALLTGMD
QPLGRAVGNALEVAEVLELLRGGGPADLRAITVELTAEMLLAGGVAPELAAARAAVEQAIGDGRGLAKLEEIVAAQGGDP
AAIRDPSRLPRAAGTYPVPSPAAGFVQAVDTEAVGLAAVALGAGRARVDDPVDPAVGILVERKLGDRVERGEPLCVVHHG
PRSEPRERIAARLAGAYRIGPAAPPAAPLFLERLT
>Mature_435_residues
MRAYEIIHAKRDGRVLPADAIAALVDGFTHGEVPDYQMAAFCMAVFFRGMDDAEVRALTEAMLRSGDVLDLSDVPGAKVD
KHSTGGVGDKVSLALAPLAAACGVKVPMISGRGLGHTGGTLDKLEAIPGFRVDLPVERFRAQVRDVGACLIGQTARLAPA
DRKLYALRDVTATVESIPLIAASIMSKKLAEGIDALVLDVKVGSGAFMKRPEDARALARTLAAIGRGMGKRVTALLTGMD
QPLGRAVGNALEVAEVLELLRGGGPADLRAITVELTAEMLLAGGVAPELAAARAAVEQAIGDGRGLAKLEEIVAAQGGDP
AAIRDPSRLPRAAGTYPVPSPAAGFVQAVDTEAVGLAAVALGAGRARVDDPVDPAVGILVERKLGDRVERGEPLCVVHHG
PRSEPRERIAARLAGAYRIGPAAPPAAPLFLERLT

Specific function: The Enzymes Which Catalyze The Reversible Phosphorolysis Of Pyrimidine Nucleosides Are Involved In The Degradation Of These Compounds And In Their Utilization As Carbon And Energy Sources, Or In The Rescue Of Pyrimidine Bases For Nucleotide Synthesis. [C

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI166158925, Length=436, Percent_Identity=47.0183486238532, Blast_Score=311, Evalue=6e-85,
Organism=Homo sapiens, GI4503445, Length=436, Percent_Identity=47.0183486238532, Blast_Score=311, Evalue=6e-85,
Organism=Homo sapiens, GI166158922, Length=436, Percent_Identity=47.0183486238532, Blast_Score=311, Evalue=6e-85,
Organism=Escherichia coli, GI1790842, Length=410, Percent_Identity=47.5609756097561, Blast_Score=343, Evalue=1e-95,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872 [H]

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C [H]

EC number: =2.4.2.2 [H]

Molecular weight: Translated: 45086; Mature: 45086

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAYEIIHAKRDGRVLPADAIAALVDGFTHGEVPDYQMAAFCMAVFFRGMDDAEVRALTE
CCCCEEEEECCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHH
AMLRSGDVLDLSDVPGAKVDKHSTGGVGDKVSLALAPLAAACGVKVPMISGRGLGHTGGT
HHHHCCCEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEECCCCCCCCCCC
LDKLEAIPGFRVDLPVERFRAQVRDVGACLIGQTARLAPADRKLYALRDVTATVESIPLI
HHHHHCCCCCEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
AASIMSKKLAEGIDALVLDVKVGSGAFMKRPEDARALARTLAAIGRGMGKRVTALLTGMD
HHHHHHHHHHCCCCEEEEEEEECCCHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCC
QPLGRAVGNALEVAEVLELLRGGGPADLRAITVELTAEMLLAGGVAPELAAARAAVEQAI
CHHHHHHHHHHHHHHHHHHHHCCCCCHHEEEEHHHHHHHHHHCCCCHHHHHHHHHHHHHH
GDGRGLAKLEEIVAAQGGDPAAIRDPSRLPRAAGTYPVPSPAAGFVQAVDTEAVGLAAVA
CCCCCHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHCHHHHHHHHHH
LGAGRARVDDPVDPAVGILVERKLGDRVERGEPLCVVHHGPRSEPRERIAARLAGAYRIG
HCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHCCCCCC
PAAPPAAPLFLERLT
CCCCCCHHHHHHHCC
>Mature Secondary Structure
MRAYEIIHAKRDGRVLPADAIAALVDGFTHGEVPDYQMAAFCMAVFFRGMDDAEVRALTE
CCCCEEEEECCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHH
AMLRSGDVLDLSDVPGAKVDKHSTGGVGDKVSLALAPLAAACGVKVPMISGRGLGHTGGT
HHHHCCCEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEECCCCCCCCCCC
LDKLEAIPGFRVDLPVERFRAQVRDVGACLIGQTARLAPADRKLYALRDVTATVESIPLI
HHHHHCCCCCEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
AASIMSKKLAEGIDALVLDVKVGSGAFMKRPEDARALARTLAAIGRGMGKRVTALLTGMD
HHHHHHHHHHCCCCEEEEEEEECCCHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCC
QPLGRAVGNALEVAEVLELLRGGGPADLRAITVELTAEMLLAGGVAPELAAARAAVEQAI
CHHHHHHHHHHHHHHHHHHHHCCCCCHHEEEEHHHHHHHHHHCCCCHHHHHHHHHHHHHH
GDGRGLAKLEEIVAAQGGDPAAIRDPSRLPRAAGTYPVPSPAAGFVQAVDTEAVGLAAVA
CCCCCHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHCHHHHHHHHHH
LGAGRARVDDPVDPAVGILVERKLGDRVERGEPLCVVHHGPRSEPRERIAARLAGAYRIG
HCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHCCCCCC
PAAPPAAPLFLERLT
CCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8987664; 9817849 [H]