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The map label for this gene is frzE [H]

Identifier: 220915757

GI number: 220915757

Start: 712260

End: 714521

Strand: Direct

Name: frzE [H]

Synonym: A2cp1_0638

Alternate gene names: 220915757

Gene position: 712260-714521 (Clockwise)

Preceding gene: 220915756

Following gene: 220915758

Centisome position: 14.16

GC content: 75.86

Gene sequence:

>2262_bases
ATGGGCATCTCCGAAGAGATCCGCCAGAAGCTGCTCCCGCGCTTCCGCGAGACCACCGCGGACCGCGTGGAGAAGATCTC
GGCGGCGCTGCTCGAGATCGAGCGCGGCGCCGCGACGCCCGAGGTGCGCGAGGAGCTGGCCCGCGAGCTCCACACGCTGA
AGGGCGAGGCCCGCATGATGGGCTTCGCGGGGATCTCCACCGTGGTGCACGCGGCGGAGGACCTGCTGAAGGCGCTCCCG
GCGGAGCGCCCGGGCGACCGGATCGACGCGCTGCTCAGCGCGTGCGACACGATCCTGCCCATGCTCGACGCGCCCGCCGA
CGGCGGCGCCGCCGCGACCGCGCTGGCGGAGCGGATGCGCGCGCTCATCTCCGGGGGGCCTGCGCCCGAGGCCACCGCGG
CGGCCCCCGCCGCGCCCGCCCCCGCCGCGCCGCCGGCCGCGCCGCCGGCCGCCCCGTCCCCCCCGCCGCGCGAGGCCGAG
GCCGCCCAGCCCGCTCCGCCCGCCGCGGTCCCGCACGCCGAGGAGGCGCCGCGCGCCGAGCTGCGCGGGGACAAGCCCGC
CGCGTCCATCCGCGTGGACGTGGACCGGCTGGACGAGATCGCCGCCCTGGCCGGCGACGTGATGGTCGAGGGCGCGCGCG
CGATGCGCCGCTCCAAGGACCTCGTCGGCCTGTTCGCCCGCTGGGCGCGGATCTCCGACCGCGTGGTGGCGCTCGCCGAG
CGCGTGCGCGACCCCCGCACCGCCAAGCTGGTCGAGCAGATCGAGGGCGACGTCCACCTGCTCCGCTCCGACACGTTCCG
CTTCGCGCGCGTCCACTCCGAGGCCGCCTCGAGCGCGCACGCGCAGCTCGGCCAGCTCTCCGAGCGGATCGGCGAGGCCC
GCCTCATCCCGCTCTCCGGCGTGCTGGCCGGCTTCCCGCGGGCGGTGCGCGACATGGCGCACGAGCAGGCGAAGGAGGTC
GAGTGCGTGGTGCGCGGCGCGGAGACCGGGGTGGACAAATCCATCCTGCTCTCGCTGAACGACCCGCTCGTCCACCTGGT
GCGCAACTCGGTCGATCACGGCGTCGAGGCGCCGGAGGAGCGCGAGGCGGCCGGGAAGCCGCGGGTGGGGCGCATCACCA
TCTCGGCGCGGACCGACGGCGACCTGCTCGCGGTGACGGTGGACGACGACGGGCGCGGCATCACCCCGGCGGCGGTGCGC
GCCGCGGCCCTGCGCAAGGGGCTCATCGGCGAGCAGCAGGCCGCGAGCCTCTCGTCGCGCGCGGCCCTGGACCTCATCTT
CACCCCCGGCTTCTCCACCCGAGAGCAGGCCGGCGAGACCAGCGGCCGCGGGGTGGGGCTCGACGTGGTCCGCAAGCGCG
TCACGGCGCTGGGCGGATCGGTGACGGTGGAGTCGAGCCCGGGCAAGGGCACGCGCTTCACGCTGCGCATGCCGCAGTCG
CTGTCGCTGATGAAGGTCCTGCTGGTCCGGATCGACGACGACGTCTACGGCGTCCCGGCGGTGGACGTGGACAGCGTGGG
CCGGCTCGACCCCAAGGACAGCACCGAGGTGGCCGGCATCCGCGCGGTGCGCTACCGCAACCGGCTCATGCCGGTGGTGG
CGCTCGGGCCGCTGCTCTCGCTGAACGGCGGCCCCCGCGCGCAGCGGCCCATGGTCGTGTACGTGAGCCACGGGTCCGAG
GGGGCCGCGGTGGTGGTGGACGGCCTGCACGGCGAGCGCGAGGTGGCGGTGAAGGCCCCGGGCGCGTTCCTGAAGGGCAT
GCGCTTCGTCACCGGCGCGGCGGCGCTGGAGGACGGGCGCGTGGCGGTGCTGCTCTCCACGCCGGACCTGGTGAACGCCG
CCCGCCGGCTCGCCTCGCCGGCCATGACCCGGGGGCGCGATCGCCGCCGGCTCCGGATCCTGCTGGTGGACGACAGCGCC
ATCGCGCGCGAGGCCGAGGCCGCGCTGCTCCGCTCGCTCGGCCACGAGGTGGACGAGGCGGTGGATGGCGAGGACGGCTG
GGCGCGGCTGCAGAACGGCCAGTACCACCTGCTCGTCACCGACGTGCAGATGCCGGTGCTCGACGGCATCGACCTGACCC
GACGGGTCAAGGCGACGCCGCGCTTCGTGAAGCTGCCCATCGTGATCATGTCCTCGCTCTCGGCGCCCGAGGAGCGGCGG
CGGGGCGTGGACGCCGGCGCCGACGCCTACCTGGTGAAGGGCGAGCTCGACGCGGAGAGCCTCGCGGTCACGCTCGAGCG
GCTGTGCGGGGTCCCCACGTGA

Upstream 100 bases:

>100_bases
CGCCGCCTCCGAGCTGACCAAGCTGGCCGAGCGGCTCGCGGAGCTGGTGAAGCGCTTCAAGGTCGAGTAGCCGCGGGGCG
CCCCGCAGACCGCCGCCGCC

Downstream 100 bases:

>100_bases
GCCTGGCCGCGGGGGACCGGCCCATCCGCGTGCTGGTCGCCGACGACTCCGAGCTGTTCCGCGAGCTGCTCGCGCGCGTG
GTCGCGGCCGAGCCCGGCTT

Product: chemotaxis protein CheA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 753; Mature: 752

Protein sequence:

>753_residues
MGISEEIRQKLLPRFRETTADRVEKISAALLEIERGAATPEVREELARELHTLKGEARMMGFAGISTVVHAAEDLLKALP
AERPGDRIDALLSACDTILPMLDAPADGGAAATALAERMRALISGGPAPEATAAAPAAPAPAAPPAAPPAAPSPPPREAE
AAQPAPPAAVPHAEEAPRAELRGDKPAASIRVDVDRLDEIAALAGDVMVEGARAMRRSKDLVGLFARWARISDRVVALAE
RVRDPRTAKLVEQIEGDVHLLRSDTFRFARVHSEAASSAHAQLGQLSERIGEARLIPLSGVLAGFPRAVRDMAHEQAKEV
ECVVRGAETGVDKSILLSLNDPLVHLVRNSVDHGVEAPEEREAAGKPRVGRITISARTDGDLLAVTVDDDGRGITPAAVR
AAALRKGLIGEQQAASLSSRAALDLIFTPGFSTREQAGETSGRGVGLDVVRKRVTALGGSVTVESSPGKGTRFTLRMPQS
LSLMKVLLVRIDDDVYGVPAVDVDSVGRLDPKDSTEVAGIRAVRYRNRLMPVVALGPLLSLNGGPRAQRPMVVYVSHGSE
GAAVVVDGLHGEREVAVKAPGAFLKGMRFVTGAAALEDGRVAVLLSTPDLVNAARRLASPAMTRGRDRRRLRILLVDDSA
IAREAEAALLRSLGHEVDEAVDGEDGWARLQNGQYHLLVTDVQMPVLDGIDLTRRVKATPRFVKLPIVIMSSLSAPEERR
RGVDAGADAYLVKGELDAESLAVTLERLCGVPT

Sequences:

>Translated_753_residues
MGISEEIRQKLLPRFRETTADRVEKISAALLEIERGAATPEVREELARELHTLKGEARMMGFAGISTVVHAAEDLLKALP
AERPGDRIDALLSACDTILPMLDAPADGGAAATALAERMRALISGGPAPEATAAAPAAPAPAAPPAAPPAAPSPPPREAE
AAQPAPPAAVPHAEEAPRAELRGDKPAASIRVDVDRLDEIAALAGDVMVEGARAMRRSKDLVGLFARWARISDRVVALAE
RVRDPRTAKLVEQIEGDVHLLRSDTFRFARVHSEAASSAHAQLGQLSERIGEARLIPLSGVLAGFPRAVRDMAHEQAKEV
ECVVRGAETGVDKSILLSLNDPLVHLVRNSVDHGVEAPEEREAAGKPRVGRITISARTDGDLLAVTVDDDGRGITPAAVR
AAALRKGLIGEQQAASLSSRAALDLIFTPGFSTREQAGETSGRGVGLDVVRKRVTALGGSVTVESSPGKGTRFTLRMPQS
LSLMKVLLVRIDDDVYGVPAVDVDSVGRLDPKDSTEVAGIRAVRYRNRLMPVVALGPLLSLNGGPRAQRPMVVYVSHGSE
GAAVVVDGLHGEREVAVKAPGAFLKGMRFVTGAAALEDGRVAVLLSTPDLVNAARRLASPAMTRGRDRRRLRILLVDDSA
IAREAEAALLRSLGHEVDEAVDGEDGWARLQNGQYHLLVTDVQMPVLDGIDLTRRVKATPRFVKLPIVIMSSLSAPEERR
RGVDAGADAYLVKGELDAESLAVTLERLCGVPT
>Mature_752_residues
GISEEIRQKLLPRFRETTADRVEKISAALLEIERGAATPEVREELARELHTLKGEARMMGFAGISTVVHAAEDLLKALPA
ERPGDRIDALLSACDTILPMLDAPADGGAAATALAERMRALISGGPAPEATAAAPAAPAPAAPPAAPPAAPSPPPREAEA
AQPAPPAAVPHAEEAPRAELRGDKPAASIRVDVDRLDEIAALAGDVMVEGARAMRRSKDLVGLFARWARISDRVVALAER
VRDPRTAKLVEQIEGDVHLLRSDTFRFARVHSEAASSAHAQLGQLSERIGEARLIPLSGVLAGFPRAVRDMAHEQAKEVE
CVVRGAETGVDKSILLSLNDPLVHLVRNSVDHGVEAPEEREAAGKPRVGRITISARTDGDLLAVTVDDDGRGITPAAVRA
AALRKGLIGEQQAASLSSRAALDLIFTPGFSTREQAGETSGRGVGLDVVRKRVTALGGSVTVESSPGKGTRFTLRMPQSL
SLMKVLLVRIDDDVYGVPAVDVDSVGRLDPKDSTEVAGIRAVRYRNRLMPVVALGPLLSLNGGPRAQRPMVVYVSHGSEG
AAVVVDGLHGEREVAVKAPGAFLKGMRFVTGAAALEDGRVAVLLSTPDLVNAARRLASPAMTRGRDRRRLRILLVDDSAI
AREAEAALLRSLGHEVDEAVDGEDGWARLQNGQYHLLVTDVQMPVLDGIDLTRRVKATPRFVKLPIVIMSSLSAPEERRR
GVDAGADAYLVKGELDAESLAVTLERLCGVPT

Specific function: FrzE is involved in a sensory transduction pathway that controls the frequency at which cells reverse their gliding direction. FrzE seems to be capable of autophosphorylating itself on an histidine residue and then to transfer that group to an aspartate r

COG id: COG0643

COG function: function code NT; Chemotaxis protein histidine kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788197, Length=468, Percent_Identity=30.982905982906, Blast_Score=206, Evalue=4e-54,
Organism=Escherichia coli, GI1788713, Length=104, Percent_Identity=35.5769230769231, Blast_Score=66, Evalue=7e-12,
Organism=Escherichia coli, GI1788191, Length=106, Percent_Identity=33.9622641509434, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002545
- InterPro:   IPR011006
- InterPro:   IPR004358
- InterPro:   IPR008207
- InterPro:   IPR005467
- InterPro:   IPR001789 [H]

Pfam domain/function: PF01584 CheW; PF02518 HATPase_c; PF01627 Hpt; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 79823; Mature: 79692

Theoretical pI: Translated: 6.48; Mature: 6.48

Prosite motif: PS50851 CHEW ; PS50894 HPT ; PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGISEEIRQKLLPRFRETTADRVEKISAALLEIERGAATPEVREELARELHTLKGEARMM
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHH
GFAGISTVVHAAEDLLKALPAERPGDRIDALLSACDTILPMLDAPADGGAAATALAERMR
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
ALISGGPAPEATAAAPAAPAPAAPPAAPPAAPSPPPREAEAAQPAPPAAVPHAEEAPRAE
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHH
LRGDKPAASIRVDVDRLDEIAALAGDVMVEGARAMRRSKDLVGLFARWARISDRVVALAE
CCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RVRDPRTAKLVEQIEGDVHLLRSDTFRFARVHSEAASSAHAQLGQLSERIGEARLIPLSG
HHCCCHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEHHH
VLAGFPRAVRDMAHEQAKEVECVVRGAETGVDKSILLSLNDPLVHLVRNSVDHGVEAPEE
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCHH
REAAGKPRVGRITISARTDGDLLAVTVDDDGRGITPAAVRAAALRKGLIGEQQAASLSSR
HHHCCCCCEEEEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHC
AALDLIFTPGFSTREQAGETSGRGVGLDVVRKRVTALGGSVTVESSPGKGTRFTLRMPQS
CEEEEEECCCCCCHHHCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCEEEEECCCC
LSLMKVLLVRIDDDVYGVPAVDVDSVGRLDPKDSTEVAGIRAVRYRNRLMPVVALGPLLS
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHCCHHC
LNGGPRAQRPMVVYVSHGSEGAAVVVDGLHGEREVAVKAPGAFLKGMRFVTGAAALEDGR
CCCCCCCCCCEEEEEECCCCCCEEEEECCCCCCEEEEECCHHHHHHHHHHHHHHEECCCC
VAVLLSTPDLVNAARRLASPAMTRGRDRRRLRILLVDDSAIAREAEAALLRSLGHEVDEA
EEEEECCCHHHHHHHHHHCHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHH
VDGEDGWARLQNGQYHLLVTDVQMPVLDGIDLTRRVKATPRFVKLPIVIMSSLSAPEERR
CCCCCCHHHHCCCEEEEEEEECCCCHHCCCCHHHHHCCCCCEEEHHHHHHHCCCCCHHHH
RGVDAGADAYLVKGELDAESLAVTLERLCGVPT
CCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
GISEEIRQKLLPRFRETTADRVEKISAALLEIERGAATPEVREELARELHTLKGEARMM
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHH
GFAGISTVVHAAEDLLKALPAERPGDRIDALLSACDTILPMLDAPADGGAAATALAERMR
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
ALISGGPAPEATAAAPAAPAPAAPPAAPPAAPSPPPREAEAAQPAPPAAVPHAEEAPRAE
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHH
LRGDKPAASIRVDVDRLDEIAALAGDVMVEGARAMRRSKDLVGLFARWARISDRVVALAE
CCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RVRDPRTAKLVEQIEGDVHLLRSDTFRFARVHSEAASSAHAQLGQLSERIGEARLIPLSG
HHCCCHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEHHH
VLAGFPRAVRDMAHEQAKEVECVVRGAETGVDKSILLSLNDPLVHLVRNSVDHGVEAPEE
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCHH
REAAGKPRVGRITISARTDGDLLAVTVDDDGRGITPAAVRAAALRKGLIGEQQAASLSSR
HHHCCCCCEEEEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHC
AALDLIFTPGFSTREQAGETSGRGVGLDVVRKRVTALGGSVTVESSPGKGTRFTLRMPQS
CEEEEEECCCCCCHHHCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCEEEEECCCC
LSLMKVLLVRIDDDVYGVPAVDVDSVGRLDPKDSTEVAGIRAVRYRNRLMPVVALGPLLS
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHCCHHC
LNGGPRAQRPMVVYVSHGSEGAAVVVDGLHGEREVAVKAPGAFLKGMRFVTGAAALEDGR
CCCCCCCCCCEEEEEECCCCCCEEEEECCCCCCEEEEECCHHHHHHHHHHHHHHEECCCC
VAVLLSTPDLVNAARRLASPAMTRGRDRRRLRILLVDDSAIAREAEAALLRSLGHEVDEA
EEEEECCCHHHHHHHHHHCHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHH
VDGEDGWARLQNGQYHLLVTDVQMPVLDGIDLTRRVKATPRFVKLPIVIMSSLSAPEERR
CCCCCCHHHHCCCEEEEEEEECCCCHHCCCCHHHHHCCCCCEEEHHHHHHHCCCCCHHHH
RGVDAGADAYLVKGELDAESLAVTLERLCGVPT
CCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2165608; 2123853 [H]