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The map label for this gene is zraR [H]

Identifier: 220915652

GI number: 220915652

Start: 610548

End: 611879

Strand: Direct

Name: zraR [H]

Synonym: A2cp1_0533

Alternate gene names: 220915652

Gene position: 610548-611879 (Clockwise)

Preceding gene: 220915651

Following gene: 220915655

Centisome position: 12.14

GC content: 78.08

Gene sequence:

>1332_bases
ATGTCCCGCGTGCTGGTGGTGGACGACGAGCCCAAGCTCGGCCGCTTCGTGCAGGAGATGCTGGAGCTGGACGGGCACGA
GGTGGTGCGCGCCGGCGGCGGGGTCGAGGCGCTGGCGCGGCTCGGCGAGGGGGCGTTCGACGTGGTCGTGACCGACCTGC
GCATGCCGCAGGTGGACGGCCTCGCGGTGCTCCGCGCGGCGCGCGCGCGCACCCCGCCGCCCGAGGTGGTGATGATGACC
GCGCACGGCTCGGCCGAGAGCGCGGTCGAGGCCATGAAGGCGGGCGCGGCCGACTACGTGACGAAGCCGTTCCCGATGGA
CGAGCTGCGGCTCCGGGTGCGCCGGCTCGCCGAGCAGCGCGCCGCCGCGGCCCGGAGCGCCGGGCTGGTGGCGCGCCTCG
CCCCGGACCTGGTGGCGGAGAGCGCGGGCATGCGCGCGGCGGTGGCGGCCGCCGAGCAGGTGGCGGCCACCGACGCGACC
GTGCTCCTGCTCGGCGAGAGCGGCACCGGGAAGAGCCAGCTCGCGCGGCTCGTCCACTGGCGGAGCCGGCGCGCGGCCGG
GCCGCTGGTGGAGGTGCACTGCGCGGCGCTGCCCGACACGCTGCTCGAGGGCGAGCTGTTCGGCCACGAGCGCGGCGCGT
TCACCGGCGCGGCGCAGCGCCGCCCCGGCCACCTGGCAGCCGCCGACGGGGGCACGCTGTTCCTCGACGAGATCGGCGAG
ATCCCGCCGTCCACCCAGGTGAAGCTGCTCCGGTTCCTGCAGGACCGCAGCTTCGTGCCGCTCGGCGCGACCGCGCCGCG
GACGGTGGACGCGCGGGTGGTGGCGGCGACGAACCGCGACCTCGCCGCGGCGGTCGGCGCGGGCGCGTTCCGCGAGGACC
TCTACTACCGGCTCGACGTCTTCGCGATCCGCGTGCCGCCGCTCCGCGAGCGGCGCGAGGACGTGCTGCCCATCGCCGAG
CGCCACCTGGCCGGCCACGGCGTGCCCCCCGAGCGGCTCGGCCCGGACGCGCGTGCGCGGCTGCTGGAGCGCCCCTGGCC
GGGGAACGTCCGCGAGCTGGAGAACGCGCTCGAGCGCGCGCTCATCCTGGCGGGCGAGGGCGAGATCCGCGCCGAGCACG
TCGCGCCCGGCGCGGCGCCGCGGGCCGCCGGGCGCGCCGCCGAGCTGCTGGTGGAGGGCTTCGGCCTGGACGCGTTCGAG
CGCGAGGTGATCGAGGCCGCGCTCGCGCGCGCCGGCGGGAACAAGACCCGCGCCGCGAGGCTGCTCGGGGTGACCCGGCG
CCGCCTGTACTCGCTGCTCGCGAGCCACGGGCTCGCGGTGGAGGGCGAGTAG

Upstream 100 bases:

>100_bases
CGCCGAGCGGCACGGCGGCGCGCTCGAGCTCGCCGACCCGGGCCCGCCCGGCGCGGCGTTCGCGCTCACCCTGCCGCTCG
AGCCCGGATAGGATCGCCGC

Downstream 100 bases:

>100_bases
GGGCCCTTCGACTCCGCCCCGCTCACCCCGACCCTTCGACTCCGGCGAGCCTGCGGCTCGCTCGCTCATCCCGAGCGTAG
CGCGGCCCCTGGGGCCGCGC

Product: two component sigma-54 specific Fis family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 443; Mature: 442

Protein sequence:

>443_residues
MSRVLVVDDEPKLGRFVQEMLELDGHEVVRAGGGVEALARLGEGAFDVVVTDLRMPQVDGLAVLRAARARTPPPEVVMMT
AHGSAESAVEAMKAGAADYVTKPFPMDELRLRVRRLAEQRAAAARSAGLVARLAPDLVAESAGMRAAVAAAEQVAATDAT
VLLLGESGTGKSQLARLVHWRSRRAAGPLVEVHCAALPDTLLEGELFGHERGAFTGAAQRRPGHLAAADGGTLFLDEIGE
IPPSTQVKLLRFLQDRSFVPLGATAPRTVDARVVAATNRDLAAAVGAGAFREDLYYRLDVFAIRVPPLRERREDVLPIAE
RHLAGHGVPPERLGPDARARLLERPWPGNVRELENALERALILAGEGEIRAEHVAPGAAPRAAGRAAELLVEGFGLDAFE
REVIEAALARAGGNKTRAARLLGVTRRRLYSLLASHGLAVEGE

Sequences:

>Translated_443_residues
MSRVLVVDDEPKLGRFVQEMLELDGHEVVRAGGGVEALARLGEGAFDVVVTDLRMPQVDGLAVLRAARARTPPPEVVMMT
AHGSAESAVEAMKAGAADYVTKPFPMDELRLRVRRLAEQRAAAARSAGLVARLAPDLVAESAGMRAAVAAAEQVAATDAT
VLLLGESGTGKSQLARLVHWRSRRAAGPLVEVHCAALPDTLLEGELFGHERGAFTGAAQRRPGHLAAADGGTLFLDEIGE
IPPSTQVKLLRFLQDRSFVPLGATAPRTVDARVVAATNRDLAAAVGAGAFREDLYYRLDVFAIRVPPLRERREDVLPIAE
RHLAGHGVPPERLGPDARARLLERPWPGNVRELENALERALILAGEGEIRAEHVAPGAAPRAAGRAAELLVEGFGLDAFE
REVIEAALARAGGNKTRAARLLGVTRRRLYSLLASHGLAVEGE
>Mature_442_residues
SRVLVVDDEPKLGRFVQEMLELDGHEVVRAGGGVEALARLGEGAFDVVVTDLRMPQVDGLAVLRAARARTPPPEVVMMTA
HGSAESAVEAMKAGAADYVTKPFPMDELRLRVRRLAEQRAAAARSAGLVARLAPDLVAESAGMRAAVAAAEQVAATDATV
LLLGESGTGKSQLARLVHWRSRRAAGPLVEVHCAALPDTLLEGELFGHERGAFTGAAQRRPGHLAAADGGTLFLDEIGEI
PPSTQVKLLRFLQDRSFVPLGATAPRTVDARVVAATNRDLAAAVGAGAFREDLYYRLDVFAIRVPPLRERREDVLPIAER
HLAGHGVPPERLGPDARARLLERPWPGNVRELENALERALILAGEGEIRAEHVAPGAAPRAAGRAAELLVEGFGLDAFER
EVIEAALARAGGNKTRAARLLGVTRRRLYSLLASHGLAVEGE

Specific function: Member of the two-component regulatory system zraS/zraR. When activated by zraS it acts in conjunction with sigma-54 to regulate the expression of zraP. Positively autoregulates the expression of the zraSR operon [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1790437, Length=446, Percent_Identity=45.5156950672646, Blast_Score=340, Evalue=8e-95,
Organism=Escherichia coli, GI1788550, Length=454, Percent_Identity=40.5286343612335, Blast_Score=329, Evalue=2e-91,
Organism=Escherichia coli, GI1788905, Length=444, Percent_Identity=39.6396396396396, Blast_Score=281, Evalue=5e-77,
Organism=Escherichia coli, GI1790299, Length=467, Percent_Identity=37.4732334047109, Blast_Score=268, Evalue=4e-73,
Organism=Escherichia coli, GI87082117, Length=239, Percent_Identity=47.6987447698745, Blast_Score=213, Evalue=3e-56,
Organism=Escherichia coli, GI1789087, Length=259, Percent_Identity=44.7876447876448, Blast_Score=208, Evalue=7e-55,
Organism=Escherichia coli, GI1789233, Length=331, Percent_Identity=38.0664652567976, Blast_Score=207, Evalue=2e-54,
Organism=Escherichia coli, GI87082152, Length=316, Percent_Identity=43.3544303797468, Blast_Score=206, Evalue=3e-54,
Organism=Escherichia coli, GI87081872, Length=325, Percent_Identity=37.2307692307692, Blast_Score=199, Evalue=3e-52,
Organism=Escherichia coli, GI1787583, Length=311, Percent_Identity=37.620578778135, Blast_Score=190, Evalue=1e-49,
Organism=Escherichia coli, GI1786524, Length=319, Percent_Identity=38.2445141065831, Blast_Score=172, Evalue=3e-44,
Organism=Escherichia coli, GI1789828, Length=330, Percent_Identity=35.1515151515151, Blast_Score=148, Evalue=7e-37,
Organism=Escherichia coli, GI87081858, Length=293, Percent_Identity=33.1058020477816, Blast_Score=128, Evalue=8e-31,
Organism=Escherichia coli, GI1786784, Length=154, Percent_Identity=31.8181818181818, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1788191, Length=121, Percent_Identity=37.1900826446281, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1787375, Length=131, Percent_Identity=34.3511450381679, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1789809, Length=113, Percent_Identity=34.5132743362832, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1786911, Length=114, Percent_Identity=34.2105263157895, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI2367329, Length=114, Percent_Identity=35.9649122807018, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1786599, Length=116, Percent_Identity=35.3448275862069, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 47185; Mature: 47053

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRVLVVDDEPKLGRFVQEMLELDGHEVVRAGGGVEALARLGEGAFDVVVTDLRMPQVDG
CCCEEEECCCCHHHHHHHHHHHCCCCCEECCCCCHHHHHHHCCCCEEEEEECCCCCCCCH
LAVLRAARARTPPPEVVMMTAHGSAESAVEAMKAGAADYVTKPFPMDELRLRVRRLAEQR
HHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHHHHHH
AAAARSAGLVARLAPDLVAESAGMRAAVAAAEQVAATDATVLLLGESGTGKSQLARLVHW
HHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHH
RSRRAAGPLVEVHCAALPDTLLEGELFGHERGAFTGAAQRRPGHLAAADGGTLFLDEIGE
HHHCCCCCEEEEEHHHCCHHHHCCHHHCCCCCCCCCCCCCCCCCEEECCCCEEEHHHHCC
IPPSTQVKLLRFLQDRSFVPLGATAPRTVDARVVAATNRDLAAAVGAGAFREDLYYRLDV
CCCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHCCHHHHHHHHEEEEE
FAIRVPPLRERREDVLPIAERHLAGHGVPPERLGPDARARLLERPWPGNVRELENALERA
EEEECCCHHHHHHHHHHHHHHHHCCCCCCHHHCCCHHHHHHHCCCCCCCHHHHHHHHHHH
LILAGEGEIRAEHVAPGAAPRAAGRAAELLVEGFGLDAFEREVIEAALARAGGNKTRAAR
EEEECCCCEEHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHH
LLGVTRRRLYSLLASHGLAVEGE
HHHHHHHHHHHHHHHCCCEECCC
>Mature Secondary Structure 
SRVLVVDDEPKLGRFVQEMLELDGHEVVRAGGGVEALARLGEGAFDVVVTDLRMPQVDG
CCEEEECCCCHHHHHHHHHHHCCCCCEECCCCCHHHHHHHCCCCEEEEEECCCCCCCCH
LAVLRAARARTPPPEVVMMTAHGSAESAVEAMKAGAADYVTKPFPMDELRLRVRRLAEQR
HHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHHHHHH
AAAARSAGLVARLAPDLVAESAGMRAAVAAAEQVAATDATVLLLGESGTGKSQLARLVHW
HHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHH
RSRRAAGPLVEVHCAALPDTLLEGELFGHERGAFTGAAQRRPGHLAAADGGTLFLDEIGE
HHHCCCCCEEEEEHHHCCHHHHCCHHHCCCCCCCCCCCCCCCCCEEECCCCEEEHHHHCC
IPPSTQVKLLRFLQDRSFVPLGATAPRTVDARVVAATNRDLAAAVGAGAFREDLYYRLDV
CCCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHCCHHHHHHHHEEEEE
FAIRVPPLRERREDVLPIAERHLAGHGVPPERLGPDARARLLERPWPGNVRELENALERA
EEEECCCHHHHHHHHHHHHHHHHCCCCCCHHHCCCHHHHHHHCCCCCCCHHHHHHHHHHH
LILAGEGEIRAEHVAPGAAPRAAGRAAELLVEGFGLDAFEREVIEAALARAGGNKTRAAR
EEEECCCCEEHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHH
LLGVTRRRLYSLLASHGLAVEGE
HHHHHHHHHHHHHHHCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]