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The map label for this gene is tetA [H]

Identifier: 220915272

GI number: 220915272

Start: 169140

End: 170336

Strand: Direct

Name: tetA [H]

Synonym: A2cp1_0151

Alternate gene names: 220915272

Gene position: 169140-170336 (Clockwise)

Preceding gene: 220915271

Following gene: 220915273

Centisome position: 3.36

GC content: 75.19

Gene sequence:

>1197_bases
GTGAAGAACCGGTCCGCCCTCGCGATCCTCTTCGTCATCGTCTTCATCGACCTGCTCGGCTTCGGGATGGTCATCCCGGT
GATGGCGCTGTACGCCGAGCGGCTCGGCGCGCCGGACGCGCAGATCGGGTGGCTGATGACCGGCTACTCGGCGATGCAGT
TCGTCTTCACGCCGATCTGGGGCCGGCTCTCGGATCGCCACGGCCGCCGGCCGCTCCTGCTCCTCTCGATCGTGATGACG
GCGGTCGGGTTCCTCGGCTACGCGCTCGCCCCGAGCTTCGCGTGGCTGCTCGTCTCGCGCCTGTTCGCCGGCGCCGCCAC
CGCCAACATCGCCATCGCGCAGGCGTACATCGCCGACGTCACGCCGCCGGAGGGGCGCGCGCGCGGCATGGGGCTCATCG
GCGCGGCGTTCGGGCTCGGCTTCGTGCTCGGGCCGGCCATCGGCGGCCTGCTCTCGGCCATCTCGCTCTCCGCGCCCGGC
TACGCGGCGGCGGCGCTCGCGGCGGCGAACGGGGTGGCGGCGTTCTTCGTGCTGCCCGAGCCGGCCGCGCACGTGCAGGC
CGAGCGCCGGCCGCACCTCGAGGCGCTGCTCGGCGGCGTGAGCCGGCCCGGGATCCGCCGGCTCATCCTCATCTACTTCA
TCGCCATCCTCGCGTTCAGCGGGATGGAGGCGACGTTCGCGCTGCTCGCGGTCCACCGCTACGGGCTCGACCAGCGGCAG
GTGAGCTACGTGTTCGCGCTCATCGGCGTGGTCGCGACGGTGGTCCAGGGCGGCCTCATCGGCCCGCTCAGCCGCCGCTT
CGGCGAGCGGGCGCTGCTCGTGGCCGGGCTGCTCTTGCAGGCGGCCGCGCTCGCGGCGCTGCCCTACGCCGGCTCGGTGG
CGGGCCTGCTCGTCGCCACCGTGCCGCTCGCGTTCGGGTCGAGCCTGACCACCCCGTCCCTGACCTCGCTCGTCTCGCGC
TCGGCGCGCGCCGAGGACCAGGGCGGCACGCTCGGCATCGGCCAGTCCGCCGCCGCGCTCGGGCGCATCGCCGGCCCCAT
CTCCGCCACCCACGCCTACAGCCAGCTCTGGTTCGCGGCGCCCTACCTCGGGGGCGCGGCGCTCATGCTCGCCGGCGCCG
CGGTGGGCTCGACGCTCCGGCGCCCGCCGCGCCACGAGCCGGTCGAGCCGGGCGCCGCGCCGGCCGAGGAGGGGTAG

Upstream 100 bases:

>100_bases
CCGCGATCCCCCGCCCTCACCCGAACGCGCCCGGCGGCGCGCGCCCGGCCCGGCAGGAAAGCCTGCGCCCCGTCCCTGGC
CGGGTTATCCTCGCGCCCGC

Downstream 100 bases:

>100_bases
CGCCGCATGCCGGATCTCCGCCGCGATCCCATCGTCGGCCGCTGGGTGATCATCGCCACCGAGCGCGCCCGCCGTCCCTC
CGACATGCAGCGCACCGCCC

Product: major facilitator superfamily protein

Products: NA

Alternate protein names: TetA(C) [H]

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MKNRSALAILFVIVFIDLLGFGMVIPVMALYAERLGAPDAQIGWLMTGYSAMQFVFTPIWGRLSDRHGRRPLLLLSIVMT
AVGFLGYALAPSFAWLLVSRLFAGAATANIAIAQAYIADVTPPEGRARGMGLIGAAFGLGFVLGPAIGGLLSAISLSAPG
YAAAALAAANGVAAFFVLPEPAAHVQAERRPHLEALLGGVSRPGIRRLILIYFIAILAFSGMEATFALLAVHRYGLDQRQ
VSYVFALIGVVATVVQGGLIGPLSRRFGERALLVAGLLLQAAALAALPYAGSVAGLLVATVPLAFGSSLTTPSLTSLVSR
SARAEDQGGTLGIGQSAAALGRIAGPISATHAYSQLWFAAPYLGGAALMLAGAAVGSTLRRPPRHEPVEPGAAPAEEG

Sequences:

>Translated_398_residues
MKNRSALAILFVIVFIDLLGFGMVIPVMALYAERLGAPDAQIGWLMTGYSAMQFVFTPIWGRLSDRHGRRPLLLLSIVMT
AVGFLGYALAPSFAWLLVSRLFAGAATANIAIAQAYIADVTPPEGRARGMGLIGAAFGLGFVLGPAIGGLLSAISLSAPG
YAAAALAAANGVAAFFVLPEPAAHVQAERRPHLEALLGGVSRPGIRRLILIYFIAILAFSGMEATFALLAVHRYGLDQRQ
VSYVFALIGVVATVVQGGLIGPLSRRFGERALLVAGLLLQAAALAALPYAGSVAGLLVATVPLAFGSSLTTPSLTSLVSR
SARAEDQGGTLGIGQSAAALGRIAGPISATHAYSQLWFAAPYLGGAALMLAGAAVGSTLRRPPRHEPVEPGAAPAEEG
>Mature_398_residues
MKNRSALAILFVIVFIDLLGFGMVIPVMALYAERLGAPDAQIGWLMTGYSAMQFVFTPIWGRLSDRHGRRPLLLLSIVMT
AVGFLGYALAPSFAWLLVSRLFAGAATANIAIAQAYIADVTPPEGRARGMGLIGAAFGLGFVLGPAIGGLLSAISLSAPG
YAAAALAAANGVAAFFVLPEPAAHVQAERRPHLEALLGGVSRPGIRRLILIYFIAILAFSGMEATFALLAVHRYGLDQRQ
VSYVFALIGVVATVVQGGLIGPLSRRFGERALLVAGLLLQAAALAALPYAGSVAGLLVATVPLAFGSSLTTPSLTSLVSR
SARAEDQGGTLGIGQSAAALGRIAGPISATHAYSQLWFAAPYLGGAALMLAGAAVGSTLRRPPRHEPVEPGAAPAEEG

Specific function: Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal-tetracycline/H(+) antiporter [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Homo sapiens, GI225703104, Length=346, Percent_Identity=30.3468208092486, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI225703102, Length=346, Percent_Identity=30.3468208092486, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI217416366, Length=394, Percent_Identity=25.6345177664975, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI94721311, Length=335, Percent_Identity=26.2686567164179, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI166064062, Length=397, Percent_Identity=25.1889168765743, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI166064060, Length=397, Percent_Identity=25.1889168765743, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI39753965, Length=339, Percent_Identity=25.6637168141593, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI22749525, Length=310, Percent_Identity=24.8387096774194, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI87081738, Length=371, Percent_Identity=26.4150943396226, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1787291, Length=383, Percent_Identity=23.4986945169713, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17551570, Length=393, Percent_Identity=27.735368956743, Blast_Score=131, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI71996331, Length=341, Percent_Identity=24.0469208211144, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17738085, Length=374, Percent_Identity=29.4117647058824, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI21357569, Length=354, Percent_Identity=24.8587570621469, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI161080926, Length=340, Percent_Identity=24.4117647058824, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI161080924, Length=340, Percent_Identity=24.4117647058824, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24656463, Length=340, Percent_Identity=24.4117647058824, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24656468, Length=340, Percent_Identity=24.4117647058824, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI221513297, Length=359, Percent_Identity=25.0696378830084, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI62471713, Length=353, Percent_Identity=24.3626062322946, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI62471717, Length=353, Percent_Identity=24.3626062322946, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI62471715, Length=353, Percent_Identity=24.3626062322946, Blast_Score=65, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 40989; Mature: 40989

Theoretical pI: Translated: 10.28; Mature: 10.28

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNRSALAILFVIVFIDLLGFGMVIPVMALYAERLGAPDAQIGWLMTGYSAMQFVFTPIW
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
GRLSDRHGRRPLLLLSIVMTAVGFLGYALAPSFAWLLVSRLFAGAATANIAIAQAYIADV
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
TPPEGRARGMGLIGAAFGLGFVLGPAIGGLLSAISLSAPGYAAAALAAANGVAAFFVLPE
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEEECCC
PAAHVQAERRPHLEALLGGVSRPGIRRLILIYFIAILAFSGMEATFALLAVHRYGLDQRQ
CHHHHHHHCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHH
VSYVFALIGVVATVVQGGLIGPLSRRFGERALLVAGLLLQAAALAALPYAGSVAGLLVAT
HHHHHHHHHHHHHHHCCCCCCHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
VPLAFGSSLTTPSLTSLVSRSARAEDQGGTLGIGQSAAALGRIAGPISATHAYSQLWFAA
HHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHH
PYLGGAALMLAGAAVGSTLRRPPRHEPVEPGAAPAEEG
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKNRSALAILFVIVFIDLLGFGMVIPVMALYAERLGAPDAQIGWLMTGYSAMQFVFTPIW
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
GRLSDRHGRRPLLLLSIVMTAVGFLGYALAPSFAWLLVSRLFAGAATANIAIAQAYIADV
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
TPPEGRARGMGLIGAAFGLGFVLGPAIGGLLSAISLSAPGYAAAALAAANGVAAFFVLPE
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEEECCC
PAAHVQAERRPHLEALLGGVSRPGIRRLILIYFIAILAFSGMEATFALLAVHRYGLDQRQ
CHHHHHHHCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHH
VSYVFALIGVVATVVQGGLIGPLSRRFGERALLVAGLLLQAAALAALPYAGSVAGLLVAT
HHHHHHHHHHHHHHHCCCCCCHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
VPLAFGSSLTTPSLTSLVSRSARAEDQGGTLGIGQSAAALGRIAGPISATHAYSQLWFAA
HHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHH
PYLGGAALMLAGAAVGSTLRRPPRHEPVEPGAAPAEEG
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 383387; 6337373; 6307828; 1517220 [H]