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The map label for this gene is divL [H]

Identifier: 220915229

GI number: 220915229

Start: 120448

End: 121866

Strand: Direct

Name: divL [H]

Synonym: A2cp1_0108

Alternate gene names: 220915229

Gene position: 120448-121866 (Clockwise)

Preceding gene: 220915228

Following gene: 220915230

Centisome position: 2.39

GC content: 78.29

Gene sequence:

>1419_bases
ATGCTCGAAGCGGCAGACGCGGCGCTCCGCGCGGCGGTGGCGGACGCGGTGCGCGAGGCGCGGAGGCGCAGCGCGGAGGC
GGTGGCCTGGATGCGCGTGGCGCTCCGCGGCGCCATCCTGCTCGTCTACCTGCCCGGCTGGCACGAGCCCGCCCCGTGGC
ACGCCGCGGCGCTCCGGGTGAGCGTCGCCTACCTGGCCTTCGCGGGGGGCGTCCTGGCGCTGCTGCGCCGTCGGTGGCGC
TGGGAGGCGGTGGCGCTCGGGGCCGCCGCCATCGATCTCGCGGTGGTCGCGGTGGGCAGCTGGCGCGTGGTCGCGCTGGC
GGGCGGCAACCTGGCGCTCGCGGTCGCGGCCGGCGCGGGCAACGGCATGATGCTGATGGTGATCCTGTTCGCCGCGCTGG
CGCTGCCGGCGGCCCCGGCCGCGGCGATCTCGGCGGTCGCGGTCGCGAACCAGATGGCGCTCGCGGCGCACTCCGACGTG
TCCTGGCGGCTGGTGCTGGTGGTCGGCCTGATGCTGTCGGCGGCCGCGTTCGTCGCCATCCGGAACACCATGCGCGCGAC
GGCGCTGGCGGCGCGGCTCGCGGCCGAGACCTACACGGCCTCGCTCTGCCGCGCGCACGGGGAGGCGATGGCGCGGGCGA
GCGCGGAGGCGGTGGCGCAGCGCGACGAGGTGGTGGCCGCGCACCGCCAGGCCCGCGACCTGGTGCGCCTGATGGTGCAC
GACCTCAAGAACCCGCTCGCCGCGCTGCTGCAGTACCTGCGCCTCGCCGAGGTCGAGCTGCGCGGCCAGCCGGGGGCGGG
GCCGGTGCGCGAGGACCTGGCGCAGGCGGAGGGCGAGGGGCAGCGGCTCTCCGAGATGATCGGCGACCTGCTCGCGATCT
CGCGCCTGGAGACGGGGCCGGTCCGCCTGGCCGCGGATCCGGTGTCGGTCGGGGACCTGCTGCAGGCGGTGGCGCGGAGC
TGCGCGCCGCACGCGCGGGAGCGCGGGGTGACGCTCTCGGTGCGCGGCGGGGAGGACCTGGTGGTCCGGATCGACCGCGA
CCTCTCGCGCCGCCTGCTCGAGAACCTGGTCTCGAACGCGCTCCGGCACTGCCGGACCGGGGACCGGGTCGAGCTGGCGG
GCGAGGCGGACGGGGAGGGGGTGCGGCTCGCGGTCCGGAACTCCGGGCCGCCGGTGCCGGCCGCCATCCGCGCCCACCTG
TTCGAGAAGTTCGCGCCGGGCGAGGCGCGCGAGTGGACCAGCGCCGGCCTGGGGCTGTACCTGTGCCGGCTGGTGGCGGA
GGCGCACGGCGGCGGGGTGGCGCTGGTGGACACGCCGGGCTGGACCGTCAGCTTCGAGGCGCGCCTCGCGCCGCCGCAGG
CCGGCGGGGAGGCGGCGCCGCACGCGGCCGCGCTGGCGCCGGAGCGCCGGCCGGGCTAA

Upstream 100 bases:

>100_bases
GCGTCCCGCCGCCGGCGTGGGAGGCGGCGGCCCGATCTCCGTCGAGCACGTACCCGGAGCGAACGCGCCCGCCGTTATGA
TGGCGGGCGGGGGTTCTGGG

Downstream 100 bases:

>100_bases
CACCCGGCCATGCCCGGGAACCTCGCGCCGCTCTCGCTGGTCCTCCTCCCGCTCGTGCTCGCCGCGTGCAACCGCCGCCC
GCCCGCCGACCCGGCGTTCG

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 472; Mature: 472

Protein sequence:

>472_residues
MLEAADAALRAAVADAVREARRRSAEAVAWMRVALRGAILLVYLPGWHEPAPWHAAALRVSVAYLAFAGGVLALLRRRWR
WEAVALGAAAIDLAVVAVGSWRVVALAGGNLALAVAAGAGNGMMLMVILFAALALPAAPAAAISAVAVANQMALAAHSDV
SWRLVLVVGLMLSAAAFVAIRNTMRATALAARLAAETYTASLCRAHGEAMARASAEAVAQRDEVVAAHRQARDLVRLMVH
DLKNPLAALLQYLRLAEVELRGQPGAGPVREDLAQAEGEGQRLSEMIGDLLAISRLETGPVRLAADPVSVGDLLQAVARS
CAPHARERGVTLSVRGGEDLVVRIDRDLSRRLLENLVSNALRHCRTGDRVELAGEADGEGVRLAVRNSGPPVPAAIRAHL
FEKFAPGEAREWTSAGLGLYLCRLVAEAHGGGVALVDTPGWTVSFEARLAPPQAGGEAAPHAAALAPERRPG

Sequences:

>Translated_472_residues
MLEAADAALRAAVADAVREARRRSAEAVAWMRVALRGAILLVYLPGWHEPAPWHAAALRVSVAYLAFAGGVLALLRRRWR
WEAVALGAAAIDLAVVAVGSWRVVALAGGNLALAVAAGAGNGMMLMVILFAALALPAAPAAAISAVAVANQMALAAHSDV
SWRLVLVVGLMLSAAAFVAIRNTMRATALAARLAAETYTASLCRAHGEAMARASAEAVAQRDEVVAAHRQARDLVRLMVH
DLKNPLAALLQYLRLAEVELRGQPGAGPVREDLAQAEGEGQRLSEMIGDLLAISRLETGPVRLAADPVSVGDLLQAVARS
CAPHARERGVTLSVRGGEDLVVRIDRDLSRRLLENLVSNALRHCRTGDRVELAGEADGEGVRLAVRNSGPPVPAAIRAHL
FEKFAPGEAREWTSAGLGLYLCRLVAEAHGGGVALVDTPGWTVSFEARLAPPQAGGEAAPHAAALAPERRPG
>Mature_472_residues
MLEAADAALRAAVADAVREARRRSAEAVAWMRVALRGAILLVYLPGWHEPAPWHAAALRVSVAYLAFAGGVLALLRRRWR
WEAVALGAAAIDLAVVAVGSWRVVALAGGNLALAVAAGAGNGMMLMVILFAALALPAAPAAAISAVAVANQMALAAHSDV
SWRLVLVVGLMLSAAAFVAIRNTMRATALAARLAAETYTASLCRAHGEAMARASAEAVAQRDEVVAAHRQARDLVRLMVH
DLKNPLAALLQYLRLAEVELRGQPGAGPVREDLAQAEGEGQRLSEMIGDLLAISRLETGPVRLAADPVSVGDLLQAVARS
CAPHARERGVTLSVRGGEDLVVRIDRDLSRRLLENLVSNALRHCRTGDRVELAGEADGEGVRLAVRNSGPPVPAAIRAHL
FEKFAPGEAREWTSAGLGLYLCRLVAEAHGGGVALVDTPGWTVSFEARLAPPQAGGEAAPHAAALAPERRPG

Specific function: Required for cell division and growth. It catalyzes the phosphorylation of CtrA and activates transcription in vitro of the cell cycle-regulated fliF promoter [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788713, Length=266, Percent_Identity=23.6842105263158, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI1788393, Length=261, Percent_Identity=24.904214559387, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786912, Length=269, Percent_Identity=23.7918215613383, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1786600, Length=219, Percent_Identity=26.027397260274, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1790346, Length=218, Percent_Identity=29.3577981651376, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI87081816, Length=259, Percent_Identity=27.027027027027, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1786783, Length=199, Percent_Identity=26.6331658291457, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI145693157, Length=227, Percent_Identity=24.6696035242291, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1789149, Length=218, Percent_Identity=24.7706422018349, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49436; Mature: 49436

Theoretical pI: Translated: 8.96; Mature: 8.96

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEAADAALRAAVADAVREARRRSAEAVAWMRVALRGAILLVYLPGWHEPAPWHAAALRV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHH
SVAYLAFAGGVLALLRRRWRWEAVALGAAAIDLAVVAVGSWRVVALAGGNLALAVAAGAG
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHEEECCEEEEEEECCCEEEEEEECCC
NGMMLMVILFAALALPAAPAAAISAVAVANQMALAAHSDVSWRLVLVVGLMLSAAAFVAI
CCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
RNTMRATALAARLAAETYTASLCRAHGEAMARASAEAVAQRDEVVAAHRQARDLVRLMVH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLKNPLAALLQYLRLAEVELRGQPGAGPVREDLAQAEGEGQRLSEMIGDLLAISRLETGP
HHCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCC
VRLAADPVSVGDLLQAVARSCAPHARERGVTLSVRGGEDLVVRIDRDLSRRLLENLVSNA
EEEEECCCCHHHHHHHHHHHCCCHHHHCCCEEEEECCCEEEEEECHHHHHHHHHHHHHHH
LRHCRTGDRVELAGEADGEGVRLAVRNSGPPVPAAIRAHLFEKFAPGEAREWTSAGLGLY
HHHCCCCCCEEECCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCHHHHHCCHHHH
LCRLVAEAHGGGVALVDTPGWTVSFEARLAPPQAGGEAAPHAAALAPERRPG
HHHHHHHCCCCCEEEEECCCCEEEEEEEECCCCCCCCCCCCHHHCCCCCCCC
>Mature Secondary Structure
MLEAADAALRAAVADAVREARRRSAEAVAWMRVALRGAILLVYLPGWHEPAPWHAAALRV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHH
SVAYLAFAGGVLALLRRRWRWEAVALGAAAIDLAVVAVGSWRVVALAGGNLALAVAAGAG
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHEEECCEEEEEEECCCEEEEEEECCC
NGMMLMVILFAALALPAAPAAAISAVAVANQMALAAHSDVSWRLVLVVGLMLSAAAFVAI
CCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
RNTMRATALAARLAAETYTASLCRAHGEAMARASAEAVAQRDEVVAAHRQARDLVRLMVH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLKNPLAALLQYLRLAEVELRGQPGAGPVREDLAQAEGEGQRLSEMIGDLLAISRLETGP
HHCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCC
VRLAADPVSVGDLLQAVARSCAPHARERGVTLSVRGGEDLVVRIDRDLSRRLLENLVSNA
EEEEECCCCHHHHHHHHHHHCCCHHHHCCCEEEEECCCEEEEEECHHHHHHHHHHHHHHH
LRHCRTGDRVELAGEADGEGVRLAVRNSGPPVPAAIRAHLFEKFAPGEAREWTSAGLGLY
HHHCCCCCCEEECCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCHHHHHCCHHHH
LCRLVAEAHGGGVALVDTPGWTVSFEARLAPPQAGGEAAPHAAALAPERRPG
HHHHHHHCCCCCEEEEECCCCEEEEEEEECCCCCCCCCCCCHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10557274; 11259647 [H]