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The map label for this gene is thiD [H]

Identifier: 220915216

GI number: 220915216

Start: 104609

End: 105370

Strand: Direct

Name: thiD [H]

Synonym: A2cp1_0095

Alternate gene names: 220915216

Gene position: 104609-105370 (Clockwise)

Preceding gene: 220915215

Following gene: 220915217

Centisome position: 2.08

GC content: 80.97

Gene sequence:

>762_bases
GTGATCCCGCGGGTCCTGGTGGTGGCCGGCCTCGACCCGTCGGGCGGGGCGGGGCTGACCGCCGATCTCGAGGCGCTCGC
CGCCGTCGGGGCGCGCGGCTGGGCGGTCGCGACCGCCCTCACCGCCCAGGGCCCCCGCGGCGCGCGCGGCGTCTCGCCCG
CGAGCGAGGCGTTCCTGCGGCTCCAGATCGACGCGCTGCTGGAGGGGCGGGAGCGGCCGCACGCCGTGAAGACCGGCATG
CTCGGGACCGCGGGCCTGGCCCGGGCGCTGGCGGCGCGGCTCGCGGAGCCGCCGATCGCGCGCGTGCCGCTGGTGGTCGA
TCCGGTGCTGCTCGCGTCCTCCGGCGCGCCGCTCCTCGACCCGGGGGGCGTCCCGCCCGGCGAGGCGCTCGCGCCGCTGC
TCGGCCGGGCGCGGCTCGTCACGCCGAACCTGCCCGAGCTCGCTGCGCTCACCGGCGTCGAGGTCGCGGACGACGAGGCG
GCGGTCCGGGCGGCGCGGATGCTCCCGGCGCGCGCGGTGCTGGTGAAGGGCGGGCACCGCGAGGGCGCGCCGGTGGACCT
GCTGGTGGAGGGGCGGCGGCGCGTGACGCGGTTCACCGGGCGGCGGCGGGCGGGGACGGCGCGCGGCACCGGCTGCCGGC
TGGCGTCGGCGATCGCCGGGCTGCTGGCGGGCGGCGCGTCGCTGGAGGAGGCGGTGCGCGGGGGGAAGCGGGTGGTGGAG
CGGTATCTGGATGCTTGCGGTCGGGGGGCGGTCGGGCGTTGA

Upstream 100 bases:

>100_bases
TCGCGCTCGGCGTGCAGTGGCACCCCGAGGCGACGCGCGACGATCCGCGCCACGCCGCCATCTACCGGGGCCTGGTGGAC
GCGGCGCGGAGCCTGCGCCG

Downstream 100 bases:

>100_bases
GGGTGCGGGCGGGGGCGAACGGACGGTGAATGGGAGAGGTCGGGGCGGGGGGGGTGGGTTGGCGGGGCCTTGAGGGTGCG
GGGGCGGTCGGGGCGGGACC

Product: phosphomethylpyrimidine kinase

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 253; Mature: 253

Protein sequence:

>253_residues
MIPRVLVVAGLDPSGGAGLTADLEALAAVGARGWAVATALTAQGPRGARGVSPASEAFLRLQIDALLEGRERPHAVKTGM
LGTAGLARALAARLAEPPIARVPLVVDPVLLASSGAPLLDPGGVPPGEALAPLLGRARLVTPNLPELAALTGVEVADDEA
AVRAARMLPARAVLVKGGHREGAPVDLLVEGRRRVTRFTGRRRAGTARGTGCRLASAIAGLLAGGASLEEAVRGGKRVVE
RYLDACGRGAVGR

Sequences:

>Translated_253_residues
MIPRVLVVAGLDPSGGAGLTADLEALAAVGARGWAVATALTAQGPRGARGVSPASEAFLRLQIDALLEGRERPHAVKTGM
LGTAGLARALAARLAEPPIARVPLVVDPVLLASSGAPLLDPGGVPPGEALAPLLGRARLVTPNLPELAALTGVEVADDEA
AVRAARMLPARAVLVKGGHREGAPVDLLVEGRRRVTRFTGRRRAGTARGTGCRLASAIAGLLAGGASLEEAVRGGKRVVE
RYLDACGRGAVGR
>Mature_253_residues
MIPRVLVVAGLDPSGGAGLTADLEALAAVGARGWAVATALTAQGPRGARGVSPASEAFLRLQIDALLEGRERPHAVKTGM
LGTAGLARALAARLAEPPIARVPLVVDPVLLASSGAPLLDPGGVPPGEALAPLLGRARLVTPNLPELAALTGVEVADDEA
AVRAARMLPARAVLVKGGHREGAPVDLLVEGRRRVTRFTGRRRAGTARGTGCRLASAIAGLLAGGASLEEAVRGGKRVVE
RYLDACGRGAVGR

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=238, Percent_Identity=38.655462184874, Blast_Score=119, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6324997, Length=261, Percent_Identity=36.3984674329502, Blast_Score=104, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6325378, Length=259, Percent_Identity=32.8185328185328, Blast_Score=103, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6324517, Length=255, Percent_Identity=34.9019607843137, Blast_Score=101, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 25590; Mature: 25590

Theoretical pI: Translated: 11.61; Mature: 11.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPRVLVVAGLDPSGGAGLTADLEALAAVGARGWAVATALTAQGPRGARGVSPASEAFLR
CCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHH
LQIDALLEGRERPHAVKTGMLGTAGLARALAARLAEPPIARVPLVVDPVLLASSGAPLLD
HHHHHHHCCCCCCCHHHHCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCC
PGGVPPGEALAPLLGRARLVTPNLPELAALTGVEVADDEAAVRAARMLPARAVLVKGGHR
CCCCCCHHHHHHHHCCCEECCCCCCHHHHHCCCCCCCHHHHHHHHHHCCHHEEEEECCCC
EGAPVDLLVEGRRRVTRFTGRRRAGTARGTGCRLASAIAGLLAGGASLEEAVRGGKRVVE
CCCCEEEEEHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
RYLDACGRGAVGR
HHHHHHCCCCCCC
>Mature Secondary Structure
MIPRVLVVAGLDPSGGAGLTADLEALAAVGARGWAVATALTAQGPRGARGVSPASEAFLR
CCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHH
LQIDALLEGRERPHAVKTGMLGTAGLARALAARLAEPPIARVPLVVDPVLLASSGAPLLD
HHHHHHHCCCCCCCHHHHCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCC
PGGVPPGEALAPLLGRARLVTPNLPELAALTGVEVADDEAAVRAARMLPARAVLVKGGHR
CCCCCCHHHHHHHHCCCEECCCCCCHHHHHCCCCCCCHHHHHHHHHHCCHHEEEEECCCC
EGAPVDLLVEGRRRVTRFTGRRRAGTARGTGCRLASAIAGLLAGGASLEEAVRGGKRVVE
CCCCEEEEEHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
RYLDACGRGAVGR
HHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11418146 [H]