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The map label for this gene is etfA [H]

Identifier: 220915186

GI number: 220915186

Start: 73674

End: 74636

Strand: Direct

Name: etfA [H]

Synonym: A2cp1_0065

Alternate gene names: 220915186

Gene position: 73674-74636 (Clockwise)

Preceding gene: 220915185

Following gene: 220915187

Centisome position: 1.46

GC content: 76.01

Gene sequence:

>963_bases
ATGTCGAACGTCCTCATCGTGGCCGAGCAGGGCGGCGGCCAGCTCCGCAAGGCGACGCTCCACGCCATCTCGGCGGGGCG
CGCCCTTGCCGCCCGCACCGGCGGCGCGCTCCACGTCGCGCTGCTCGGCCAGGGCGTGCGCCCGCTCGCCGACGCGCTGG
CCGCGACCGGCGCCGAGGTGCACGTGGCCGACGCGCCCGCGCTCGAGCACCCGCTCGCCGACGCGTGGGCGCCGGTGATC
GCGGAGATCGCGAAGGCCTGCGGGGCCGCGTACGTGGGCGCCGCCGCGACCGCGCAGGGCAAGGACCTCCTCCCCCGCGT
GGCGGCCCGGCTCGGCGCCGGGATGGCGACCGAGGTGCTCGGCTTCGGCGGCGACGGCGCGGCCGTGACGTTCCGCCGGC
CCATGTGGGCGGGCAACGTGCTCGCCGAGGTGGAGATCGCGACGCCGGTGAAGGTGTTCACGGTGCGTGCGACGGAGTTC
CCAGCCGCCGAGCCGGGCGCCGGCAAGGGCGCGGTGCACGAGGTGGCGGTCCAGGTGCCGGCCGGCCTGCGCACCCGGCA
CGTGGCCTTCCGCGAGGTGAAGAGCGAGCGGCCCGAGCTGACCGAGGCGCGGGTGGTGGTGTCGGGCGGCCGCGGCACGA
AGGGCGACTTCAAGCCGGTCGAGGCGCTGGCCGATGCGCTCGGCGCCGCGGTGGGCGCGAGCCGCGCCGCGGTGGACGCG
GGCTGGGTGCCGAACGACTGGCAGGTGGGGCAGACCGGCAAGGTGGTCGCGCCGGACCTCTACGTGGCGGCGGGCATCTC
CGGCGCCATCCAGCACCTCGCCGGCATGAAGGGCTCGAAGGTGATCGTGGCGGTGAACAAGGACCCGGACGCGCCGGTGT
TCCAGATCGCCGACTACGGCCTGGTGGCGGACCTGTTCCAGGCGCTGCCGGCGCTCACCGAGAAGGTGAAGGCCTCGAAG
TGA

Upstream 100 bases:

>100_bases
GGCCGACGTCGAGGAGCTCTGGAAGAAGCTGCACGACGAGGCGAAGGTCCTCTAGCCCACCGTCCGCGCGCCGCGCGGCG
ATCGAACCTCCGGAGGCGAC

Downstream 100 bases:

>100_bases
GGGCGCCGCGGGGCGCGGCGGTGCGAGCGTGACCGAGGCGGATCTCGAGGGGCTCGGCGTCCACCGCATCGCCATCCCGG
TTCCGTTCCCGCAGGCGGGC

Product: Electron transfer flavoprotein alpha subunit

Products: NA

Alternate protein names: Alpha-ETF; Electron transfer flavoprotein large subunit; ETFLS [H]

Number of amino acids: Translated: 320; Mature: 319

Protein sequence:

>320_residues
MSNVLIVAEQGGGQLRKATLHAISAGRALAARTGGALHVALLGQGVRPLADALAATGAEVHVADAPALEHPLADAWAPVI
AEIAKACGAAYVGAAATAQGKDLLPRVAARLGAGMATEVLGFGGDGAAVTFRRPMWAGNVLAEVEIATPVKVFTVRATEF
PAAEPGAGKGAVHEVAVQVPAGLRTRHVAFREVKSERPELTEARVVVSGGRGTKGDFKPVEALADALGAAVGASRAAVDA
GWVPNDWQVGQTGKVVAPDLYVAAGISGAIQHLAGMKGSKVIVAVNKDPDAPVFQIADYGLVADLFQALPALTEKVKASK

Sequences:

>Translated_320_residues
MSNVLIVAEQGGGQLRKATLHAISAGRALAARTGGALHVALLGQGVRPLADALAATGAEVHVADAPALEHPLADAWAPVI
AEIAKACGAAYVGAAATAQGKDLLPRVAARLGAGMATEVLGFGGDGAAVTFRRPMWAGNVLAEVEIATPVKVFTVRATEF
PAAEPGAGKGAVHEVAVQVPAGLRTRHVAFREVKSERPELTEARVVVSGGRGTKGDFKPVEALADALGAAVGASRAAVDA
GWVPNDWQVGQTGKVVAPDLYVAAGISGAIQHLAGMKGSKVIVAVNKDPDAPVFQIADYGLVADLFQALPALTEKVKASK
>Mature_319_residues
SNVLIVAEQGGGQLRKATLHAISAGRALAARTGGALHVALLGQGVRPLADALAATGAEVHVADAPALEHPLADAWAPVIA
EIAKACGAAYVGAAATAQGKDLLPRVAARLGAGMATEVLGFGGDGAAVTFRRPMWAGNVLAEVEIATPVKVFTVRATEFP
AAEPGAGKGAVHEVAVQVPAGLRTRHVAFREVKSERPELTEARVVVSGGRGTKGDFKPVEALADALGAAVGASRAAVDAG
WVPNDWQVGQTGKVVAPDLYVAAGISGAIQHLAGMKGSKVIVAVNKDPDAPVFQIADYGLVADLFQALPALTEKVKASK

Specific function: The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) [H]

COG id: COG2025

COG function: function code C; Electron transfer flavoprotein, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ETF alpha-subunit/fixB family [H]

Homologues:

Organism=Homo sapiens, GI4503607, Length=321, Percent_Identity=46.1059190031153, Blast_Score=253, Evalue=1e-67,
Organism=Homo sapiens, GI189181759, Length=279, Percent_Identity=49.4623655913978, Blast_Score=240, Evalue=1e-63,
Organism=Escherichia coli, GI1786226, Length=247, Percent_Identity=36.8421052631579, Blast_Score=137, Evalue=7e-34,
Organism=Escherichia coli, GI1787990, Length=250, Percent_Identity=32, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI87082157, Length=224, Percent_Identity=32.5892857142857, Blast_Score=88, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17506929, Length=320, Percent_Identity=47.1875, Blast_Score=248, Evalue=4e-66,
Organism=Saccharomyces cerevisiae, GI6325261, Length=253, Percent_Identity=44.2687747035573, Blast_Score=205, Evalue=8e-54,
Organism=Drosophila melanogaster, GI17136898, Length=322, Percent_Identity=46.8944099378882, Blast_Score=256, Evalue=2e-68,
Organism=Drosophila melanogaster, GI24652801, Length=322, Percent_Identity=46.8944099378882, Blast_Score=256, Evalue=2e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001308
- InterPro:   IPR014730
- InterPro:   IPR014731
- InterPro:   IPR018206
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01012 ETF; PF00766 ETF_alpha [H]

EC number: NA

Molecular weight: Translated: 32388; Mature: 32257

Theoretical pI: Translated: 8.49; Mature: 8.49

Prosite motif: PS00696 ETF_ALPHA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNVLIVAEQGGGQLRKATLHAISAGRALAARTGGALHVALLGQGVRPLADALAATGAEV
CCCEEEEEECCCCHHHHHHHHHHHCCCCCEECCCCEEEEEECCCCCHHHHHHHHHCCCEE
HVADAPALEHPLADAWAPVIAEIAKACGAAYVGAAATAQGKDLLPRVAARLGAGMATEVL
EECCCCCHHCCHHHHHHHHHHHHHHHHCHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHE
GFGGDGAAVTFRRPMWAGNVLAEVEIATPVKVFTVRATEFPAAEPGAGKGAVHEVAVQVP
EECCCCCEEEEECCCCCCCEEEEEEECCCEEEEEEEECCCCCCCCCCCCCCHHHEEEECC
AGLRTRHVAFREVKSERPELTEARVVVSGGRGTKGDFKPVEALADALGAAVGASRAAVDA
CCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCHHHCCC
GWVPNDWQVGQTGKVVAPDLYVAAGISGAIQHLAGMKGSKVIVAVNKDPDAPVFQIADYG
CCCCCCCCCCCCCCEECCCHHHHHCHHHHHHHHHCCCCCEEEEEECCCCCCCEEEECCCH
LVADLFQALPALTEKVKASK
HHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SNVLIVAEQGGGQLRKATLHAISAGRALAARTGGALHVALLGQGVRPLADALAATGAEV
CCEEEEEECCCCHHHHHHHHHHHCCCCCEECCCCEEEEEECCCCCHHHHHHHHHCCCEE
HVADAPALEHPLADAWAPVIAEIAKACGAAYVGAAATAQGKDLLPRVAARLGAGMATEVL
EECCCCCHHCCHHHHHHHHHHHHHHHHCHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHE
GFGGDGAAVTFRRPMWAGNVLAEVEIATPVKVFTVRATEFPAAEPGAGKGAVHEVAVQVP
EECCCCCEEEEECCCCCCCEEEEEEECCCEEEEEEEECCCCCCCCCCCCCCHHHEEEECC
AGLRTRHVAFREVKSERPELTEARVVVSGGRGTKGDFKPVEALADALGAAVGASRAAVDA
CCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCHHHCCC
GWVPNDWQVGQTGKVVAPDLYVAAGISGAIQHLAGMKGSKVIVAVNKDPDAPVFQIADYG
CCCCCCCCCCCCCCEECCCHHHHHCHHHHHHHHHCCCCCEEEEEECCCCCCCEEEECCCH
LVADLFQALPALTEKVKASK
HHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]