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The map label for this gene is dapE [H]

Identifier: 220915013

GI number: 220915013

Start: 388662

End: 389783

Strand: Reverse

Name: dapE [H]

Synonym: Mnod_8178

Alternate gene names: 220915013

Gene position: 389783-388662 (Counterclockwise)

Preceding gene: 220915014

Following gene: 220915012

Centisome position: 85.09

GC content: 68.63

Gene sequence:

>1122_bases
ATGAATAATCCCGAGGTATTGGCTCTCGATCTGGTGCGCTTCGATACGATCAGCCCGCCGGGCTCAGAGAGCGCCTGCGC
GGCGCACCTTGCGGTGCTGCTCCGCCGGGCTGGCTTCGATGTAACCGACTATCCGTTCGCCCCCGGCCGCACGAGCTTGG
TTGCCCGCCTGCCGGGCACGAACCCGGCCCTCGCCCCGCTTGTCTTCACCGGTCACCTCGACACGGTCCCGCTCGGCAGC
GCACCGTGGTCGTTCGACCCACGCGGTGAGATCCGTGACGGGCGCCTCTACGGACGGGGCGCGTCCGACATGAAGGCCGG
CGTCGCCGCCTTCGTCGCGGCGGTGCTCGATGTGGCCCACTCCGCAGCGGTGCTGACGCGCGGGGTCACCCTGGTGCTCA
CGGCAGGTGAGGAGACCGGATGCCTGGGGGCCGCCGATCTCGCCCGGCGCGGCGTGCTGGGTGAAGCCAGCGGCCTTGTT
GTCGCCGAGCCGACCTCCAACCGTTTGGCCCTCGCTCATAAGGGCGCGCTCCACCTGCGCGCCCGAACGCATGGTGCAAC
GGCCCACGGGTCCATGCCCGAACTCGGCGACAATGCCGTGCTCAAGGCAACGCGTGCAGTCGAGGCGCTCCGGAATTTCG
AGTTCGGCGTTCCCACTCACCCACTGCTTGGATCGCCGACGCTGGCCGTGACGAGCCTGCACGGTGGCGAGGCTGTCAAC
GTCATCCCGGACAGCTGCACGCTGACCCTCGACCTTCGCACCCTGCCCGGTCAGGACCACGCTCGCACGCTCGCCATGCT
GCAGGACCAGCTGGGGCCGGATGTCGTGTTCGACCCTCCACTGGCCGATCTGCCCGCGGTCGGTACCGAGCCATCGGATG
GGTTCGCGATGGCGGCCGCGCGGAGCGTTCGTAAGGTCACGCAGGAGGTGGGCGAGGCGATCGGGATGCCGTATTTCACC
GACGGCTCGGTGCTGCAGGGGGCCTTCGGTGGGTGCCCGACCGTGATCCTCGGCCCTGGTGAGCCCGGACAAGCGCATCA
GACGAACGAGTGGTGCGCGACAAGCGCCATTACGATCGCGCACCGGATTTATGGCGCTCTGGTCCAGGAATGGTGCGCCT
GA

Upstream 100 bases:

>100_bases
CGCGCCGTGTGGGATACCCAAAAATGGCTCATCCGTCGCTTGCATCGCACTCCGCACATCCCTTACCTCTGATCCAGGCG
TGCGAGGGGCTATCGAGCCG

Downstream 100 bases:

>100_bases
GACTGTGAAGCGGCTGGCGGAGTTCAACGACCGCCTCGCCGACCACTGCGGCCGCGCGCTGCTGCTGGTCGGCACCGCGG
CGGATCACTCGGCCAGGGTC

Product: peptidase M20

Products: NA

Alternate protein names: SDAP desuccinylase [H]

Number of amino acids: Translated: 373; Mature: 373

Protein sequence:

>373_residues
MNNPEVLALDLVRFDTISPPGSESACAAHLAVLLRRAGFDVTDYPFAPGRTSLVARLPGTNPALAPLVFTGHLDTVPLGS
APWSFDPRGEIRDGRLYGRGASDMKAGVAAFVAAVLDVAHSAAVLTRGVTLVLTAGEETGCLGAADLARRGVLGEASGLV
VAEPTSNRLALAHKGALHLRARTHGATAHGSMPELGDNAVLKATRAVEALRNFEFGVPTHPLLGSPTLAVTSLHGGEAVN
VIPDSCTLTLDLRTLPGQDHARTLAMLQDQLGPDVVFDPPLADLPAVGTEPSDGFAMAAARSVRKVTQEVGEAIGMPYFT
DGSVLQGAFGGCPTVILGPGEPGQAHQTNEWCATSAITIAHRIYGALVQEWCA

Sequences:

>Translated_373_residues
MNNPEVLALDLVRFDTISPPGSESACAAHLAVLLRRAGFDVTDYPFAPGRTSLVARLPGTNPALAPLVFTGHLDTVPLGS
APWSFDPRGEIRDGRLYGRGASDMKAGVAAFVAAVLDVAHSAAVLTRGVTLVLTAGEETGCLGAADLARRGVLGEASGLV
VAEPTSNRLALAHKGALHLRARTHGATAHGSMPELGDNAVLKATRAVEALRNFEFGVPTHPLLGSPTLAVTSLHGGEAVN
VIPDSCTLTLDLRTLPGQDHARTLAMLQDQLGPDVVFDPPLADLPAVGTEPSDGFAMAAARSVRKVTQEVGEAIGMPYFT
DGSVLQGAFGGCPTVILGPGEPGQAHQTNEWCATSAITIAHRIYGALVQEWCA
>Mature_373_residues
MNNPEVLALDLVRFDTISPPGSESACAAHLAVLLRRAGFDVTDYPFAPGRTSLVARLPGTNPALAPLVFTGHLDTVPLGS
APWSFDPRGEIRDGRLYGRGASDMKAGVAAFVAAVLDVAHSAAVLTRGVTLVLTAGEETGCLGAADLARRGVLGEASGLV
VAEPTSNRLALAHKGALHLRARTHGATAHGSMPELGDNAVLKATRAVEALRNFEFGVPTHPLLGSPTLAVTSLHGGEAVN
VIPDSCTLTLDLRTLPGQDHARTLAMLQDQLGPDVVFDPPLADLPAVGTEPSDGFAMAAARSVRKVTQEVGEAIGMPYFT
DGSVLQGAFGGCPTVILGPGEPGQAHQTNEWCATSAITIAHRIYGALVQEWCA

Specific function: Displays A Broad Specificity And Can Also Deacylate Substrates Such As Acetylarginine, Acetylhistidine Or Acetylglutamate Semialdehyde. [C]

COG id: COG0624

COG function: function code E; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20A family [H]

Homologues:

Organism=Homo sapiens, GI4501901, Length=277, Percent_Identity=27.0758122743682, Blast_Score=89, Evalue=7e-18,
Organism=Escherichia coli, GI1790395, Length=362, Percent_Identity=29.2817679558011, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1789236, Length=399, Percent_Identity=25.062656641604, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788816, Length=388, Percent_Identity=26.2886597938144, Blast_Score=77, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17538642, Length=385, Percent_Identity=25.7142857142857, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17551016, Length=361, Percent_Identity=22.7146814404432, Blast_Score=82, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI71982082, Length=281, Percent_Identity=23.8434163701068, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71982085, Length=281, Percent_Identity=23.8434163701068, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71982710, Length=385, Percent_Identity=24.6753246753247, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17538640, Length=389, Percent_Identity=25.706940874036, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24649206, Length=280, Percent_Identity=26.7857142857143, Blast_Score=85, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24649210, Length=270, Percent_Identity=24.4444444444444, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001261
- InterPro:   IPR010182
- InterPro:   IPR002933
- InterPro:   IPR011650 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.5.1.18 [H]

Molecular weight: Translated: 38628; Mature: 38628

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: PS00759 ARGE_DAPE_CPG2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNPEVLALDLVRFDTISPPGSESACAAHLAVLLRRAGFDVTDYPFAPGRTSLVARLPGT
CCCCCEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCC
NPALAPLVFTGHLDTVPLGSAPWSFDPRGEIRDGRLYGRGASDMKAGVAAFVAAVLDVAH
CCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHH
SAAVLTRGVTLVLTAGEETGCLGAADLARRGVLGEASGLVVAEPTSNRLALAHKGALHLR
HHHHHHCCEEEEEECCCCCCCCCHHHHHHCCCCCCCCCEEEECCCCCCEEEEECCEEEEE
ARTHGATAHGSMPELGDNAVLKATRAVEALRNFEFGVPTHPLLGSPTLAVTSLHGGEAVN
EECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCEEE
VIPDSCTLTLDLRTLPGQDHARTLAMLQDQLGPDVVFDPPLADLPAVGTEPSDGFAMAAA
EECCCEEEEEEEEECCCCHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCHHHHHH
RSVRKVTQEVGEAIGMPYFTDGSVLQGAFGGCPTVILGPGEPGQAHQTNEWCATSAITIA
HHHHHHHHHHHHHHCCCEECCCCHHHHHCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHH
HRIYGALVQEWCA
HHHHHHHHHHHCC
>Mature Secondary Structure
MNNPEVLALDLVRFDTISPPGSESACAAHLAVLLRRAGFDVTDYPFAPGRTSLVARLPGT
CCCCCEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCC
NPALAPLVFTGHLDTVPLGSAPWSFDPRGEIRDGRLYGRGASDMKAGVAAFVAAVLDVAH
CCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHH
SAAVLTRGVTLVLTAGEETGCLGAADLARRGVLGEASGLVVAEPTSNRLALAHKGALHLR
HHHHHHCCEEEEEECCCCCCCCCHHHHHHCCCCCCCCCEEEECCCCCCEEEEECCEEEEE
ARTHGATAHGSMPELGDNAVLKATRAVEALRNFEFGVPTHPLLGSPTLAVTSLHGGEAVN
EECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCEEE
VIPDSCTLTLDLRTLPGQDHARTLAMLQDQLGPDVVFDPPLADLPAVGTEPSDGFAMAAA
EECCCEEEEEEEEECCCCHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCHHHHHH
RSVRKVTQEVGEAIGMPYFTDGSVLQGAFGGCPTVILGPGEPGQAHQTNEWCATSAITIA
HHHHHHHHHHHHHHCCCEECCCCHHHHHCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHH
HRIYGALVQEWCA
HHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA