Click here to switch to the map view.

The map label for this gene is ygeZ [C]

Identifier: 220914792

GI number: 220914792

Start: 153048

End: 154472

Strand: Reverse

Name: ygeZ [C]

Synonym: Mnod_7926

Alternate gene names: 220914792

Gene position: 154472-153048 (Counterclockwise)

Preceding gene: 220914793

Following gene: 220914791

Centisome position: 33.72

GC content: 61.75

Gene sequence:

>1425_bases
ATGAGCAAATACGATCTGATCATTCGCGGTGGCACCGTGGTCACGGCAGCCGATACGATCCGGGCGGACGTGGCAATCCA
TGCTGGCCGAATCGTCGCCGTCGCCGACAGGCTCTCCGGCGGTACGCGCGAGATCGACGCCGGCGGCCTGCTGGTCATGC
CAGGAGGTATCGACAGCCACGTCCACCTTGCTCAGCCCGCGTTCGGCGGGCCAGCGATGGCCGACGACTTCGAATCCGGA
ACGCGCTCGGCCATCGCCGGTGGCACGACAACGATCCTGCCCTTCGCGCTCCAACCCCGAGGCGCCTCCTTGCGACAGAG
CGTCCTCGACTACCATAAGGAAGCAGACGGCAAGAGCTACTGCGATTACGGGTTCCACCTGATCATCTCGGACCCAACAC
CCAGCGTTCTTGGGCAGGAGCTGCCCGCCCTGGTGGCGGACGGTTATACCTCGTTCAAAGTCTTCATGACTTATGACGAC
TTGGTTCTGAACGATCGGCAGTTGCTTGAGGTATTCGACTGCGCGCGGGACTGTGGTGCCCTCGTCATGGTCCATTGCGA
GGGCTACGACGCAATCCGCTTCATGACGGAGAAGCTCGAACGCGCAGGAAAGACCGCGCCTTACTATCACGCTGCGTCGC
GTCCGGCCTCGGTCGAACGCGAGGCGACTCACCGGGCGATCAGCCACGCCGAGCTGGTCGAGGTGCCAATCATGATCGTC
CACGTCTCAGGCCGCGAGCCAATGGAGCAGATCCGTTGGGCGCAGCAGAAGGGGCTGAAGGTCTATGGCGAAACCTGCCC
TCAATACATCGCTCTGACTGCCGACGATCTCAAGGGCCTTAACATGGACGAGAGCGGCGGGAAGTATGTCTGCTCTCCGC
CGCCGCGCGATCGCGCGAGCTGGGATGCGATCTGGGAAGGCATCCGGACGGGCGTCTTCCAGACCTTCTCCTCCGACCAT
TGTCCATTCTTCTACGAGGGCAATCAGGGCAAGCTGAACCCGAAGGCACGAACCTCATTCCGCTGGGTCCCGAATGGGAT
TCCGGGTGTCGAGACGCGGCTCCAAATTCTGTTCTCGAAGGGCGTGGTTGAAGGACGGATCACGCTCAACGACTTCGTCG
CGCTGACCTCTACCAACCACGCCAAGATGTACGGCCTCTATCCGGGAAAAGGCTCCATCGCGCCGGGCTTCGATGCCGAT
ATCGTGATCTGGGATCCGAACCGGAAGGAGACGATTCGCCAAGAGCTGATGCACCACGGCGCCGACTACACGCCCTATGA
AGGAATTGCCGTCACAGGTTGGCCGATCATGACGATCTTGCGAGGGAAGCTCGTCGCGGAGGAAGGCCGTATCCTCGGAA
CGCCTGGCCGAGGCAGATTTCTGAAGCGGTCGCTGTCGCCCTTTGCAGAGCCGCGTCACTCGTAG

Upstream 100 bases:

>100_bases
CAGAGGCGCGATTCACGGGCGCAGTGCCGCCATGTCCTGCTGTGCGGGGCAGAACCTCTCACCCAACGGCGGCGACGTGA
TGATCTGAGGGACACGGTCG

Downstream 100 bases:

>100_bases
TATTTCACGCGAGGTGAGCACTGCGAGATCCTGACGATCGCCCCGAGCGTGTCGGCCTAAGCAGGTTTCGGAAAAGTGCC
CTGCGGTTTTCCGTCAAAAA

Product: phenylhydantoinase

Products: 3-ureidopropanoate

Alternate protein names: NA

Number of amino acids: Translated: 474; Mature: 473

Protein sequence:

>474_residues
MSKYDLIIRGGTVVTAADTIRADVAIHAGRIVAVADRLSGGTREIDAGGLLVMPGGIDSHVHLAQPAFGGPAMADDFESG
TRSAIAGGTTTILPFALQPRGASLRQSVLDYHKEADGKSYCDYGFHLIISDPTPSVLGQELPALVADGYTSFKVFMTYDD
LVLNDRQLLEVFDCARDCGALVMVHCEGYDAIRFMTEKLERAGKTAPYYHAASRPASVEREATHRAISHAELVEVPIMIV
HVSGREPMEQIRWAQQKGLKVYGETCPQYIALTADDLKGLNMDESGGKYVCSPPPRDRASWDAIWEGIRTGVFQTFSSDH
CPFFYEGNQGKLNPKARTSFRWVPNGIPGVETRLQILFSKGVVEGRITLNDFVALTSTNHAKMYGLYPGKGSIAPGFDAD
IVIWDPNRKETIRQELMHHGADYTPYEGIAVTGWPIMTILRGKLVAEEGRILGTPGRGRFLKRSLSPFAEPRHS

Sequences:

>Translated_474_residues
MSKYDLIIRGGTVVTAADTIRADVAIHAGRIVAVADRLSGGTREIDAGGLLVMPGGIDSHVHLAQPAFGGPAMADDFESG
TRSAIAGGTTTILPFALQPRGASLRQSVLDYHKEADGKSYCDYGFHLIISDPTPSVLGQELPALVADGYTSFKVFMTYDD
LVLNDRQLLEVFDCARDCGALVMVHCEGYDAIRFMTEKLERAGKTAPYYHAASRPASVEREATHRAISHAELVEVPIMIV
HVSGREPMEQIRWAQQKGLKVYGETCPQYIALTADDLKGLNMDESGGKYVCSPPPRDRASWDAIWEGIRTGVFQTFSSDH
CPFFYEGNQGKLNPKARTSFRWVPNGIPGVETRLQILFSKGVVEGRITLNDFVALTSTNHAKMYGLYPGKGSIAPGFDAD
IVIWDPNRKETIRQELMHHGADYTPYEGIAVTGWPIMTILRGKLVAEEGRILGTPGRGRFLKRSLSPFAEPRHS
>Mature_473_residues
SKYDLIIRGGTVVTAADTIRADVAIHAGRIVAVADRLSGGTREIDAGGLLVMPGGIDSHVHLAQPAFGGPAMADDFESGT
RSAIAGGTTTILPFALQPRGASLRQSVLDYHKEADGKSYCDYGFHLIISDPTPSVLGQELPALVADGYTSFKVFMTYDDL
VLNDRQLLEVFDCARDCGALVMVHCEGYDAIRFMTEKLERAGKTAPYYHAASRPASVEREATHRAISHAELVEVPIMIVH
VSGREPMEQIRWAQQKGLKVYGETCPQYIALTADDLKGLNMDESGGKYVCSPPPRDRASWDAIWEGIRTGVFQTFSSDHC
PFFYEGNQGKLNPKARTSFRWVPNGIPGVETRLQILFSKGVVEGRITLNDFVALTSTNHAKMYGLYPGKGSIAPGFDADI
VIWDPNRKETIRQELMHHGADYTPYEGIAVTGWPIMTILRGKLVAEEGRILGTPGRGRFLKRSLSPFAEPRHS

Specific function: Catalyzes the stereospecific hydrolysis of the cyclic amide bond of D-hydantoin. Has no activity on dihydropyrimidines [H]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503375, Length=475, Percent_Identity=39.1578947368421, Blast_Score=286, Evalue=2e-77,
Organism=Homo sapiens, GI4503051, Length=467, Percent_Identity=36.830835117773, Blast_Score=282, Evalue=5e-76,
Organism=Homo sapiens, GI62422571, Length=467, Percent_Identity=36.830835117773, Blast_Score=280, Evalue=2e-75,
Organism=Homo sapiens, GI190194363, Length=468, Percent_Identity=35.6837606837607, Blast_Score=274, Evalue=1e-73,
Organism=Homo sapiens, GI4503379, Length=470, Percent_Identity=35.1063829787234, Blast_Score=273, Evalue=2e-73,
Organism=Homo sapiens, GI4503377, Length=467, Percent_Identity=36.1884368308351, Blast_Score=270, Evalue=2e-72,
Organism=Homo sapiens, GI19923821, Length=460, Percent_Identity=36.304347826087, Blast_Score=258, Evalue=9e-69,
Organism=Homo sapiens, GI18105007, Length=420, Percent_Identity=26.6666666666667, Blast_Score=116, Evalue=6e-26,
Organism=Escherichia coli, GI87082175, Length=470, Percent_Identity=38.7234042553192, Blast_Score=305, Evalue=5e-84,
Organism=Escherichia coli, GI1786722, Length=470, Percent_Identity=29.5744680851064, Blast_Score=191, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI17539558, Length=463, Percent_Identity=36.2850971922246, Blast_Score=254, Evalue=5e-68,
Organism=Caenorhabditis elegans, GI71989490, Length=480, Percent_Identity=36.0416666666667, Blast_Score=248, Evalue=7e-66,
Organism=Caenorhabditis elegans, GI86575075, Length=470, Percent_Identity=30.6382978723404, Blast_Score=178, Evalue=7e-45,
Organism=Caenorhabditis elegans, GI193204318, Length=422, Percent_Identity=24.8815165876777, Blast_Score=103, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6322218, Length=403, Percent_Identity=28.287841191067, Blast_Score=141, Evalue=2e-34,
Organism=Drosophila melanogaster, GI221377917, Length=469, Percent_Identity=37.3134328358209, Blast_Score=281, Evalue=1e-75,
Organism=Drosophila melanogaster, GI17137462, Length=469, Percent_Identity=36.4605543710021, Blast_Score=274, Evalue=1e-73,
Organism=Drosophila melanogaster, GI24644287, Length=297, Percent_Identity=37.7104377104377, Blast_Score=168, Evalue=6e-42,
Organism=Drosophila melanogaster, GI24644289, Length=232, Percent_Identity=41.3793103448276, Blast_Score=152, Evalue=5e-37,
Organism=Drosophila melanogaster, GI24642586, Length=454, Percent_Identity=25.7709251101322, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI18859883, Length=442, Percent_Identity=27.6018099547511, Blast_Score=108, Evalue=6e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011778
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: 3.5.2.2

Molecular weight: Translated: 51915; Mature: 51783

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKYDLIIRGGTVVTAADTIRADVAIHAGRIVAVADRLSGGTREIDAGGLLVMPGGIDSH
CCCEEEEEECCEEEEEHHHHHEEEEEECCEEEEEEECCCCCCEEECCCCEEEECCCCCCC
VHLAQPAFGGPAMADDFESGTRSAIAGGTTTILPFALQPRGASLRQSVLDYHKEADGKSY
EEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHCCCCCCC
CDYGFHLIISDPTPSVLGQELPALVADGYTSFKVFMTYDDLVLNDRQLLEVFDCARDCGA
CCCCCEEEECCCCHHHHHHHHHHHHHCCCCEEEEEEEECCEEECCHHHHHHHHHHHCCCE
LVMVHCEGYDAIRFMTEKLERAGKTAPYYHAASRPASVEREATHRAISHAELVEVPIMIV
EEEEEECCCHHHHHHHHHHHHCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHEEEEEEEE
HVSGREPMEQIRWAQQKGLKVYGETCPQYIALTADDLKGLNMDESGGKYVCSPPPRDRAS
EECCCCHHHHHHHHHHCCCEEECCCCCCEEEEEHHHCCCCCCCCCCCEEEECCCCCCCCC
WDAIWEGIRTGVFQTFSSDHCPFFYEGNQGKLNPKARTSFRWVPNGIPGVETRLQILFSK
HHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHC
GVVEGRITLNDFVALTSTNHAKMYGLYPGKGSIAPGFDADIVIWDPNRKETIRQELMHHG
CCEEEEEEEEEEEEEECCCCEEEEEEECCCCCCCCCCCCEEEEECCCHHHHHHHHHHHCC
ADYTPYEGIAVTGWPIMTILRGKLVAEEGRILGTPGRGRFLKRSLSPFAEPRHS
CCCCCCCCEEEECCHHHHHHHHHHEECCCCEEECCCCCHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
SKYDLIIRGGTVVTAADTIRADVAIHAGRIVAVADRLSGGTREIDAGGLLVMPGGIDSH
CCEEEEEECCEEEEEHHHHHEEEEEECCEEEEEEECCCCCCEEECCCCEEEECCCCCCC
VHLAQPAFGGPAMADDFESGTRSAIAGGTTTILPFALQPRGASLRQSVLDYHKEADGKSY
EEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHCCCCCCC
CDYGFHLIISDPTPSVLGQELPALVADGYTSFKVFMTYDDLVLNDRQLLEVFDCARDCGA
CCCCCEEEECCCCHHHHHHHHHHHHHCCCCEEEEEEEECCEEECCHHHHHHHHHHHCCCE
LVMVHCEGYDAIRFMTEKLERAGKTAPYYHAASRPASVEREATHRAISHAELVEVPIMIV
EEEEEECCCHHHHHHHHHHHHCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHEEEEEEEE
HVSGREPMEQIRWAQQKGLKVYGETCPQYIALTADDLKGLNMDESGGKYVCSPPPRDRAS
EECCCCHHHHHHHHHHCCCEEECCCCCCEEEEEHHHCCCCCCCCCCCEEEECCCCCCCCC
WDAIWEGIRTGVFQTFSSDHCPFFYEGNQGKLNPKARTSFRWVPNGIPGVETRLQILFSK
HHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHC
GVVEGRITLNDFVALTSTNHAKMYGLYPGKGSIAPGFDADIVIWDPNRKETIRQELMHHG
CCEEEEEEEEEEEEEECCCCEEEEEEECCCCCCCCCCCCEEEEECCCHHHHHHHHHHHCC
ADYTPYEGIAVTGWPIMTILRGKLVAEEGRILGTPGRGRFLKRSLSPFAEPRHS
CCCCCCCCEEEECCHHHHHHHHHHEECCCCEEECCCCCHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 5,6-dihydrouracil; H2O

Specific reaction: 5,6-dihydrouracil + H2O = 3-ureidopropanoate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7765480 [H]