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The map label for this gene is pcoA [H]

Identifier: 220914757

GI number: 220914757

Start: 104633

End: 106027

Strand: Reverse

Name: pcoA [H]

Synonym: Mnod_7874

Alternate gene names: 220914757

Gene position: 106027-104633 (Counterclockwise)

Preceding gene: 220914758

Following gene: 220914756

Centisome position: 23.15

GC content: 58.92

Gene sequence:

>1395_bases
ATGTCAGTTTCACGTCGAAATTTTCTCAGTGCTGCTGGCGGTATAACGCTCGTCAGCGCCAGTGCGGTCTCTGGTCGAAC
GGCCTTCGCTTCGGTGCCTGAGGCGCCGACGATGAAGAGCCCTCAGATGCAGCCGCCGCTCGTGCCCAAAACCGGACCTG
ACTACAATCCGGTGGTGACGCTCAATGGCTGGACCCTGCCATGGCGCATGAACGGCGATTGGAAGGAGTTTCATCTCGTT
GCCGAGCCTGTGGTGCGCGAGTTCGCGCCCGGCATGGTTGGGCATTTGTGGGGCTATAACGGCCAGTCGCCTGGACCGAC
CATCGAGGCGGTGGAAGGCGACAAGGTCCGCCTCTTCGTCACCAACAAACTGCCTGAACATACGACGATCCATTGGCACG
GGCAGCTTCTGCCCAGCGGCATGGACGGCGTCGGCGGTCTCACGCAGCCGCACATCCCCGTCGGCAAGACATTCGTCTAC
GAGTTTCAACTGCAGAAGAGTGGGACATTCATGTACCACCCGCATGCCGATGAAATGGTGCAGATGGCCATGGGCATGAT
GGGGTTCTTCGTCGTGCATCCGAAGGATCCAGCCTTCCGGCGGGTCGATCGTGACTTCGTCTTCTTGATGGCGTCATACG
ACATCGAGCCTGGTACCTATGTGCCGCGCGTCGCCGAGATGACCGACTTCAATATGTGGACGTGGAACACGCGCGTTTTC
CCCGGCATCGATCACATCGTTGCTGGCAAAGGCGACAAAGTCCGCATCCGCTTTGGCAATCTTACCATGACGAATCATCT
GATCCATATGCATGGCTACGATTTCAAAGTGTCGTGCACGGACGGCGGCTGGGTGCCGGAGGAGGCGGCGTGGCCTGAAG
TGACGATCGATTGCGCGGTCGGGCAGATGCGCGCTTTCGACTTCGTTGCCGATAAACCGGGCGACTGGGCGATCCACTGC
CACAAGTCGCATCATACGATGAATGCCATGGGGCACGATCTCAATACGTTCATCGGCGTCGACAAACGAAAGGTGGCCAA
GAAGATCAAAAGGCTCGTGCCAGACTACATGCCGATGGGCACCGCAGGCATGGCGGACATGGGCGAGATGGAAATGCCAC
TGCCTGACAACACCCTGCCGATGATGACCGGCTGGGGGCAATTCGGCTCCATCGAAATGGGCGGCATGTTTTCTGTCGTG
AAGGTGCGAGAGGGCCTCGCTGCCAATGATTACAAGGATCCGGGATGGTTCAAGCACCCGGAAGGTACGGTCGCCTGCGA
ATGGAAGGGTGAACCGAAGAAGACCGAACGCGCACCCTCCCCAACGCCTGCGCGCCGAACTGCCGAGTTCAATGTCGTGA
AGCCCGGCAGAAAATCCCCCCACGACAATCATTGA

Upstream 100 bases:

>100_bases
TTCATCGCCCGTGTCGATTTCGACGCGGCAATTCAGGGTGGCGGCTCAGGGCCCGGCGCGGCGATCCGCGTTGCCGCCGG
CCAGTAATCGGGAGAACATC

Downstream 100 bases:

>100_bases
GAAGGAGCCATCATGAAGATCCAGATCATCCTCGCTGGCGCCGCGGCCATGTTCTTATCAACCGCTGCGTTAGCAGACCC
TGGCCACTCCCATGGCGATG

Product: multicopper oxidase type 3

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 464; Mature: 463

Protein sequence:

>464_residues
MSVSRRNFLSAAGGITLVSASAVSGRTAFASVPEAPTMKSPQMQPPLVPKTGPDYNPVVTLNGWTLPWRMNGDWKEFHLV
AEPVVREFAPGMVGHLWGYNGQSPGPTIEAVEGDKVRLFVTNKLPEHTTIHWHGQLLPSGMDGVGGLTQPHIPVGKTFVY
EFQLQKSGTFMYHPHADEMVQMAMGMMGFFVVHPKDPAFRRVDRDFVFLMASYDIEPGTYVPRVAEMTDFNMWTWNTRVF
PGIDHIVAGKGDKVRIRFGNLTMTNHLIHMHGYDFKVSCTDGGWVPEEAAWPEVTIDCAVGQMRAFDFVADKPGDWAIHC
HKSHHTMNAMGHDLNTFIGVDKRKVAKKIKRLVPDYMPMGTAGMADMGEMEMPLPDNTLPMMTGWGQFGSIEMGGMFSVV
KVREGLAANDYKDPGWFKHPEGTVACEWKGEPKKTERAPSPTPARRTAEFNVVKPGRKSPHDNH

Sequences:

>Translated_464_residues
MSVSRRNFLSAAGGITLVSASAVSGRTAFASVPEAPTMKSPQMQPPLVPKTGPDYNPVVTLNGWTLPWRMNGDWKEFHLV
AEPVVREFAPGMVGHLWGYNGQSPGPTIEAVEGDKVRLFVTNKLPEHTTIHWHGQLLPSGMDGVGGLTQPHIPVGKTFVY
EFQLQKSGTFMYHPHADEMVQMAMGMMGFFVVHPKDPAFRRVDRDFVFLMASYDIEPGTYVPRVAEMTDFNMWTWNTRVF
PGIDHIVAGKGDKVRIRFGNLTMTNHLIHMHGYDFKVSCTDGGWVPEEAAWPEVTIDCAVGQMRAFDFVADKPGDWAIHC
HKSHHTMNAMGHDLNTFIGVDKRKVAKKIKRLVPDYMPMGTAGMADMGEMEMPLPDNTLPMMTGWGQFGSIEMGGMFSVV
KVREGLAANDYKDPGWFKHPEGTVACEWKGEPKKTERAPSPTPARRTAEFNVVKPGRKSPHDNH
>Mature_463_residues
SVSRRNFLSAAGGITLVSASAVSGRTAFASVPEAPTMKSPQMQPPLVPKTGPDYNPVVTLNGWTLPWRMNGDWKEFHLVA
EPVVREFAPGMVGHLWGYNGQSPGPTIEAVEGDKVRLFVTNKLPEHTTIHWHGQLLPSGMDGVGGLTQPHIPVGKTFVYE
FQLQKSGTFMYHPHADEMVQMAMGMMGFFVVHPKDPAFRRVDRDFVFLMASYDIEPGTYVPRVAEMTDFNMWTWNTRVFP
GIDHIVAGKGDKVRIRFGNLTMTNHLIHMHGYDFKVSCTDGGWVPEEAAWPEVTIDCAVGQMRAFDFVADKPGDWAIHCH
KSHHTMNAMGHDLNTFIGVDKRKVAKKIKRLVPDYMPMGTAGMADMGEMEMPLPDNTLPMMTGWGQFGSIEMGGMFSVVK
VREGLAANDYKDPGWFKHPEGTVACEWKGEPKKTERAPSPTPARRTAEFNVVKPGRKSPHDNH

Specific function: Required for the copper-inducible expression of copper resistance. May have oxidase activity [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family. CopA subfamily [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6323703, Length=104, Percent_Identity=40.3846153846154, Blast_Score=64, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6321067, Length=112, Percent_Identity=35.7142857142857, Blast_Score=63, Evalue=8e-11,
Organism=Drosophila melanogaster, GI18859919, Length=108, Percent_Identity=41.6666666666667, Blast_Score=72, Evalue=7e-13,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR006376
- InterPro:   IPR002355
- InterPro:   IPR008972
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 51662; Mature: 51531

Theoretical pI: Translated: 7.40; Mature: 7.40

Prosite motif: PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
6.5 %Met     (Translated Protein)
7.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
6.3 %Met     (Mature Protein)
7.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVSRRNFLSAAGGITLVSASAVSGRTAFASVPEAPTMKSPQMQPPLVPKTGPDYNPVVT
CCCCHHHHHHHCCCEEEEEECCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEE
LNGWTLPWRMNGDWKEFHLVAEPVVREFAPGMVGHLWGYNGQSPGPTIEAVEGDKVRLFV
ECCEEEEEEECCCHHEEEEHHHHHHHHHCCCHHHHHCCCCCCCCCCEEEEECCCEEEEEE
TNKLPEHTTIHWHGQLLPSGMDGVGGLTQPHIPVGKTFVYEFQLQKSGTFMYHPHADEMV
ECCCCCCCEEEEECEECCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCEEEECCCHHHHH
QMAMGMMGFFVVHPKDPAFRRVDRDFVFLMASYDIEPGTYVPRVAEMTDFNMWTWNTRVF
HHHHHHEEEEEECCCCHHHHHCCCCEEEEEEEECCCCCCCCCCCHHHCCCEEEEECCEEC
PGIDHIVAGKGDKVRIRFGNLTMTNHLIHMHGYDFKVSCTDGGWVPEEAAWPEVTIDCAV
CCCCEEECCCCCEEEEEECCEEEEEEEEEEECCEEEEEECCCCCCCCCCCCCCEEEEEEC
GQMRAFDFVADKPGDWAIHCHKSHHTMNAMGHDLNTFIGVDKRKVAKKIKRLVPDYMPMG
CCEEEEEEECCCCCCEEEEEECCCCCHHHHCCCCHHHHCCCHHHHHHHHHHHCCCCCCCC
TAGMADMGEMEMPLPDNTLPMMTGWGQFGSIEMGGMFSVVKVREGLAANDYKDPGWFKHP
CCCCCCCCCCCCCCCCCCCCCEECCCCCCCEEECCCEEEEHHHCCCCCCCCCCCCCEECC
EGTVACEWKGEPKKTERAPSPTPARRTAEFNVVKPGRKSPHDNH
CCCEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCC
>Mature Secondary Structure 
SVSRRNFLSAAGGITLVSASAVSGRTAFASVPEAPTMKSPQMQPPLVPKTGPDYNPVVT
CCCHHHHHHHCCCEEEEEECCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEE
LNGWTLPWRMNGDWKEFHLVAEPVVREFAPGMVGHLWGYNGQSPGPTIEAVEGDKVRLFV
ECCEEEEEEECCCHHEEEEHHHHHHHHHCCCHHHHHCCCCCCCCCCEEEEECCCEEEEEE
TNKLPEHTTIHWHGQLLPSGMDGVGGLTQPHIPVGKTFVYEFQLQKSGTFMYHPHADEMV
ECCCCCCCEEEEECEECCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCEEEECCCHHHHH
QMAMGMMGFFVVHPKDPAFRRVDRDFVFLMASYDIEPGTYVPRVAEMTDFNMWTWNTRVF
HHHHHHEEEEEECCCCHHHHHCCCCEEEEEEEECCCCCCCCCCCHHHCCCEEEEECCEEC
PGIDHIVAGKGDKVRIRFGNLTMTNHLIHMHGYDFKVSCTDGGWVPEEAAWPEVTIDCAV
CCCCEEECCCCCEEEEEECCEEEEEEEEEEECCEEEEEECCCCCCCCCCCCCCEEEEEEC
GQMRAFDFVADKPGDWAIHCHKSHHTMNAMGHDLNTFIGVDKRKVAKKIKRLVPDYMPMG
CCEEEEEEECCCCCCEEEEEECCCCCHHHHCCCCHHHHCCCHHHHHHHHHHHCCCCCCCC
TAGMADMGEMEMPLPDNTLPMMTGWGQFGSIEMGGMFSVVKVREGLAANDYKDPGWFKHP
CCCCCCCCCCCCCCCCCCCCCEECCCCCCCEEECCCEEEEHHHCCCCCCCCCCCCCEECC
EGTVACEWKGEPKKTERAPSPTPARRTAEFNVVKPGRKSPHDNH
CCCEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8594334 [H]