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The map label for this gene is garD [H]

Identifier: 220905635

GI number: 220905635

Start: 2863725

End: 2864885

Strand: Direct

Name: garD [H]

Synonym: Ddes_2375

Alternate gene names: 220905635

Gene position: 2863725-2864885 (Clockwise)

Preceding gene: 220905634

Following gene: 220905636

Centisome position: 99.66

GC content: 60.29

Gene sequence:

>1161_bases
ATGAACAAGACATTTATGGGCTACCGCCGCGAAAACGGACGTGTGGGTATTCGCAACCATGTGATCATTCTGCCCCTGGA
TGACCTTTCCAACGCCGCCTGCGAGGCTGTGGCAAACAACATCAAGGGAACCATGGCCCTGCCCCATGCTTACGGCCGCC
TGCAGTTCGGTGAAGACCTCGACCTGCACTTCCGCACCCTTATCGGCACGGGCTGCAACCCCAACGTGGCCGCCGTAGTG
GTTATCGGCATCGAGCCGGTGTGGACCCAGCGCGTGGTGGACGGCATTGCCAAAACCGGCAAACCCGTGGTGGGCTTTGG
CATCGAGCAGCACGGCGATCTGGAAACCATCCGCGCCGCTTCCCTCAAGGCCAAGGAATTTGTGCACTACGCCAGCGAAC
TGCAGCGCACCCAATGTACGGTGGATGAGCTGTGGGTTTCCTGCAAGTGCGGCGAGTCCGACACTACCTCCGGCATCGCC
TCCAACCCCACCGTGGGCAACGCCTTCGACAAGCTGTGGGAAGCCGAGGCCACCACCCTGTTTGGCGAAACCACTGAAAT
TACCGGCGGCGAGCATCTGGTGATGGAACGCTGCGCCAACGAAGAAGTGCGCGCCAAGTTCAAGGCATTTTTCGACCGCT
ACGCCAAGGTGGTGGACGACCACAAAACCAATGACCTCTGCGACTCGCAGCCCACCAAGGGCAACATTGAGGGCGGCCTG
ACGACCATTGAGGAAAAAGCCCTGGGCAACGTCCAGAAGATCGGCCGCAAGGCGCCTGTGGTCGGCTGCCTCGACAAGGC
CGAGTCTCCCACCGGTCCCGGCCTGTGGTTTATGGATTCCTCTTCCGCTGCTGCCGAAATGGTTACCCTGTGTGCCGCTT
CGGGCTTTGTGGCCCACTTCTTCCCCACCGGCCAGGGCAACATCATCGGCAACCCCATTCTGCCGGTCATCAAGCTCTCG
GCCAACCCGCGCACCGTGCGCACCATGAACGAGCATATCGATGTGGACGTTTCCGGCCTTCTGCGCCGGGAAATAAACAT
GGACCAGGCGGGAGACATGCTGCTTGAAATGCTCATCCGCACCTGCAACGGCCGCAACACCTCGGCTGAAGCCCTGGGTC
ACCGTGAATTTATCATGACCCGGCTTTACGAAAGCGCGTAA

Upstream 100 bases:

>100_bases
ATTATCAAGTACAGCACGGATATCGGCAAGGTGGTCAAGCCCATCAAGCGCGGCGAACACCTGCATGTACACAACGTCAA
AACCAAAAGGTGGTAAACCG

Downstream 100 bases:

>100_bases
AACACGTTTCGGGGGAAAGGGCTTGTGTCCTTTCCCCCGAAACATCTTCACTACTTGGGCCTAAAAAGGAGGACCGTATG
AGAATAAAGACTGCATTGCC

Product: Altronate dehydratase

Products: NA

Alternate protein names: GalcD [H]

Number of amino acids: Translated: 386; Mature: 386

Protein sequence:

>386_residues
MNKTFMGYRRENGRVGIRNHVIILPLDDLSNAACEAVANNIKGTMALPHAYGRLQFGEDLDLHFRTLIGTGCNPNVAAVV
VIGIEPVWTQRVVDGIAKTGKPVVGFGIEQHGDLETIRAASLKAKEFVHYASELQRTQCTVDELWVSCKCGESDTTSGIA
SNPTVGNAFDKLWEAEATTLFGETTEITGGEHLVMERCANEEVRAKFKAFFDRYAKVVDDHKTNDLCDSQPTKGNIEGGL
TTIEEKALGNVQKIGRKAPVVGCLDKAESPTGPGLWFMDSSSAAAEMVTLCAASGFVAHFFPTGQGNIIGNPILPVIKLS
ANPRTVRTMNEHIDVDVSGLLRREINMDQAGDMLLEMLIRTCNGRNTSAEALGHREFIMTRLYESA

Sequences:

>Translated_386_residues
MNKTFMGYRRENGRVGIRNHVIILPLDDLSNAACEAVANNIKGTMALPHAYGRLQFGEDLDLHFRTLIGTGCNPNVAAVV
VIGIEPVWTQRVVDGIAKTGKPVVGFGIEQHGDLETIRAASLKAKEFVHYASELQRTQCTVDELWVSCKCGESDTTSGIA
SNPTVGNAFDKLWEAEATTLFGETTEITGGEHLVMERCANEEVRAKFKAFFDRYAKVVDDHKTNDLCDSQPTKGNIEGGL
TTIEEKALGNVQKIGRKAPVVGCLDKAESPTGPGLWFMDSSSAAAEMVTLCAASGFVAHFFPTGQGNIIGNPILPVIKLS
ANPRTVRTMNEHIDVDVSGLLRREINMDQAGDMLLEMLIRTCNGRNTSAEALGHREFIMTRLYESA
>Mature_386_residues
MNKTFMGYRRENGRVGIRNHVIILPLDDLSNAACEAVANNIKGTMALPHAYGRLQFGEDLDLHFRTLIGTGCNPNVAAVV
VIGIEPVWTQRVVDGIAKTGKPVVGFGIEQHGDLETIRAASLKAKEFVHYASELQRTQCTVDELWVSCKCGESDTTSGIA
SNPTVGNAFDKLWEAEATTLFGETTEITGGEHLVMERCANEEVRAKFKAFFDRYAKVVDDHKTNDLCDSQPTKGNIEGGL
TTIEEKALGNVQKIGRKAPVVGCLDKAESPTGPGLWFMDSSSAAAEMVTLCAASGFVAHFFPTGQGNIIGNPILPVIKLS
ANPRTVRTMNEHIDVDVSGLLRREINMDQAGDMLLEMLIRTCNGRNTSAEALGHREFIMTRLYESA

Specific function: D-galactarate metabolism; first step. [C]

COG id: COG2721

COG function: function code G; Altronate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uxaA family [H]

Homologues:

Organism=Escherichia coli, GI1789516, Length=393, Percent_Identity=28.2442748091603, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1789475, Length=392, Percent_Identity=29.3367346938776, Blast_Score=132, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007392
- InterPro:   IPR017654
- InterPro:   IPR013974 [H]

Pfam domain/function: PF04295 GD_AH_C; PF08666 SAF [H]

EC number: =4.2.1.42 [H]

Molecular weight: Translated: 42001; Mature: 42001

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKTFMGYRRENGRVGIRNHVIILPLDDLSNAACEAVANNIKGTMALPHAYGRLQFGEDL
CCCCCCCEECCCCCEEECCCEEEEECCCCCHHHHHHHHHCCCCEEECCCHHCCCCCCCCC
DLHFRTLIGTGCNPNVAAVVVIGIEPVWTQRVVDGIAKTGKPVVGFGIEQHGDLETIRAA
CHHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHH
SLKAKEFVHYASELQRTQCTVDELWVSCKCGESDTTSGIASNPTVGNAFDKLWEAEATTL
HHHHHHHHHHHHHHHHHHCCHHHHEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHEE
FGETTEITGGEHLVMERCANEEVRAKFKAFFDRYAKVVDDHKTNDLCDSQPTKGNIEGGL
ECCCEECCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
TTIEEKALGNVQKIGRKAPVVGCLDKAESPTGPGLWFMDSSSAAAEMVTLCAASGFVAHF
HHHHHHHHCCHHHHCCCCCEEEEHHCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCEEEE
FPTGQGNIIGNPILPVIKLSANPRTVRTMNEHIDVDVSGLLRREINMDQAGDMLLEMLIR
EECCCCCCCCCCCCEEEEECCCCCEEHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHH
TCNGRNTSAEALGHREFIMTRLYESA
HCCCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNKTFMGYRRENGRVGIRNHVIILPLDDLSNAACEAVANNIKGTMALPHAYGRLQFGEDL
CCCCCCCEECCCCCEEECCCEEEEECCCCCHHHHHHHHHCCCCEEECCCHHCCCCCCCCC
DLHFRTLIGTGCNPNVAAVVVIGIEPVWTQRVVDGIAKTGKPVVGFGIEQHGDLETIRAA
CHHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHH
SLKAKEFVHYASELQRTQCTVDELWVSCKCGESDTTSGIASNPTVGNAFDKLWEAEATTL
HHHHHHHHHHHHHHHHHHCCHHHHEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHEE
FGETTEITGGEHLVMERCANEEVRAKFKAFFDRYAKVVDDHKTNDLCDSQPTKGNIEGGL
ECCCEECCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
TTIEEKALGNVQKIGRKAPVVGCLDKAESPTGPGLWFMDSSSAAAEMVTLCAASGFVAHF
HHHHHHHHCCHHHHCCCCCEEEEHHCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCEEEE
FPTGQGNIIGNPILPVIKLSANPRTVRTMNEHIDVDVSGLLRREINMDQAGDMLLEMLIR
EECCCCCCCCCCCCEEEEECCCCCEEHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHH
TCNGRNTSAEALGHREFIMTRLYESA
HCCCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 2407727; 9772162; 10762278 [H]