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The map label for this gene is dinB [H]

Identifier: 220905578

GI number: 220905578

Start: 2785978

End: 2787258

Strand: Direct

Name: dinB [H]

Synonym: Ddes_2317

Alternate gene names: 220905578

Gene position: 2785978-2787258 (Clockwise)

Preceding gene: 220905577

Following gene: 220905581

Centisome position: 96.96

GC content: 61.83

Gene sequence:

>1281_bases
ATGATCATTCACATCGATATGGACGCTTTTTTTGCTTCTGTGGAGCAGATGGACAACCCCGACCTGCGGGGCCGCCCGGT
TATTGTGGGTGGCAGCAGCGACAGAGGGGTGGTTTCCACCTGTTCCTACGAAGCCCGCACCTTTGGCGTACACTCGGCCA
TGCCTATGGTCGTGGCGCGCCGCCTGTGCCCGCAGGCCGTGATCGTGCGGGGGCGCTACCAGCGTTATGCCGAGCTTTCC
CACGCCATCATGTCTGCCCTGAAAGATTTTTCCCCCCTTGTGGAACCGGCCAGCGTGGACGAGGCCTATATGGACGCCAC
AGGCCTTGAGCGGCTTTTCGGTCCGCTGGAAGAACTTGTGGCAGGCATCAAGACCCGCATCGTGGATGTGACCGGAGGGC
TGACCTGCTCTGTGGGTGCGGCTCCGGTAAAATTTCTTGCCAAGATATGCTCGGACGTCAACAAGCCCGACGGCGTGTTC
ATCCTGCGGCAGGAAAATATGGACGCCTTCCTGTGCGCCCTGCCTGTAGGCAGGATACCCGGGGTCGGCAAACGCACGGT
GCAGAGCCTTCAGGACCTCGGCGTCAGGACAGTCGCCCAGCTGCGCCGCTTCAGCCCGGATTTTATGGAGCGCCGTTTCG
GCAAGTGGGGGCTTGCGCTCTATGAGCGGGCGCAAGGGCGCGACAGCCGCAAGGTGGAAACTGAACGCGAGGCCAAGAGC
GAAAGCGCGGAGTGTACCTTTGCCGAAGACACGCGGGACAGGGATTTTTTACAGCGCATGCTCATGGCCCACGCCGAGCG
CGTGGGCAGCTCCCTGCGGCGCCACGGCTACAGGGGGCGCACCATCACCCTGAAGGTAAAATTCTGCGATTTCAGGCAGA
TCACGCGCTCCCGCACACTGGAAGAAGCCGTCAGTGCTACGGAAACCATTTTTGAAACAGGCTGCCGCCTGCTGGCAGAA
CTGCCCCTGCCGCAGCCCGTGCGCCTTATCGGCCTTGGCGTGTCGGGCTTTGACGCGCCCCCCGGCCAGCTTTTTCTGCC
GGGCACTGGCAAGGCCGCAGGGCAGAAGCTCGATCCGCAGGTGGAAGCCAAAAGGCAGAAACTTGACGCCGCGCTGGACA
GCCTGCGCGAAAAATTCGGCAAACAGGCTGTCCAGCGCGGGCGGCTGTTTACTCTGGCCCGCCAGCAGGACGCGCCGGAG
CGCGTCAACAACGGCAAGGGTGATGGTGTGGAACAACCGCCGGAAGACAACGGCAGAAAAAATCAGGAAGAAACGCCATA
A

Upstream 100 bases:

>100_bases
GCGGTCCGGCCTTCAATATGAGTTTCCGGCCTTGCCGGAAGCGGGGCCTGTGGGGTAAAACAGCCCACACCCTTTGACCA
GCCCCGCCGGGCCGCCCGCC

Downstream 100 bases:

>100_bases
GGCATTTTGCGGGGGTCTGGTAGCAGCACAGGATGCCCGCCCGCAGGCGGCCCACACGAAGACAGTAAGGGCATTGCAAC
CGCCGGCAGAATCTATGGCA

Product: DNA-directed DNA polymerase

Products: NA

Alternate protein names: Pol IV [H]

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MIIHIDMDAFFASVEQMDNPDLRGRPVIVGGSSDRGVVSTCSYEARTFGVHSAMPMVVARRLCPQAVIVRGRYQRYAELS
HAIMSALKDFSPLVEPASVDEAYMDATGLERLFGPLEELVAGIKTRIVDVTGGLTCSVGAAPVKFLAKICSDVNKPDGVF
ILRQENMDAFLCALPVGRIPGVGKRTVQSLQDLGVRTVAQLRRFSPDFMERRFGKWGLALYERAQGRDSRKVETEREAKS
ESAECTFAEDTRDRDFLQRMLMAHAERVGSSLRRHGYRGRTITLKVKFCDFRQITRSRTLEEAVSATETIFETGCRLLAE
LPLPQPVRLIGLGVSGFDAPPGQLFLPGTGKAAGQKLDPQVEAKRQKLDAALDSLREKFGKQAVQRGRLFTLARQQDAPE
RVNNGKGDGVEQPPEDNGRKNQEETP

Sequences:

>Translated_426_residues
MIIHIDMDAFFASVEQMDNPDLRGRPVIVGGSSDRGVVSTCSYEARTFGVHSAMPMVVARRLCPQAVIVRGRYQRYAELS
HAIMSALKDFSPLVEPASVDEAYMDATGLERLFGPLEELVAGIKTRIVDVTGGLTCSVGAAPVKFLAKICSDVNKPDGVF
ILRQENMDAFLCALPVGRIPGVGKRTVQSLQDLGVRTVAQLRRFSPDFMERRFGKWGLALYERAQGRDSRKVETEREAKS
ESAECTFAEDTRDRDFLQRMLMAHAERVGSSLRRHGYRGRTITLKVKFCDFRQITRSRTLEEAVSATETIFETGCRLLAE
LPLPQPVRLIGLGVSGFDAPPGQLFLPGTGKAAGQKLDPQVEAKRQKLDAALDSLREKFGKQAVQRGRLFTLARQQDAPE
RVNNGKGDGVEQPPEDNGRKNQEETP
>Mature_426_residues
MIIHIDMDAFFASVEQMDNPDLRGRPVIVGGSSDRGVVSTCSYEARTFGVHSAMPMVVARRLCPQAVIVRGRYQRYAELS
HAIMSALKDFSPLVEPASVDEAYMDATGLERLFGPLEELVAGIKTRIVDVTGGLTCSVGAAPVKFLAKICSDVNKPDGVF
ILRQENMDAFLCALPVGRIPGVGKRTVQSLQDLGVRTVAQLRRFSPDFMERRFGKWGLALYERAQGRDSRKVETEREAKS
ESAECTFAEDTRDRDFLQRMLMAHAERVGSSLRRHGYRGRTITLKVKFCDFRQITRSRTLEEAVSATETIFETGCRLLAE
LPLPQPVRLIGLGVSGFDAPPGQLFLPGTGKAAGQKLDPQVEAKRQKLDAALDSLREKFGKQAVQRGRLFTLARQQDAPE
RVNNGKGDGVEQPPEDNGRKNQEETP

Specific function: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits

COG id: COG0389

COG function: function code L; Nucleotidyltransferase/DNA polymerase involved in DNA repair

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 umuC domain [H]

Homologues:

Organism=Homo sapiens, GI84043967, Length=381, Percent_Identity=28.0839895013123, Blast_Score=135, Evalue=8e-32,
Organism=Homo sapiens, GI7706681, Length=382, Percent_Identity=28.0104712041885, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI154350220, Length=316, Percent_Identity=30.0632911392405, Blast_Score=129, Evalue=8e-30,
Organism=Homo sapiens, GI7705344, Length=106, Percent_Identity=46.2264150943396, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI5729982, Length=348, Percent_Identity=25.8620689655172, Blast_Score=82, Evalue=6e-16,
Organism=Escherichia coli, GI1786425, Length=344, Percent_Identity=39.5348837209302, Blast_Score=222, Evalue=4e-59,
Organism=Escherichia coli, GI1787432, Length=304, Percent_Identity=29.9342105263158, Blast_Score=102, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI193205700, Length=105, Percent_Identity=41.9047619047619, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI193205702, Length=230, Percent_Identity=32.1739130434783, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI115534089, Length=122, Percent_Identity=40.1639344262295, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17537959, Length=196, Percent_Identity=27.0408163265306, Blast_Score=82, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6324921, Length=247, Percent_Identity=25.5060728744939, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21355641, Length=268, Percent_Identity=31.3432835820896, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24644984, Length=268, Percent_Identity=31.3432835820896, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI19923006, Length=401, Percent_Identity=24.4389027431421, Blast_Score=111, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017962
- InterPro:   IPR017961
- InterPro:   IPR001126
- InterPro:   IPR017963
- InterPro:   IPR022880 [H]

Pfam domain/function: PF00817 IMS [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 47128; Mature: 47128

Theoretical pI: Translated: 8.73; Mature: 8.73

Prosite motif: PS50173 UMUC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIHIDMDAFFASVEQMDNPDLRGRPVIVGGSSDRGVVSTCSYEARTFGVHSAMPMVVAR
CEEEEEHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCEEECCCHHHHHCHHHHHHHHHHH
RLCPQAVIVRGRYQRYAELSHAIMSALKDFSPLVEPASVDEAYMDATGLERLFGPLEELV
HHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
AGIKTRIVDVTGGLTCSVGAAPVKFLAKICSDVNKPDGVFILRQENMDAFLCALPVGRIP
HHHHHHEEEECCCCEECCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEECCCCCCCC
GVGKRTVQSLQDLGVRTVAQLRRFSPDFMERRFGKWGLALYERAQGRDSRKVETEREAKS
CCCHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHCC
ESAECTFAEDTRDRDFLQRMLMAHAERVGSSLRRHGYRGRTITLKVKFCDFRQITRSRTL
CCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCHHHHHHHHHH
EEAVSATETIFETGCRLLAELPLPQPVRLIGLGVSGFDAPPGQLFLPGTGKAAGQKLDPQ
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCEEECCCCCCCCCCCCHH
VEAKRQKLDAALDSLREKFGKQAVQRGRLFTLARQQDAPERVNNGKGDGVEQPPEDNGRK
HHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHCCCHHHHCCCCCCCCCCCCCCCCCC
NQEETP
CCCCCC
>Mature Secondary Structure
MIIHIDMDAFFASVEQMDNPDLRGRPVIVGGSSDRGVVSTCSYEARTFGVHSAMPMVVAR
CEEEEEHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCEEECCCHHHHHCHHHHHHHHHHH
RLCPQAVIVRGRYQRYAELSHAIMSALKDFSPLVEPASVDEAYMDATGLERLFGPLEELV
HHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
AGIKTRIVDVTGGLTCSVGAAPVKFLAKICSDVNKPDGVFILRQENMDAFLCALPVGRIP
HHHHHHEEEECCCCEECCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEECCCCCCCC
GVGKRTVQSLQDLGVRTVAQLRRFSPDFMERRFGKWGLALYERAQGRDSRKVETEREAKS
CCCHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHCC
ESAECTFAEDTRDRDFLQRMLMAHAERVGSSLRRHGYRGRTITLKVKFCDFRQITRSRTL
CCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCHHHHHHHHHH
EEAVSATETIFETGCRLLAELPLPQPVRLIGLGVSGFDAPPGQLFLPGTGKAAGQKLDPQ
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCEEECCCCCCCCCCCCHH
VEAKRQKLDAALDSLREKFGKQAVQRGRLFTLARQQDAPERVNNGKGDGVEQPPEDNGRK
HHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHCCCHHHHCCCCCCCCCCCCCCCCCC
NQEETP
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]