Click here to switch to the map view.

The map label for this gene is hom [H]

Identifier: 220905575

GI number: 220905575

Start: 2782899

End: 2784098

Strand: Direct

Name: hom [H]

Synonym: Ddes_2314

Alternate gene names: 220905575

Gene position: 2782899-2784098 (Clockwise)

Preceding gene: 220905574

Following gene: 220905576

Centisome position: 96.85

GC content: 61.58

Gene sequence:

>1200_bases
ATGCCAAAAAGGCGCGCAGCGTCCCCCCTGCCCGAAGGGGCCGAACTGACCACCAATCCGCGTGATCTTACGGACGATCC
GCAGATAGACGTGCTGGTAGAGCTTATGGGTGGCATTGACCACGCCCGCGACCTCATCGACCGCGCCCTGGACCAGGGCA
AGCACATCGTCACGGCCAACAAGGCGCTGCTGGCCGAAGAAGGCCTTTCCCTCTTTCAGAAGGCTGACCGCAAAAAACGC
ATTTTGCGCTACGAGGCCAGCGTGGCCGGAGCCGTACCCATTGTGGAAGCCCTCAAGGAAAGCCTCACAGGCAACCGCAT
CCAGTCTCTCATGGGCATTCTGAACGGCACGAGCAACTACATCCTGTCCGAAATGACCTCCAACGGGCTGGATTTTGACG
TTGCCCTCAAGCAGGCCCAACAACTGGGGTATGCCGAGGCCGATCCCACACTGGACATTGACGGGCATGATGCGGCCCAC
AAGCTGATTCTGCTTATCCGCCTTGCCTTCGGGGCCAATTATCCCTACACAGCCCTTTCTGTACGGGGCATTCGTGGCCT
TTCAGCCCTGGACATCCGGCTGGCCCGGGAATTCGGCTACCGCATAAAGCTCATCGGCCAGGTGCGGCAGGTTCCCTGCC
CCGAAGAAAAAATCGGTGGCAATGACTGCGGCGAAGGCCCGGTGCGCCTTGAAGCCGGTGTTTTTCCGGCCCTTGTGTAT
CACAAGTACCTGCTGGCCCGCGTGGGCGGCGCGTACAATGCCGTGCGGGTGGATGCCAACGCCTCGGGACCTCTCTTTTT
CCACGGGCGCGGCGCGGGCGACATGCCCACCGCAGGGGCCGTGCTGGCCGACCTGCTGGCCGTAGCCCGCGATGAGCGCC
CCAACAATACGGGCTTTGTGGGCAAGGAACTGCCCAAGGCTGCCATTGTGCCGCCCGAAGAATGGCGCTCGTGCTACTAC
GTGCGCGTTATGGTGCAGGATGCCCCGGGTGTGCTGCGCGATCTTTCGGGCTGTATGGCCGCAGAAGGCATCAGCATGGC
CCAGGTCATCCAGAAATCTGACGAGGGCCAGGGTGTGCCCCTTGTTTTCATGACTCACGAAACTACAGCCCAGGCCATGA
GCGACGCCCTGCAGCGCACTCTTGACGCCGGGCTGCTCAAAGAACCCGCGGTGTATTTCCGTGTGCTGGGTGGTGAATGA

Upstream 100 bases:

>100_bases
ACAGTAGGCGGCGGCCTCGTGCGCCTGCTTGAAGAAAACGCGGACCTCATCCGCCGCCGCTCGGGTCGGGATATCCTGAT
CAGAAAGGTGCTCGTGCGCA

Downstream 100 bases:

>100_bases
TAATTCTCGATCAACCGTATGTTTCGCCGGAGCTGGCGGCCTATGCCGCCAACCGGCAGGAACCTGTGCTGGATAACGAA
ATGGCCCGCGCCTGCGCGGC

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 399; Mature: 398

Protein sequence:

>399_residues
MPKRRAASPLPEGAELTTNPRDLTDDPQIDVLVELMGGIDHARDLIDRALDQGKHIVTANKALLAEEGLSLFQKADRKKR
ILRYEASVAGAVPIVEALKESLTGNRIQSLMGILNGTSNYILSEMTSNGLDFDVALKQAQQLGYAEADPTLDIDGHDAAH
KLILLIRLAFGANYPYTALSVRGIRGLSALDIRLAREFGYRIKLIGQVRQVPCPEEKIGGNDCGEGPVRLEAGVFPALVY
HKYLLARVGGAYNAVRVDANASGPLFFHGRGAGDMPTAGAVLADLLAVARDERPNNTGFVGKELPKAAIVPPEEWRSCYY
VRVMVQDAPGVLRDLSGCMAAEGISMAQVIQKSDEGQGVPLVFMTHETTAQAMSDALQRTLDAGLLKEPAVYFRVLGGE

Sequences:

>Translated_399_residues
MPKRRAASPLPEGAELTTNPRDLTDDPQIDVLVELMGGIDHARDLIDRALDQGKHIVTANKALLAEEGLSLFQKADRKKR
ILRYEASVAGAVPIVEALKESLTGNRIQSLMGILNGTSNYILSEMTSNGLDFDVALKQAQQLGYAEADPTLDIDGHDAAH
KLILLIRLAFGANYPYTALSVRGIRGLSALDIRLAREFGYRIKLIGQVRQVPCPEEKIGGNDCGEGPVRLEAGVFPALVY
HKYLLARVGGAYNAVRVDANASGPLFFHGRGAGDMPTAGAVLADLLAVARDERPNNTGFVGKELPKAAIVPPEEWRSCYY
VRVMVQDAPGVLRDLSGCMAAEGISMAQVIQKSDEGQGVPLVFMTHETTAQAMSDALQRTLDAGLLKEPAVYFRVLGGE
>Mature_398_residues
PKRRAASPLPEGAELTTNPRDLTDDPQIDVLVELMGGIDHARDLIDRALDQGKHIVTANKALLAEEGLSLFQKADRKKRI
LRYEASVAGAVPIVEALKESLTGNRIQSLMGILNGTSNYILSEMTSNGLDFDVALKQAQQLGYAEADPTLDIDGHDAAHK
LILLIRLAFGANYPYTALSVRGIRGLSALDIRLAREFGYRIKLIGQVRQVPCPEEKIGGNDCGEGPVRLEAGVFPALVYH
KYLLARVGGAYNAVRVDANASGPLFFHGRGAGDMPTAGAVLADLLAVARDERPNNTGFVGKELPKAAIVPPEEWRSCYYV
RVMVQDAPGVLRDLSGCMAAEGISMAQVIQKSDEGQGVPLVFMTHETTAQAMSDALQRTLDAGLLKEPAVYFRVLGGE

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=262, Percent_Identity=26.7175572519084, Blast_Score=73, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6322599, Length=183, Percent_Identity=26.2295081967213, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 43012; Mature: 42881

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKRRAASPLPEGAELTTNPRDLTDDPQIDVLVELMGGIDHARDLIDRALDQGKHIVTAN
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCEEEECC
KALLAEEGLSLFQKADRKKRILRYEASVAGAVPIVEALKESLTGNRIQSLMGILNGTSNY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCHHH
ILSEMTSNGLDFDVALKQAQQLGYAEADPTLDIDGHDAAHKLILLIRLAFGANYPYTALS
HHHHHHCCCCCHHHHHHHHHHCCCCCCCCCEECCCCHHHHHHHHHHHHHHCCCCCCCEEE
VRGIRGLSALDIRLAREFGYRIKLIGQVRQVPCPEEKIGGNDCGEGPVRLEAGVFPALVY
ECCCCCCHHHHHHHHHHHCCEEEEEEHHHCCCCCHHHCCCCCCCCCCEEEECCHHHHHHH
HKYLLARVGGAYNAVRVDANASGPLFFHGRGAGDMPTAGAVLADLLAVARDERPNNTGFV
HHHHHHHHCCCCCEEEEECCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCC
GKELPKAAIVPPEEWRSCYYVRVMVQDAPGVLRDLSGCMAAEGISMAQVIQKSDEGQGVP
CCCCCCCCCCCCHHHCCEEEEEEEEECCCHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCC
LVFMTHETTAQAMSDALQRTLDAGLLKEPAVYFRVLGGE
EEEEECCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCC
>Mature Secondary Structure 
PKRRAASPLPEGAELTTNPRDLTDDPQIDVLVELMGGIDHARDLIDRALDQGKHIVTAN
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCEEEECC
KALLAEEGLSLFQKADRKKRILRYEASVAGAVPIVEALKESLTGNRIQSLMGILNGTSNY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCHHH
ILSEMTSNGLDFDVALKQAQQLGYAEADPTLDIDGHDAAHKLILLIRLAFGANYPYTALS
HHHHHHCCCCCHHHHHHHHHHCCCCCCCCCEECCCCHHHHHHHHHHHHHHCCCCCCCEEE
VRGIRGLSALDIRLAREFGYRIKLIGQVRQVPCPEEKIGGNDCGEGPVRLEAGVFPALVY
ECCCCCCHHHHHHHHHHHCCEEEEEEHHHCCCCCHHHCCCCCCCCCCEEEECCHHHHHHH
HKYLLARVGGAYNAVRVDANASGPLFFHGRGAGDMPTAGAVLADLLAVARDERPNNTGFV
HHHHHHHHCCCCCEEEEECCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCC
GKELPKAAIVPPEEWRSCYYVRVMVQDAPGVLRDLSGCMAAEGISMAQVIQKSDEGQGVP
CCCCCCCCCCCCHHHCCEEEEEEEEECCCHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCC
LVFMTHETTAQAMSDALQRTLDAGLLKEPAVYFRVLGGE
EEEEECCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]