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The map label for this gene is atpB

Identifier: 220905515

GI number: 220905515

Start: 2713972

End: 2714676

Strand: Direct

Name: atpB

Synonym: Ddes_2254

Alternate gene names: 220905515

Gene position: 2713972-2714676 (Clockwise)

Preceding gene: 220905514

Following gene: 220905516

Centisome position: 94.45

GC content: 53.76

Gene sequence:

>705_bases
ATGGCAGGTGGTTTGCCGCATCCGGTATTGCTCTCCACATTTATGGGCATGGACGAAATCACCATCGGTGGACAGGTGGT
GGAATTCAAACATGTATTCTACTCCTGGGTCTGCATGGCCATTCTGTTTGCTGTGGCCTGGGTCCTGCGAAGACGCCTGA
CGCTGGTGCCAGGCGGCTTGCAGAACTTTTTTGAGGCCATGGTAGACACCATCGAAAACTTTATCGTTTCCACCATGGGT
GAGAACGGGCGCAAGTTCGTTCCCCTGCTGGCGGGCATTTTCATTTACATTTTCGGCATGAACCTCATGGGCCTTGTGCC
CGGCTTCGACGCGCCTACCGCCAACCTCAACACCACGGTCTGTATGGCTCTCTTTGTGCTGGTGTTTTACAACGCGGTGG
GTCTTATCCGCTGGAAAACGCATTATATCCACCATTTCACCGGGCCTTCCAAGTTCCTTATCCCGCTAATGTTCCCGCTT
GAGGTGGTGTCGCACCTTTCCCGCCCGGTTTCGCTTTCACTCCGTCTTTTCGGCAACATCCGGGGTGAAGAAATCGTTAT
GGTGCTGTTTTTCATCATGGCGCCCATCCTGGGAACGCTGCCCATCTACGCGCTTTTCCTTCTGGGCAAGACCATGCAGG
CTTTCGTGTTCTTCATGCTGACCATGTTCTACATCAAGGGCGCTCTTGAGGCTCCCGAACACTAG

Upstream 100 bases:

>100_bases
CCGGATCATGACGCGGGCAGCACGAAAATTTTTGGGGAATGGCCTTAGGGCTTTACATCAACGCAGCGCCTAGGCGCGTA
TCGACCAGGAGGCATGGCTC

Downstream 100 bases:

>100_bases
CCTTGCCACGGGCGGCCCTGCCGCCCTTCCCGCCGGCGGCAACCCGGCGGCGTCTCCTGCCGGACGTAAAACAGGCACGC
TATAGTGGGGAATGGTCGTA

Product: ATP synthase F0 subunit A

Products: ADP; phosphate; H+

Alternate protein names: ATP synthase F0 sector subunit a; F-ATPase subunit 6

Number of amino acids: Translated: 234; Mature: 233

Protein sequence:

>234_residues
MAGGLPHPVLLSTFMGMDEITIGGQVVEFKHVFYSWVCMAILFAVAWVLRRRLTLVPGGLQNFFEAMVDTIENFIVSTMG
ENGRKFVPLLAGIFIYIFGMNLMGLVPGFDAPTANLNTTVCMALFVLVFYNAVGLIRWKTHYIHHFTGPSKFLIPLMFPL
EVVSHLSRPVSLSLRLFGNIRGEEIVMVLFFIMAPILGTLPIYALFLLGKTMQAFVFFMLTMFYIKGALEAPEH

Sequences:

>Translated_234_residues
MAGGLPHPVLLSTFMGMDEITIGGQVVEFKHVFYSWVCMAILFAVAWVLRRRLTLVPGGLQNFFEAMVDTIENFIVSTMG
ENGRKFVPLLAGIFIYIFGMNLMGLVPGFDAPTANLNTTVCMALFVLVFYNAVGLIRWKTHYIHHFTGPSKFLIPLMFPL
EVVSHLSRPVSLSLRLFGNIRGEEIVMVLFFIMAPILGTLPIYALFLLGKTMQAFVFFMLTMFYIKGALEAPEH
>Mature_233_residues
AGGLPHPVLLSTFMGMDEITIGGQVVEFKHVFYSWVCMAILFAVAWVLRRRLTLVPGGLQNFFEAMVDTIENFIVSTMGE
NGRKFVPLLAGIFIYIFGMNLMGLVPGFDAPTANLNTTVCMALFVLVFYNAVGLIRWKTHYIHHFTGPSKFLIPLMFPLE
VVSHLSRPVSLSLRLFGNIRGEEIVMVLFFIMAPILGTLPIYALFLLGKTMQAFVFFMLTMFYIKGALEAPEH

Specific function: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane

COG id: COG0356

COG function: function code C; F0F1-type ATP synthase, subunit a

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase A chain family

Homologues:

Organism=Escherichia coli, GI1790176, Length=222, Percent_Identity=31.0810810810811, Blast_Score=76, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ATP6_DESDA (B8J4L9)

Other databases:

- EMBL:   CP001358
- RefSeq:   YP_002480827.1
- GeneID:   7285971
- GenomeReviews:   CP001358_GR
- KEGG:   dds:Ddes_2254
- HOGENOM:   HBG734175
- HAMAP:   MF_01393
- InterPro:   IPR000568
- InterPro:   IPR023011
- Gene3D:   G3DSA:1.20.120.220
- PANTHER:   PTHR11410
- PRINTS:   PR00123
- TIGRFAMs:   TIGR01131

Pfam domain/function: PF00119 ATP-synt_A; SSF81336 ATPase_F0_A

EC number: 3.6.3.14

Molecular weight: Translated: 26268; Mature: 26137

Theoretical pI: Translated: 8.25; Mature: 8.25

Prosite motif: PS00449 ATPASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x91f9ed4)-; HASH(0x213e1100)-; HASH(0x214aaafc)-; HASH(0x21720c14)-; HASH(0x21bed334)-;

Cys/Met content:

0.9 %Cys     (Translated Protein)
6.4 %Met     (Translated Protein)
7.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
6.0 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGGLPHPVLLSTFMGMDEITIGGQVVEFKHVFYSWVCMAILFAVAWVLRRRLTLVPGGL
CCCCCCCHHHHHHHCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
QNFFEAMVDTIENFIVSTMGENGRKFVPLLAGIFIYIFGMNLMGLVPGFDAPTANLNTTV
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
CMALFVLVFYNAVGLIRWKTHYIHHFTGPSKFLIPLMFPLEVVSHLSRPVSLSLRLFGNI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCC
RGEEIVMVLFFIMAPILGTLPIYALFLLGKTMQAFVFFMLTMFYIKGALEAPEH
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
>Mature Secondary Structure 
AGGLPHPVLLSTFMGMDEITIGGQVVEFKHVFYSWVCMAILFAVAWVLRRRLTLVPGGL
CCCCCCHHHHHHHCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
QNFFEAMVDTIENFIVSTMGENGRKFVPLLAGIFIYIFGMNLMGLVPGFDAPTANLNTTV
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
CMALFVLVFYNAVGLIRWKTHYIHHFTGPSKFLIPLMFPLEVVSHLSRPVSLSLRLFGNI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCC
RGEEIVMVLFFIMAPILGTLPIYALFLLGKTMQAFVFFMLTMFYIKGALEAPEH
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: Borate; diphosphate; HCO3- [C]

Metal ions: Co2+; Fe2+; Mn2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Ca2+; CN-; Efrapeptin; Ethidiumbromide; Guanidines analogs; Oligomycin; Quercetin; Trialkyl tin derivatives; Venturicidin [C]

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA