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The map label for this gene is lepA

Identifier: 220905455

GI number: 220905455

Start: 2642472

End: 2644277

Strand: Direct

Name: lepA

Synonym: Ddes_2193

Alternate gene names: 220905455

Gene position: 2642472-2644277 (Clockwise)

Preceding gene: 220905451

Following gene: 220905459

Centisome position: 91.96

GC content: 57.14

Gene sequence:

>1806_bases
ATGGTAAAGCAAGAAAATATACGCAATTTTTGCATTATTGCCCACATCGACCACGGCAAGTCAACCCTGGCCGACCGCAT
TCTTGAGCTTACCCAGGTGGTTAGCCAGCGTGAGGCGCGGCAGCAATATCTTGACAGAATGGATCTCGAACGCGAACGGG
GCATTACCATCAAGGCCCAGACCGTCCGCATTCCCTACATTGCCGCCGATGGTCAGGAATATGAGCTGAACCTCATCGAT
ACCCCCGGCCACGTGGACTTCAACTATGAAGTTTCACGCTCGCTGGCGGCCTGCGAAGGCGCTCTTCTGGTGGTGGACGC
CACCCAGGGTGTGGAAGCGCAGACCCTGGCCAACGTCTATCTGGCTCTGGACCACGACCATGAAGTCATTCCCGTGCTCA
ACAAGATAGACCTGCCCAGCGCTGAGGTTGACCGCGTCAAGGCTGAAATTGAAGAAAGCATCGGCCTCGACTGCTCCCAG
GCCCTCCCCGTGTCCGCTAAAACAGGCATGGGCGTGGACGCCGTGCTGGAAGCCATCGTGCACCATCTGCCCGCGCCCAA
AGGAGACCGGGCGGCCCCGCTCAAGGCACTTATTTTTGACTCCTGGTACGACAGCTACCAGGGCGTGGTGGTGCTTTTTC
GCATCATGGACGGCAGCGTACGCAAGGGCGACACCGTGCGCCTCATGAGTACCGGCAAGGAATACGAAGTGCTGCGCCTG
GGTGTTTTTTCGCCCGAGCCTACTGACGTCAAAGAACTTTTCGCCGGCGAGGTGGGTTTTCTCTGCGGCTCGATCAAGGA
ACTGGGCGATGCCCGTGTGGGTGATACCATCACCCATGCCGACCGCCCCGCAGAAACGGCGGTTCCCGGCTTCAAGGAAG
TGAAAGCCATGGTTTTCTGCGGGCTTTACCCCACAGAATCCGAAGATTATGAAAACCTCAAGGCTGCACTGGAAAAACTC
CAGCTCAACGACGCCGCATTTTCCTACGAACCGGAAACTTCGCAGGCTCTCGGCTTCGGCTTCCGCTGCGGTTTTCTGGG
TCTTCTGCATATGGAAATCATCCAGGAGCGCCTGGAGCGGGAATTTGAGGTGGGGCTTATCGCCACCGCGCCTTCCGTGG
TTTACAAGGTGGTGACGATGGACGGCAAAACGCTGGAAATTGACAACCCCAGCCACCTGCCCGACCCTACAAAAATCGAC
ACCCTTTATGAACCCTACGTGAGTATGGATATTCATGTGCCCAACGAATACGTGGGCAACGTCATGAAACTTTGCGAAGA
AAAACGCGGCACACAGAAAAACCTGCACTACCTTGCCGCCAACCGCGTGGTGGTTACCTACGAACTGCCTTTTGCCGAAA
TTGTTTACGATTTCTTTGACCGGCTCAAATCGGCCACGCGCGGCTATGCCTCTATGGATTATCATCCGCTGGACTACCGT
GCCTCTGACCTGGTGCGCCTGGACATCATGCTCAACAGCGAACCCGTCGACGCCCTGGCCGTCATCGTGCACCGCGACCG
TGCCTATACCTACGGCCGCGGACTGGCCCTCAAGCTCAAGCGCACCATTCCGCGCCAGCTTTTCCAGGTAGCCATTCAGG
CGGCCATCGGCCAGAAGATTATCGCCCGCGAAACGGTCTCCGCCTTCCGCAAGGACGTGACAGCCAAATGTTACGGCGGC
GATATAAGCCGTAAACGCAAGCTCCTGGAAAAACAGAAAGAAGGTAAACGCCGTATGAAGCGCATGGGCAACGTGGAACT
GCCGCAGGAGGCATTTCTGGCGGCCCTCAAGGTGGGCGACGAGTAG

Upstream 100 bases:

>100_bases
TGCGAAGCGCGCCGGGAAACCGCTGGCCTTTGCATGGACTTCATGACAAATTTTGGCTATACAATGCTGCTACGCAACCA
GATTTTACGCAGGAAAACAC

Downstream 100 bases:

>100_bases
GGCAGATACACAATCTGGCGCAAACGGAAGGGAATCTTTTTACAGAAAGCTTCCCTTCTTTCGCTTCCTCATGTGGCAGC
GTCACGCGCAACTGCCCTAT

Product: GTP-binding protein LepA

Products: NA

Alternate protein names: EF-4; Ribosomal back-translocase LepA

Number of amino acids: Translated: 601; Mature: 601

Protein sequence:

>601_residues
MVKQENIRNFCIIAHIDHGKSTLADRILELTQVVSQREARQQYLDRMDLERERGITIKAQTVRIPYIAADGQEYELNLID
TPGHVDFNYEVSRSLAACEGALLVVDATQGVEAQTLANVYLALDHDHEVIPVLNKIDLPSAEVDRVKAEIEESIGLDCSQ
ALPVSAKTGMGVDAVLEAIVHHLPAPKGDRAAPLKALIFDSWYDSYQGVVVLFRIMDGSVRKGDTVRLMSTGKEYEVLRL
GVFSPEPTDVKELFAGEVGFLCGSIKELGDARVGDTITHADRPAETAVPGFKEVKAMVFCGLYPTESEDYENLKAALEKL
QLNDAAFSYEPETSQALGFGFRCGFLGLLHMEIIQERLEREFEVGLIATAPSVVYKVVTMDGKTLEIDNPSHLPDPTKID
TLYEPYVSMDIHVPNEYVGNVMKLCEEKRGTQKNLHYLAANRVVVTYELPFAEIVYDFFDRLKSATRGYASMDYHPLDYR
ASDLVRLDIMLNSEPVDALAVIVHRDRAYTYGRGLALKLKRTIPRQLFQVAIQAAIGQKIIARETVSAFRKDVTAKCYGG
DISRKRKLLEKQKEGKRRMKRMGNVELPQEAFLAALKVGDE

Sequences:

>Translated_601_residues
MVKQENIRNFCIIAHIDHGKSTLADRILELTQVVSQREARQQYLDRMDLERERGITIKAQTVRIPYIAADGQEYELNLID
TPGHVDFNYEVSRSLAACEGALLVVDATQGVEAQTLANVYLALDHDHEVIPVLNKIDLPSAEVDRVKAEIEESIGLDCSQ
ALPVSAKTGMGVDAVLEAIVHHLPAPKGDRAAPLKALIFDSWYDSYQGVVVLFRIMDGSVRKGDTVRLMSTGKEYEVLRL
GVFSPEPTDVKELFAGEVGFLCGSIKELGDARVGDTITHADRPAETAVPGFKEVKAMVFCGLYPTESEDYENLKAALEKL
QLNDAAFSYEPETSQALGFGFRCGFLGLLHMEIIQERLEREFEVGLIATAPSVVYKVVTMDGKTLEIDNPSHLPDPTKID
TLYEPYVSMDIHVPNEYVGNVMKLCEEKRGTQKNLHYLAANRVVVTYELPFAEIVYDFFDRLKSATRGYASMDYHPLDYR
ASDLVRLDIMLNSEPVDALAVIVHRDRAYTYGRGLALKLKRTIPRQLFQVAIQAAIGQKIIARETVSAFRKDVTAKCYGG
DISRKRKLLEKQKEGKRRMKRMGNVELPQEAFLAALKVGDE
>Mature_601_residues
MVKQENIRNFCIIAHIDHGKSTLADRILELTQVVSQREARQQYLDRMDLERERGITIKAQTVRIPYIAADGQEYELNLID
TPGHVDFNYEVSRSLAACEGALLVVDATQGVEAQTLANVYLALDHDHEVIPVLNKIDLPSAEVDRVKAEIEESIGLDCSQ
ALPVSAKTGMGVDAVLEAIVHHLPAPKGDRAAPLKALIFDSWYDSYQGVVVLFRIMDGSVRKGDTVRLMSTGKEYEVLRL
GVFSPEPTDVKELFAGEVGFLCGSIKELGDARVGDTITHADRPAETAVPGFKEVKAMVFCGLYPTESEDYENLKAALEKL
QLNDAAFSYEPETSQALGFGFRCGFLGLLHMEIIQERLEREFEVGLIATAPSVVYKVVTMDGKTLEIDNPSHLPDPTKID
TLYEPYVSMDIHVPNEYVGNVMKLCEEKRGTQKNLHYLAANRVVVTYELPFAEIVYDFFDRLKSATRGYASMDYHPLDYR
ASDLVRLDIMLNSEPVDALAVIVHRDRAYTYGRGLALKLKRTIPRQLFQVAIQAAIGQKIIARETVSAFRKDVTAKCYGG
DISRKRKLLEKQKEGKRRMKRMGNVELPQEAFLAALKVGDE

Specific function: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- transloc

COG id: COG0481

COG function: function code M; Membrane GTPase LepA

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. LepA subfamily

Homologues:

Organism=Homo sapiens, GI157426893, Length=601, Percent_Identity=49.5840266222962, Blast_Score=631, Evalue=0.0,
Organism=Homo sapiens, GI94966754, Length=133, Percent_Identity=45.1127819548872, Blast_Score=119, Evalue=7e-27,
Organism=Homo sapiens, GI310132016, Length=110, Percent_Identity=43.6363636363636, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI310110807, Length=110, Percent_Identity=43.6363636363636, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI310123363, Length=110, Percent_Identity=43.6363636363636, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI4503483, Length=149, Percent_Identity=38.255033557047, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI25306283, Length=151, Percent_Identity=43.046357615894, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI25306287, Length=151, Percent_Identity=43.046357615894, Blast_Score=98, Evalue=3e-20,
Organism=Homo sapiens, GI19923640, Length=151, Percent_Identity=43.046357615894, Blast_Score=98, Evalue=3e-20,
Organism=Homo sapiens, GI18390331, Length=143, Percent_Identity=36.3636363636364, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI217272892, Length=139, Percent_Identity=34.5323741007194, Blast_Score=83, Evalue=7e-16,
Organism=Homo sapiens, GI217272894, Length=139, Percent_Identity=34.5323741007194, Blast_Score=83, Evalue=7e-16,
Organism=Homo sapiens, GI53729339, Length=239, Percent_Identity=31.7991631799163, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI53729337, Length=239, Percent_Identity=31.7991631799163, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI54607086, Length=258, Percent_Identity=24.031007751938, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1788922, Length=597, Percent_Identity=61.641541038526, Blast_Score=718, Evalue=0.0,
Organism=Escherichia coli, GI48994988, Length=480, Percent_Identity=31.4583333333333, Blast_Score=167, Evalue=2e-42,
Organism=Escherichia coli, GI1789738, Length=208, Percent_Identity=33.1730769230769, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1790835, Length=171, Percent_Identity=30.9941520467836, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1789559, Length=225, Percent_Identity=29.7777777777778, Blast_Score=80, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17557151, Length=613, Percent_Identity=42.5774877650897, Blast_Score=503, Evalue=1e-143,
Organism=Caenorhabditis elegans, GI71988811, Length=274, Percent_Identity=30.2919708029197, Blast_Score=101, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI71988819, Length=274, Percent_Identity=30.2919708029197, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17556745, Length=153, Percent_Identity=33.9869281045752, Blast_Score=93, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17533571, Length=143, Percent_Identity=39.8601398601399, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17506493, Length=161, Percent_Identity=33.5403726708075, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17552882, Length=133, Percent_Identity=34.5864661654135, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI115532067, Length=272, Percent_Identity=26.4705882352941, Blast_Score=68, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI115532065, Length=272, Percent_Identity=26.4705882352941, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI25141371, Length=288, Percent_Identity=28.4722222222222, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6323320, Length=601, Percent_Identity=46.2562396006656, Blast_Score=541, Evalue=1e-155,
Organism=Saccharomyces cerevisiae, GI6324707, Length=149, Percent_Identity=38.9261744966443, Blast_Score=103, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6320593, Length=149, Percent_Identity=38.9261744966443, Blast_Score=103, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6323098, Length=194, Percent_Identity=31.4432989690722, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6322359, Length=112, Percent_Identity=39.2857142857143, Blast_Score=90, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6324166, Length=141, Percent_Identity=39.0070921985816, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6324761, Length=246, Percent_Identity=26.4227642276423, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI78706572, Length=601, Percent_Identity=46.089850249584, Blast_Score=546, Evalue=1e-155,
Organism=Drosophila melanogaster, GI28574573, Length=140, Percent_Identity=42.8571428571429, Blast_Score=107, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24582462, Length=186, Percent_Identity=34.4086021505376, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24585711, Length=153, Percent_Identity=37.2549019607843, Blast_Score=93, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24585713, Length=153, Percent_Identity=37.2549019607843, Blast_Score=93, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24585709, Length=153, Percent_Identity=37.2549019607843, Blast_Score=93, Evalue=5e-19,
Organism=Drosophila melanogaster, GI221458488, Length=151, Percent_Identity=36.4238410596026, Blast_Score=87, Evalue=4e-17,
Organism=Drosophila melanogaster, GI21357743, Length=133, Percent_Identity=33.8345864661654, Blast_Score=83, Evalue=6e-16,
Organism=Drosophila melanogaster, GI28572034, Length=224, Percent_Identity=26.3392857142857, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI19921738, Length=234, Percent_Identity=31.1965811965812, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI281363316, Length=240, Percent_Identity=27.9166666666667, Blast_Score=69, Evalue=8e-12,
Organism=Drosophila melanogaster, GI17864358, Length=240, Percent_Identity=27.9166666666667, Blast_Score=69, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LEPA_DESDA (B8J444)

Other databases:

- EMBL:   CP001358
- RefSeq:   YP_002480767.1
- GeneID:   7285909
- GenomeReviews:   CP001358_GR
- KEGG:   dds:Ddes_2193
- HOGENOM:   HBG286375
- ProtClustDB:   PRK05433
- GO:   GO:0006412
- HAMAP:   MF_00071
- InterPro:   IPR009022
- InterPro:   IPR006297
- InterPro:   IPR013842
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR000640
- InterPro:   IPR004161
- InterPro:   IPR009000
- Gene3D:   G3DSA:3.30.70.240
- PRINTS:   PR00315
- SMART:   SM00838
- TIGRFAMs:   TIGR01393
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF00679 EFG_C; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2; PF06421 LepA_C; SSF54980 EFG_III_V; SSF50447 Translat_factor

EC number: NA

Molecular weight: Translated: 67177; Mature: 67177

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKQENIRNFCIIAHIDHGKSTLADRILELTQVVSQREARQQYLDRMDLERERGITIKAQ
CCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCEEEEE
TVRIPYIAADGQEYELNLIDTPGHVDFNYEVSRSLAACEGALLVVDATQGVEAQTLANVY
EEEEEEEEECCCEEEEEEECCCCCEEECHHHHHHHHHCCCCEEEEECCCCCCHHHHEEEE
LALDHDHEVIPVLNKIDLPSAEVDRVKAEIEESIGLDCSQALPVSAKTGMGVDAVLEAIV
EEECCCCCEEHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHH
HHLPAPKGDRAAPLKALIFDSWYDSYQGVVVLFRIMDGSVRKGDTVRLMSTGKEYEVLRL
HHCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCEEEEEECCCCEEEEEE
GVFSPEPTDVKELFAGEVGFLCGSIKELGDARVGDTITHADRPAETAVPGFKEVKAMVFC
ECCCCCCCCHHHHHCCHHHHHHHHHHHHCCCCCCCCHHCCCCCCHHCCCCHHHHHHHHHC
GLYPTESEDYENLKAALEKLQLNDAAFSYEPETSQALGFGFRCGFLGLLHMEIIQERLER
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHH
EFEVGLIATAPSVVYKVVTMDGKTLEIDNPSHLPDPTKIDTLYEPYVSMDIHVPNEYVGN
HHCCEEEEECHHHEEEEEEECCCEEECCCCCCCCCCCCCHHHHCCEEEEEEECCHHHHHH
VMKLCEEKRGTQKNLHYLAANRVVVTYELPFAEIVYDFFDRLKSATRGYASMDYHPLDYR
HHHHHHHHCCCHHHHEEEEECCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
ASDLVRLDIMLNSEPVDALAVIVHRDRAYTYGRGLALKLKRTIPRQLFQVAIQAAIGQKI
CCCEEEEEEEECCCCCCCEEEEEECCCCEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHH
IARETVSAFRKDVTAKCYGGDISRKRKLLEKQKEGKRRMKRMGNVELPQEAFLAALKVGD
HHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCC
E
C
>Mature Secondary Structure
MVKQENIRNFCIIAHIDHGKSTLADRILELTQVVSQREARQQYLDRMDLERERGITIKAQ
CCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCEEEEE
TVRIPYIAADGQEYELNLIDTPGHVDFNYEVSRSLAACEGALLVVDATQGVEAQTLANVY
EEEEEEEEECCCEEEEEEECCCCCEEECHHHHHHHHHCCCCEEEEECCCCCCHHHHEEEE
LALDHDHEVIPVLNKIDLPSAEVDRVKAEIEESIGLDCSQALPVSAKTGMGVDAVLEAIV
EEECCCCCEEHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHH
HHLPAPKGDRAAPLKALIFDSWYDSYQGVVVLFRIMDGSVRKGDTVRLMSTGKEYEVLRL
HHCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCEEEEEECCCCEEEEEE
GVFSPEPTDVKELFAGEVGFLCGSIKELGDARVGDTITHADRPAETAVPGFKEVKAMVFC
ECCCCCCCCHHHHHCCHHHHHHHHHHHHCCCCCCCCHHCCCCCCHHCCCCHHHHHHHHHC
GLYPTESEDYENLKAALEKLQLNDAAFSYEPETSQALGFGFRCGFLGLLHMEIIQERLER
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHH
EFEVGLIATAPSVVYKVVTMDGKTLEIDNPSHLPDPTKIDTLYEPYVSMDIHVPNEYVGN
HHCCEEEEECHHHEEEEEEECCCEEECCCCCCCCCCCCCHHHHCCEEEEEEECCHHHHHH
VMKLCEEKRGTQKNLHYLAANRVVVTYELPFAEIVYDFFDRLKSATRGYASMDYHPLDYR
HHHHHHHHCCCHHHHEEEEECCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
ASDLVRLDIMLNSEPVDALAVIVHRDRAYTYGRGLALKLKRTIPRQLFQVAIQAAIGQKI
CCCEEEEEEEECCCCCCCEEEEEECCCCEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHH
IARETVSAFRKDVTAKCYGGDISRKRKLLEKQKEGKRRMKRMGNVELPQEAFLAALKVGD
HHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCC
E
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA