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The map label for this gene is yhdR [H]

Identifier: 220905351

GI number: 220905351

Start: 2516499

End: 2517695

Strand: Direct

Name: yhdR [H]

Synonym: Ddes_2089

Alternate gene names: 220905351

Gene position: 2516499-2517695 (Clockwise)

Preceding gene: 220905349

Following gene: 220905352

Centisome position: 87.58

GC content: 60.15

Gene sequence:

>1197_bases
ATGTCTATTCTTGCCGACAGTGTTACCGGCTACCTCGAACACGCATCGTGGATACGCCGCATGTTTGAAGCCGGAGGACA
TCTCAAGGCGCGTTACGGCGCGGACAAGGTGTATGATTTCAGCCTGGGCAACCCCGACCTGCCCGCCCCGCCCGCTGTGG
CCGAAGGTTTGCGCGCCTTTGCCGCGCACGCTCATGAACCGTTTGCTTTCGGCTACATGCCCAACGGCGGCTTTGCCTGG
GCCCGGGAAAAACTGGCTGACTACCTGAGCCGCGAGCAGGGCGTAGCCCTGACGGCTGAAGACGTGATTCTGGGCTGCGG
CGCGGCTGGCGTACTCAACGCCTTTTTGCGCGCCGTGCTCAATCCCGGCGAAGAAATGCTGGCTTTTGCTCCCTATTTTG
TGGAGTACGGTTTTTACGTGTCCAACCACGGTGGCGTCTTCAAGGCCGTGCAAAGCAAAAAAGACACCTTTGCGCCCGAT
CTGGACGCGCTGGAAGCCGCCATCAACGAAAAAACCCGCGTAGTGCTCATCAACTCGCCCCACAACCCCACGGGCGTAGT
CTACAGGCGCAAGGAAATATCGGCCATTGCCGACCTGCTGCTCAACAAGAGCCAGGAATACGGCAAACCGATCTGGCTGG
TGGCTGACGAGCCTTACCGCTTTCTGGCCTATGACGGCGTGGAAGTTCCCTCGGTGCTGCCTCTCTATCCTTATGCCATT
GCCATCAGCTCTTTTTCAAAAAGCCTTTCCCTGCCGGGTGAACGCCTGGGCTATGCCGCTGTTTCGCCCAAGCTGCCCGC
AGAAGAGAAAAAGCTGCTCATGGCCGCCCTTACCCTCACCACCCGAATTCTGGGCTTTGTCAATCCCCCCGTGGTTGGTC
AGCACATCATGGCCGCGGCCCTGGGCAGCCAGGTGGACCTTGAGGTCTACGCGGCCCGCCGCAAGGCCATGGCCGAGGTG
CTTGAGCAGGCAGGCTACGAATTCCAGATGCCTTCGGGAGCCTTTTACTTCTTCCCCAAGGCTCCCGGCGGCGACGACGT
GGCCTTTGTAAACGCCCTGCTTGAAGAGCGTGTGCTCGCCGTACCCGGCACCGGCTTCGGCTGCCCGGGCTATTTCCGCC
TGGCCTTCTGCGTGGACGAAAGCGTTATCCGCAATGCGGCCGAAGGCTTTGCCAAAGCCCGCGCCACAGTAAAATAA

Upstream 100 bases:

>100_bases
TCAAAACGCATCAGAGCCTCCAAATGACAATTGCTTTATGCGGCTTTTGGAAGCATAACCAATAGTCATGGCGAATACAA
CAACCACTGGGAGTCGTTTT

Downstream 100 bases:

>100_bases
TATTGGCGCAAACACCTGTTCCGGCGACAGTGCCGCGCCCTGCTCGGCAAAGGCGTGGCACTGCCTGCCCGACCCGCATA
CCGGCCGGCACGCGCATACG

Product: aspartate aminotransferase

Products: NA

Alternate protein names: AspAT; Transaminase A [H]

Number of amino acids: Translated: 398; Mature: 397

Protein sequence:

>398_residues
MSILADSVTGYLEHASWIRRMFEAGGHLKARYGADKVYDFSLGNPDLPAPPAVAEGLRAFAAHAHEPFAFGYMPNGGFAW
AREKLADYLSREQGVALTAEDVILGCGAAGVLNAFLRAVLNPGEEMLAFAPYFVEYGFYVSNHGGVFKAVQSKKDTFAPD
LDALEAAINEKTRVVLINSPHNPTGVVYRRKEISAIADLLLNKSQEYGKPIWLVADEPYRFLAYDGVEVPSVLPLYPYAI
AISSFSKSLSLPGERLGYAAVSPKLPAEEKKLLMAALTLTTRILGFVNPPVVGQHIMAAALGSQVDLEVYAARRKAMAEV
LEQAGYEFQMPSGAFYFFPKAPGGDDVAFVNALLEERVLAVPGTGFGCPGYFRLAFCVDESVIRNAAEGFAKARATVK

Sequences:

>Translated_398_residues
MSILADSVTGYLEHASWIRRMFEAGGHLKARYGADKVYDFSLGNPDLPAPPAVAEGLRAFAAHAHEPFAFGYMPNGGFAW
AREKLADYLSREQGVALTAEDVILGCGAAGVLNAFLRAVLNPGEEMLAFAPYFVEYGFYVSNHGGVFKAVQSKKDTFAPD
LDALEAAINEKTRVVLINSPHNPTGVVYRRKEISAIADLLLNKSQEYGKPIWLVADEPYRFLAYDGVEVPSVLPLYPYAI
AISSFSKSLSLPGERLGYAAVSPKLPAEEKKLLMAALTLTTRILGFVNPPVVGQHIMAAALGSQVDLEVYAARRKAMAEV
LEQAGYEFQMPSGAFYFFPKAPGGDDVAFVNALLEERVLAVPGTGFGCPGYFRLAFCVDESVIRNAAEGFAKARATVK
>Mature_397_residues
SILADSVTGYLEHASWIRRMFEAGGHLKARYGADKVYDFSLGNPDLPAPPAVAEGLRAFAAHAHEPFAFGYMPNGGFAWA
REKLADYLSREQGVALTAEDVILGCGAAGVLNAFLRAVLNPGEEMLAFAPYFVEYGFYVSNHGGVFKAVQSKKDTFAPDL
DALEAAINEKTRVVLINSPHNPTGVVYRRKEISAIADLLLNKSQEYGKPIWLVADEPYRFLAYDGVEVPSVLPLYPYAIA
ISSFSKSLSLPGERLGYAAVSPKLPAEEKKLLMAALTLTTRILGFVNPPVVGQHIMAAALGSQVDLEVYAARRKAMAEVL
EQAGYEFQMPSGAFYFFPKAPGGDDVAFVNALLEERVLAVPGTGFGCPGYFRLAFCVDESVIRNAAEGFAKARATVK

Specific function: Unknown

COG id: COG0436

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4507369, Length=395, Percent_Identity=25.5696202531646, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI56713256, Length=412, Percent_Identity=24.2718446601942, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI56713254, Length=412, Percent_Identity=24.2718446601942, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI1788627, Length=365, Percent_Identity=28.2191780821918, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1786816, Length=372, Percent_Identity=27.6881720430108, Blast_Score=107, Evalue=9e-25,
Organism=Escherichia coli, GI1788722, Length=384, Percent_Identity=25.2604166666667, Blast_Score=93, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17567369, Length=365, Percent_Identity=27.6712328767123, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17567663, Length=374, Percent_Identity=27.2727272727273, Blast_Score=98, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI71994476, Length=369, Percent_Identity=26.2872628726287, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI71994472, Length=369, Percent_Identity=26.2872628726287, Blast_Score=92, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6322401, Length=387, Percent_Identity=24.031007751938, Blast_Score=86, Evalue=9e-18,
Organism=Drosophila melanogaster, GI18859735, Length=405, Percent_Identity=25.679012345679, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI28573069, Length=237, Percent_Identity=28.6919831223629, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24646114, Length=237, Percent_Identity=28.6919831223629, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI28573067, Length=237, Percent_Identity=28.6919831223629, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI28573065, Length=237, Percent_Identity=28.6919831223629, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001176
- InterPro:   IPR004839
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.1 [H]

Molecular weight: Translated: 43077; Mature: 42946

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSILADSVTGYLEHASWIRRMFEAGGHLKARYGADKVYDFSLGNPDLPAPPAVAEGLRAF
CCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCEEEEECCCCCCCCCCHHHHHHHHHH
AAHAHEPFAFGYMPNGGFAWAREKLADYLSREQGVALTAEDVILGCGAAGVLNAFLRAVL
HHHCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEHHHHEEECCHHHHHHHHHHHHH
NPGEEMLAFAPYFVEYGFYVSNHGGVFKAVQSKKDTFAPDLDALEAAINEKTRVVLINSP
CCCHHHHHHHHHHHHHCCEEECCCCCHHHHHCCCCCCCCCHHHHHHHHCCCEEEEEEECC
HNPTGVVYRRKEISAIADLLLNKSQEYGKPIWLVADEPYRFLAYDGVEVPSVLPLYPYAI
CCCCCEEEEHHHHHHHHHHHHCCCHHHCCEEEEEECCCEEEEEECCCCCCCCCCHHHHHH
AISSFSKSLSLPGERLGYAAVSPKLPAEEKKLLMAALTLTTRILGFVNPPVVGQHIMAAA
HHHHHHHHCCCCHHHCCCEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
LGSQVDLEVYAARRKAMAEVLEQAGYEFQMPSGAFYFFPKAPGGDDVAFVNALLEERVLA
HCCCCCHHHHHHHHHHHHHHHHHCCCEEECCCCCEEEEECCCCCCHHHHHHHHHHCCEEE
VPGTGFGCPGYFRLAFCVDESVIRNAAEGFAKARATVK
CCCCCCCCCHHHEEHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SILADSVTGYLEHASWIRRMFEAGGHLKARYGADKVYDFSLGNPDLPAPPAVAEGLRAF
CCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCEEEEECCCCCCCCCCHHHHHHHHHH
AAHAHEPFAFGYMPNGGFAWAREKLADYLSREQGVALTAEDVILGCGAAGVLNAFLRAVL
HHHCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEHHHHEEECCHHHHHHHHHHHHH
NPGEEMLAFAPYFVEYGFYVSNHGGVFKAVQSKKDTFAPDLDALEAAINEKTRVVLINSP
CCCHHHHHHHHHHHHHCCEEECCCCCHHHHHCCCCCCCCCHHHHHHHHCCCEEEEEEECC
HNPTGVVYRRKEISAIADLLLNKSQEYGKPIWLVADEPYRFLAYDGVEVPSVLPLYPYAI
CCCCCEEEEHHHHHHHHHHHHCCCHHHCCEEEEEECCCEEEEEECCCCCCCCCCHHHHHH
AISSFSKSLSLPGERLGYAAVSPKLPAEEKKLLMAALTLTTRILGFVNPPVVGQHIMAAA
HHHHHHHHCCCCHHHCCCEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
LGSQVDLEVYAARRKAMAEVLEQAGYEFQMPSGAFYFFPKAPGGDDVAFVNALLEERVLA
HCCCCCHHHHHHHHHHHHHHHHHCCCEEECCCCCEEEEECCCCCCHHHHHHHHHHCCEEE
VPGTGFGCPGYFRLAFCVDESVIRNAAEGFAKARATVK
CCCCCCCCCHHHEEHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]