Click here to switch to the map view.

The map label for this gene is moeA [C]

Identifier: 220905312

GI number: 220905312

Start: 2463350

End: 2465338

Strand: Direct

Name: moeA [C]

Synonym: Ddes_2050

Alternate gene names: 220905312

Gene position: 2463350-2465338 (Clockwise)

Preceding gene: 220905304

Following gene: 220905323

Centisome position: 85.73

GC content: 64.91

Gene sequence:

>1989_bases
ATGGCTCCCCAAAGCAATATCTACACGCAAACCGTGCCGTTGGGCGACGCGCTCGACAAGCTGCTCGGCGCCCTGGACAC
GGCCCGCGCCGCTGACGGCCAGAACCGGCTGCCGCAGCCTGTATCCTGCCCGACACAAGCTGCCGACGGGCGCGTGTTGA
GTGAATTTGTCATTGCGGCCGCCGACGTTCCTCCTTCGCCCCTGGCCGCCGCGAAGGGATATGCTCTCAGGGCTGCGGAC
ACCTATACCGCCGACAGCAACAATCCCGCTCTGCTGCAGGCGGGAAAAAACTGCTTTGCCGTCCGGCCCGGCGAGATTCT
TCCCCCGGGCTGCGATGCCGTGGCCCTGCCGGTTCACGCTGCAGTGGACGGCAAGGGCGGCGTCAGTATTACGGCCCCCA
TGCTGCCGTGGCTGCATGTGCGCAGAGCCGGAGCGGACATGGCGGCAGGAGAAACCCTCTTCCCGCGCAATCACATCCTC
CGCCCCGCGGATATGGGCGCGCTGCTGGCGGCGGGAATTACCGAAGTGCAGGTGTGGGACCGCCTGCAACTGCACCTCGC
GGCTGTGGCTGACCCTGCCCCAACGCCCAAAAAAAACGGGCCTGCCGTAACTGCCGCTGCGGACGGCATCATCCCGGCCC
TGGCAGCCCTGGCTCAGGATATCGACTGTCACGTGCAAACAGCACCCTGCCTGCCCGCCGATGCCGGTGTTGTGCGTGAT
TTTTTGCAGTCCGCCCTGAAGGCCGGGGCCCACGCCCTGCTGCTGTGCGCCACAGGTGATGACGCCCTGACGGCCGTACG
CGACCTGATGGAACGTGAAGGAAGAATTGTGGCCCCCGACATCGGCCTGCTGCCCGGGGCACCGGCCATGACGGCCGTAT
ATGAAGGCAGGCCTGTCTTTTGCCTGCCGTGCTCGCCCGCAGGCAGTCTCACGGCTTTTGACGCATTGGTGGCCCCGGCC
CTGCTGCTCATGTCGCGTCGCCCGGGCCTGTGTTATGCCAAAACACTTGCCGGCGATGCCGATGCTGCCGGAAAGCTGAC
GGCGGAGCTGGCGGCCAGTCTGCCCGCGCACCCCGGCCTTGATGTTTTTGCCCCCCTGGCCCTGGCGCGGGTCGCGGAAA
AGACGATAGCCATGCCCCTGCGAATGGGCGAGGGGCATAAAAGCGCGGTCCGGACTCAGGCGCTTGCCCACATCACGGCC
AGCGGCAAGGGTATAGCCCTTGGCAGCACGGTGCGCGCCCGGCCCCTGCGCCCGGCCGACAGCCTGTACAACACGCTGTT
CTGCGCCGGGGGCGATGATGTGGCGCTGGACCTGCTCGCCGACGGGTTATTGCGCCTGCCGCACGCCGTGCATCTTGTCT
GCGCGGGCGCGGATGCCGCCGATGCCGTACAGGCCCTGAAAAACCGGCACTGCCATATGGCCGTGCTGCATATGGCTGAC
GACGACAAGGGCGGCTTCAACTTCGCCTTTGTGCAACAGCACTGGCCCGAGGGCAAGATTGCCCTGATCAATCTGGTTAT
CCGTCAGGTCGGGCTGGTGGTTCCTGCGGGCAATCCACGCGGACTCAAAAGCGTGGCCGACATTAAAAACATGAAGCTGC
GCTGCGTTAACCGTCAGGCAGGTTCAAGCACCCGCATGCAGTTTGACGCCCTTTTGCGCCATGCCGGCATGACCCCGCAG
GATGTTCCGGGCTATGAAAATGAGGTGGAAAGCCAGCTTGCCGTAGCCGCCGCCGTACTTACGGGAAAGGCCGACTGTGG
TCCCGGCGTGGCGGCCGCAGCCAGAGCCGTGGGACTGGATTTTATACCCCTGGCGGGCGAGCGCTGGGACCTTGCCGTTC
CCGAAGCATTCAGGGAGGATCCCCGAGTGGTCAGTGTAGAAAGCCTGCTGCAGAAACCGGAATTCAAAAAACGCCTTGAG
GCCCTTGGCGGCTACAACACCCGTCTGACCGGGCAAAAACTTGAGCTTGGCGTCCGCCTTGGGGCGTGA

Upstream 100 bases:

>100_bases
GCGATTGACCGCGAACCTGCCGCGTACGCCTTTCCGGCGGGCGCCCGCCCCTGCGGCCGCCAGAGCAACTTCAAGGCAAG
ATTGCCCGCAAGGAGGATAT

Downstream 100 bases:

>100_bases
TAAGAAAAAGCCCCGCCGTCGGCAAACGGAGGGGCTGGGTATGGACCGGACTGCGGCAGATCAGTCCGGCCCTGGAGGAG
GATGGGCAATTTCACATCAT

Product: MoeA domain-containing protein domain I and II

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 662; Mature: 661

Protein sequence:

>662_residues
MAPQSNIYTQTVPLGDALDKLLGALDTARAADGQNRLPQPVSCPTQAADGRVLSEFVIAAADVPPSPLAAAKGYALRAAD
TYTADSNNPALLQAGKNCFAVRPGEILPPGCDAVALPVHAAVDGKGGVSITAPMLPWLHVRRAGADMAAGETLFPRNHIL
RPADMGALLAAGITEVQVWDRLQLHLAAVADPAPTPKKNGPAVTAAADGIIPALAALAQDIDCHVQTAPCLPADAGVVRD
FLQSALKAGAHALLLCATGDDALTAVRDLMEREGRIVAPDIGLLPGAPAMTAVYEGRPVFCLPCSPAGSLTAFDALVAPA
LLLMSRRPGLCYAKTLAGDADAAGKLTAELAASLPAHPGLDVFAPLALARVAEKTIAMPLRMGEGHKSAVRTQALAHITA
SGKGIALGSTVRARPLRPADSLYNTLFCAGGDDVALDLLADGLLRLPHAVHLVCAGADAADAVQALKNRHCHMAVLHMAD
DDKGGFNFAFVQQHWPEGKIALINLVIRQVGLVVPAGNPRGLKSVADIKNMKLRCVNRQAGSSTRMQFDALLRHAGMTPQ
DVPGYENEVESQLAVAAAVLTGKADCGPGVAAAARAVGLDFIPLAGERWDLAVPEAFREDPRVVSVESLLQKPEFKKRLE
ALGGYNTRLTGQKLELGVRLGA

Sequences:

>Translated_662_residues
MAPQSNIYTQTVPLGDALDKLLGALDTARAADGQNRLPQPVSCPTQAADGRVLSEFVIAAADVPPSPLAAAKGYALRAAD
TYTADSNNPALLQAGKNCFAVRPGEILPPGCDAVALPVHAAVDGKGGVSITAPMLPWLHVRRAGADMAAGETLFPRNHIL
RPADMGALLAAGITEVQVWDRLQLHLAAVADPAPTPKKNGPAVTAAADGIIPALAALAQDIDCHVQTAPCLPADAGVVRD
FLQSALKAGAHALLLCATGDDALTAVRDLMEREGRIVAPDIGLLPGAPAMTAVYEGRPVFCLPCSPAGSLTAFDALVAPA
LLLMSRRPGLCYAKTLAGDADAAGKLTAELAASLPAHPGLDVFAPLALARVAEKTIAMPLRMGEGHKSAVRTQALAHITA
SGKGIALGSTVRARPLRPADSLYNTLFCAGGDDVALDLLADGLLRLPHAVHLVCAGADAADAVQALKNRHCHMAVLHMAD
DDKGGFNFAFVQQHWPEGKIALINLVIRQVGLVVPAGNPRGLKSVADIKNMKLRCVNRQAGSSTRMQFDALLRHAGMTPQ
DVPGYENEVESQLAVAAAVLTGKADCGPGVAAAARAVGLDFIPLAGERWDLAVPEAFREDPRVVSVESLLQKPEFKKRLE
ALGGYNTRLTGQKLELGVRLGA
>Mature_661_residues
APQSNIYTQTVPLGDALDKLLGALDTARAADGQNRLPQPVSCPTQAADGRVLSEFVIAAADVPPSPLAAAKGYALRAADT
YTADSNNPALLQAGKNCFAVRPGEILPPGCDAVALPVHAAVDGKGGVSITAPMLPWLHVRRAGADMAAGETLFPRNHILR
PADMGALLAAGITEVQVWDRLQLHLAAVADPAPTPKKNGPAVTAAADGIIPALAALAQDIDCHVQTAPCLPADAGVVRDF
LQSALKAGAHALLLCATGDDALTAVRDLMEREGRIVAPDIGLLPGAPAMTAVYEGRPVFCLPCSPAGSLTAFDALVAPAL
LLMSRRPGLCYAKTLAGDADAAGKLTAELAASLPAHPGLDVFAPLALARVAEKTIAMPLRMGEGHKSAVRTQALAHITAS
GKGIALGSTVRARPLRPADSLYNTLFCAGGDDVALDLLADGLLRLPHAVHLVCAGADAADAVQALKNRHCHMAVLHMADD
DKGGFNFAFVQQHWPEGKIALINLVIRQVGLVVPAGNPRGLKSVADIKNMKLRCVNRQAGSSTRMQFDALLRHAGMTPQD
VPGYENEVESQLAVAAAVLTGKADCGPGVAAAARAVGLDFIPLAGERWDLAVPEAFREDPRVVSVESLLQKPEFKKRLEA
LGGYNTRLTGQKLELGVRLGA

Specific function: Involved In The Biosynthesis Of A Demolybdo-Cofactor (Molybdopterin), Necessary For Molybdo-Enzymes. Seems To Be Involved In A Step Of Activation Of Molybdenum In The Form Of Thiomolybdenum. [C]

COG id: COG1910

COG function: function code P; Periplasmic molybdate-binding protein/domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Escherichia coli, GI1787049, Length=357, Percent_Identity=24.0896358543417, Blast_Score=72, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 68753; Mature: 68622

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPQSNIYTQTVPLGDALDKLLGALDTARAADGQNRLPQPVSCPTQAADGRVLSEFVIAA
CCCCCCCEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
ADVPPSPLAAAKGYALRAADTYTADSNNPALLQAGKNCFAVRPGEILPPGCDAVALPVHA
CCCCCCCHHHCCCCEEEECCCEECCCCCCCEEECCCCEEEECCCCCCCCCCCEEEEEEEE
AVDGKGGVSITAPMLPWLHVRRAGADMAAGETLFPRNHILRPADMGALLAAGITEVQVWD
EECCCCCEEEECCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHH
RLQLHLAAVADPAPTPKKNGPAVTAAADGIIPALAALAQDIDCHVQTAPCLPADAGVVRD
HHHHHHHHHCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHH
FLQSALKAGAHALLLCATGDDALTAVRDLMEREGRIVAPDIGLLPGAPAMTAVYEGRPVF
HHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHCCCEECCCCCCCCCCCHHHEEECCCEEE
CLPCSPAGSLTAFDALVAPALLLMSRRPGLCYAKTLAGDADAAGKLTAELAASLPAHPGL
EEECCCCCCHHHHHHHHHHHHHHHCCCCCCEEEHHHCCCCCCCHHHHHHHHHHCCCCCCC
DVFAPLALARVAEKTIAMPLRMGEGHKSAVRTQALAHITASGKGIALGSTVRARPLRPAD
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHEECCCCCEEECCCCCCCCCCCHH
SLYNTLFCAGGDDVALDLLADGLLRLPHAVHLVCAGADAADAVQALKNRHCHMAVLHMAD
HHHHEEEECCCCHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHCCCCEEEEEEECC
DDKGGFNFAFVQQHWPEGKIALINLVIRQVGLVVPAGNPRGLKSVADIKNMKLRCVNRQA
CCCCCEEEEEEECCCCCCCHHHHHHHHHHHCEEEECCCCCCHHHHHHHHCCEEEEECCCC
GSSTRMQFDALLRHAGMTPQDVPGYENEVESQLAVAAAVLTGKADCGPGVAAAARAVGLD
CCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCC
FIPLAGERWDLAVPEAFREDPRVVSVESLLQKPEFKKRLEALGGYNTRLTGQKLELGVRL
EEECCCCCCCCCCCHHHCCCCCEEEHHHHHCCCHHHHHHHHHCCCCCEECCCEEEEEEEE
GA
CC
>Mature Secondary Structure 
APQSNIYTQTVPLGDALDKLLGALDTARAADGQNRLPQPVSCPTQAADGRVLSEFVIAA
CCCCCCEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
ADVPPSPLAAAKGYALRAADTYTADSNNPALLQAGKNCFAVRPGEILPPGCDAVALPVHA
CCCCCCCHHHCCCCEEEECCCEECCCCCCCEEECCCCEEEECCCCCCCCCCCEEEEEEEE
AVDGKGGVSITAPMLPWLHVRRAGADMAAGETLFPRNHILRPADMGALLAAGITEVQVWD
EECCCCCEEEECCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHH
RLQLHLAAVADPAPTPKKNGPAVTAAADGIIPALAALAQDIDCHVQTAPCLPADAGVVRD
HHHHHHHHHCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHH
FLQSALKAGAHALLLCATGDDALTAVRDLMEREGRIVAPDIGLLPGAPAMTAVYEGRPVF
HHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHCCCEECCCCCCCCCCCHHHEEECCCEEE
CLPCSPAGSLTAFDALVAPALLLMSRRPGLCYAKTLAGDADAAGKLTAELAASLPAHPGL
EEECCCCCCHHHHHHHHHHHHHHHCCCCCCEEEHHHCCCCCCCHHHHHHHHHHCCCCCCC
DVFAPLALARVAEKTIAMPLRMGEGHKSAVRTQALAHITASGKGIALGSTVRARPLRPAD
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHEECCCCCEEECCCCCCCCCCCHH
SLYNTLFCAGGDDVALDLLADGLLRLPHAVHLVCAGADAADAVQALKNRHCHMAVLHMAD
HHHHEEEECCCCHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHCCCCEEEEEEECC
DDKGGFNFAFVQQHWPEGKIALINLVIRQVGLVVPAGNPRGLKSVADIKNMKLRCVNRQA
CCCCCEEEEEEECCCCCCCHHHHHHHHHHHCEEEECCCCCCHHHHHHHHCCEEEEECCCC
GSSTRMQFDALLRHAGMTPQDVPGYENEVESQLAVAAAVLTGKADCGPGVAAAARAVGLD
CCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCC
FIPLAGERWDLAVPEAFREDPRVVSVESLLQKPEFKKRLEALGGYNTRLTGQKLELGVRL
EEECCCCCCCCCCCHHHCCCCCEEEHHHHHCCCHHHHHHHHHCCCCCEECCCEEEEEEEE
GA
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]