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The map label for this gene is dapA [H]

Identifier: 220905204

GI number: 220905204

Start: 2338080

End: 2338958

Strand: Direct

Name: dapA [H]

Synonym: Ddes_1942

Alternate gene names: 220905204

Gene position: 2338080-2338958 (Clockwise)

Preceding gene: 220905203

Following gene: 220905209

Centisome position: 81.37

GC content: 59.73

Gene sequence:

>879_bases
ATGCTGTTTTCAGGTGCACTGACAGCGCTAGTCACCCCGTTCAAGGATGAGGCCCTGGACGAGGAAGCCTACCGGAATTT
CATCGAATTCCAGATTACGGAAGGCATCCACGGCCTGGTACCCTGCGGCACCACCGGTGAATCCGCCACGCTCAGCCACG
AAGAGCACGAAAGGGTTATTGAAATCTGCATTGATCAGGCCAGGGGCCGCGTACCCGTGCTGGCCGGGGCCGGGTCCAAC
AACACGGCAGAGGCCGTGCGCCTGACCCGCTTTGCCCAGAAAGCCGGGGCAAACGGGGCCCTGCTTATCACCCCCTACTA
CAACAAACCCACGCAGGAAGGCCTGTATCGCCATTACAAGGCCATAGCCGAAGCCGTGGAAATGCCTCTTGTTCCCTACA
ATGTGCCTGGCCGCACGGGCTGCAACCTGCTGCCCGAAACCCTGGCCCGCCTGGCCAAAGAATTTTCACACATTGTAGGC
GTCAAGGAAGCTACCGGCGACATGGCCCAGGGCAGCAAAACCCTGTCGAGCTGTCCCGCGGGCTTCAGCGTGCTTTCCGG
CGACGACTTCACTGCCCTGCCGCTTATGGCGCTGGGCGGCAAAGGGGTCATCTCCGTTACGTCCAATATCGTGCCTGGCC
GCATGGCCGCCATGTGCAACGCCTTTAATAAGGGCGATGTGGCCGAAGCCGCGCGCATCCATCACGAACTTTTCCCCCTG
CATGAAGCCATGTTCTTTGAGAGCAATCCCATTCCGGCCAAAACGGCCCTGAGCCTTATGGGCAAAATGGAAGCCGGGTT
GCGCCTGCCGCTCTGCCCCATGAGCGCGGCAGCCAAAGAAAAACTCGCAGGTGTGCTGCGCGGATTACAGCTTATTTAA

Upstream 100 bases:

>100_bases
GCGGCCTTGCCGCCACCTGAGCCGAACCACGTGAAGGCCTGCCTTCAGTTCTCGGTGCTCGGCCATCCATGGGCGCGCAG
AGCGCGCCAAGGAGTTTGTC

Downstream 100 bases:

>100_bases
GGGATTGCAGGGTAAGCTTGCCTTTGAAGCTGCCCTGACGGCTGCGCAACAGACGCGCGCTACTATGGCGTAACGAAAAC
CGTTGCCCGAAGGACATGCT

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS [H]

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MLFSGALTALVTPFKDEALDEEAYRNFIEFQITEGIHGLVPCGTTGESATLSHEEHERVIEICIDQARGRVPVLAGAGSN
NTAEAVRLTRFAQKAGANGALLITPYYNKPTQEGLYRHYKAIAEAVEMPLVPYNVPGRTGCNLLPETLARLAKEFSHIVG
VKEATGDMAQGSKTLSSCPAGFSVLSGDDFTALPLMALGGKGVISVTSNIVPGRMAAMCNAFNKGDVAEAARIHHELFPL
HEAMFFESNPIPAKTALSLMGKMEAGLRLPLCPMSAAAKEKLAGVLRGLQLI

Sequences:

>Translated_292_residues
MLFSGALTALVTPFKDEALDEEAYRNFIEFQITEGIHGLVPCGTTGESATLSHEEHERVIEICIDQARGRVPVLAGAGSN
NTAEAVRLTRFAQKAGANGALLITPYYNKPTQEGLYRHYKAIAEAVEMPLVPYNVPGRTGCNLLPETLARLAKEFSHIVG
VKEATGDMAQGSKTLSSCPAGFSVLSGDDFTALPLMALGGKGVISVTSNIVPGRMAAMCNAFNKGDVAEAARIHHELFPL
HEAMFFESNPIPAKTALSLMGKMEAGLRLPLCPMSAAAKEKLAGVLRGLQLI
>Mature_292_residues
MLFSGALTALVTPFKDEALDEEAYRNFIEFQITEGIHGLVPCGTTGESATLSHEEHERVIEICIDQARGRVPVLAGAGSN
NTAEAVRLTRFAQKAGANGALLITPYYNKPTQEGLYRHYKAIAEAVEMPLVPYNVPGRTGCNLLPETLARLAKEFSHIVG
VKEATGDMAQGSKTLSSCPAGFSVLSGDDFTALPLMALGGKGVISVTSNIVPGRMAAMCNAFNKGDVAEAARIHHELFPL
HEAMFFESNPIPAKTALSLMGKMEAGLRLPLCPMSAAAKEKLAGVLRGLQLI

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI31543060, Length=254, Percent_Identity=25.9842519685039, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI13540533, Length=234, Percent_Identity=24.7863247863248, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1788823, Length=288, Percent_Identity=45.4861111111111, Blast_Score=268, Evalue=4e-73,
Organism=Escherichia coli, GI87082415, Length=287, Percent_Identity=34.8432055749129, Blast_Score=154, Evalue=7e-39,
Organism=Escherichia coli, GI1786463, Length=243, Percent_Identity=34.156378600823, Blast_Score=145, Evalue=4e-36,
Organism=Escherichia coli, GI1789620, Length=270, Percent_Identity=29.6296296296296, Blast_Score=119, Evalue=2e-28,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 31095; Mature: 31095

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00665 DHDPS_1 ; PS00666 DHDPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFSGALTALVTPFKDEALDEEAYRNFIEFQITEGIHGLVPCGTTGESATLSHEEHERVI
CCCCHHHHHHHCCCHHHHCCHHHHHHHHHEEECCCCCCCCCCCCCCCCCCCCHHHHHHHH
EICIDQARGRVPVLAGAGSNNTAEAVRLTRFAQKAGANGALLITPYYNKPTQEGLYRHYK
HHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHH
AIAEAVEMPLVPYNVPGRTGCNLLPETLARLAKEFSHIVGVKEATGDMAQGSKTLSSCPA
HHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHCCCHHHCCHHHHHCCC
GFSVLSGDDFTALPLMALGGKGVISVTSNIVPGRMAAMCNAFNKGDVAEAARIHHELFPL
CCEEECCCCCHHHHHHHCCCCCEEEECCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHH
HEAMFFESNPIPAKTALSLMGKMEAGLRLPLCPMSAAAKEKLAGVLRGLQLI
HHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLFSGALTALVTPFKDEALDEEAYRNFIEFQITEGIHGLVPCGTTGESATLSHEEHERVI
CCCCHHHHHHHCCCHHHHCCHHHHHHHHHEEECCCCCCCCCCCCCCCCCCCCHHHHHHHH
EICIDQARGRVPVLAGAGSNNTAEAVRLTRFAQKAGANGALLITPYYNKPTQEGLYRHYK
HHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHH
AIAEAVEMPLVPYNVPGRTGCNLLPETLARLAKEFSHIVGVKEATGDMAQGSKTLSSCPA
HHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHCCCHHHCCHHHHHCCC
GFSVLSGDDFTALPLMALGGKGVISVTSNIVPGRMAAMCNAFNKGDVAEAARIHHELFPL
CCEEECCCCCHHHHHHHCCCCCEEEECCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHH
HEAMFFESNPIPAKTALSLMGKMEAGLRLPLCPMSAAAKEKLAGVLRGLQLI
HHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA