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The map label for this gene is gpsA

Identifier: 220905141

GI number: 220905141

Start: 2265273

End: 2266271

Strand: Direct

Name: gpsA

Synonym: Ddes_1879

Alternate gene names: 220905141

Gene position: 2265273-2266271 (Clockwise)

Preceding gene: 220905140

Following gene: 220905142

Centisome position: 78.83

GC content: 63.46

Gene sequence:

>999_bases
ATGGCTGATAAAATATCCGTCTGTGTAGCCGGGGGCGGCAGTTGGGGCACGGCCCTCGGGCATCTGCTGGCCCGTGGTGG
ACACGATGTCAGCATATGGCTGCGCGATGATGCTGTGGCCCGGACCATCAACCGGAAACACGAAAATCCGCGCTACCTGC
CCGGCCTGCCGCTTGATCCTCGCCTCGCGGCCACAACAGACCCGGCCGTGCTCGCCCGGCCTCTGGTGGTGCTTGCTGTT
CCCTGCCAGCAGTTGCGCCCCTGGCTTGCCGGTCATGCCTGCCATTTTCAGCCGGGCGTAACCCTCGTCAATGCTGCCAA
AGGCATAGAAACAGGCTCTCTGGCAACCTGCGCCGAAATAACGGCTCAGGAACTGGGCGGCCTCAACCCGCGCTACGCGG
TTCTGTCCGGCCCGTCCTTTGCCGCTGACGTGCTGCGCGACCTGCCCACGGCCGTTGTGCTGGCTTCGTATGACGAAGCT
TTGGGCCGTTACCTGCGCGGCGTCTTTTCCGGCCCTGCCTTTCGCTGCTATTCCAGCACGGATGTGGTTGGAGTGGAAAT
GGGCGGCGCGCTCAAAAACGTCATGGCCATTGCGGCAGGCACATGCGACGGTCTGGGTCTTGGAGCCAACAGCCGCGCTG
CGCTCGTCACCCGCGGGCTGGCGGAAATGAGCCGCCTTGGTGTCGCGCGCGGCGCGCAAGCGCACACCTTTATGGGCCTT
TCCGGATTGGGAGACCTTACCCTGACCTGCACCGACGACCTTTCACGAAACCGCCAGGTGGGGCTGCGGCTTGGTCGGGG
AGAAAAGCTCGAGCATATCACGCAAAGCCTCGGCATGGTGGCCGAAGGCGTAAAAACCACTGCCGCCATCCATGAGATGG
CGCAAAAGCTCCAGGTGGAGGCCCCGCTGACCAGGGCTGTTTACGGCATCCTTTACAAGGAAATGGCCCCGCCCACCGTG
CTGAGCGACCTGATGGCCAGGGACCTGCGCGAAGAATAG

Upstream 100 bases:

>100_bases
CTGCTGCACCTCCGGGCGCTGCCCGGAAGGGGGGCTTTCCCGGGCAGCAAATCGGCATTTTTACGTTGAACTGCTTTATA
AAGACAAGTACAGGAAAAAC

Downstream 100 bases:

>100_bases
CCCCCACACCCAGCCCGCACTTCAGTTTCCTCCGGGTACACCCTGCGTGTTTTTGCAGGCGAAGCAGTCTGACGTTAAAA
TACATTCGACGGCTGCGCCA

Product: glycerol-3-phosphate dehydrogenase (NAD(P)(+))

Products: NA

Alternate protein names: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Number of amino acids: Translated: 332; Mature: 331

Protein sequence:

>332_residues
MADKISVCVAGGGSWGTALGHLLARGGHDVSIWLRDDAVARTINRKHENPRYLPGLPLDPRLAATTDPAVLARPLVVLAV
PCQQLRPWLAGHACHFQPGVTLVNAAKGIETGSLATCAEITAQELGGLNPRYAVLSGPSFAADVLRDLPTAVVLASYDEA
LGRYLRGVFSGPAFRCYSSTDVVGVEMGGALKNVMAIAAGTCDGLGLGANSRAALVTRGLAEMSRLGVARGAQAHTFMGL
SGLGDLTLTCTDDLSRNRQVGLRLGRGEKLEHITQSLGMVAEGVKTTAAIHEMAQKLQVEAPLTRAVYGILYKEMAPPTV
LSDLMARDLREE

Sequences:

>Translated_332_residues
MADKISVCVAGGGSWGTALGHLLARGGHDVSIWLRDDAVARTINRKHENPRYLPGLPLDPRLAATTDPAVLARPLVVLAV
PCQQLRPWLAGHACHFQPGVTLVNAAKGIETGSLATCAEITAQELGGLNPRYAVLSGPSFAADVLRDLPTAVVLASYDEA
LGRYLRGVFSGPAFRCYSSTDVVGVEMGGALKNVMAIAAGTCDGLGLGANSRAALVTRGLAEMSRLGVARGAQAHTFMGL
SGLGDLTLTCTDDLSRNRQVGLRLGRGEKLEHITQSLGMVAEGVKTTAAIHEMAQKLQVEAPLTRAVYGILYKEMAPPTV
LSDLMARDLREE
>Mature_331_residues
ADKISVCVAGGGSWGTALGHLLARGGHDVSIWLRDDAVARTINRKHENPRYLPGLPLDPRLAATTDPAVLARPLVVLAVP
CQQLRPWLAGHACHFQPGVTLVNAAKGIETGSLATCAEITAQELGGLNPRYAVLSGPSFAADVLRDLPTAVVLASYDEAL
GRYLRGVFSGPAFRCYSSTDVVGVEMGGALKNVMAIAAGTCDGLGLGANSRAALVTRGLAEMSRLGVARGAQAHTFMGLS
GLGDLTLTCTDDLSRNRQVGLRLGRGEKLEHITQSLGMVAEGVKTTAAIHEMAQKLQVEAPLTRAVYGILYKEMAPPTVL
SDLMARDLREE

Specific function: De novo phospholipid biosynthesis; glycerol-3 phosphate formation. [C]

COG id: COG0240

COG function: function code C; Glycerol-3-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family

Homologues:

Organism=Homo sapiens, GI33695088, Length=344, Percent_Identity=31.3953488372093, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI24307999, Length=349, Percent_Identity=29.2263610315186, Blast_Score=124, Evalue=9e-29,
Organism=Escherichia coli, GI1790037, Length=310, Percent_Identity=42.9032258064516, Blast_Score=238, Evalue=5e-64,
Organism=Caenorhabditis elegans, GI17507425, Length=342, Percent_Identity=30.1169590643275, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI32564399, Length=335, Percent_Identity=28.6567164179104, Blast_Score=111, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI193210136, Length=344, Percent_Identity=28.4883720930233, Blast_Score=111, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI32564403, Length=343, Percent_Identity=28.8629737609329, Blast_Score=110, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI193210134, Length=340, Percent_Identity=26.7647058823529, Blast_Score=92, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6324513, Length=345, Percent_Identity=28.695652173913, Blast_Score=117, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6320181, Length=363, Percent_Identity=27.8236914600551, Blast_Score=110, Evalue=4e-25,
Organism=Drosophila melanogaster, GI17136204, Length=346, Percent_Identity=28.0346820809249, Blast_Score=118, Evalue=5e-27,
Organism=Drosophila melanogaster, GI17136202, Length=346, Percent_Identity=28.0346820809249, Blast_Score=118, Evalue=5e-27,
Organism=Drosophila melanogaster, GI17136200, Length=346, Percent_Identity=28.0346820809249, Blast_Score=118, Evalue=5e-27,
Organism=Drosophila melanogaster, GI22026922, Length=335, Percent_Identity=27.1641791044776, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI45551945, Length=352, Percent_Identity=26.7045454545455, Blast_Score=91, Evalue=8e-19,
Organism=Drosophila melanogaster, GI281362270, Length=242, Percent_Identity=28.5123966942149, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24648969, Length=308, Percent_Identity=26.9480519480519, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GPDA_DESDA (B8J2B6)

Other databases:

- EMBL:   CP001358
- RefSeq:   YP_002480453.1
- ProteinModelPortal:   B8J2B6
- GeneID:   7285594
- GenomeReviews:   CP001358_GR
- KEGG:   dds:Ddes_1879
- HOGENOM:   HBG586392
- HAMAP:   MF_00394
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR006168
- InterPro:   IPR006109
- InterPro:   IPR011128
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR11728
- PIRSF:   PIRSF000114
- PRINTS:   PR00077

Pfam domain/function: PF07479 NAD_Gly3P_dh_C; PF01210 NAD_Gly3P_dh_N; SSF48179 6DGDH_C_like

EC number: =1.1.1.94

Molecular weight: Translated: 34942; Mature: 34811

Theoretical pI: Translated: 7.81; Mature: 7.81

Prosite motif: PS00957 NAD_G3PDH

Important sites: ACT_SITE 192-192 BINDING 107-107 BINDING 107-107 BINDING 141-141 BINDING 256-256 BINDING 282-282

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADKISVCVAGGGSWGTALGHLLARGGHDVSIWLRDDAVARTINRKHENPRYLPGLPLDP
CCCCEEEEEECCCCHHHHHHHHHHCCCCEEEEEEECHHHHHHHHHCCCCCCCCCCCCCCC
RLAATTDPAVLARPLVVLAVPCQQLRPWLAGHACHFQPGVTLVNAAKGIETGSLATCAEI
CCCCCCCHHHHHCCHHHEECCHHHHHHHHCCCCEECCCCCEEEHHHCCCCCCCCHHHHHH
TAQELGGLNPRYAVLSGPSFAADVLRDLPTAVVLASYDEALGRYLRGVFSGPAFRCYSST
HHHHHCCCCCCEEEEECCHHHHHHHHHCCHHEEHHHHHHHHHHHHHHHHCCCCEEEECCC
DVVGVEMGGALKNVMAIAAGTCDGLGLGANSRAALVTRGLAEMSRLGVARGAQAHTFMGL
CEEEEECCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHEEECC
SGLGDLTLTCTDDLSRNRQVGLRLGRGEKLEHITQSLGMVAEGVKTTAAIHEMAQKLQVE
CCCCCEEEEECCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
APLTRAVYGILYKEMAPPTVLSDLMARDLREE
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ADKISVCVAGGGSWGTALGHLLARGGHDVSIWLRDDAVARTINRKHENPRYLPGLPLDP
CCCEEEEEECCCCHHHHHHHHHHCCCCEEEEEEECHHHHHHHHHCCCCCCCCCCCCCCC
RLAATTDPAVLARPLVVLAVPCQQLRPWLAGHACHFQPGVTLVNAAKGIETGSLATCAEI
CCCCCCCHHHHHCCHHHEECCHHHHHHHHCCCCEECCCCCEEEHHHCCCCCCCCHHHHHH
TAQELGGLNPRYAVLSGPSFAADVLRDLPTAVVLASYDEALGRYLRGVFSGPAFRCYSST
HHHHHCCCCCCEEEEECCHHHHHHHHHCCHHEEHHHHHHHHHHHHHHHHCCCCEEEECCC
DVVGVEMGGALKNVMAIAAGTCDGLGLGANSRAALVTRGLAEMSRLGVARGAQAHTFMGL
CEEEEECCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHEEECC
SGLGDLTLTCTDDLSRNRQVGLRLGRGEKLEHITQSLGMVAEGVKTTAAIHEMAQKLQVE
CCCCCEEEEECCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
APLTRAVYGILYKEMAPPTVLSDLMARDLREE
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA