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The map label for this gene is mutM [H]

Identifier: 220905063

GI number: 220905063

Start: 2174868

End: 2175809

Strand: Reverse

Name: mutM [H]

Synonym: Ddes_1800

Alternate gene names: 220905063

Gene position: 2175809-2174868 (Counterclockwise)

Preceding gene: 220905064

Following gene: 220905047

Centisome position: 75.72

GC content: 61.25

Gene sequence:

>942_bases
ATGCCTGAGCTGCCGGAAGTGGAGACTGTTGCCCGCACCCTGCGGCCCCATGTGCAGGGTCGCATTATTGCTGACGCGCA
GGTTTTGCGCCCCACCAGCCAGCATCCCCTGAGCCTGCCCCTGCAGGACCTGCGGGGATGCCGCATCGCTGACGTAGTGC
GCCGGGGCAAACTGCTCTTGCTGCTGCTTGACCCAACCGAAGCGGAAAAAACGTGTGTACGCGGCATGCAAAACCTGTGT
CTGGCCGTGCACTTGCGCATGACGGGGCGCCTTATGACCTATGCGGCGAAAACGTCGCCAGGCACGCATACCCGCTGTAT
CCTTGATCTGAAAGCATTGCCCGCCACGGCTGGCGGGCAGGCCGCGGCGGAATGTGGGCCTGCCGGAGGAGCAGGCGTGC
CCGGGGCTGAAGACTGTTTGACGTCCGGCGAGCGTCGCCTGTTTTTTGACGACGTGCGCGCCTTCGGAACCATGCTGGCA
GGCACGCCGGAGATGTTTGCCCGCTGGCCTTTCTGGCGGGAGCTTGGCCCCGAGCCTCTGGATATTACGGAAGCGGCCTT
TGCCGCAAGCATTGCCGCAAAAAGGTCTGCCATCAAGGCTGTGCTGCTGGATCAGAAAATGCTGGCCGGGGTAGGCAATA
TCTATGCGGACGAAAGCCTGTTTGCCGCAGGCATTGACCCGCGCCGGAAAGGTTCTGAGCTGACGCGGCTTCAGGCCGAC
CGCCTTTTGCAATGCCTGCGGGATGTGCTTTTACTGTCCATCTCCCAGTGCGGCAGTTCCATTCGTGATTACAGGGATGC
CGACGGCAATGTGGGGGCCTTTCAGAATACCTTTGCCGTGTACGGGCGCGGCGGGCAAAAGTGCAAGACTTGCGGAAGCC
TTCTGGAAAAGGCCAAAGTGGCTGGCAGGAGTACAGTTTTTTGCCCGCAGTGTCAGCATTAG

Upstream 100 bases:

>100_bases
AAGCGGGTTTTTTACTTGCGAACCTTTGCTGCCCGGCCTTGCCATGCAGTAGGCGCGCCTTATAGTTAGTTCATGTTATT
TGCCCAATCAGAGGATGACC

Downstream 100 bases:

>100_bases
CCCCATGTGCGCTCGCGCCTTTACCCGGATTTTTCTGTTTCTGGCTGGCGCATTAATTATGGGGATATGTCATCTCAAGA
CAGCATGACATCCATTACGG

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM [H]

Number of amino acids: Translated: 313; Mature: 312

Protein sequence:

>313_residues
MPELPEVETVARTLRPHVQGRIIADAQVLRPTSQHPLSLPLQDLRGCRIADVVRRGKLLLLLLDPTEAEKTCVRGMQNLC
LAVHLRMTGRLMTYAAKTSPGTHTRCILDLKALPATAGGQAAAECGPAGGAGVPGAEDCLTSGERRLFFDDVRAFGTMLA
GTPEMFARWPFWRELGPEPLDITEAAFAASIAAKRSAIKAVLLDQKMLAGVGNIYADESLFAAGIDPRRKGSELTRLQAD
RLLQCLRDVLLLSISQCGSSIRDYRDADGNVGAFQNTFAVYGRGGQKCKTCGSLLEKAKVAGRSTVFCPQCQH

Sequences:

>Translated_313_residues
MPELPEVETVARTLRPHVQGRIIADAQVLRPTSQHPLSLPLQDLRGCRIADVVRRGKLLLLLLDPTEAEKTCVRGMQNLC
LAVHLRMTGRLMTYAAKTSPGTHTRCILDLKALPATAGGQAAAECGPAGGAGVPGAEDCLTSGERRLFFDDVRAFGTMLA
GTPEMFARWPFWRELGPEPLDITEAAFAASIAAKRSAIKAVLLDQKMLAGVGNIYADESLFAAGIDPRRKGSELTRLQAD
RLLQCLRDVLLLSISQCGSSIRDYRDADGNVGAFQNTFAVYGRGGQKCKTCGSLLEKAKVAGRSTVFCPQCQH
>Mature_312_residues
PELPEVETVARTLRPHVQGRIIADAQVLRPTSQHPLSLPLQDLRGCRIADVVRRGKLLLLLLDPTEAEKTCVRGMQNLCL
AVHLRMTGRLMTYAAKTSPGTHTRCILDLKALPATAGGQAAAECGPAGGAGVPGAEDCLTSGERRLFFDDVRAFGTMLAG
TPEMFARWPFWRELGPEPLDITEAAFAASIAAKRSAIKAVLLDQKMLAGVGNIYADESLFAAGIDPRRKGSELTRLQADR
LLQCLRDVLLLSISQCGSSIRDYRDADGNVGAFQNTFAVYGRGGQKCKTCGSLLEKAKVAGRSTVFCPQCQH

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger [H]

Homologues:

Organism=Escherichia coli, GI1790066, Length=314, Percent_Identity=34.0764331210191, Blast_Score=153, Evalue=1e-38,
Organism=Escherichia coli, GI1786932, Length=319, Percent_Identity=25.705329153605, Blast_Score=80, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663 [H]

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS [H]

EC number: =3.2.2.23; =4.2.99.18 [H]

Molecular weight: Translated: 33745; Mature: 33614

Theoretical pI: Translated: 8.56; Mature: 8.56

Prosite motif: PS51066 ZF_FPG_2 ; PS51068 FPG_CAT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
3.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVETVARTLRPHVQGRIIADAQVLRPTSQHPLSLPLQDLRGCRIADVVRRGKLLL
CCCCCHHHHHHHHHHHHHCCEEEECHHHHCCCCCCCCCCCHHHHCCCHHHHHHHCCCEEE
LLLDPTEAEKTCVRGMQNLCLAVHLRMTGRLMTYAAKTSPGTHTRCILDLKALPATAGGQ
EEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCEEEEEEEHHCCCCCCCC
AAAECGPAGGAGVPGAEDCLTSGERRLFFDDVRAFGTMLAGTPEMFARWPFWRELGPEPL
HHHHCCCCCCCCCCCHHHHHCCCCCEEHHHHHHHHHHHHCCCHHHHHCCCCHHHCCCCCC
DITEAAFAASIAAKRSAIKAVLLDQKMLAGVGNIYADESLFAAGIDPRRKGSELTRLQAD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCHHCCCCCCCCCCCHHHHHHHH
RLLQCLRDVLLLSISQCGSSIRDYRDADGNVGAFQNTFAVYGRGGQKCKTCGSLLEKAKV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCEEEECCCCCHHHHHHHHHHHHHH
AGRSTVFCPQCQH
CCCCCCCCCCCCC
>Mature Secondary Structure 
PELPEVETVARTLRPHVQGRIIADAQVLRPTSQHPLSLPLQDLRGCRIADVVRRGKLLL
CCCCHHHHHHHHHHHHHCCEEEECHHHHCCCCCCCCCCCHHHHCCCHHHHHHHCCCEEE
LLLDPTEAEKTCVRGMQNLCLAVHLRMTGRLMTYAAKTSPGTHTRCILDLKALPATAGGQ
EEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCEEEEEEEHHCCCCCCCC
AAAECGPAGGAGVPGAEDCLTSGERRLFFDDVRAFGTMLAGTPEMFARWPFWRELGPEPL
HHHHCCCCCCCCCCCHHHHHCCCCCEEHHHHHHHHHHHHCCCHHHHHCCCCHHHCCCCCC
DITEAAFAASIAAKRSAIKAVLLDQKMLAGVGNIYADESLFAAGIDPRRKGSELTRLQAD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCHHCCCCCCCCCCCHHHHHHHH
RLLQCLRDVLLLSISQCGSSIRDYRDADGNVGAFQNTFAVYGRGGQKCKTCGSLLEKAKV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCEEEECCCCCHHHHHHHHHHHHHH
AGRSTVFCPQCQH
CCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA