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The map label for this gene is modD [H]

Identifier: 220904990

GI number: 220904990

Start: 2089311

End: 2090183

Strand: Direct

Name: modD [H]

Synonym: Ddes_1726

Alternate gene names: 220904990

Gene position: 2089311-2090183 (Clockwise)

Preceding gene: 220904989

Following gene: 220904995

Centisome position: 72.71

GC content: 62.31

Gene sequence:

>873_bases
ATGCATATTTTCAAGTCAGCATCATGGATTGACAGCCTTTTGACCGACGACTGTCCCGGCCCGGACCTGACCGTGGAAAT
GCTGGGCATCGGCCCGCAAAGCGGCGCAATGCGTTTCAGCCCCCGCGAGGACGGCATCATCAGCGGCGTGGAAGAGGCGG
AGCAGCTCCTGACACGCTGCGGGCTTTCCGTCACACGCATGGCCGATAACGGAAACGTACTTCAGGCCGGTCAGGTCTTT
CTTGACGCCAGGGGACGCGCCGCCGCCCTGCATAAGGGCTGGAAAGCGGCTCAGGTTCTTATGGAATACATGTCGGGCAT
TGCCCGCCGCTGCGCTTTCATGCTGGAGCGCGCCCGCGCCGTGCGGCCCGGTGTACAGGTGGCCGTGACGCGCAAGACCT
TTCCCGGGGCCAAGGCCCTGTGCCTCGAAGCGGCCCTGAACGGCGGAGCCATCATACACCGGCAAAACCTTTCAGAGTCT
GTTTTGCTGTTTGCGCAGCACCTGCTGTTTTTTCCCGGCAGTGAAAACCTGTCCGCACTGGAAGCCCTCGCCCGTCAGAC
ACGGGACCTGCGCGCCCGCATGCCGGAAAAAAACATCGCCATCGAAGTGGACTGCCTCGATGACGCCCTGCTGGCGGCAG
GAGCCGGGCTGGACATCATCCAGTGCGAAAAGTTCTCCTGCCAGGATCTGGCGGCCACCGTCGGCGCGCTGAAATCCGCA
CGGCCCGACATTCTCATTCTGGCTGCAGGCGGCATCAACGGCGACAATGCGGCGGAATACGCCGCAACGGGCGTGGATGT
GCTTGTAACCAGTTGGCCTTACTGGGGCAGACCGGCAGACATACAGGTTGTCATGGAGGCTGATGCCCGGTAG

Upstream 100 bases:

>100_bases
AAGCTGCCCGCACCGGCAATGCGCTGCTGCCCCGGCAGAAGAAACACGCGGAGCAGCGACAGGGCAACGCCGGGTACGGC
ATAACAACAGGCGGTACTTC

Downstream 100 bases:

>100_bases
ACGAGGCGTCTTTACAGCGCCCCCAGGTAATTCCACTGCCGCGGACGGGGAGTTTTGCCGGCAGCACGGATGCCCCCGGT
CGCAGGTCAGGCAGGCGGGG

Product: modD protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MHIFKSASWIDSLLTDDCPGPDLTVEMLGIGPQSGAMRFSPREDGIISGVEEAEQLLTRCGLSVTRMADNGNVLQAGQVF
LDARGRAAALHKGWKAAQVLMEYMSGIARRCAFMLERARAVRPGVQVAVTRKTFPGAKALCLEAALNGGAIIHRQNLSES
VLLFAQHLLFFPGSENLSALEALARQTRDLRARMPEKNIAIEVDCLDDALLAAGAGLDIIQCEKFSCQDLAATVGALKSA
RPDILILAAGGINGDNAAEYAATGVDVLVTSWPYWGRPADIQVVMEADAR

Sequences:

>Translated_290_residues
MHIFKSASWIDSLLTDDCPGPDLTVEMLGIGPQSGAMRFSPREDGIISGVEEAEQLLTRCGLSVTRMADNGNVLQAGQVF
LDARGRAAALHKGWKAAQVLMEYMSGIARRCAFMLERARAVRPGVQVAVTRKTFPGAKALCLEAALNGGAIIHRQNLSES
VLLFAQHLLFFPGSENLSALEALARQTRDLRARMPEKNIAIEVDCLDDALLAAGAGLDIIQCEKFSCQDLAATVGALKSA
RPDILILAAGGINGDNAAEYAATGVDVLVTSWPYWGRPADIQVVMEADAR
>Mature_290_residues
MHIFKSASWIDSLLTDDCPGPDLTVEMLGIGPQSGAMRFSPREDGIISGVEEAEQLLTRCGLSVTRMADNGNVLQAGQVF
LDARGRAAALHKGWKAAQVLMEYMSGIARRCAFMLERARAVRPGVQVAVTRKTFPGAKALCLEAALNGGAIIHRQNLSES
VLLFAQHLLFFPGSENLSALEALARQTRDLRARMPEKNIAIEVDCLDDALLAAGAGLDIIQCEKFSCQDLAATVGALKSA
RPDILILAAGGINGDNAAEYAATGVDVLVTSWPYWGRPADIQVVMEADAR

Specific function: NAD biosynthesis; aspartate to NaMN; third (last) step. [C]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=264, Percent_Identity=30.6818181818182, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI1786299, Length=250, Percent_Identity=26.8, Blast_Score=70, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6321162, Length=280, Percent_Identity=26.7857142857143, Blast_Score=85, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006242
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: 2.4.2.-

Molecular weight: Translated: 31034; Mature: 31034

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHIFKSASWIDSLLTDDCPGPDLTVEMLGIGPQSGAMRFSPREDGIISGVEEAEQLLTRC
CCCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCEEECCCCCCCCCCHHHHHHHHHHC
GLSVTRMADNGNVLQAGQVFLDARGRAAALHKGWKAAQVLMEYMSGIARRCAFMLERARA
CCEEEEECCCCCEEEECCEEEECCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRPGVQVAVTRKTFPGAKALCLEAALNGGAIIHRQNLSESVLLFAQHLLFFPGSENLSAL
HCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCHHHH
EALARQTRDLRARMPEKNIAIEVDCLDDALLAAGAGLDIIQCEKFSCQDLAATVGALKSA
HHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHCC
RPDILILAAGGINGDNAAEYAATGVDVLVTSWPYWGRPADIQVVMEADAR
CCCEEEEEECCCCCCCCHHHHHCCCEEEEECCCCCCCCCCEEEEEECCCC
>Mature Secondary Structure
MHIFKSASWIDSLLTDDCPGPDLTVEMLGIGPQSGAMRFSPREDGIISGVEEAEQLLTRC
CCCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCEEECCCCCCCCCCHHHHHHHHHHC
GLSVTRMADNGNVLQAGQVFLDARGRAAALHKGWKAAQVLMEYMSGIARRCAFMLERARA
CCEEEEECCCCCEEEECCEEEECCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRPGVQVAVTRKTFPGAKALCLEAALNGGAIIHRQNLSESVLLFAQHLLFFPGSENLSAL
HCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCHHHH
EALARQTRDLRARMPEKNIAIEVDCLDDALLAAGAGLDIIQCEKFSCQDLAATVGALKSA
HHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHCC
RPDILILAAGGINGDNAAEYAATGVDVLVTSWPYWGRPADIQVVMEADAR
CCCEEEEEECCCCCCCCHHHHHCCCEEEEECCCCCCCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA