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The map label for this gene is yveA [H]

Identifier: 220904955

GI number: 220904955

Start: 2035856

End: 2037424

Strand: Direct

Name: yveA [H]

Synonym: Ddes_1691

Alternate gene names: 220904955

Gene position: 2035856-2037424 (Clockwise)

Preceding gene: 220904954

Following gene: 220904964

Centisome position: 70.85

GC content: 53.92

Gene sequence:

>1569_bases
ATGACAGAGCAAGGTAAATTCAAAAAGGAACTGAATACCACAGACCTGACCTTTGTGGCCCTGGGAGCCATCTTCGGGTC
CGGCTGGCTGTTCGGTGCAAGCTATGTGGCGCAATACGCGGGACCCGCGGGTATTATTTCGTGGGTCATTGGCGGTATCA
CAGTATTCTTTCTGGGCCTGGTCTATTGCGAGCTGGGGGCGGCTCTGCCAAAGGCCGGAGGCATTATACGCTTTCCTGTT
TTTTCCCATGGCGAACTTGTCGGTTATCTGCTTGCGTCACTGACCGTTATCGCCTTCTCAAGCCTTATTGCCATTGAAGT
GGTGGCCGCGCGCCAGTACGCCGCAGCGTGGCTGCCCTGGCTCACAGCCGATGCAACCGGCACCCCCACAATGGCCGGCT
GGATCGCGCAGCTTCTACTGACGGTACTCTTTTTTGTAATCAACTACAAAGGGGTAAAATCATTCGCCATTGCCAATAAC
ATCATCAGTCTTTTCAAGTTTATTGTCCCTGCCCTGGTCATGATTGTGCTGATGTATTATTTTCAACCGGAAAACCTGAC
CGCCCACGGCTTTGCCCCCTTCGGGAGCCACGGAGTGCAAATGGCGGTCACTGCGGGCGGTGTCATATTTGCCTATCTGG
GGCTTACCCCGGTTGTTTCTGTAGCCAGCGAAGTCAAAAACCCGCAACGCACCATTCCCATTGCCCTCTTGCTGTCCATT
GTGCTTTCCACAGTCATCTATATTGTTCTGCAACTGGTCTTTCTCGGCAGCATTCCTCCGGACATGCTCGCAGATGGATG
GGGAAGCATAGCCGCCAAGTTTTCTCTGCCATATCATGATATTGCCCTTCTCCTGGGCCTCGGCTGGCTTGGCATACTCG
TTGTGGCCGATGCGGTCATTTCACCCGCAGGAACAGGGAATATCTATATGGTTGCCACACCGCGCGTCATATATGCGTGG
TCGCGCAGCGGTACATTTTTCAACCGTTTTTCAGCAGTGGATAAAAAATCCGGCATTCCGCGCCCGGCGCTGTGGCTGAC
CCTTGGCCTCTCAATTTTCTGGACCATGCCCTTTCCTTCGTGGAAAGAGCTGATCAACGTGGTTTCTGGCGCCCTCTGCC
TGAGCTACGCCCTTGCACCCATTGCGTGCGGCGCCCTGCGCATCAATGCTCCTGACCTGCCGCGCCCCTTCAGGGTGCGC
GGTCTGAAAATCATATCGCCCCTGACCTTCATCATCGCTTCACTCATTGTATACTGGTCTGGATGGAGCGTTATCTGCTG
GCTGTATCCTATCGAAATAGTGCTTTTTTTCTGCTACATCCTTGCCGGAAAAAAAGTACCCTCCGAGCACGTGAGCCTGC
AGCAGCAAATCCGTTCAGCGCTTTGGCTTGTGGGCTACTATGTCCTCACTCTTATCATCTCATATCTTGGTTCATTCGGC
GGCAAGGGCGTTCTCACCTCACCATGGGATGTCATCGCCATGGCAGTTGTATCTCTGGTCTGCTACTACTGGGCCATGAA
AACCTGCCTGCCTACGGCCAACATCACAGAAGCCCCTGACGCCGACTAG

Upstream 100 bases:

>100_bases
ACAGCATGTTGCACAAGTGTGTAGCCCGGAAACATGAAGCCTTTTCCAAGGCGGACATGCTCCGGCTTCAGGCCCTCTAC
GCTTTCAGGAGGAGAATCTC

Downstream 100 bases:

>100_bases
GCTGCGTCCCCATACACTCCCCCTAAACCGTATGTGCCGGTGTTGCAGAGCACCGGCACATACCTATGAATCCCAATTCT
ATTGGCAGGCGCTGACTCCA

Product: amino acid permease-associated protein

Products: Proton [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: L-aspartate transporter [H]

Number of amino acids: Translated: 522; Mature: 521

Protein sequence:

>522_residues
MTEQGKFKKELNTTDLTFVALGAIFGSGWLFGASYVAQYAGPAGIISWVIGGITVFFLGLVYCELGAALPKAGGIIRFPV
FSHGELVGYLLASLTVIAFSSLIAIEVVAARQYAAAWLPWLTADATGTPTMAGWIAQLLLTVLFFVINYKGVKSFAIANN
IISLFKFIVPALVMIVLMYYFQPENLTAHGFAPFGSHGVQMAVTAGGVIFAYLGLTPVVSVASEVKNPQRTIPIALLLSI
VLSTVIYIVLQLVFLGSIPPDMLADGWGSIAAKFSLPYHDIALLLGLGWLGILVVADAVISPAGTGNIYMVATPRVIYAW
SRSGTFFNRFSAVDKKSGIPRPALWLTLGLSIFWTMPFPSWKELINVVSGALCLSYALAPIACGALRINAPDLPRPFRVR
GLKIISPLTFIIASLIVYWSGWSVICWLYPIEIVLFFCYILAGKKVPSEHVSLQQQIRSALWLVGYYVLTLIISYLGSFG
GKGVLTSPWDVIAMAVVSLVCYYWAMKTCLPTANITEAPDAD

Sequences:

>Translated_522_residues
MTEQGKFKKELNTTDLTFVALGAIFGSGWLFGASYVAQYAGPAGIISWVIGGITVFFLGLVYCELGAALPKAGGIIRFPV
FSHGELVGYLLASLTVIAFSSLIAIEVVAARQYAAAWLPWLTADATGTPTMAGWIAQLLLTVLFFVINYKGVKSFAIANN
IISLFKFIVPALVMIVLMYYFQPENLTAHGFAPFGSHGVQMAVTAGGVIFAYLGLTPVVSVASEVKNPQRTIPIALLLSI
VLSTVIYIVLQLVFLGSIPPDMLADGWGSIAAKFSLPYHDIALLLGLGWLGILVVADAVISPAGTGNIYMVATPRVIYAW
SRSGTFFNRFSAVDKKSGIPRPALWLTLGLSIFWTMPFPSWKELINVVSGALCLSYALAPIACGALRINAPDLPRPFRVR
GLKIISPLTFIIASLIVYWSGWSVICWLYPIEIVLFFCYILAGKKVPSEHVSLQQQIRSALWLVGYYVLTLIISYLGSFG
GKGVLTSPWDVIAMAVVSLVCYYWAMKTCLPTANITEAPDAD
>Mature_521_residues
TEQGKFKKELNTTDLTFVALGAIFGSGWLFGASYVAQYAGPAGIISWVIGGITVFFLGLVYCELGAALPKAGGIIRFPVF
SHGELVGYLLASLTVIAFSSLIAIEVVAARQYAAAWLPWLTADATGTPTMAGWIAQLLLTVLFFVINYKGVKSFAIANNI
ISLFKFIVPALVMIVLMYYFQPENLTAHGFAPFGSHGVQMAVTAGGVIFAYLGLTPVVSVASEVKNPQRTIPIALLLSIV
LSTVIYIVLQLVFLGSIPPDMLADGWGSIAAKFSLPYHDIALLLGLGWLGILVVADAVISPAGTGNIYMVATPRVIYAWS
RSGTFFNRFSAVDKKSGIPRPALWLTLGLSIFWTMPFPSWKELINVVSGALCLSYALAPIACGALRINAPDLPRPFRVRG
LKIISPLTFIIASLIVYWSGWSVICWLYPIEIVLFFCYILAGKKVPSEHVSLQQQIRSALWLVGYYVLTLIISYLGSFGG
KGVLTSPWDVIAMAVVSLVCYYWAMKTCLPTANITEAPDAD

Specific function: Uptake of L-aspartate with the concomitant import of a proton. Can also transport aspartate hydroxamate and L-glutamate with lower affinity and efficiency [H]

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. AGT (TC 2.A.3.11) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=358, Percent_Identity=25.6983240223464, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI181337167, Length=400, Percent_Identity=24, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI186910308, Length=421, Percent_Identity=23.9904988123515, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI186910306, Length=421, Percent_Identity=23.9904988123515, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI186910304, Length=421, Percent_Identity=23.9904988123515, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI33286428, Length=433, Percent_Identity=24.9422632794457, Blast_Score=73, Evalue=7e-13,
Organism=Homo sapiens, GI258614003, Length=428, Percent_Identity=23.3644859813084, Blast_Score=73, Evalue=8e-13,
Organism=Homo sapiens, GI258614005, Length=428, Percent_Identity=23.3644859813084, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI187423910, Length=413, Percent_Identity=24.6973365617433, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI7657591, Length=413, Percent_Identity=24.6973365617433, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI258645169, Length=385, Percent_Identity=23.1168831168831, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI115648063, Length=422, Percent_Identity=22.5118483412322, Blast_Score=66, Evalue=7e-11,
Organism=Homo sapiens, GI115648022, Length=422, Percent_Identity=22.5118483412322, Blast_Score=66, Evalue=7e-11,
Organism=Escherichia coli, GI1788480, Length=362, Percent_Identity=27.6243093922652, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1790653, Length=352, Percent_Identity=23.5795454545455, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI87081708, Length=361, Percent_Identity=23.5457063711911, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87082250, Length=364, Percent_Identity=26.3736263736264, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1786302, Length=405, Percent_Identity=23.7037037037037, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1786602, Length=361, Percent_Identity=24.6537396121884, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17540018, Length=409, Percent_Identity=25.9168704156479, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17532491, Length=366, Percent_Identity=23.7704918032787, Blast_Score=82, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17533459, Length=418, Percent_Identity=22.9665071770335, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17531343, Length=362, Percent_Identity=24.8618784530387, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17568033, Length=406, Percent_Identity=25.1231527093596, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71993915, Length=364, Percent_Identity=23.6263736263736, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24667468, Length=350, Percent_Identity=25.4285714285714, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI221512776, Length=429, Percent_Identity=23.7762237762238, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24666159, Length=429, Percent_Identity=23.7762237762238, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI45550968, Length=426, Percent_Identity=24.6478873239437, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI19921172, Length=426, Percent_Identity=24.6478873239437, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21357367, Length=356, Percent_Identity=26.4044943820225, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24651635, Length=416, Percent_Identity=23.7980769230769, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24651633, Length=416, Percent_Identity=23.7980769230769, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI161077963, Length=353, Percent_Identity=26.0623229461756, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI221331183, Length=349, Percent_Identity=25.5014326647564, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17647653, Length=349, Percent_Identity=25.5014326647564, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24664379, Length=349, Percent_Identity=25.5014326647564, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 56456; Mature: 56324

Theoretical pI: Translated: 8.88; Mature: 8.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEQGKFKKELNTTDLTFVALGAIFGSGWLFGASYVAQYAGPAGIISWVIGGITVFFLGL
CCCCCCHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
VYCELGAALPKAGGIIRFPVFSHGELVGYLLASLTVIAFSSLIAIEVVAARQYAAAWLPW
HHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTADATGTPTMAGWIAQLLLTVLFFVINYKGVKSFAIANNIISLFKFIVPALVMIVLMYY
HCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FQPENLTAHGFAPFGSHGVQMAVTAGGVIFAYLGLTPVVSVASEVKNPQRTIPIALLLSI
HCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
VLSTVIYIVLQLVFLGSIPPDMLADGWGSIAAKFSLPYHDIALLLGLGWLGILVVADAVI
HHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHH
SPAGTGNIYMVATPRVIYAWSRSGTFFNRFSAVDKKSGIPRPALWLTLGLSIFWTMPFPS
CCCCCCCEEEEECCEEEEEECCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHEEECCCCC
WKELINVVSGALCLSYALAPIACGALRINAPDLPRPFRVRGLKIISPLTFIIASLIVYWS
HHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHC
GWSVICWLYPIEIVLFFCYILAGKKVPSEHVSLQQQIRSALWLVGYYVLTLIISYLGSFG
CHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GKGVLTSPWDVIAMAVVSLVCYYWAMKTCLPTANITEAPDAD
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
TEQGKFKKELNTTDLTFVALGAIFGSGWLFGASYVAQYAGPAGIISWVIGGITVFFLGL
CCCCCHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
VYCELGAALPKAGGIIRFPVFSHGELVGYLLASLTVIAFSSLIAIEVVAARQYAAAWLPW
HHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTADATGTPTMAGWIAQLLLTVLFFVINYKGVKSFAIANNIISLFKFIVPALVMIVLMYY
HCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FQPENLTAHGFAPFGSHGVQMAVTAGGVIFAYLGLTPVVSVASEVKNPQRTIPIALLLSI
HCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
VLSTVIYIVLQLVFLGSIPPDMLADGWGSIAAKFSLPYHDIALLLGLGWLGILVVADAVI
HHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHH
SPAGTGNIYMVATPRVIYAWSRSGTFFNRFSAVDKKSGIPRPALWLTLGLSIFWTMPFPS
CCCCCCCEEEEECCEEEEEECCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHEEECCCCC
WKELINVVSGALCLSYALAPIACGALRINAPDLPRPFRVRGLKIISPLTFIIASLIVYWS
HHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHC
GWSVICWLYPIEIVLFFCYILAGKKVPSEHVSLQQQIRSALWLVGYYVLTLIISYLGSFG
CHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GKGVLTSPWDVIAMAVVSLVCYYWAMKTCLPTANITEAPDAD
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-lysine [Periplasm] = Proton [Cytoplasm] + L-lysine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 12730183 [H]