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The map label for this gene is namA [H]

Identifier: 220904914

GI number: 220904914

Start: 1983925

End: 1985022

Strand: Direct

Name: namA [H]

Synonym: Ddes_1649

Alternate gene names: 220904914

Gene position: 1983925-1985022 (Clockwise)

Preceding gene: 220904913

Following gene: 220904915

Centisome position: 69.04

GC content: 60.75

Gene sequence:

>1098_bases
ATGAACACGCTTTTTTCTCCCATCAAGCTTGGCGGGCTGGAGCTTGCTAACCGCATTGTCATCCCCCCCATGGACCAGTA
TTCGGCTGATGAGGGGCGTCCAACCCAATGGCATCACATGCATTACGGCCACCTGGCTGTTTCCGGCGCGGGGCTGCTCA
TTGTTGAGGCCACCGCCGTGGAACCTGCCGGCAGAATATCTCCGGGCGACCTCGGCCTGTGGAATGACGAACACGAAAAC
CTGCATAAAGGCATGCTGGAATTCATAGCCGCTTTTTCTTCCATACCCACGGCTGTCCAGCTGGGACACTCCGGGCGCAA
AGGATCCACGGCCCGCCCTTGGGAAGGGCGTGGTCCCCTGGGCCTGCATGAGGGCGGTTGGGATGTCTGCGCGCCTTCTG
CCCTTCCCTTTGACGCCGCCTCTCCCGTTCCCTCAGCCTTGAGCACCGCAGACATTGACCGCCTGACCGCTTCTTTTGTA
ACAGCGGCACAACGGGCACAACGCGCGGGCTACAAGGCTGTGGAACTGCATGCGGCCCACGGCTACCTGCTGCACGAATT
TCTCTCGCCCCTGTCCAATAAAAGAGAAGACGAATACGGCGGCAGCCTCGAAAACAGAATGCGTTTTCCCTTGCAGGTGT
TTGCGGCGGTGCGCAAAGCCCTGCCCTCTGTCATACCGGTGGGAATGCGTGTTTCAGGTACAGACTTCACCCCGGGTGGC
TGGGATGTGCAAGAATGCGCAGTGCTGGCGCAACGGCTCGAAAAGGCCGGTGGCGCCTTTATCCACGTTTCCGGCGGTGG
GCTGACCCCCGAGCAGAAAATACGCCTTGCCCCCGGCTATCAGGTGCATCTGGCCCAGGCGGTCAAGCAGGCTGTTGACA
GCATGCCCGTCATAGCTGTGGGCCTTATCACGGAGCCGGAGCTGGCAGCGGGCATTATCGTTACCGGACAAGCCGATATG
GTGGCCGTGGGACGCGGCATGATGTATGACCCGCGCTGGCCCTGGCATGCCGCAGCCGCCCTGGGTGTCTCCATTGCCGG
AACTCCCCGGCAATACCTGCGTTGCCAGCCCCACAGGCTGAAAAACCTCTTTATCTGA

Upstream 100 bases:

>100_bases
CATCCGGCTCGGGATGCGCCATACCAATTTTCTGTCGAAGACCTCACCAGCACGGCAGACATAAAATACAGGCCTTGAGG
CTGCAAAGGCAGGAGGCTGC

Downstream 100 bases:

>100_bases
TGCGCTGAATACCTGAATACTTGAAATACGGCTTCCGGCAGGCAACGTCCGCCTGTGCCTGTTTCACGCAGGGTTTGAGA
ACAACTGCCTGTGGGTACTT

Product: NADH:flavin oxidoreductase/NADH oxidase

Products: NA

Alternate protein names: Xenobiotic reductase [H]

Number of amino acids: Translated: 365; Mature: 365

Protein sequence:

>365_residues
MNTLFSPIKLGGLELANRIVIPPMDQYSADEGRPTQWHHMHYGHLAVSGAGLLIVEATAVEPAGRISPGDLGLWNDEHEN
LHKGMLEFIAAFSSIPTAVQLGHSGRKGSTARPWEGRGPLGLHEGGWDVCAPSALPFDAASPVPSALSTADIDRLTASFV
TAAQRAQRAGYKAVELHAAHGYLLHEFLSPLSNKREDEYGGSLENRMRFPLQVFAAVRKALPSVIPVGMRVSGTDFTPGG
WDVQECAVLAQRLEKAGGAFIHVSGGGLTPEQKIRLAPGYQVHLAQAVKQAVDSMPVIAVGLITEPELAAGIIVTGQADM
VAVGRGMMYDPRWPWHAAAALGVSIAGTPRQYLRCQPHRLKNLFI

Sequences:

>Translated_365_residues
MNTLFSPIKLGGLELANRIVIPPMDQYSADEGRPTQWHHMHYGHLAVSGAGLLIVEATAVEPAGRISPGDLGLWNDEHEN
LHKGMLEFIAAFSSIPTAVQLGHSGRKGSTARPWEGRGPLGLHEGGWDVCAPSALPFDAASPVPSALSTADIDRLTASFV
TAAQRAQRAGYKAVELHAAHGYLLHEFLSPLSNKREDEYGGSLENRMRFPLQVFAAVRKALPSVIPVGMRVSGTDFTPGG
WDVQECAVLAQRLEKAGGAFIHVSGGGLTPEQKIRLAPGYQVHLAQAVKQAVDSMPVIAVGLITEPELAAGIIVTGQADM
VAVGRGMMYDPRWPWHAAAALGVSIAGTPRQYLRCQPHRLKNLFI
>Mature_365_residues
MNTLFSPIKLGGLELANRIVIPPMDQYSADEGRPTQWHHMHYGHLAVSGAGLLIVEATAVEPAGRISPGDLGLWNDEHEN
LHKGMLEFIAAFSSIPTAVQLGHSGRKGSTARPWEGRGPLGLHEGGWDVCAPSALPFDAASPVPSALSTADIDRLTASFV
TAAQRAQRAGYKAVELHAAHGYLLHEFLSPLSNKREDEYGGSLENRMRFPLQVFAAVRKALPSVIPVGMRVSGTDFTPGG
WDVQECAVLAQRLEKAGGAFIHVSGGGLTPEQKIRLAPGYQVHLAQAVKQAVDSMPVIAVGLITEPELAAGIIVTGQADM
VAVGRGMMYDPRWPWHAAAALGVSIAGTPRQYLRCQPHRLKNLFI

Specific function: Catalyzes the reduction of the double bond of an array of alpha, beta-unsaturated aldehydes and ketones. It also reduces the nitro group of nitroester and nitroaromatic compounds. It could have a role in detoxification processes [H]

COG id: COG1902

COG function: function code C; NADH:flavin oxidoreductases, Old Yellow Enzyme family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NADH:flavin oxidoreductase/NADH oxidase family. NamA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789463, Length=333, Percent_Identity=29.1291291291291, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1787939, Length=354, Percent_Identity=31.9209039548023, Blast_Score=113, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17559802, Length=320, Percent_Identity=28.75, Blast_Score=111, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI72001454, Length=318, Percent_Identity=24.8427672955975, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17564188, Length=347, Percent_Identity=24.207492795389, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17540738, Length=270, Percent_Identity=27.4074074074074, Blast_Score=105, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17559804, Length=350, Percent_Identity=23.1428571428571, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17565138, Length=200, Percent_Identity=29, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17566914, Length=279, Percent_Identity=27.2401433691756, Blast_Score=91, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6325086, Length=256, Percent_Identity=31.25, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6321973, Length=295, Percent_Identity=30.5084745762712, Blast_Score=99, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR001155 [H]

Pfam domain/function: PF00724 Oxidored_FMN [H]

EC number: =1.6.99.1 [H]

Molecular weight: Translated: 39110; Mature: 39110

Theoretical pI: Translated: 7.26; Mature: 7.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTLFSPIKLGGLELANRIVIPPMDQYSADEGRPTQWHHMHYGHLAVSGAGLLIVEATAV
CCCCCCCHHHCCHHHHCEEECCCCCCCCCCCCCCCCEEEEECCEEEECCCCEEEEEEEEC
EPAGRISPGDLGLWNDEHENLHKGMLEFIAAFSSIPTAVQLGHSGRKGSTARPWEGRGPL
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHEEECCCCCCCCCCCCCCCCCCC
GLHEGGWDVCAPSALPFDAASPVPSALSTADIDRLTASFVTAAQRAQRAGYKAVELHAAH
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECHH
GYLLHEFLSPLSNKREDEYGGSLENRMRFPLQVFAAVRKALPSVIPVGMRVSGTDFTPGG
HHHHHHHHHHHHCCCCHHCCCCHHHHHCCHHHHHHHHHHHHHHHCCCCEEECCCCCCCCC
WDVQECAVLAQRLEKAGGAFIHVSGGGLTPEQKIRLAPGYQVHLAQAVKQAVDSMPVIAV
CCHHHHHHHHHHHHHCCCEEEEEECCCCCHHHCEEECCCCCHHHHHHHHHHHHCCCEEEE
GLITEPELAAGIIVTGQADMVAVGRGMMYDPRWPWHAAAALGVSIAGTPRQYLRCQPHRL
EEECCCCHHCCEEEECCCCEEEECCCCEECCCCCHHHHHHHCEEECCCCHHHHCCCCHHH
KNLFI
HHCCC
>Mature Secondary Structure
MNTLFSPIKLGGLELANRIVIPPMDQYSADEGRPTQWHHMHYGHLAVSGAGLLIVEATAV
CCCCCCCHHHCCHHHHCEEECCCCCCCCCCCCCCCCEEEEECCEEEECCCCEEEEEEEEC
EPAGRISPGDLGLWNDEHENLHKGMLEFIAAFSSIPTAVQLGHSGRKGSTARPWEGRGPL
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHEEECCCCCCCCCCCCCCCCCCC
GLHEGGWDVCAPSALPFDAASPVPSALSTADIDRLTASFVTAAQRAQRAGYKAVELHAAH
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECHH
GYLLHEFLSPLSNKREDEYGGSLENRMRFPLQVFAAVRKALPSVIPVGMRVSGTDFTPGG
HHHHHHHHHHHHCCCCHHCCCCHHHHHCCHHHHHHHHHHHHHHHCCCCEEECCCCCCCCC
WDVQECAVLAQRLEKAGGAFIHVSGGGLTPEQKIRLAPGYQVHLAQAVKQAVDSMPVIAV
CCHHHHHHHHHHHHHCCCEEEEEECCCCCHHHCEEECCCCCHHHHHHHHHHHHCCCEEEE
GLITEPELAAGIIVTGQADMVAVGRGMMYDPRWPWHAAAALGVSIAGTPRQYLRCQPHRL
EEECCCCHHCCEEEECCCCEEEECCCCEECCCCCHHHHHHHCEEECCCCHHHHCCCCHHH
KNLFI
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA