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The map label for this gene is penA [H]

Identifier: 220904378

GI number: 220904378

Start: 1297640

End: 1299772

Strand: Direct

Name: penA [H]

Synonym: Ddes_1107

Alternate gene names: 220904378

Gene position: 1297640-1299772 (Clockwise)

Preceding gene: 220904377

Following gene: 220904379

Centisome position: 45.16

GC content: 56.92

Gene sequence:

>2133_bases
ATGTTCAAATTCAATTCGCGCAAGGCCAACAGGCATACCGATGCCCCCAGGGCCGAAAAGAAATCACGCGTTTCCAATCG
CATGAAGACTCCGGCCCCCGAAGGCAAATCGCGCTTTGCATGGGCGGGGCAGATCGATTGGGGCCGTGTGCGCATCAAGA
TGGTTGTTGTTGTTTTTTGTCTGCTGTGGGCAGGCCTGTGGGGCCGTGCATGGTATCTGCAGATGATTGAAGGCCCGCGC
CTGGCCGAGCGCGCACGGCGGCAGCATATGGCCTCGGAGCTGGTGACAGGCCGCCGCGGCATGATTTTTGACCGTAACGG
ACAGGTGCTGGCCCGGAGTATTGAGGCCCGTTCCATTTACGCCCGGCCGCAGGAAATTGAAGACTTTCAGACCATGGCCA
ATACTCTTGGCCCTATTCTGGGTATAGAGCCACAGAAGCTCTACAATGATCTTTCCCAGACGAAACGCCGGTTTGTCTGG
ATAAAACGCAAGGTTGACGATTTTACCGCCGAAGCGGTGCGCAAGACCAATCTGGCCGGCATCGGCCTTTCCAAGGAATA
TGACCGCGTTTATCCCTTCAAGCACATGGCTGGTCAGGTGCTTGGTTTTGTGGGGTTGGATGACAAAGGGCTTGAGGGCA
TCGAGCGCTCGATGGAAGCGCGCCTGGGCTGCATCCCTACCCGCCAGATAGTGCAGCGAGATGCCATGGGCCGCCGTTTT
TATCTGCATGAAGAAGGGCAGAGCGAACCGCGTGGTCAGGATCTCACATTGACCATCGATGTGCAGATGCAGTTTATCGT
GGAAGAAGCCGTGTCACGCGCCGTGCGCGATTATGACGCCCGTTGGGGCGGGGCGCTGGTAGTGGATGTGCCTTCGGGAG
AAATTGTGGCCTGGGCGCAATATCCTTTTTTCAATCCCAATACTTATAAAGACACAAGTCCTCTCGTGTATCGCAACCGT
CTGGCGGCTGATGCCCTGGAGCCTGGTTCTACCTTCAAGCCTTTTGTTATGGCCGCCGCCATTCAGGAAAAAAAAATCAG
CACCAGTACCGCCATTGATTGTGAAAGCGGCAGGTGGGTGGCTAAAAATTTTACTATTCGTGACACTTCACGGCAGGGGG
TGCTGCCCGCCAACAAGGTGCTGCGCTACTCTTCCAACATCGGCATGGCCAAGATCGGCCTGATGATGGGCGCACCTACG
TTTTACAAGTATTTGCACGCGCTTGGCTTCGGACAGCGTACCAATGTGCCGGTGGCCGACAGCAAGGGCATTTTGCGCAT
CCCCCGTGACTGGAGTGAGGTGGATATCATGTCCACGGCATTCGGGCAGAGTATTTCCGTCACGGGGCTGCAAATGGCCC
AGGCGTATCTGACGCTGCTTAACAACGGCGTCTACAAACCGCTGCGCCTCACTCGTGAAGACAATAATGTTGAGGAAGTA
CCCCAACGTATATTCTCGCAAACCACCGTGCGCGATGTCATGCGCATGATGCGTGATGTGGTTGAAGAAAGCGACGGCAC
AGGCAAGCGCGCCCGCATTGACGGCATTGAAGTGGCTGGCAAAACCGGCACCGCACAGAAGGCCGACCATCGTGCAGGCA
CCTATGGCAGCAAAAGATTGGCGTCTTTTGTGGGATTTTTTCCGGCAGACAAGCCGCGTTACCTCATCCTGGTCATGGTG
GACGAACCCACACGCAATCAGTACGGCGGCGTGGTTGCGGCCCCGGTCTTCAAGGAAATAGCCAGCCGCACACTGACATT
TACGGGCATTGTTCCGGATACCAAGGTGGCGACAGGAACCGAAAGTCCTGCTGCTCCCGCTGCGGGGCGCAGGCGCGGCC
TGAAGTTGGCTGGCCTGGATGTGCCCTATGTCAACGAAGTTCAAAAAACTGCTGCCCAGGGGCAGGATGCGGGTATGCGT
CTGCCGGGGCATCTGGCAAAGGCGGGCAGCCGCGTGCCTGATGTGATGGGGAAATCCGTGCGCAATGCGGTAGAACTTTT
TGCCCGGGCGGGCGTTGTGCCGGAACTCAAGGGATCCGGCAGTCGCGTGATCAAGCAGACTCCGGCTCCGGGGGCGGCAT
GGCCCGAAGAAGATAACAAGACAGAATATATCCTCTGGCTCTCGGAACGTTAA

Upstream 100 bases:

>100_bases
CGTCGCGCCAGTTTATTCCGGATATGCGGCAAGCCGGAGGCGGCAACATAAATACTATCAGTAAAAAACCGGACCAACCC
GGAAGTCATCGAGACACGCC

Downstream 100 bases:

>100_bases
GGTTGAATGTTGCCGGTCACTGTTGTCGCGTTTGTCTGGAGCCGGCCCGGTAGCGGCGAGACGAGAAGGGGCGGCAGGGG
GCGGAGAGTTTCCCGGTGAG

Product: peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 710; Mature: 710

Protein sequence:

>710_residues
MFKFNSRKANRHTDAPRAEKKSRVSNRMKTPAPEGKSRFAWAGQIDWGRVRIKMVVVVFCLLWAGLWGRAWYLQMIEGPR
LAERARRQHMASELVTGRRGMIFDRNGQVLARSIEARSIYARPQEIEDFQTMANTLGPILGIEPQKLYNDLSQTKRRFVW
IKRKVDDFTAEAVRKTNLAGIGLSKEYDRVYPFKHMAGQVLGFVGLDDKGLEGIERSMEARLGCIPTRQIVQRDAMGRRF
YLHEEGQSEPRGQDLTLTIDVQMQFIVEEAVSRAVRDYDARWGGALVVDVPSGEIVAWAQYPFFNPNTYKDTSPLVYRNR
LAADALEPGSTFKPFVMAAAIQEKKISTSTAIDCESGRWVAKNFTIRDTSRQGVLPANKVLRYSSNIGMAKIGLMMGAPT
FYKYLHALGFGQRTNVPVADSKGILRIPRDWSEVDIMSTAFGQSISVTGLQMAQAYLTLLNNGVYKPLRLTREDNNVEEV
PQRIFSQTTVRDVMRMMRDVVEESDGTGKRARIDGIEVAGKTGTAQKADHRAGTYGSKRLASFVGFFPADKPRYLILVMV
DEPTRNQYGGVVAAPVFKEIASRTLTFTGIVPDTKVATGTESPAAPAAGRRRGLKLAGLDVPYVNEVQKTAAQGQDAGMR
LPGHLAKAGSRVPDVMGKSVRNAVELFARAGVVPELKGSGSRVIKQTPAPGAAWPEEDNKTEYILWLSER

Sequences:

>Translated_710_residues
MFKFNSRKANRHTDAPRAEKKSRVSNRMKTPAPEGKSRFAWAGQIDWGRVRIKMVVVVFCLLWAGLWGRAWYLQMIEGPR
LAERARRQHMASELVTGRRGMIFDRNGQVLARSIEARSIYARPQEIEDFQTMANTLGPILGIEPQKLYNDLSQTKRRFVW
IKRKVDDFTAEAVRKTNLAGIGLSKEYDRVYPFKHMAGQVLGFVGLDDKGLEGIERSMEARLGCIPTRQIVQRDAMGRRF
YLHEEGQSEPRGQDLTLTIDVQMQFIVEEAVSRAVRDYDARWGGALVVDVPSGEIVAWAQYPFFNPNTYKDTSPLVYRNR
LAADALEPGSTFKPFVMAAAIQEKKISTSTAIDCESGRWVAKNFTIRDTSRQGVLPANKVLRYSSNIGMAKIGLMMGAPT
FYKYLHALGFGQRTNVPVADSKGILRIPRDWSEVDIMSTAFGQSISVTGLQMAQAYLTLLNNGVYKPLRLTREDNNVEEV
PQRIFSQTTVRDVMRMMRDVVEESDGTGKRARIDGIEVAGKTGTAQKADHRAGTYGSKRLASFVGFFPADKPRYLILVMV
DEPTRNQYGGVVAAPVFKEIASRTLTFTGIVPDTKVATGTESPAAPAAGRRRGLKLAGLDVPYVNEVQKTAAQGQDAGMR
LPGHLAKAGSRVPDVMGKSVRNAVELFARAGVVPELKGSGSRVIKQTPAPGAAWPEEDNKTEYILWLSER
>Mature_710_residues
MFKFNSRKANRHTDAPRAEKKSRVSNRMKTPAPEGKSRFAWAGQIDWGRVRIKMVVVVFCLLWAGLWGRAWYLQMIEGPR
LAERARRQHMASELVTGRRGMIFDRNGQVLARSIEARSIYARPQEIEDFQTMANTLGPILGIEPQKLYNDLSQTKRRFVW
IKRKVDDFTAEAVRKTNLAGIGLSKEYDRVYPFKHMAGQVLGFVGLDDKGLEGIERSMEARLGCIPTRQIVQRDAMGRRF
YLHEEGQSEPRGQDLTLTIDVQMQFIVEEAVSRAVRDYDARWGGALVVDVPSGEIVAWAQYPFFNPNTYKDTSPLVYRNR
LAADALEPGSTFKPFVMAAAIQEKKISTSTAIDCESGRWVAKNFTIRDTSRQGVLPANKVLRYSSNIGMAKIGLMMGAPT
FYKYLHALGFGQRTNVPVADSKGILRIPRDWSEVDIMSTAFGQSISVTGLQMAQAYLTLLNNGVYKPLRLTREDNNVEEV
PQRIFSQTTVRDVMRMMRDVVEESDGTGKRARIDGIEVAGKTGTAQKADHRAGTYGSKRLASFVGFFPADKPRYLILVMV
DEPTRNQYGGVVAAPVFKEIASRTLTFTGIVPDTKVATGTESPAAPAAGRRRGLKLAGLDVPYVNEVQKTAAQGQDAGMR
LPGHLAKAGSRVPDVMGKSVRNAVELFARAGVVPELKGSGSRVIKQTPAPGAAWPEEDNKTEYILWLSER

Specific function: Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=561, Percent_Identity=32.7985739750446, Blast_Score=277, Evalue=2e-75,
Organism=Escherichia coli, GI1786854, Length=636, Percent_Identity=22.4842767295597, Blast_Score=102, Evalue=7e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 79064; Mature: 79064

Theoretical pI: Translated: 10.37; Mature: 10.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKFNSRKANRHTDAPRAEKKSRVSNRMKTPAPEGKSRFAWAGQIDWGRVRIKMVVVVFC
CCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHH
LLWAGLWGRAWYLQMIEGPRLAERARRQHMASELVTGRRGMIFDRNGQVLARSIEARSIY
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEECCCCCEEEHHHHHHHHH
ARPQEIEDFQTMANTLGPILGIEPQKLYNDLSQTKRRFVWIKRKVDDFTAEAVRKTNLAG
CCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHCCCCC
IGLSKEYDRVYPFKHMAGQVLGFVGLDDKGLEGIERSMEARLGCIPTRQIVQRDAMGRRF
CCCCCCHHHCCCHHHHHHHHHEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCEE
YLHEEGQSEPRGQDLTLTIDVQMQFIVEEAVSRAVRDYDARWGGALVVDVPSGEIVAWAQ
EEECCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEEE
YPFFNPNTYKDTSPLVYRNRLAADALEPGSTFKPFVMAAAIQEKKISTSTAIDCESGRWV
CCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCEEECCCCCEE
AKNFTIRDTSRQGVLPANKVLRYSSNIGMAKIGLMMGAPTFYKYLHALGFGQRTNVPVAD
EEEEEEEECCCCCCCCHHHHHHCCCCCCHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCC
SKGILRIPRDWSEVDIMSTAFGQSISVTGLQMAQAYLTLLNNGVYKPLRLTREDNNVEEV
CCCEEECCCCCCHHHHHHHHCCCCEEHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHH
PQRIFSQTTVRDVMRMMRDVVEESDGTGKRARIDGIEVAGKTGTAQKADHRAGTYGSKRL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCEEEECCCCCCCCCCCCCCCCHHHHH
ASFVGFFPADKPRYLILVMVDEPTRNQYGGVVAAPVFKEIASRTLTFTGIVPDTKVATGT
HHHHHCCCCCCCCEEEEEEECCCCCCCCCCEEEHHHHHHHHHCEEEEEECCCCCCCCCCC
ESPAAPAAGRRRGLKLAGLDVPYVNEVQKTAAQGQDAGMRLPGHLAKAGSRVPDVMGKSV
CCCCCCCCHHHCCCEEECCCCCHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCHHHHHHHH
RNAVELFARAGVVPELKGSGSRVIKQTPAPGAAWPEEDNKTEYILWLSER
HHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCEEEEEEEECC
>Mature Secondary Structure
MFKFNSRKANRHTDAPRAEKKSRVSNRMKTPAPEGKSRFAWAGQIDWGRVRIKMVVVVFC
CCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHH
LLWAGLWGRAWYLQMIEGPRLAERARRQHMASELVTGRRGMIFDRNGQVLARSIEARSIY
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEECCCCCEEEHHHHHHHHH
ARPQEIEDFQTMANTLGPILGIEPQKLYNDLSQTKRRFVWIKRKVDDFTAEAVRKTNLAG
CCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHCCCCC
IGLSKEYDRVYPFKHMAGQVLGFVGLDDKGLEGIERSMEARLGCIPTRQIVQRDAMGRRF
CCCCCCHHHCCCHHHHHHHHHEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCEE
YLHEEGQSEPRGQDLTLTIDVQMQFIVEEAVSRAVRDYDARWGGALVVDVPSGEIVAWAQ
EEECCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEEE
YPFFNPNTYKDTSPLVYRNRLAADALEPGSTFKPFVMAAAIQEKKISTSTAIDCESGRWV
CCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCEEECCCCCEE
AKNFTIRDTSRQGVLPANKVLRYSSNIGMAKIGLMMGAPTFYKYLHALGFGQRTNVPVAD
EEEEEEEECCCCCCCCHHHHHHCCCCCCHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCC
SKGILRIPRDWSEVDIMSTAFGQSISVTGLQMAQAYLTLLNNGVYKPLRLTREDNNVEEV
CCCEEECCCCCCHHHHHHHHCCCCEEHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHH
PQRIFSQTTVRDVMRMMRDVVEESDGTGKRARIDGIEVAGKTGTAQKADHRAGTYGSKRL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCEEEECCCCCCCCCCCCCCCCHHHHH
ASFVGFFPADKPRYLILVMVDEPTRNQYGGVVAAPVFKEIASRTLTFTGIVPDTKVATGT
HHHHHCCCCCCCCEEEEEEECCCCCCCCCCEEEHHHHHHHHHCEEEEEECCCCCCCCCCC
ESPAAPAAGRRRGLKLAGLDVPYVNEVQKTAAQGQDAGMRLPGHLAKAGSRVPDVMGKSV
CCCCCCCCHHHCCCEEECCCCCHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCHHHHHHHH
RNAVELFARAGVVPELKGSGSRVIKQTPAPGAAWPEEDNKTEYILWLSER
HHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3126399 [H]