Click here to switch to the map view.

The map label for this gene is purQ [H]

Identifier: 220904249

GI number: 220904249

Start: 1137845

End: 1138654

Strand: Direct

Name: purQ [H]

Synonym: Ddes_0976

Alternate gene names: 220904249

Gene position: 1137845-1138654 (Clockwise)

Preceding gene: 220904241

Following gene: 220904254

Centisome position: 39.6

GC content: 58.4

Gene sequence:

>810_bases
ATGGGCACGGTCAATACACTGGTCATCACCGGTTACGGAACAAATTCTCATCTGGAAACGGCCCATGCGGCCCGTCTTGC
TGGTGCAGACAGGGCTGATGTGGTCCATTTTTCAGACATCGTAGCGGCCAAGGTGCGTCTGGCTGACTACCATTTTCTGG
TTTTCCCCGGCGGCTTTCTGGATGGTGATGATTTGGGGGCGGCTCAGGCCGCAGTAATGCGCTGGCGCTATCTGAAAGAT
GCGCAGGGCGTTCCCCTGCTACAGAGTTTGCGCGACTTTCTGGATGAGGGCAAGCTCATTCTCGGAATTTGTAACGGTTT
TCAGCTTTTGGCCAAACTGGGCCTGTTACCCGCGCTTGGCGGCGTGCGCTTTGAGCGCCAGGTTTCGCTGGGTCATAACG
ATTCTGCCCGTTATGAAGACCGGTGGGTTCATCTTTTGCCCAATGCAAAAAGCCCCTGTGTCTTCACAAAAGGCATGCCC
ATGCTGTGCATGCCTGTGCGCCACGGTGAGGGCAAGCTTGTGCCCCGCGATGAAGACTGCCTGCGCCGTTTGCAGGAAGA
AAACCTCATCGCCCTGCAATACGCTGACCCCGAAACGGGGCAGCCTACGCAGGAGTATCCGCTCAATCCCAACGGTTCGG
CCTTGGCCATTGCCGGCCTGACCGATCCCACGGGCCGGGTGCTCGGCCTTATGCCGCATCCGGAAGCCTTCCACCATGTG
ACCAACCATCCTGCCTGGACGCGCGGTGAGCTGGACCCGCCAGGAACGCTTCTGTTTGTCAATGCCGTGCGCTATCTGCG
CGGGCAGTAA

Upstream 100 bases:

>100_bases
GGTGCGGGCTCATTGCGGCCCACGGGCCGCGCGGCGCGCGCCTGGTACGCACTTGCCCGCACTCTGAAAGATCTGCTCAA
GCCAAGGAGGCTTTACCCGC

Downstream 100 bases:

>100_bases
GCGCGCTTTTACTTTGACGATTGCTCAAAGTCTTTAGGCGCCCATTGCGGCCTTTACTGCTCGGGAACACGGTACTTACG
CCTGCGAGGTGGATGCCTGC

Product: phosphoribosylformylglycinamidine synthase

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase I; FGAM synthase I [H]

Number of amino acids: Translated: 269; Mature: 268

Protein sequence:

>269_residues
MGTVNTLVITGYGTNSHLETAHAARLAGADRADVVHFSDIVAAKVRLADYHFLVFPGGFLDGDDLGAAQAAVMRWRYLKD
AQGVPLLQSLRDFLDEGKLILGICNGFQLLAKLGLLPALGGVRFERQVSLGHNDSARYEDRWVHLLPNAKSPCVFTKGMP
MLCMPVRHGEGKLVPRDEDCLRRLQEENLIALQYADPETGQPTQEYPLNPNGSALAIAGLTDPTGRVLGLMPHPEAFHHV
TNHPAWTRGELDPPGTLLFVNAVRYLRGQ

Sequences:

>Translated_269_residues
MGTVNTLVITGYGTNSHLETAHAARLAGADRADVVHFSDIVAAKVRLADYHFLVFPGGFLDGDDLGAAQAAVMRWRYLKD
AQGVPLLQSLRDFLDEGKLILGICNGFQLLAKLGLLPALGGVRFERQVSLGHNDSARYEDRWVHLLPNAKSPCVFTKGMP
MLCMPVRHGEGKLVPRDEDCLRRLQEENLIALQYADPETGQPTQEYPLNPNGSALAIAGLTDPTGRVLGLMPHPEAFHHV
TNHPAWTRGELDPPGTLLFVNAVRYLRGQ
>Mature_268_residues
GTVNTLVITGYGTNSHLETAHAARLAGADRADVVHFSDIVAAKVRLADYHFLVFPGGFLDGDDLGAAQAAVMRWRYLKDA
QGVPLLQSLRDFLDEGKLILGICNGFQLLAKLGLLPALGGVRFERQVSLGHNDSARYEDRWVHLLPNAKSPCVFTKGMPM
LCMPVRHGEGKLVPRDEDCLRRLQEENLIALQYADPETGQPTQEYPLNPNGSALAIAGLTDPTGRVLGLMPHPEAFHHVT
NHPAWTRGELDPPGTLLFVNAVRYLRGQ

Specific function: Unknown

COG id: COG0047

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI31657129, Length=245, Percent_Identity=33.8775510204082, Blast_Score=104, Evalue=8e-23,
Organism=Escherichia coli, GI48994899, Length=271, Percent_Identity=39.1143911439114, Blast_Score=128, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17553022, Length=245, Percent_Identity=28.5714285714286, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6321498, Length=270, Percent_Identity=30, Blast_Score=100, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24582111, Length=272, Percent_Identity=35.2941176470588, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24582109, Length=272, Percent_Identity=35.2941176470588, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI17137292, Length=272, Percent_Identity=35.2941176470588, Blast_Score=133, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017926
- InterPro:   IPR011698
- InterPro:   IPR010075 [H]

Pfam domain/function: PF07685 GATase_3 [H]

EC number: =6.3.5.3 [H]

Molecular weight: Translated: 29459; Mature: 29328

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTVNTLVITGYGTNSHLETAHAARLAGADRADVVHFSDIVAAKVRLADYHFLVFPGGFL
CCCEEEEEEEECCCCCCCHHHHHHHHCCCCCCCEEEHHHHHHHHEEEEEEEEEEECCCCC
DGDDLGAAQAAVMRWRYLKDAQGVPLLQSLRDFLDEGKLILGICNGFQLLAKLGLLPALG
CCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHCCC
GVRFERQVSLGHNDSARYEDRWVHLLPNAKSPCVFTKGMPMLCMPVRHGEGKLVPRDEDC
CCEEEEEEECCCCCCCCCCCCEEEECCCCCCCEEEECCCCEEEEEEECCCCCCCCCCHHH
LRRLQEENLIALQYADPETGQPTQEYPLNPNGSALAIAGLTDPTGRVLGLMPHPEAFHHV
HHHHHHCCEEEEEECCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCEEEECCCCHHHHHH
TNHPAWTRGELDPPGTLLFVNAVRYLRGQ
CCCCCCCCCCCCCCCCEEHEEHHHHHCCC
>Mature Secondary Structure 
GTVNTLVITGYGTNSHLETAHAARLAGADRADVVHFSDIVAAKVRLADYHFLVFPGGFL
CCEEEEEEEECCCCCCCHHHHHHHHCCCCCCCEEEHHHHHHHHEEEEEEEEEEECCCCC
DGDDLGAAQAAVMRWRYLKDAQGVPLLQSLRDFLDEGKLILGICNGFQLLAKLGLLPALG
CCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHCCC
GVRFERQVSLGHNDSARYEDRWVHLLPNAKSPCVFTKGMPMLCMPVRHGEGKLVPRDEDC
CCEEEEEEECCCCCCCCCCCCEEEECCCCCCCEEEECCCCEEEEEEECCCCCCCCCCHHH
LRRLQEENLIALQYADPETGQPTQEYPLNPNGSALAIAGLTDPTGRVLGLMPHPEAFHHV
HHHHHHCCEEEEEECCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCEEEECCCCHHHHHH
TNHPAWTRGELDPPGTLLFVNAVRYLRGQ
CCCCCCCCCCCCCCCCEEHEEHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA