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The map label for this gene is focA [H]

Identifier: 220904206

GI number: 220904206

Start: 1088619

End: 1089509

Strand: Reverse

Name: focA [H]

Synonym: Ddes_0933

Alternate gene names: 220904206

Gene position: 1089509-1088619 (Counterclockwise)

Preceding gene: 220904207

Following gene: 220904194

Centisome position: 37.92

GC content: 52.86

Gene sequence:

>891_bases
ATGCATGATCCTTCCTCCTTCGAGGCACTGAATCCCCAGCAGATGTGTCACAAGGCGGTGGTGATAATGGCAGGCAAGGC
GCTCAGGCCAGCGCCCAATGCTTTTATGCTTGCTGTTATGGCGGGCGTGTTCATCGGCCTGGGCTTTGTTTACTGTGCCG
TAGCCAACACGGCAGGAGCGGGAAAAATAGTCGGCGGGCTGGTGTTCAGTCTCGGCCTCATGCTTGTTATCGTTCTGGGT
GCGGATCTGTTTACCTCTACAACCATGACGCTTCTTCCGCGTGCCAGCCGCAAGATTACCTGGGGACAAATGTTCTCGAA
CTGGGGAATAGTATATGCAGGAAATTTTGTGGGCAGTCTTTTTTTGGCGGCGCTCATTTTGCTGAGCGGACACCCGTGGG
CCTCTGGTGGTGATATAGCTGTTTTTTATATCAACACCACAGAAAACAAACTCACACACACCTTCATTGAAGCCATTTTT
CTGGGTACCATGTGCAATCTGCTGGTCTGCCTCGGCGTATGGATGAGCTATGCCGGACGCTCACTGATTGATAAAATGGC
CGCCTGCCTGTTTCCTGTAGGCCTTTTCATTGCTTGCGGATTTGAGCACAGCGTAGCAAACATGTTCATGATTCCTATCG
GTATCCTGTGTAACGACATGATGCCTCCCGCTGTGGCTGCCCGGCTGACCGATCCCGAGCATACCGCGACTGTGCTGACC
TGGTCGAATTTCATCTTCAAAAACCTTATCCCCGTAACACTTGGCAACATCCTTGGCGGCGGAGTGTTTGTTGGCATGTT
TCACTGGCTGATCTATCTGCGCAGCGGGCATGGCGGTCACAAACATACCGGCAGGGCTGCGGTGCAAAAACAAGTCCGGT
CCACCGACTAG

Upstream 100 bases:

>100_bases
GATGTAAACATCGAAACGAATTTGAGCCGTGGGTATTCGTGTTTTCGATATGTGCAAGAAATGTAAATTTGGCATTTTAT
CCCATGCAAAGGAGAACACC

Downstream 100 bases:

>100_bases
CTGCCGAAGCCCACGATCAGAAGCGTCAAGCGCAGCCGCGTCAAAACAAGCGCGTGATCCGATAAAAATACCATGCGGGC
AATAGCGGTCCCTACGAAAA

Product: formate/nitrite transporter

Products: formate [Periplasm]; formate [Cytoplasm] [C]

Alternate protein names: Formate channel 1 [H]

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MHDPSSFEALNPQQMCHKAVVIMAGKALRPAPNAFMLAVMAGVFIGLGFVYCAVANTAGAGKIVGGLVFSLGLMLVIVLG
ADLFTSTTMTLLPRASRKITWGQMFSNWGIVYAGNFVGSLFLAALILLSGHPWASGGDIAVFYINTTENKLTHTFIEAIF
LGTMCNLLVCLGVWMSYAGRSLIDKMAACLFPVGLFIACGFEHSVANMFMIPIGILCNDMMPPAVAARLTDPEHTATVLT
WSNFIFKNLIPVTLGNILGGGVFVGMFHWLIYLRSGHGGHKHTGRAAVQKQVRSTD

Sequences:

>Translated_296_residues
MHDPSSFEALNPQQMCHKAVVIMAGKALRPAPNAFMLAVMAGVFIGLGFVYCAVANTAGAGKIVGGLVFSLGLMLVIVLG
ADLFTSTTMTLLPRASRKITWGQMFSNWGIVYAGNFVGSLFLAALILLSGHPWASGGDIAVFYINTTENKLTHTFIEAIF
LGTMCNLLVCLGVWMSYAGRSLIDKMAACLFPVGLFIACGFEHSVANMFMIPIGILCNDMMPPAVAARLTDPEHTATVLT
WSNFIFKNLIPVTLGNILGGGVFVGMFHWLIYLRSGHGGHKHTGRAAVQKQVRSTD
>Mature_296_residues
MHDPSSFEALNPQQMCHKAVVIMAGKALRPAPNAFMLAVMAGVFIGLGFVYCAVANTAGAGKIVGGLVFSLGLMLVIVLG
ADLFTSTTMTLLPRASRKITWGQMFSNWGIVYAGNFVGSLFLAALILLSGHPWASGGDIAVFYINTTENKLTHTFIEAIF
LGTMCNLLVCLGVWMSYAGRSLIDKMAACLFPVGLFIACGFEHSVANMFMIPIGILCNDMMPPAVAARLTDPEHTATVLT
WSNFIFKNLIPVTLGNILGGGVFVGMFHWLIYLRSGHGGHKHTGRAAVQKQVRSTD

Specific function: Involved in the bidirectional transport of formate [H]

COG id: COG2116

COG function: function code P; Formate/nitrite family of transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FNT transporter (TC 2.A.44) family [H]

Homologues:

Organism=Escherichia coli, GI1787132, Length=281, Percent_Identity=46.6192170818505, Blast_Score=241, Evalue=3e-65,
Organism=Escherichia coli, GI1788837, Length=280, Percent_Identity=39.6428571428571, Blast_Score=185, Evalue=3e-48,
Organism=Escherichia coli, GI87082249, Length=242, Percent_Identity=31.8181818181818, Blast_Score=84, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6321779, Length=289, Percent_Identity=26.9896193771626, Blast_Score=84, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000292 [H]

Pfam domain/function: PF01226 Form_Nir_trans [H]

EC number: NA

Molecular weight: Translated: 31763; Mature: 31763

Theoretical pI: Translated: 8.69; Mature: 8.69

Prosite motif: PS01005 FORMATE_NITRITE_TP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
7.8 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
7.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHDPSSFEALNPQQMCHKAVVIMAGKALRPAPNAFMLAVMAGVFIGLGFVYCAVANTAGA
CCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GKIVGGLVFSLGLMLVIVLGADLFTSTTMTLLPRASRKITWGQMFSNWGIVYAGNFVGSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCEEEEHHHHHHH
FLAALILLSGHPWASGGDIAVFYINTTENKLTHTFIEAIFLGTMCNLLVCLGVWMSYAGR
HHHHHHHHCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLIDKMAACLFPVGLFIACGFEHSVANMFMIPIGILCNDMMPPAVAARLTDPEHTATVLT
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCHHEEEEH
WSNFIFKNLIPVTLGNILGGGVFVGMFHWLIYLRSGHGGHKHTGRAAVQKQVRSTD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MHDPSSFEALNPQQMCHKAVVIMAGKALRPAPNAFMLAVMAGVFIGLGFVYCAVANTAGA
CCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GKIVGGLVFSLGLMLVIVLGADLFTSTTMTLLPRASRKITWGQMFSNWGIVYAGNFVGSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCEEEEHHHHHHH
FLAALILLSGHPWASGGDIAVFYINTTENKLTHTFIEAIFLGTMCNLLVCLGVWMSYAGR
HHHHHHHHCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLIDKMAACLFPVGLFIACGFEHSVANMFMIPIGILCNDMMPPAVAARLTDPEHTATVLT
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCHHEEEEH
WSNFIFKNLIPVTLGNILGGGVFVGMFHWLIYLRSGHGGHKHTGRAAVQKQVRSTD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: formate [Cytoplasm]; formate [Periplasm] [C]

Specific reaction: formate [Cytoplasm] = formate [Periplasm] formate [Periplasm] = formate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]