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The map label for this gene is speA [H]

Identifier: 220904174

GI number: 220904174

Start: 1050140

End: 1052056

Strand: Direct

Name: speA [H]

Synonym: Ddes_0901

Alternate gene names: 220904174

Gene position: 1050140-1052056 (Clockwise)

Preceding gene: 220904172

Following gene: 220904180

Centisome position: 36.55

GC content: 57.17

Gene sequence:

>1917_bases
TTGGCAAAAAACCGCGCATTGCAGCAGTGGCGGGTGGAGGATTCCATCGAACTGTACGGCATCCGCAATTGGGGGGCCGG
ATATTTTGACGTTTCCGATGCGGGCGAAGTGGTTATCTGCCCGCAAGGTCCCAAAGGCCCGCAGGTTTCCATTCCGGAGA
TCATCTCCGGTCTGCGTGACAGGGGCTATGACATGCCCGTGCTTTTGCGCGTGGAAAATATTCTGGACTCGCGGATAGCG
AACATTCATGAAAGTTTTCGTAAGGCCATAAAAAATCTCGGCTATACCGGAGCCTACCGCGGCGTTTTTCCCATCAAGGT
GAATCAGCAGCAGCAGGTGGTGGAAAAGATCGCCCAGTTCGGCGCACAGTACCACCACGGGCTTGAGGTCGGTTCAAAGG
CCGAGCTTATTGCCGCAGTGTCGCTCATGCAGGACAGGGAAGCCTGCATCGTGTGTAACGGGTACAAGGATGAAGAGTTC
ATGGACCTGGGCCTTCAGGCCCTGCGCATGGGCTTTAACGTATTTTTTGTGCTTGAAATGCCCAGCGAGCTGAACGTGCT
GCTGGAACGCAGCAAGGCCCTCGGGGTGCGCCCCAATATCGGCGTGCGTGCCAAGCTGGCCGTAAAGGCTGGCGGCCACT
GGACGGATTCCGGCGGCGAGCGCTCCACCTTCGGGCTTTCCCCGGCGCAGGTGGTGGACGTGGTGGACACCCTCAAAAGC
CACGACATGCTGGACTGCTTCAAGCTGCTGCACTACCATCTTGGTTCGCAGGTTTCCAACATCCGCGACATCCGCACGGG
AGTGATGGAAGGCGCACGCCTTTATGTGGGCCTCATTCAGGAAGGCGCACCCATGGGGTATCTTGACCTGGGCGGCGGCC
TAGCTGTGGACTATGACGGTTCGCACACCAACTTCATTTCTTCGCGCAACTATAATCTGGATGAATACTGCACCGACGTG
GTGGAAACCATCATGAGCATCCTGGATGAGGAAAATGTGCCTCACCCGCACATCATCACCGAGTCCGGCCGCGCCACCGT
GGCGTACTATTCGGTGCTGCTTTTCAACGTGCTGGACGTCAGCATGATTGAAGAAGTGCAGCTGCCAGAAAGCCTGCCCG
AAGGCATGCCCGAGCCGGTGCAGAACCTGCGGGAAACCCTGGCCAACATCAGCCTGCGCAATCTGCAGGAATGCTATAAC
GACGCCATCTATTACCGCGATGAAATGCGTCAGCTTTTCTCCACCGGCCGGGTGAATCTGCGTCAGCGCACCATTGCCGA
GCGTTTTTTCTGGGCTATCATCATGCGCATCGCCCAGGAAAAAACCCGTCTCAAGAATGTGCCGCGCGATCTGGCCGACA
TTGATGTGAGCCTGGCCGACATCTATTACGGCAACTTCAGCGTGTTCCAGTCCTTGCCCGATACCTGGGCCATCGACCAG
CTTTTCCCGGTCATGCCCATACACAGGCTCAGGGAGTTCCCTGCGCGTCATGCCATCATCTCGGACATCACCTGCGATTC
CGATGGCCGTATCGATCAGTTTATCGACCCCCAGGGCATGAAACCCACGCTGGAACTGCACCCCCTGCGCGACGGCGAGG
AGTACTATCTTGGCGTGTTCCTTGTGGGCGCATATCAGGAAACCCTGGGTGACCTGCATAACCTTATGGGTGACACCAAC
GTGGTGTCCATCCGTGTAGCCGAGGATGGAAGCTACGAGTACGTGCGTGAAATCCGTGGCGACTCTGTGGCGGATATTCT
GAGCTATGTGGAGTACGACCCTCGCCGCATACTTGAAGACCTGCGCAGCACCGCGGAACTGGCCGTTCGGCAGGGCCGCA
TTTCGCCAAGCGAGAGGTTTTCTGTCATGCAGGCCTTTGAAGACGGATTGCGCGGCTATACCTATTTTGAACGATAG

Upstream 100 bases:

>100_bases
TTGCCAATATTGACTTTCACCCTCTTACCGGCATAATTACGCCTCTTTTTTGGGTGCAGTATTTTAACCCTCGCCCGCCG
GGCGATACAAGGAGTGAGAA

Downstream 100 bases:

>100_bases
AGAGCCTGAAACAGAACGGCCCGTGCCAAAAGCACGGGCCGTTCTTCGTTATGCGGGCGAACGGGTAGCGGCTGGCTGCC
CGCAGTTCCGTGGCAGCGTC

Product: arginine decarboxylase

Products: NA

Alternate protein names: ADC [H]

Number of amino acids: Translated: 638; Mature: 637

Protein sequence:

>638_residues
MAKNRALQQWRVEDSIELYGIRNWGAGYFDVSDAGEVVICPQGPKGPQVSIPEIISGLRDRGYDMPVLLRVENILDSRIA
NIHESFRKAIKNLGYTGAYRGVFPIKVNQQQQVVEKIAQFGAQYHHGLEVGSKAELIAAVSLMQDREACIVCNGYKDEEF
MDLGLQALRMGFNVFFVLEMPSELNVLLERSKALGVRPNIGVRAKLAVKAGGHWTDSGGERSTFGLSPAQVVDVVDTLKS
HDMLDCFKLLHYHLGSQVSNIRDIRTGVMEGARLYVGLIQEGAPMGYLDLGGGLAVDYDGSHTNFISSRNYNLDEYCTDV
VETIMSILDEENVPHPHIITESGRATVAYYSVLLFNVLDVSMIEEVQLPESLPEGMPEPVQNLRETLANISLRNLQECYN
DAIYYRDEMRQLFSTGRVNLRQRTIAERFFWAIIMRIAQEKTRLKNVPRDLADIDVSLADIYYGNFSVFQSLPDTWAIDQ
LFPVMPIHRLREFPARHAIISDITCDSDGRIDQFIDPQGMKPTLELHPLRDGEEYYLGVFLVGAYQETLGDLHNLMGDTN
VVSIRVAEDGSYEYVREIRGDSVADILSYVEYDPRRILEDLRSTAELAVRQGRISPSERFSVMQAFEDGLRGYTYFER

Sequences:

>Translated_638_residues
MAKNRALQQWRVEDSIELYGIRNWGAGYFDVSDAGEVVICPQGPKGPQVSIPEIISGLRDRGYDMPVLLRVENILDSRIA
NIHESFRKAIKNLGYTGAYRGVFPIKVNQQQQVVEKIAQFGAQYHHGLEVGSKAELIAAVSLMQDREACIVCNGYKDEEF
MDLGLQALRMGFNVFFVLEMPSELNVLLERSKALGVRPNIGVRAKLAVKAGGHWTDSGGERSTFGLSPAQVVDVVDTLKS
HDMLDCFKLLHYHLGSQVSNIRDIRTGVMEGARLYVGLIQEGAPMGYLDLGGGLAVDYDGSHTNFISSRNYNLDEYCTDV
VETIMSILDEENVPHPHIITESGRATVAYYSVLLFNVLDVSMIEEVQLPESLPEGMPEPVQNLRETLANISLRNLQECYN
DAIYYRDEMRQLFSTGRVNLRQRTIAERFFWAIIMRIAQEKTRLKNVPRDLADIDVSLADIYYGNFSVFQSLPDTWAIDQ
LFPVMPIHRLREFPARHAIISDITCDSDGRIDQFIDPQGMKPTLELHPLRDGEEYYLGVFLVGAYQETLGDLHNLMGDTN
VVSIRVAEDGSYEYVREIRGDSVADILSYVEYDPRRILEDLRSTAELAVRQGRISPSERFSVMQAFEDGLRGYTYFER
>Mature_637_residues
AKNRALQQWRVEDSIELYGIRNWGAGYFDVSDAGEVVICPQGPKGPQVSIPEIISGLRDRGYDMPVLLRVENILDSRIAN
IHESFRKAIKNLGYTGAYRGVFPIKVNQQQQVVEKIAQFGAQYHHGLEVGSKAELIAAVSLMQDREACIVCNGYKDEEFM
DLGLQALRMGFNVFFVLEMPSELNVLLERSKALGVRPNIGVRAKLAVKAGGHWTDSGGERSTFGLSPAQVVDVVDTLKSH
DMLDCFKLLHYHLGSQVSNIRDIRTGVMEGARLYVGLIQEGAPMGYLDLGGGLAVDYDGSHTNFISSRNYNLDEYCTDVV
ETIMSILDEENVPHPHIITESGRATVAYYSVLLFNVLDVSMIEEVQLPESLPEGMPEPVQNLRETLANISLRNLQECYND
AIYYRDEMRQLFSTGRVNLRQRTIAERFFWAIIMRIAQEKTRLKNVPRDLADIDVSLADIYYGNFSVFQSLPDTWAIDQL
FPVMPIHRLREFPARHAIISDITCDSDGRIDQFIDPQGMKPTLELHPLRDGEEYYLGVFLVGAYQETLGDLHNLMGDTNV
VSIRVAEDGSYEYVREIRGDSVADILSYVEYDPRRILEDLRSTAELAVRQGRISPSERFSVMQAFEDGLRGYTYFER

Specific function: Catalyzes the biosynthesis of agmatine from arginine [H]

COG id: COG1166

COG function: function code E; Arginine decarboxylase (spermidine biosynthesis)

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789307, Length=639, Percent_Identity=38.9671361502347, Blast_Score=462, Evalue=1e-131,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002985
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.19 [H]

Molecular weight: Translated: 72072; Mature: 71941

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS00878 ODR_DC_2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKNRALQQWRVEDSIELYGIRNWGAGYFDVSDAGEVVICPQGPKGPQVSIPEIISGLRD
CCCCHHHHHHCCCCCEEEEEEECCCCCEEEECCCCCEEECCCCCCCCCCCHHHHHHHHHH
RGYDMPVLLRVENILDSRIANIHESFRKAIKNLGYTGAYRGVFPIKVNQQQQVVEKIAQF
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCHHHHHHHHHHH
GAQYHHGLEVGSKAELIAAVSLMQDREACIVCNGYKDEEFMDLGLQALRMGFNVFFVLEM
HHHHHHCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHCCCEEEEEEC
PSELNVLLERSKALGVRPNIGVRAKLAVKAGGHWTDSGGERSTFGLSPAQVVDVVDTLKS
CHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHC
HDMLDCFKLLHYHLGSQVSNIRDIRTGVMEGARLYVGLIQEGAPMGYLDLGGGLAVDYDG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEECCCCEEEECCC
SHTNFISSRNYNLDEYCTDVVETIMSILDEENVPHPHIITESGRATVAYYSVLLFNVLDV
CCCCEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHH
SMIEEVQLPESLPEGMPEPVQNLRETLANISLRNLQECYNDAIYYRDEMRQLFSTGRVNL
HHHHHHCCCHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
RQRTIAERFFWAIIMRIAQEKTRLKNVPRDLADIDVSLADIYYGNFSVFQSLPDTWAIDQ
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCHHHEEECCHHHHHCCCCCCCHHH
LFPVMPIHRLREFPARHAIISDITCDSDGRIDQFIDPQGMKPTLELHPLRDGEEYYLGVF
HHHHHHHHHHHHCCHHHHHHHCCCCCCCCCHHHCCCCCCCCCCEEEECCCCCCCEEEEEE
LVGAYQETLGDLHNLMGDTNVVSIRVAEDGSYEYVREIRGDSVADILSYVEYDPRRILED
EEHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHCCCHHHHHHHHHCCCHHHHHHH
LRSTAELAVRQGRISPSERFSVMQAFEDGLRGYTYFER
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
AKNRALQQWRVEDSIELYGIRNWGAGYFDVSDAGEVVICPQGPKGPQVSIPEIISGLRD
CCCHHHHHHCCCCCEEEEEEECCCCCEEEECCCCCEEECCCCCCCCCCCHHHHHHHHHH
RGYDMPVLLRVENILDSRIANIHESFRKAIKNLGYTGAYRGVFPIKVNQQQQVVEKIAQF
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCHHHHHHHHHHH
GAQYHHGLEVGSKAELIAAVSLMQDREACIVCNGYKDEEFMDLGLQALRMGFNVFFVLEM
HHHHHHCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHCCCEEEEEEC
PSELNVLLERSKALGVRPNIGVRAKLAVKAGGHWTDSGGERSTFGLSPAQVVDVVDTLKS
CHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHC
HDMLDCFKLLHYHLGSQVSNIRDIRTGVMEGARLYVGLIQEGAPMGYLDLGGGLAVDYDG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEECCCCEEEECCC
SHTNFISSRNYNLDEYCTDVVETIMSILDEENVPHPHIITESGRATVAYYSVLLFNVLDV
CCCCEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHH
SMIEEVQLPESLPEGMPEPVQNLRETLANISLRNLQECYNDAIYYRDEMRQLFSTGRVNL
HHHHHHCCCHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
RQRTIAERFFWAIIMRIAQEKTRLKNVPRDLADIDVSLADIYYGNFSVFQSLPDTWAIDQ
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCHHHEEECCHHHHHCCCCCCCHHH
LFPVMPIHRLREFPARHAIISDITCDSDGRIDQFIDPQGMKPTLELHPLRDGEEYYLGVF
HHHHHHHHHHHHCCHHHHHHHCCCCCCCCCHHHCCCCCCCCCCEEEECCCCCCCEEEEEE
LVGAYQETLGDLHNLMGDTNVVSIRVAEDGSYEYVREIRGDSVADILSYVEYDPRRILED
EEHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHCCCHHHHHHHHHCCCHHHHHHH
LRSTAELAVRQGRISPSERFSVMQAFEDGLRGYTYFER
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14621292 [H]