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The map label for this gene is glcD [H]

Identifier: 220904155

GI number: 220904155

Start: 1031475

End: 1032896

Strand: Direct

Name: glcD [H]

Synonym: Ddes_0882

Alternate gene names: 220904155

Gene position: 1031475-1032896 (Clockwise)

Preceding gene: 220904154

Following gene: 220904156

Centisome position: 35.9

GC content: 62.1

Gene sequence:

>1422_bases
ATGACGCAAACGCCATTTCTTAATCCACTGCCCCGCAGTGCCGATGCCCAACCCTACGCGGACAGGCTCGAACCTGCGGA
TATGGATTTTTTACGCCGTACGCTGGGCGGGGACCTGCTTGTTACGGCGGAAGAACTACATGTCTATGCTTCCGATGCCA
GCCTGAAAACGGGCAGCCCGCTCGCTGCCGCCCGGCCCCGGTGTGTGGAGCAGGTGCAGGACCTGCTGGCCTGGGCGCAG
GACAGGCGCATGCCCGTCTACGTGCGCGGCCGGGGAACAAACCTGGTGGGCGACTGTGTGCCCGTGTTGCCGGGGCTGGT
TGTTTCCACGCTGCTGATGGACAGGATAGAGGAAATTTCCGCTACGGATTTTGTGGCCGTGGTGGAGCCGGGGCTGACCA
CGGGCCGCCTTCAGGATGCCTGCGAGGCCCGGGGGCTTTATTATCCGCCGGACCCGGCCACGGTGCGTTCTTCCAGCATC
GGCGGCAATGTCATTACCTGTGCCGGGGGCATGCGCGCGCTCAAATATGGTGTTACCCGCGACTTTGTGCTGGGTATTGA
GGCAGTTTTACCCGGCGGCCGCCTGGTGTGCTTCGGCGGGCGCACCCACAAGAACGTAGTGGGGTTGGACTTGGCCCGGC
TTATGGTGGGGTCGGAAGGCACGCTGGGCTTCATCAGCAAGCTCTGGCTCAAGCTTTTGCCCAAACCGGAAGCCTCGGCC
ACCATTATGGCGGGGTATGGCTCGCATGCGGAGGCTCTGGGCGCAGTGGGCGAAATTTTTGCGGCGGGTATCGTTCCCTG
TGCTCTGGAGTATATCGGCGACGGCATTATTGACCTTATGGCCGGGAGCCGTCCTGTACCCTGGCCCCGTGAGGTGCGCT
CGATCCTGCTCATCCGGCTGGACGGCAGCGCCGATACCCTGCCGCTGGAAGCGGACCGCCTGCTGCGAAACATGGCTACG
GCCCTCTGGCATACGACGGGGCTGAATCCGCAGGATGAGGAACGCCTGTGGGAAATACGCCGCCGCATCAATCCCACCAC
CTTTCTGGCCGGGCCGGACAAGATGGCCGACGATGTCACCGTGCCGCGCGGGCAGCTTGTACGGGCGCTTGCAGAAATGG
AAAAAATTGCGCGCGAGCATGACGTGACGTTTCTGCATTTCGGCCATGTGGGAGACGGCAATATCCACGCCAATATTCTT
TATGACGCGGCCGACGAAAACATGGCCCGCCGTGTGGAAGAAGCGCGCCTTGGCATGGAGCAGGCCGTGCTGCGGCTCGG
GGGCGTCATGTCGGGCGAGCACGGCTGTGGCATCTGCAAGAATGCCGGTTTGCAGATTCCTCCGGTGGAGCGGGCGCTTA
TGCATGATATAAAGGCTGTTTTTGATCCCAGGGGCATCATGAATCCCGGCAAGGGCTATTAG

Upstream 100 bases:

>100_bases
GCCTGTCGCACCCGATTTTCTGGTGCCGTACCGGGCGGCCCGGAGTGGGTTTGCCCGGTTCATGTGCGGCCGACACTTTA
GCTGCCCGGGAGCGGGGTTC

Downstream 100 bases:

>100_bases
GCATGGCGGCGCTCAAGCAGTGCACGCAGTGCGGGGCCTGCCTGGAAAGCTGCCCGGTATTCCTGCTGCGCAAAAGTGAG
GAGTTCAGCCCCAAGGCCAA

Product: FAD linked oxidase domain-containing protein

Products: 2-oxo acid; H2O2

Alternate protein names: NA

Number of amino acids: Translated: 473; Mature: 472

Protein sequence:

>473_residues
MTQTPFLNPLPRSADAQPYADRLEPADMDFLRRTLGGDLLVTAEELHVYASDASLKTGSPLAAARPRCVEQVQDLLAWAQ
DRRMPVYVRGRGTNLVGDCVPVLPGLVVSTLLMDRIEEISATDFVAVVEPGLTTGRLQDACEARGLYYPPDPATVRSSSI
GGNVITCAGGMRALKYGVTRDFVLGIEAVLPGGRLVCFGGRTHKNVVGLDLARLMVGSEGTLGFISKLWLKLLPKPEASA
TIMAGYGSHAEALGAVGEIFAAGIVPCALEYIGDGIIDLMAGSRPVPWPREVRSILLIRLDGSADTLPLEADRLLRNMAT
ALWHTTGLNPQDEERLWEIRRRINPTTFLAGPDKMADDVTVPRGQLVRALAEMEKIAREHDVTFLHFGHVGDGNIHANIL
YDAADENMARRVEEARLGMEQAVLRLGGVMSGEHGCGICKNAGLQIPPVERALMHDIKAVFDPRGIMNPGKGY

Sequences:

>Translated_473_residues
MTQTPFLNPLPRSADAQPYADRLEPADMDFLRRTLGGDLLVTAEELHVYASDASLKTGSPLAAARPRCVEQVQDLLAWAQ
DRRMPVYVRGRGTNLVGDCVPVLPGLVVSTLLMDRIEEISATDFVAVVEPGLTTGRLQDACEARGLYYPPDPATVRSSSI
GGNVITCAGGMRALKYGVTRDFVLGIEAVLPGGRLVCFGGRTHKNVVGLDLARLMVGSEGTLGFISKLWLKLLPKPEASA
TIMAGYGSHAEALGAVGEIFAAGIVPCALEYIGDGIIDLMAGSRPVPWPREVRSILLIRLDGSADTLPLEADRLLRNMAT
ALWHTTGLNPQDEERLWEIRRRINPTTFLAGPDKMADDVTVPRGQLVRALAEMEKIAREHDVTFLHFGHVGDGNIHANIL
YDAADENMARRVEEARLGMEQAVLRLGGVMSGEHGCGICKNAGLQIPPVERALMHDIKAVFDPRGIMNPGKGY
>Mature_472_residues
TQTPFLNPLPRSADAQPYADRLEPADMDFLRRTLGGDLLVTAEELHVYASDASLKTGSPLAAARPRCVEQVQDLLAWAQD
RRMPVYVRGRGTNLVGDCVPVLPGLVVSTLLMDRIEEISATDFVAVVEPGLTTGRLQDACEARGLYYPPDPATVRSSSIG
GNVITCAGGMRALKYGVTRDFVLGIEAVLPGGRLVCFGGRTHKNVVGLDLARLMVGSEGTLGFISKLWLKLLPKPEASAT
IMAGYGSHAEALGAVGEIFAAGIVPCALEYIGDGIIDLMAGSRPVPWPREVRSILLIRLDGSADTLPLEADRLLRNMATA
LWHTTGLNPQDEERLWEIRRRINPTTFLAGPDKMADDVTVPRGQLVRALAEMEKIAREHDVTFLHFGHVGDGNIHANILY
DAADENMARRVEEARLGMEQAVLRLGGVMSGEHGCGICKNAGLQIPPVERALMHDIKAVFDPRGIMNPGKGY

Specific function: Unknown

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI37595756, Length=457, Percent_Identity=32.1663019693654, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI37595754, Length=480, Percent_Identity=30.625, Blast_Score=176, Evalue=6e-44,
Organism=Homo sapiens, GI119964728, Length=466, Percent_Identity=29.3991416309013, Blast_Score=159, Evalue=7e-39,
Organism=Homo sapiens, GI4501993, Length=199, Percent_Identity=27.6381909547739, Blast_Score=73, Evalue=6e-13,
Organism=Escherichia coli, GI1789351, Length=467, Percent_Identity=32.9764453961456, Blast_Score=211, Evalue=1e-55,
Organism=Escherichia coli, GI48994914, Length=122, Percent_Identity=36.0655737704918, Blast_Score=77, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71992373, Length=453, Percent_Identity=29.1390728476821, Blast_Score=172, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI71992381, Length=453, Percent_Identity=28.0353200883002, Blast_Score=157, Evalue=8e-39,
Organism=Caenorhabditis elegans, GI71992392, Length=382, Percent_Identity=28.2722513089005, Blast_Score=144, Evalue=9e-35,
Organism=Caenorhabditis elegans, GI17534361, Length=436, Percent_Identity=26.605504587156, Blast_Score=135, Evalue=6e-32,
Organism=Saccharomyces cerevisiae, GI6320023, Length=482, Percent_Identity=29.045643153527, Blast_Score=164, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6320764, Length=500, Percent_Identity=25.4, Blast_Score=149, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6320027, Length=446, Percent_Identity=27.1300448430493, Blast_Score=144, Evalue=4e-35,
Organism=Drosophila melanogaster, GI18921117, Length=491, Percent_Identity=25.8655804480652, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24639277, Length=491, Percent_Identity=25.8655804480652, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24639275, Length=491, Percent_Identity=25.8655804480652, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24653753, Length=177, Percent_Identity=29.3785310734463, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR004113
- InterPro:   IPR004490
- InterPro:   IPR006094
- InterPro:   IPR016171 [H]

Pfam domain/function: PF02913 FAD-oxidase_C; PF01565 FAD_binding_4 [H]

EC number: 1.1.3.15

Molecular weight: Translated: 51153; Mature: 51022

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQTPFLNPLPRSADAQPYADRLEPADMDFLRRTLGGDLLVTAEELHVYASDASLKTGSP
CCCCCCCCCCCCCCCCCCHHHHCCCCCHHHHHHHHCCCEEEEHHHEEEEECCCCCCCCCC
LAAARPRCVEQVQDLLAWAQDRRMPVYVRGRGTNLVGDCVPVLPGLVVSTLLMDRIEEIS
CHHCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
ATDFVAVVEPGLTTGRLQDACEARGLYYPPDPATVRSSSIGGNVITCAGGMRALKYGVTR
CCCEEEEECCCCCCHHHHHHHHHCCCCCCCCCCCEECCCCCCCEEEECCCHHHHHHCCCH
DFVLGIEAVLPGGRLVCFGGRTHKNVVGLDLARLMVGSEGTLGFISKLWLKLLPKPEASA
HHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCE
TIMAGYGSHAEALGAVGEIFAAGIVPCALEYIGDGIIDLMAGSRPVPWPREVRSILLIRL
EEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCHHHHHEEEEEEE
DGSADTLPLEADRLLRNMATALWHTTGLNPQDEERLWEIRRRINPTTFLAGPDKMADDVT
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEECCCCCCCCCCC
VPRGQLVRALAEMEKIAREHDVTFLHFGHVGDGNIHANILYDAADENMARRVEEARLGME
CCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEEEEECCCHHHHHHHHHHHHCHH
QAVLRLGGVMSGEHGCGICKNAGLQIPPVERALMHDIKAVFDPRGIMNPGKGY
HHHHHHCCCCCCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
TQTPFLNPLPRSADAQPYADRLEPADMDFLRRTLGGDLLVTAEELHVYASDASLKTGSP
CCCCCCCCCCCCCCCCCHHHHCCCCCHHHHHHHHCCCEEEEHHHEEEEECCCCCCCCCC
LAAARPRCVEQVQDLLAWAQDRRMPVYVRGRGTNLVGDCVPVLPGLVVSTLLMDRIEEIS
CHHCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
ATDFVAVVEPGLTTGRLQDACEARGLYYPPDPATVRSSSIGGNVITCAGGMRALKYGVTR
CCCEEEEECCCCCCHHHHHHHHHCCCCCCCCCCCEECCCCCCCEEEECCCHHHHHHCCCH
DFVLGIEAVLPGGRLVCFGGRTHKNVVGLDLARLMVGSEGTLGFISKLWLKLLPKPEASA
HHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCE
TIMAGYGSHAEALGAVGEIFAAGIVPCALEYIGDGIIDLMAGSRPVPWPREVRSILLIRL
EEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCHHHHHEEEEEEE
DGSADTLPLEADRLLRNMATALWHTTGLNPQDEERLWEIRRRINPTTFLAGPDKMADDVT
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEECCCCCCCCCCC
VPRGQLVRALAEMEKIAREHDVTFLHFGHVGDGNIHANILYDAADENMARRVEEARLGME
CCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEEEEECCCHHHHHHHHHHHHCHH
QAVLRLGGVMSGEHGCGICKNAGLQIPPVERALMHDIKAVFDPRGIMNPGKGY
HHHHHHCCCCCCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-2-hydroxy acid; O2

Specific reaction: (S)-2-hydroxy acid + O2 = 2-oxo acid + H2O2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]