Click here to switch to the map view.

The map label for this gene is moeA [H]

Identifier: 220904102

GI number: 220904102

Start: 972738

End: 973994

Strand: Reverse

Name: moeA [H]

Synonym: Ddes_0828

Alternate gene names: 220904102

Gene position: 973994-972738 (Counterclockwise)

Preceding gene: 220904103

Following gene: 220904101

Centisome position: 33.9

GC content: 66.75

Gene sequence:

>1257_bases
ATGTCGCACTGCCCGCATTCGCCGGCGGCTTCAGCGCAGGGCATGCTGCCTCTGGAAAAAGCGCTGGCTGCCCTGCTGGC
CTGCGCCGCCCCGGTGGAGCAGACTCTTTCGCTTCCCCTGCTGGAGGCCGACAGGCGGATATGCGCAACAGACATGTATG
CCGTGTTGCCGCAGCCTCCGTTTGACCGCGCACAGGTGGACGGCTACGCCGCGCGCAGCGCCGACCTTGTCGCAGCAAGC
CCGAAAGCTCCGGCCGCCCTGCAGGTGACCCAGTTTCTCTATGCGGGTAGCGGACCGGGTGTGCCGGTGCAACCCGGCCA
GGCCGCACGCATAACCACCGGAGCCATGCTGCCCCCCGGAGCCGACTGTGTGATCTGGCAGGAAGATACCACCAGGCACG
GCCACAGCATCAGCGTGTGCCACAGCCTTGCGCCCGGGCGCAACTGTCACGCCCAGGGACGTGATGTCGCCCCGGGACGA
CTGCTTGTAGGCAGGGGCGACATGCTGCACAGCGGCACCCTCGGCCTGCTGGCCGGTCAGGGGCATACCCATGTACCTGT
ATATGGCAGCCCCGCAGCAAGCATGCTCGCCACGGGCGATGAGCTGTGTCCGCCGGGCCTGCCGCTGCCCAAGGGAGGCA
TATACAATACCAGCGCCACCTTGCTGGGCGTACGCCTGCAACGGCTCGGCGCGCGTATTGCCGACATGCGGGTCTGCCCC
GATGACGACGCGCTTTTGCTGCAACATATGGAAGACCTGCTGCCCCACAGCGCCCTTGTCATTACCACTGGCGGCGTTTC
GTGGGGACCGCGTGACCTTGTCCCCCGCCTGGCGGCCAGGCTCACCGCCCGGCACGGCGGCCGCCTGCTTTTCCGGGGGC
TGAGCATGAAGCCGGGAACCATGACCCTGGGCGCCGTTGTGGGCAAGACCATCCTGCTTGGCCTTTCGGGAACCCCCGTA
GCTGCCGCAGCAGCCTTTGAGCTGCTGGCCGGGCCGCTTATCAAAAAGCTCTCCGGCCGCGCCCGCTATGGCCTGACCCG
ACAGCGCGGCATCATGAGCAACGACTTCGGCACATGCCGCAAAGACTCGCGCCGCCTTGTCATGGCCCGGCTTGAGGGTA
CTGATGTTTTTCTGCGCCCACGCGGCGAAGGCGTGGGGCAGCCAGCCCTGCGTGACGACTGTAACTGCTTTGTGGACATA
CCCGCCGGATGCCCGCCCCTGCGGCGTGGAGACGAGGTGGCTGTCATTCTGCCGTAA

Upstream 100 bases:

>100_bases
GCGGCAGTGGAACTGGCAAGGGCCGTCGACATCTCCATTCTGGGTTTTGTGCGTCAGGGCAATATCAATATATATACCTG
TCCGCACAGGATTGTCTGAC

Downstream 100 bases:

>100_bases
CCAGTGCCGCCACAAAAATATCCGCCCGCGGGGCAGCCCCGGGGCGCTTCCCCTGACGCACGCATGTCTCGCAGGCAATC
GCCAGTGCGGCTGGCGTCCC

Product: molybdenum cofactor synthesis domain-containing protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 418; Mature: 417

Protein sequence:

>418_residues
MSHCPHSPAASAQGMLPLEKALAALLACAAPVEQTLSLPLLEADRRICATDMYAVLPQPPFDRAQVDGYAARSADLVAAS
PKAPAALQVTQFLYAGSGPGVPVQPGQAARITTGAMLPPGADCVIWQEDTTRHGHSISVCHSLAPGRNCHAQGRDVAPGR
LLVGRGDMLHSGTLGLLAGQGHTHVPVYGSPAASMLATGDELCPPGLPLPKGGIYNTSATLLGVRLQRLGARIADMRVCP
DDDALLLQHMEDLLPHSALVITTGGVSWGPRDLVPRLAARLTARHGGRLLFRGLSMKPGTMTLGAVVGKTILLGLSGTPV
AAAAAFELLAGPLIKKLSGRARYGLTRQRGIMSNDFGTCRKDSRRLVMARLEGTDVFLRPRGEGVGQPALRDDCNCFVDI
PAGCPPLRRGDEVAVILP

Sequences:

>Translated_418_residues
MSHCPHSPAASAQGMLPLEKALAALLACAAPVEQTLSLPLLEADRRICATDMYAVLPQPPFDRAQVDGYAARSADLVAAS
PKAPAALQVTQFLYAGSGPGVPVQPGQAARITTGAMLPPGADCVIWQEDTTRHGHSISVCHSLAPGRNCHAQGRDVAPGR
LLVGRGDMLHSGTLGLLAGQGHTHVPVYGSPAASMLATGDELCPPGLPLPKGGIYNTSATLLGVRLQRLGARIADMRVCP
DDDALLLQHMEDLLPHSALVITTGGVSWGPRDLVPRLAARLTARHGGRLLFRGLSMKPGTMTLGAVVGKTILLGLSGTPV
AAAAAFELLAGPLIKKLSGRARYGLTRQRGIMSNDFGTCRKDSRRLVMARLEGTDVFLRPRGEGVGQPALRDDCNCFVDI
PAGCPPLRRGDEVAVILP
>Mature_417_residues
SHCPHSPAASAQGMLPLEKALAALLACAAPVEQTLSLPLLEADRRICATDMYAVLPQPPFDRAQVDGYAARSADLVAASP
KAPAALQVTQFLYAGSGPGVPVQPGQAARITTGAMLPPGADCVIWQEDTTRHGHSISVCHSLAPGRNCHAQGRDVAPGRL
LVGRGDMLHSGTLGLLAGQGHTHVPVYGSPAASMLATGDELCPPGLPLPKGGIYNTSATLLGVRLQRLGARIADMRVCPD
DDALLLQHMEDLLPHSALVITTGGVSWGPRDLVPRLAARLTARHGGRLLFRGLSMKPGTMTLGAVVGKTILLGLSGTPVA
AAAAFELLAGPLIKKLSGRARYGLTRQRGIMSNDFGTCRKDSRRLVMARLEGTDVFLRPRGEGVGQPALRDDCNCFVDIP
AGCPPLRRGDEVAVILP

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=333, Percent_Identity=30.3303303303303, Blast_Score=125, Evalue=5e-29,
Organism=Homo sapiens, GI10880983, Length=333, Percent_Identity=30.3303303303303, Blast_Score=125, Evalue=8e-29,
Organism=Escherichia coli, GI1787049, Length=337, Percent_Identity=31.7507418397626, Blast_Score=157, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI25147659, Length=316, Percent_Identity=27.8481012658228, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI17136978, Length=384, Percent_Identity=28.90625, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24638841, Length=384, Percent_Identity=28.90625, Blast_Score=99, Evalue=4e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 43723; Mature: 43592

Theoretical pI: Translated: 8.68; Mature: 8.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHCPHSPAASAQGMLPLEKALAALLACAAPVEQTLSLPLLEADRRICATDMYAVLPQPP
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHCCCHHHHCCCHHHHHHHHCCCCCC
FDRAQVDGYAARSADLVAASPKAPAALQVTQFLYAGSGPGVPVQPGQAARITTGAMLPPG
CCCHHCCCCCCCCCCEEEECCCCCCHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCC
ADCVIWQEDTTRHGHSISVCHSLAPGRNCHAQGRDVAPGRLLVGRGDMLHSGTLGLLAGQ
CCEEEECCCCCCCCCEEEHHHHCCCCCCCCCCCCCCCCCEEEEECCCEEECCCEEEEECC
GHTHVPVYGSPAASMLATGDELCPPGLPLPKGGIYNTSATLLGVRLQRLGARIADMRVCP
CCCCCEEECCCHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHEEECC
DDDALLLQHMEDLLPHSALVITTGGVSWGPRDLVPRLAARLTARHGGRLLFRGLSMKPGT
CCHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCC
MTLGAVVGKTILLGLSGTPVAAAAAFELLAGPLIKKLSGRARYGLTRQRGIMSNDFGTCR
CHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCHHCCCHHHCCCCCCCCCCCC
KDSRRLVMARLEGTDVFLRPRGEGVGQPALRDDCNCFVDIPAGCPPLRRGDEVAVILP
CCCCEEEEEEECCCEEEEEECCCCCCCCCCCCCCCEEEECCCCCCCCCCCCEEEEEEC
>Mature Secondary Structure 
SHCPHSPAASAQGMLPLEKALAALLACAAPVEQTLSLPLLEADRRICATDMYAVLPQPP
CCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHCCCHHHHCCCHHHHHHHHCCCCCC
FDRAQVDGYAARSADLVAASPKAPAALQVTQFLYAGSGPGVPVQPGQAARITTGAMLPPG
CCCHHCCCCCCCCCCEEEECCCCCCHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCC
ADCVIWQEDTTRHGHSISVCHSLAPGRNCHAQGRDVAPGRLLVGRGDMLHSGTLGLLAGQ
CCEEEECCCCCCCCCEEEHHHHCCCCCCCCCCCCCCCCCEEEEECCCEEECCCEEEEECC
GHTHVPVYGSPAASMLATGDELCPPGLPLPKGGIYNTSATLLGVRLQRLGARIADMRVCP
CCCCCEEECCCHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHEEECC
DDDALLLQHMEDLLPHSALVITTGGVSWGPRDLVPRLAARLTARHGGRLLFRGLSMKPGT
CCHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCC
MTLGAVVGKTILLGLSGTPVAAAAAFELLAGPLIKKLSGRARYGLTRQRGIMSNDFGTCR
CHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCHHCCCHHHCCCCCCCCCCCC
KDSRRLVMARLEGTDVFLRPRGEGVGQPALRDDCNCFVDIPAGCPPLRRGDEVAVILP
CCCCEEEEEEECCCEEEEEECCCCCCCCCCCCCCCEEEECCCCCCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA