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The map label for this gene is nadC [H]

Identifier: 220904082

GI number: 220904082

Start: 946793

End: 947665

Strand: Reverse

Name: nadC [H]

Synonym: Ddes_0808

Alternate gene names: 220904082

Gene position: 947665-946793 (Counterclockwise)

Preceding gene: 220904092

Following gene: 220904081

Centisome position: 32.98

GC content: 62.54

Gene sequence:

>873_bases
ATGTATACGCCCTGGGCCGCTTTTTTTTCTCCCGAAGGACGGCGGCTTCTACAAAAATCCATAGATCTCGCCCTTGAAGA
AGACGGTCCGGAACTGACTGCCATGGGCCTTTTCTCTCCTGATGCGTACCTGAATGCGGCCATACGAGCCAAAGAGGATA
CCCTGGTGGTGGGGCTGCCCGTGATCGGCCCGGTATTCCGCAGCCTGGGCGCGCCCTTCAGATGGCAGGCCCTTGTACCC
GAGACGGCCCGCGTACCGGCCATGACGGAGGTGGCCCGCATTACCGCTCCGGCTGTGCCCATGCTCAAGGCCGAACGCGT
TATCCTGAACTTCATAACCCATCTTTCGGGCATAGCCAACCTCACGGCCCGTTATGTGCGGGAACTTGAGGGAACCGGCG
TTCGCCTGCTCGATACGCGCAAGACCACCCCCGGCCTGCGCTGGCCGGAAAAATACGCCGTGCAGGCAGGCGGCGCGTCC
AACCACCGCAAAAACCTTGCTGAAATGCTTATGCTCAAGGATAATCACATCGATGCGGCCGGCTCCATTGCCTCGGCCGT
TGCTGCCCTGCGCAGCCGCTACAGCCCCTGCCCCCCCATTGAGGTGGAGTGCCGCACCATCGCGCATGTGCGCGAGGCCA
TTGCCGCGCGCGCCGATCGCATTATGATGGACAATATGGGCGGAGCGCTTTTGAGCGAGGCTCTGGCTCTGGTTCCCCCG
GATATTGAAACCGAAGTCAGCGGCGGCGTGCGGCTGGAAAATCTGCGCGAACTGGCCCTTACGGCCCCCCGCAGGCCGGA
CTTCATCTCCGTGGGACGGCTAACCCATTCCGCCGTGGCGGCGGACTTCAGCATGACCCTGCTGCCGGCCTGA

Upstream 100 bases:

>100_bases
ACGGCGCAGGACGCCGTGTGGGGTCAACGTGCCGCGCGTGGCATTCTGACCGGGGCGGCACCCCTTCACTTAGCATGCGA
AAGGAATGGGAACAAGCGCA

Downstream 100 bases:

>100_bases
TGCCGCGCGGGGCTGCCACTTTCAGCACAGGGACAAGACAATGCAAGACATCAGTGCCGGTATTCAGGCTATCAAGCGCC
AGCTTGGCGACAGGCTCTGC

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: General stress protein 70; GSP70; Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MYTPWAAFFSPEGRRLLQKSIDLALEEDGPELTAMGLFSPDAYLNAAIRAKEDTLVVGLPVIGPVFRSLGAPFRWQALVP
ETARVPAMTEVARITAPAVPMLKAERVILNFITHLSGIANLTARYVRELEGTGVRLLDTRKTTPGLRWPEKYAVQAGGAS
NHRKNLAEMLMLKDNHIDAAGSIASAVAALRSRYSPCPPIEVECRTIAHVREAIAARADRIMMDNMGGALLSEALALVPP
DIETEVSGGVRLENLRELALTAPRRPDFISVGRLTHSAVAADFSMTLLPA

Sequences:

>Translated_290_residues
MYTPWAAFFSPEGRRLLQKSIDLALEEDGPELTAMGLFSPDAYLNAAIRAKEDTLVVGLPVIGPVFRSLGAPFRWQALVP
ETARVPAMTEVARITAPAVPMLKAERVILNFITHLSGIANLTARYVRELEGTGVRLLDTRKTTPGLRWPEKYAVQAGGAS
NHRKNLAEMLMLKDNHIDAAGSIASAVAALRSRYSPCPPIEVECRTIAHVREAIAARADRIMMDNMGGALLSEALALVPP
DIETEVSGGVRLENLRELALTAPRRPDFISVGRLTHSAVAADFSMTLLPA
>Mature_290_residues
MYTPWAAFFSPEGRRLLQKSIDLALEEDGPELTAMGLFSPDAYLNAAIRAKEDTLVVGLPVIGPVFRSLGAPFRWQALVP
ETARVPAMTEVARITAPAVPMLKAERVILNFITHLSGIANLTARYVRELEGTGVRLLDTRKTTPGLRWPEKYAVQAGGAS
NHRKNLAEMLMLKDNHIDAAGSIASAVAALRSRYSPCPPIEVECRTIAHVREAIAARADRIMMDNMGGALLSEALALVPP
DIETEVSGGVRLENLRELALTAPRRPDFISVGRLTHSAVAADFSMTLLPA

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=273, Percent_Identity=35.8974358974359, Blast_Score=140, Evalue=1e-33,
Organism=Escherichia coli, GI1786299, Length=296, Percent_Identity=36.4864864864865, Blast_Score=134, Evalue=6e-33,
Organism=Saccharomyces cerevisiae, GI6321162, Length=279, Percent_Identity=33.6917562724014, Blast_Score=136, Evalue=3e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 31441; Mature: 31441

Theoretical pI: Translated: 7.63; Mature: 7.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYTPWAAFFSPEGRRLLQKSIDLALEEDGPELTAMGLFSPDAYLNAAIRAKEDTLVVGLP
CCCCCCHHCCCCHHHHHHHHHCEEECCCCCCEEEEECCCCHHHHHHHEEECCCEEEEECH
VIGPVFRSLGAPFRWQALVPETARVPAMTEVARITAPAVPMLKAERVILNFITHLSGIAN
HHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
LTARYVRELEGTGVRLLDTRKTTPGLRWPEKYAVQAGGASNHRKNLAEMLMLKDNHIDAA
HHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHEECCCCCHHHHHHHHHHHHCCCCCCHH
GSIASAVAALRSRYSPCPPIEVECRTIAHVREAIAARADRIMMDNMGGALLSEALALVPP
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCC
DIETEVSGGVRLENLRELALTAPRRPDFISVGRLTHSAVAADFSMTLLPA
CCCCCCCCCEEHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHCCEEEECCC
>Mature Secondary Structure
MYTPWAAFFSPEGRRLLQKSIDLALEEDGPELTAMGLFSPDAYLNAAIRAKEDTLVVGLP
CCCCCCHHCCCCHHHHHHHHHCEEECCCCCCEEEEECCCCHHHHHHHEEECCCEEEEECH
VIGPVFRSLGAPFRWQALVPETARVPAMTEVARITAPAVPMLKAERVILNFITHLSGIAN
HHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
LTARYVRELEGTGVRLLDTRKTTPGLRWPEKYAVQAGGASNHRKNLAEMLMLKDNHIDAA
HHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHEECCCCCHHHHHHHHHHHHCCCCCCHH
GSIASAVAALRSRYSPCPPIEVECRTIAHVREAIAARADRIMMDNMGGALLSEALALVPP
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCC
DIETEVSGGVRLENLRELALTAPRRPDFISVGRLTHSAVAADFSMTLLPA
CCCCCCCCCEEHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 8444804; 9298659 [H]