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The map label for this gene is zraR [H]

Identifier: 220904043

GI number: 220904043

Start: 901973

End: 903334

Strand: Direct

Name: zraR [H]

Synonym: Ddes_0769

Alternate gene names: 220904043

Gene position: 901973-903334 (Clockwise)

Preceding gene: 220904042

Following gene: 220904044

Centisome position: 31.39

GC content: 59.91

Gene sequence:

>1362_bases
ATGACTGCAAAAACGGCCGTAAAGCTGCTGGTGGTAGATGACGACCGCAATCACCGCGAAATGCTGCGCGCCCTGCTGGA
AGAGTGGGGCTATGCCCCCGTCACCGTGGACAATGGCGAAGAAGCCGTGGCCCTGTGCCAGGAAAGCCCCTTTGACCTTA
TCCTCATGGACGTGCGCATGGGCGGCATGAGCGGCATTGAGGCCACCCGCGCCATCAAGGGGTATAATCCGGCCATTCCC
GTGCTGATCATGACGGCCTACTCCGATGTGGCCAACGCTGTGGAGGCCCTCAAGGCCGGGGCTTACGACTATCTCACCAA
GCCGCTGGCTTTTGACGCCCTCAAACTGGCTCTGGAACGCGCCCTTGACCATGCGAGCCTGCGGGACGAAGTGCGGGCCT
TGCGGCATGAGCTGGCGGCCAATGTGGATTCGCGCGATGTCATCGGTCAAAGTCCGGCCATGCGCCAGATGCTGGGGCTG
GTTTCGGCCATTGCGCCCTCAGAGGCCACCGTACTTATCACGGGTGAATCCGGCACGGGCAAAGAAGTTATCGCCAAACT
CATTCACGCCAACAGCGGCAGAAGCAAGGGGCCTTATGTGGCCGTCAACTGTGCCGCGCTGACAGAAACCCTGCTGGAAT
CCGAACTGTTCGGGCATGAAAAAGGCGCGTTCACCGGCGCGGAAAAACGCCGTGAAGGGCGTTTTCTGGCGGCCAACAAA
GGCACGATTTTTCTGGACGAGATCGGCGAAATTCCGCTGTCCATGCAGGTCAAACTGTTGCGGGTGATTCAGGAGCGCGA
ACTGCAGCGTGTGGGTGGCGACCAGAACCTCAAGGTGGACGTGCGCATTCTGGCGGCTACCAATAAGGATCTGGCGCAGG
AGGTGGACGAGGGGCGTTTTCGCCAGGACCTGTATTACCGCCTCAATGTGGTGGCCCTGCAATTGCCGCCCCTGCGCGAC
CGTCAGGAGGACATCCCCCTGCTGGCCATGCACTTTATGAAGCTTTTTGCCGAGCGCAACGGCAAAACGGTCAAGGGTTT
TACCCCTGCCGCCATGGACAGGTTGCTCAAGCACAACTGGCCCGGCAATGTGCGTGAACTGGAAAATGCCGTGGAGCGGG
CTGTGGTGCTGCTGGTGGGAGAATATATCAGCGAACGTGAACTGCCGCCCACCATTCTGGACGTGGAAGAGGAAAATACG
CGTCCGGCGCGGCTGGATTTTGCCAACATGACGCTGGAAGAAATCGAGCGCCTGGCCGTGCAGGATACGCTTGAGCAGGT
GGGCGGCAACAAGAGCGAGGCCGCGCGGCGTCTTGGCATCAACCGCAAGACGCTTTTATCGAAACTCGGGGATGGGAAGT
AG

Upstream 100 bases:

>100_bases
TACCCTTGAACTGCCGGTGCGGGGCAGGGATGCTGCTCCGGCGGGCGGATAAATGTTCAGACAAAAACAACGGAATACTC
AAGCTGCCGAGGAAGATGAA

Downstream 100 bases:

>100_bases
CGGAGCGCTGCCGTGGGCCGCGCCCCTCATAACGGACTGCCATGCTGAAAAAAATATGCGATGTACTTTACAGGCGCTGT
GTCGGGGCAACGCGTTATTC

Product: Fis family two component sigma-54 specific transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 453; Mature: 452

Protein sequence:

>453_residues
MTAKTAVKLLVVDDDRNHREMLRALLEEWGYAPVTVDNGEEAVALCQESPFDLILMDVRMGGMSGIEATRAIKGYNPAIP
VLIMTAYSDVANAVEALKAGAYDYLTKPLAFDALKLALERALDHASLRDEVRALRHELAANVDSRDVIGQSPAMRQMLGL
VSAIAPSEATVLITGESGTGKEVIAKLIHANSGRSKGPYVAVNCAALTETLLESELFGHEKGAFTGAEKRREGRFLAANK
GTIFLDEIGEIPLSMQVKLLRVIQERELQRVGGDQNLKVDVRILAATNKDLAQEVDEGRFRQDLYYRLNVVALQLPPLRD
RQEDIPLLAMHFMKLFAERNGKTVKGFTPAAMDRLLKHNWPGNVRELENAVERAVVLLVGEYISERELPPTILDVEEENT
RPARLDFANMTLEEIERLAVQDTLEQVGGNKSEAARRLGINRKTLLSKLGDGK

Sequences:

>Translated_453_residues
MTAKTAVKLLVVDDDRNHREMLRALLEEWGYAPVTVDNGEEAVALCQESPFDLILMDVRMGGMSGIEATRAIKGYNPAIP
VLIMTAYSDVANAVEALKAGAYDYLTKPLAFDALKLALERALDHASLRDEVRALRHELAANVDSRDVIGQSPAMRQMLGL
VSAIAPSEATVLITGESGTGKEVIAKLIHANSGRSKGPYVAVNCAALTETLLESELFGHEKGAFTGAEKRREGRFLAANK
GTIFLDEIGEIPLSMQVKLLRVIQERELQRVGGDQNLKVDVRILAATNKDLAQEVDEGRFRQDLYYRLNVVALQLPPLRD
RQEDIPLLAMHFMKLFAERNGKTVKGFTPAAMDRLLKHNWPGNVRELENAVERAVVLLVGEYISERELPPTILDVEEENT
RPARLDFANMTLEEIERLAVQDTLEQVGGNKSEAARRLGINRKTLLSKLGDGK
>Mature_452_residues
TAKTAVKLLVVDDDRNHREMLRALLEEWGYAPVTVDNGEEAVALCQESPFDLILMDVRMGGMSGIEATRAIKGYNPAIPV
LIMTAYSDVANAVEALKAGAYDYLTKPLAFDALKLALERALDHASLRDEVRALRHELAANVDSRDVIGQSPAMRQMLGLV
SAIAPSEATVLITGESGTGKEVIAKLIHANSGRSKGPYVAVNCAALTETLLESELFGHEKGAFTGAEKRREGRFLAANKG
TIFLDEIGEIPLSMQVKLLRVIQERELQRVGGDQNLKVDVRILAATNKDLAQEVDEGRFRQDLYYRLNVVALQLPPLRDR
QEDIPLLAMHFMKLFAERNGKTVKGFTPAAMDRLLKHNWPGNVRELENAVERAVVLLVGEYISERELPPTILDVEEENTR
PARLDFANMTLEEIERLAVQDTLEQVGGNKSEAARRLGINRKTLLSKLGDGK

Specific function: Member of the two-component regulatory system zraS/zraR. When activated by zraS it acts in conjunction with sigma-54 to regulate the expression of zraP. Positively autoregulates the expression of the zraSR operon [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1790437, Length=449, Percent_Identity=58.7973273942094, Blast_Score=518, Evalue=1e-148,
Organism=Escherichia coli, GI1788550, Length=450, Percent_Identity=48, Blast_Score=424, Evalue=1e-120,
Organism=Escherichia coli, GI1790299, Length=463, Percent_Identity=42.548596112311, Blast_Score=350, Evalue=7e-98,
Organism=Escherichia coli, GI1788905, Length=446, Percent_Identity=41.7040358744395, Blast_Score=328, Evalue=5e-91,
Organism=Escherichia coli, GI87082117, Length=336, Percent_Identity=47.6190476190476, Blast_Score=291, Evalue=6e-80,
Organism=Escherichia coli, GI1789233, Length=314, Percent_Identity=48.0891719745223, Blast_Score=280, Evalue=1e-76,
Organism=Escherichia coli, GI1789087, Length=327, Percent_Identity=48.3180428134557, Blast_Score=271, Evalue=8e-74,
Organism=Escherichia coli, GI87082152, Length=236, Percent_Identity=52.9661016949153, Blast_Score=244, Evalue=1e-65,
Organism=Escherichia coli, GI1786524, Length=360, Percent_Identity=41.9444444444444, Blast_Score=241, Evalue=8e-65,
Organism=Escherichia coli, GI87081872, Length=309, Percent_Identity=44.0129449838188, Blast_Score=239, Evalue=3e-64,
Organism=Escherichia coli, GI1787583, Length=332, Percent_Identity=37.3493975903614, Blast_Score=196, Evalue=2e-51,
Organism=Escherichia coli, GI1789828, Length=270, Percent_Identity=35.5555555555556, Blast_Score=148, Evalue=6e-37,
Organism=Escherichia coli, GI87081858, Length=298, Percent_Identity=30.8724832214765, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI1786784, Length=105, Percent_Identity=34.2857142857143, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1789149, Length=223, Percent_Identity=26.9058295964126, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1786599, Length=107, Percent_Identity=37.3831775700935, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI87082012, Length=163, Percent_Identity=30.0613496932515, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1789809, Length=102, Percent_Identity=31.3725490196078, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 50041; Mature: 49910

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAKTAVKLLVVDDDRNHREMLRALLEEWGYAPVTVDNGEEAVALCQESPFDLILMDVRM
CCCCCEEEEEEEECCCCHHHHHHHHHHHCCCCCEEECCCCHHHHHHCCCCCCEEEEEECC
GGMSGIEATRAIKGYNPAIPVLIMTAYSDVANAVEALKAGAYDYLTKPLAFDALKLALER
CCCCCHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHHHCCCHHHHHCHHHHHHHHHHHHH
ALDHASLRDEVRALRHELAANVDSRDVIGQSPAMRQMLGLVSAIAPSEATVLITGESGTG
HHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCC
KEVIAKLIHANSGRSKGPYVAVNCAALTETLLESELFGHEKGAFTGAEKRREGRFLAANK
HHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCEEEECC
GTIFLDEIGEIPLSMQVKLLRVIQERELQRVGGDQNLKVDVRILAATNKDLAQEVDEGRF
CEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCHHHHHHHHHHHH
RQDLYYRLNVVALQLPPLRDRQEDIPLLAMHFMKLFAERNGKTVKGFTPAAMDRLLKHNW
HHHHHHEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHCCC
PGNVRELENAVERAVVLLVGEYISERELPPTILDVEEENTRPARLDFANMTLEEIERLAV
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCEEEHHHCCHHHHHHHHH
QDTLEQVGGNKSEAARRLGINRKTLLSKLGDGK
HHHHHHHCCCHHHHHHHHCCCHHHHHHHHCCCC
>Mature Secondary Structure 
TAKTAVKLLVVDDDRNHREMLRALLEEWGYAPVTVDNGEEAVALCQESPFDLILMDVRM
CCCCEEEEEEEECCCCHHHHHHHHHHHCCCCCEEECCCCHHHHHHCCCCCCEEEEEECC
GGMSGIEATRAIKGYNPAIPVLIMTAYSDVANAVEALKAGAYDYLTKPLAFDALKLALER
CCCCCHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHHHCCCHHHHHCHHHHHHHHHHHHH
ALDHASLRDEVRALRHELAANVDSRDVIGQSPAMRQMLGLVSAIAPSEATVLITGESGTG
HHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCC
KEVIAKLIHANSGRSKGPYVAVNCAALTETLLESELFGHEKGAFTGAEKRREGRFLAANK
HHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCEEEECC
GTIFLDEIGEIPLSMQVKLLRVIQERELQRVGGDQNLKVDVRILAATNKDLAQEVDEGRF
CEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCHHHHHHHHHHHH
RQDLYYRLNVVALQLPPLRDRQEDIPLLAMHFMKLFAERNGKTVKGFTPAAMDRLLKHNW
HHHHHHEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHCCC
PGNVRELENAVERAVVLLVGEYISERELPPTILDVEEENTRPARLDFANMTLEEIERLAV
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCEEEHHHCCHHHHHHHHH
QDTLEQVGGNKSEAARRLGINRKTLLSKLGDGK
HHHHHHHCCCHHHHHHHHCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]