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The map label for this gene is cyp18 [H]

Identifier: 220904013

GI number: 220904013

Start: 872058

End: 872657

Strand: Direct

Name: cyp18 [H]

Synonym: Ddes_0739

Alternate gene names: 220904013

Gene position: 872058-872657 (Clockwise)

Preceding gene: 220904008

Following gene: 220904019

Centisome position: 30.35

GC content: 54.5

Gene sequence:

>600_bases
ATGAAATCTTTCCGTACCGGCGTCGTGTTTCGCGCCCTCGCCCTGGCGTTTTGCCTTATGGCCGCGCCTTTCATGACTCC
GGCCCAGGCCGCCACGCCCGATCCGGCAGTGAAGCTTGAAACAAACTTTGGCGAAATTGTCGTGCGCCTGGACGCCCGCA
AGGCTCCCATCAGCACAGCCAACTTTGTGCAATATGTCAAATCCGGCTTTTACGACGGCACGATCTTTCACCGGGTCATC
AAGAATTTCATGATCCAGGGCGGTGGTTTTACGCCGGACATGAAGCAGAAAGAAACCCGCGCCGCCATCCGCAACGAAGC
GGATAATGGGCTTAAAAACAAAAAATACACCATAGCCATGGCCCGTACCGGCGAACCCCATTCGGCCACGGCCCAGTTTT
TCATCAATACCAAGGACAACGATTTTCTGGACTTCAAAAGCCAGACTCCCCAGGGCTGGGGCTACGCTGTTTTCGGCAAG
GTGATCAAGGGGCAGGAAGTGGTGGACAAGATTGCCGCTGTCATGACCGGCAAAAAGGGGTATTATGATGACGTGCCCAG
GGAAAACGTCATCATCAAAAAGGCCGTGGTGGTGGAATAG

Upstream 100 bases:

>100_bases
GCAACTGTGGCAACTTGATGGACGCGTGCGGGCATGGTAGTTTTTCATGCACCGCCGGATTTTTCCGGTCTTTATACCGC
AGCAGCGCAAGGAGATACAT

Downstream 100 bases:

>100_bases
AGCATTTTACCTTTGAGAAAAGTTAGATGCGCTAACGTTGCACAAAAGTGCGGCGCGCCGTAACACGACGTGGATTCTGC
CGGAAATTTATTTTTCGGCA

Product: cyclophilin type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase cyp18; SanCyp18; Rotamase cyp18 [H]

Number of amino acids: Translated: 199; Mature: 199

Protein sequence:

>199_residues
MKSFRTGVVFRALALAFCLMAAPFMTPAQAATPDPAVKLETNFGEIVVRLDARKAPISTANFVQYVKSGFYDGTIFHRVI
KNFMIQGGGFTPDMKQKETRAAIRNEADNGLKNKKYTIAMARTGEPHSATAQFFINTKDNDFLDFKSQTPQGWGYAVFGK
VIKGQEVVDKIAAVMTGKKGYYDDVPRENVIIKKAVVVE

Sequences:

>Translated_199_residues
MKSFRTGVVFRALALAFCLMAAPFMTPAQAATPDPAVKLETNFGEIVVRLDARKAPISTANFVQYVKSGFYDGTIFHRVI
KNFMIQGGGFTPDMKQKETRAAIRNEADNGLKNKKYTIAMARTGEPHSATAQFFINTKDNDFLDFKSQTPQGWGYAVFGK
VIKGQEVVDKIAAVMTGKKGYYDDVPRENVIIKKAVVVE
>Mature_199_residues
MKSFRTGVVFRALALAFCLMAAPFMTPAQAATPDPAVKLETNFGEIVVRLDARKAPISTANFVQYVKSGFYDGTIFHRVI
KNFMIQGGGFTPDMKQKETRAAIRNEADNGLKNKKYTIAMARTGEPHSATAQFFINTKDNDFLDFKSQTPQGWGYAVFGK
VIKGQEVVDKIAAVMTGKKGYYDDVPRENVIIKKAVVVE

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI7706339, Length=173, Percent_Identity=34.1040462427746, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI24308049, Length=178, Percent_Identity=33.1460674157303, Blast_Score=78, Evalue=6e-15,
Organism=Homo sapiens, GI19557636, Length=165, Percent_Identity=32.1212121212121, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI22547215, Length=164, Percent_Identity=32.3170731707317, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI22547212, Length=164, Percent_Identity=32.3170731707317, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI7657473, Length=164, Percent_Identity=32.3170731707317, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI4758950, Length=201, Percent_Identity=30.8457711442786, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI64276486, Length=128, Percent_Identity=34.375, Blast_Score=64, Evalue=9e-11,
Organism=Escherichia coli, GI1786736, Length=163, Percent_Identity=58.2822085889571, Blast_Score=203, Evalue=7e-54,
Organism=Escherichia coli, GI1789763, Length=188, Percent_Identity=54.2553191489362, Blast_Score=186, Evalue=8e-49,
Organism=Caenorhabditis elegans, GI17532641, Length=164, Percent_Identity=32.9268292682927, Blast_Score=77, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17539496, Length=175, Percent_Identity=32, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17506311, Length=157, Percent_Identity=32.484076433121, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71980594, Length=147, Percent_Identity=34.0136054421769, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI71980590, Length=147, Percent_Identity=34.0136054421769, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17552780, Length=159, Percent_Identity=37.1069182389937, Blast_Score=71, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17506307, Length=155, Percent_Identity=33.5483870967742, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71997782, Length=128, Percent_Identity=32.03125, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI17986117, Length=174, Percent_Identity=34.4827586206897, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI19922912, Length=154, Percent_Identity=35.7142857142857, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI19922376, Length=164, Percent_Identity=28.6585365853659, Blast_Score=75, Evalue=3e-14,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 22029; Mature: 22029

Theoretical pI: Translated: 10.19; Mature: 10.19

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSFRTGVVFRALALAFCLMAAPFMTPAQAATPDPAVKLETNFGEIVVRLDARKAPISTA
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCEEEEEECCCCCCCCHH
NFVQYVKSGFYDGTIFHRVIKNFMIQGGGFTPDMKQKETRAAIRNEADNGLKNKKYTIAM
HHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEE
ARTGEPHSATAQFFINTKDNDFLDFKSQTPQGWGYAVFGKVIKGQEVVDKIAAVMTGKKG
EECCCCCCCEEEEEEECCCCCEECCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHCCCCC
YYDDVPRENVIIKKAVVVE
CCCCCCCCCEEEEEEEECC
>Mature Secondary Structure
MKSFRTGVVFRALALAFCLMAAPFMTPAQAATPDPAVKLETNFGEIVVRLDARKAPISTA
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCEEEEEECCCCCCCCHH
NFVQYVKSGFYDGTIFHRVIKNFMIQGGGFTPDMKQKETRAAIRNEADNGLKNKKYTIAM
HHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEE
ARTGEPHSATAQFFINTKDNDFLDFKSQTPQGWGYAVFGKVIKGQEVVDKIAAVMTGKKG
EECCCCCCCEEEEEEECCCCCEECCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHCCCCC
YYDDVPRENVIIKKAVVVE
CCCCCCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10400660 [H]