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The map label for this gene is lktD [H]

Identifier: 220903911

GI number: 220903911

Start: 768271

End: 770295

Strand: Direct

Name: lktD [H]

Synonym: Ddes_0636

Alternate gene names: 220903911

Gene position: 768271-770295 (Clockwise)

Preceding gene: 220903910

Following gene: 220903912

Centisome position: 26.74

GC content: 59.95

Gene sequence:

>2025_bases
ATGCAGTTGACACCACAAGATAAAGATAAAGAAAAAGGCCCCATTGCTCCGGCGGCAAGCCCTGCGGAATCCGCTGTGCC
CGACGGTGCCCGGGGGCAGGAGTCCGGCGGTCCGGCCGCTTCCGGGGCCGTTTCTCCGGATTCTTCTTCCCGTACCGCGC
CGCAGCCGGATTTTAATGCGGCTTTTTGCGGCACGGCCGAGAACGGGTTTTTGTGTTACCTGCCCTCGGGGCAGGCTCCC
TTTGGCGCGCCAAAGCCGGTCCATAAAGATGATGCCCTGCCCGCCATGCCCGGTGCGGGATCGGAAGGAGCCGCGCCCAT
CGTCATGCCTGTGTCTGGCGAGCATGATGGTCACTGGACGGATGATCAGGTGGACGGCATCGGCTTTCTCCCGCTGGGGC
ATGGTGAGGAGAGCCGTCATGACATGCCGCACCCCGTCGGCCCGGAAGGGAGCGTTCCCGCGCCTGTCGAGCAGAGCGGC
CCCAAGGCTTTTCTGCGCGACCTGCTCATGGGCGGCGAGCATGAGCAGCGGCCGGATAAAAGTCTCCGCCAGTCCATCGC
CGAAACCCTGAACCGCCTGAAAGGCGGTGAGGGAGCGCCGCCACCCGGCCAGCAGCAGGGCAATCCCGGTCTTTTTGCTG
CTATGGACGCACCCCTCAACGGCCTGACACCCGACGACATACAGTTTGCCAGCGAGGTGGACGCCGCGCTGGCGCGCAGG
CCCCATTTCGGTGTCCGGGCGCTCTCCATCTGCGTGGCGGTCATGTTTTTGTGTCTCATCATCTGGGCTGCCTTTGCCAG
TGTGGACGAAGTGACCCACGCCGAAGGCACGGTGGTGGGGTCACAGCGTACCCAAACCATACAGAACCTTGAAGGCGGCA
TTCTGCGTGCCGTTATGGTGCGCGAAGGCCAGATTGTGGACAAGGGGACAATACTGGCCCAGCTGGATAACGAAATGGCC
GAGAGCGCGTACCGCGATGCCGTGAACAAGGCTATGGAAAACAGTCTGGCAATAGCCCGCCTTGAGGCGGAAATAAAAAG
TGAGCCACCTGTTTTTCCGGAGCATCTTGAAGCATGGGCCAGTCAGCTTATTGGCCGCAGGGTGGACGAATCCGTCCTGG
CCCGCGCCCGCCAGATCATGCAGGACCAGGAAAATGCCTATCAGGTGCGTCGTGTACAACTGAATGCTGAAGTCGAGGTA
TTGCAGTCGCAATACACCCAGCGCATGCACGATGTCGAGGAGCAGACAGCCCGCAAGGTACAGCTTGACCGCAGCCTGGC
CCTGGCCATTGAGCAGCGTGATACTGCCTATGCGCTGGTGCAGCGCAACAACTTTTCCAAGATGGAATATCTCGGCCTGC
AGCAGCGGGTGGTGGAACTGCAGGGGCAGATTGACGCCCTGGCCGCAGCCATACCCAAGGCGCAGGCTGCGGCTGAAGAA
TCGCGGCAGCGCATAGCTTCGCGCCGTGCGGAGCAGGCCTCGGCCATTACGGAAGAAATCAATAAAAGACGCCAGGAGCT
GAACTCGCTGCGCGAAAGCATCTCTGCCGGACGCGACCGGGTGACCCGCACCGAACTTCGCGCGCCTGTGCGCGGCACGG
TAAAGCAGATATACATTTCTACCGTGGGCGGCGTGGTAAAGCCCGGTGAACCCATCATGGACATCGTGCCCCTGGACGAT
ACCCTGCTGGTGGAGGCCAAGGTCAAGCCGCAGGACGTGGCTTTTCTGCGTCCCGGGCAGGATGTGATGGTCAAGGTTTC
TGCCTATGACTTTTCCATTTACGGCGGTCTTGAGGGCAAGCTTGAGTCCATCAGTGCCGACACCATTGAGGACAAGAAGG
GCGAGCATTTTTATCTGGTCAAGGTGCGTACCCAGAAAAATGCCATTGTCTATCACAAGGAATATCTGCCCATTATCCCC
GGCATGATTGTGACCACAGATATTCTCATCGGCAAAAAAACTGTTCTGGATTATCTGCTCAAGCCCATTCTCAAGGCCAA
GCAGAACGCCCTGCGAGAGCGCTGA

Upstream 100 bases:

>100_bases
GCCGTTTTGCAGCGTCTGCGTGACCGTTCACGGCAAAGCATGGATACGGCACGACAGGGACAGGGCGCTCCGGCGCAACG
GCCCGCGGAGAATATGTAGC

Downstream 100 bases:

>100_bases
TCCGTCGCGAAAGGAACGATTATGGCATTACAGGATTCTTCCGACATAAAGTCGCGCAACCGCGCCGCAGCCCGGATCAT
GCTGGCTGTCTTTGCGGTGA

Product: HlyD family type I secretion membrane fusion protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 674; Mature: 674

Protein sequence:

>674_residues
MQLTPQDKDKEKGPIAPAASPAESAVPDGARGQESGGPAASGAVSPDSSSRTAPQPDFNAAFCGTAENGFLCYLPSGQAP
FGAPKPVHKDDALPAMPGAGSEGAAPIVMPVSGEHDGHWTDDQVDGIGFLPLGHGEESRHDMPHPVGPEGSVPAPVEQSG
PKAFLRDLLMGGEHEQRPDKSLRQSIAETLNRLKGGEGAPPPGQQQGNPGLFAAMDAPLNGLTPDDIQFASEVDAALARR
PHFGVRALSICVAVMFLCLIIWAAFASVDEVTHAEGTVVGSQRTQTIQNLEGGILRAVMVREGQIVDKGTILAQLDNEMA
ESAYRDAVNKAMENSLAIARLEAEIKSEPPVFPEHLEAWASQLIGRRVDESVLARARQIMQDQENAYQVRRVQLNAEVEV
LQSQYTQRMHDVEEQTARKVQLDRSLALAIEQRDTAYALVQRNNFSKMEYLGLQQRVVELQGQIDALAAAIPKAQAAAEE
SRQRIASRRAEQASAITEEINKRRQELNSLRESISAGRDRVTRTELRAPVRGTVKQIYISTVGGVVKPGEPIMDIVPLDD
TLLVEAKVKPQDVAFLRPGQDVMVKVSAYDFSIYGGLEGKLESISADTIEDKKGEHFYLVKVRTQKNAIVYHKEYLPIIP
GMIVTTDILIGKKTVLDYLLKPILKAKQNALRER

Sequences:

>Translated_674_residues
MQLTPQDKDKEKGPIAPAASPAESAVPDGARGQESGGPAASGAVSPDSSSRTAPQPDFNAAFCGTAENGFLCYLPSGQAP
FGAPKPVHKDDALPAMPGAGSEGAAPIVMPVSGEHDGHWTDDQVDGIGFLPLGHGEESRHDMPHPVGPEGSVPAPVEQSG
PKAFLRDLLMGGEHEQRPDKSLRQSIAETLNRLKGGEGAPPPGQQQGNPGLFAAMDAPLNGLTPDDIQFASEVDAALARR
PHFGVRALSICVAVMFLCLIIWAAFASVDEVTHAEGTVVGSQRTQTIQNLEGGILRAVMVREGQIVDKGTILAQLDNEMA
ESAYRDAVNKAMENSLAIARLEAEIKSEPPVFPEHLEAWASQLIGRRVDESVLARARQIMQDQENAYQVRRVQLNAEVEV
LQSQYTQRMHDVEEQTARKVQLDRSLALAIEQRDTAYALVQRNNFSKMEYLGLQQRVVELQGQIDALAAAIPKAQAAAEE
SRQRIASRRAEQASAITEEINKRRQELNSLRESISAGRDRVTRTELRAPVRGTVKQIYISTVGGVVKPGEPIMDIVPLDD
TLLVEAKVKPQDVAFLRPGQDVMVKVSAYDFSIYGGLEGKLESISADTIEDKKGEHFYLVKVRTQKNAIVYHKEYLPIIP
GMIVTTDILIGKKTVLDYLLKPILKAKQNALRER
>Mature_674_residues
MQLTPQDKDKEKGPIAPAASPAESAVPDGARGQESGGPAASGAVSPDSSSRTAPQPDFNAAFCGTAENGFLCYLPSGQAP
FGAPKPVHKDDALPAMPGAGSEGAAPIVMPVSGEHDGHWTDDQVDGIGFLPLGHGEESRHDMPHPVGPEGSVPAPVEQSG
PKAFLRDLLMGGEHEQRPDKSLRQSIAETLNRLKGGEGAPPPGQQQGNPGLFAAMDAPLNGLTPDDIQFASEVDAALARR
PHFGVRALSICVAVMFLCLIIWAAFASVDEVTHAEGTVVGSQRTQTIQNLEGGILRAVMVREGQIVDKGTILAQLDNEMA
ESAYRDAVNKAMENSLAIARLEAEIKSEPPVFPEHLEAWASQLIGRRVDESVLARARQIMQDQENAYQVRRVQLNAEVEV
LQSQYTQRMHDVEEQTARKVQLDRSLALAIEQRDTAYALVQRNNFSKMEYLGLQQRVVELQGQIDALAAAIPKAQAAAEE
SRQRIASRRAEQASAITEEINKRRQELNSLRESISAGRDRVTRTELRAPVRGTVKQIYISTVGGVVKPGEPIMDIVPLDD
TLLVEAKVKPQDVAFLRPGQDVMVKVSAYDFSIYGGLEGKLESISADTIEDKKGEHFYLVKVRTQKNAIVYHKEYLPIIP
GMIVTTDILIGKKTVLDYLLKPILKAKQNALRER

Specific function: Involved in the transport of the Leukotoxin [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003997
- InterPro:   IPR006143
- InterPro:   IPR006144
- InterPro:   IPR010129 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 73146; Mature: 73146

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS00543 HLYD_FAMILY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLTPQDKDKEKGPIAPAASPAESAVPDGARGQESGGPAASGAVSPDSSSRTAPQPDFNA
CCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
AFCGTAENGFLCYLPSGQAPFGAPKPVHKDDALPAMPGAGSEGAAPIVMPVSGEHDGHWT
EEECCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCC
DDQVDGIGFLPLGHGEESRHDMPHPVGPEGSVPAPVEQSGPKAFLRDLLMGGEHEQRPDK
CCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHH
SLRQSIAETLNRLKGGEGAPPPGQQQGNPGLFAAMDAPLNGLTPDDIQFASEVDAALARR
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCC
PHFGVRALSICVAVMFLCLIIWAAFASVDEVTHAEGTVVGSQRTQTIQNLEGGILRAVMV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHCCHHHHHHHH
REGQIVDKGTILAQLDNEMAESAYRDAVNKAMENSLAIARLEAEIKSEPPVFPEHLEAWA
HCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
SQLIGRRVDESVLARARQIMQDQENAYQVRRVQLNAEVEVLQSQYTQRMHDVEEQTARKV
HHHHHHHCCHHHHHHHHHHHHHHHHHHEEHHEEECHHHHHHHHHHHHHHHHHHHHHHHHH
QLDRSLALAIEQRDTAYALVQRNNFSKMEYLGLQQRVVELQGQIDALAAAIPKAQAAAEE
HHHHHHHEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
SRQRIASRRAEQASAITEEINKRRQELNSLRESISAGRDRVTRTELRAPVRGTVKQIYIS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
TVGGVVKPGEPIMDIVPLDDTLLVEAKVKPQDVAFLRPGQDVMVKVSAYDFSIYGGLEGK
HHCCCCCCCCCCEEEECCCCEEEEEEECCCCCEEEECCCCCEEEEEEEEEEEEECCCCCH
LESISADTIEDKKGEHFYLVKVRTQKNAIVYHKEYLPIIPGMIVTTDILIGKKTVLDYLL
HHHCCCCCCCCCCCCEEEEEEEEECCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHH
KPILKAKQNALRER
HHHHHHHHHHHCCC
>Mature Secondary Structure
MQLTPQDKDKEKGPIAPAASPAESAVPDGARGQESGGPAASGAVSPDSSSRTAPQPDFNA
CCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
AFCGTAENGFLCYLPSGQAPFGAPKPVHKDDALPAMPGAGSEGAAPIVMPVSGEHDGHWT
EEECCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCC
DDQVDGIGFLPLGHGEESRHDMPHPVGPEGSVPAPVEQSGPKAFLRDLLMGGEHEQRPDK
CCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHH
SLRQSIAETLNRLKGGEGAPPPGQQQGNPGLFAAMDAPLNGLTPDDIQFASEVDAALARR
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCC
PHFGVRALSICVAVMFLCLIIWAAFASVDEVTHAEGTVVGSQRTQTIQNLEGGILRAVMV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHCCHHHHHHHH
REGQIVDKGTILAQLDNEMAESAYRDAVNKAMENSLAIARLEAEIKSEPPVFPEHLEAWA
HCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
SQLIGRRVDESVLARARQIMQDQENAYQVRRVQLNAEVEVLQSQYTQRMHDVEEQTARKV
HHHHHHHCCHHHHHHHHHHHHHHHHHHEEHHEEECHHHHHHHHHHHHHHHHHHHHHHHHH
QLDRSLALAIEQRDTAYALVQRNNFSKMEYLGLQQRVVELQGQIDALAAAIPKAQAAAEE
HHHHHHHEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
SRQRIASRRAEQASAITEEINKRRQELNSLRESISAGRDRVTRTELRAPVRGTVKQIYIS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
TVGGVVKPGEPIMDIVPLDDTLLVEAKVKPQDVAFLRPGQDVMVKVSAYDFSIYGGLEGK
HHCCCCCCCCCCEEEECCCCEEEEEEECCCCCEEEECCCCCEEEEEEEEEEEEECCCCCH
LESISADTIEDKKGEHFYLVKVRTQKNAIVYHKEYLPIIPGMIVTTDILIGKKTVLDYLL
HHHCCCCCCCCCCCCEEEEEEEEECCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHH
KPILKAKQNALRER
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3040588; 2914876; 2707120 [H]