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The map label for this gene is lolC [H]

Identifier: 220903888

GI number: 220903888

Start: 741710

End: 742945

Strand: Reverse

Name: lolC [H]

Synonym: Ddes_0613

Alternate gene names: 220903888

Gene position: 742945-741710 (Counterclockwise)

Preceding gene: 220903895

Following gene: 220903887

Centisome position: 25.86

GC content: 58.66

Gene sequence:

>1236_bases
ATGCCGCAAATGTCGTTCGAACTCTTCGTGGCCTTGCGCTATTTGTTTTCAAGACGCAAGCAGACCTTCATCTACATCAT
ATCGCTCATGTCCATTCTGGGCGTGGCACTCGGCGTTGGCGCGCTGGTGGTGGTGCTTGGCGTGTACAACGGCATGACCA
CCGATATGCGGGACAAGATCCTCGGCGCCAATTCACACGCCATAGTCATGTCCTATCTGCCCTCAGCCTTTGAAAACGAT
GACGGCCTGCTGGAGCGCATCCGTTCCATCAAGGGCGTCACCGGGGCCACCCCCTTTGTCTATACCGAGGTGATGCTTTC
AACTGCCAACGGCGTAAAGGGCGTGGTGCTGCGCGGCATTGACCCTGAATCCGGGCCGCGTGTGCTCTCCATGCTGCGCC
AGATGCGTTCCGGTTCTGCTGCCGACCTGCAAAAAGAAGGAGCGCCCGGCCTTATCATCGGTGAAGAACTGGCCAAGCGC
CTTGGCCTTGCGGTGGGCAGCCGGGTGAACCTGCTCTCCCCGTCCGGGCAGAAGACCGCATCGGGCTACGCGCCGCGCAT
CCGCCCCTTCGAGGTGGTGGGCGTCTTCAAGACAGGCATGTTTGAATACGACTCGTCCCTGGCGTTCGTGCATCTTTCCG
CAGCCCGCGATGTGCTCGGCCTGCCCGAAAAATATCTTTCGGGCGTGGAACTCACCGTGAACGACCTCTTCAAGGCCGAT
CAGATATCCAGCCGCGTAGCCACCGAACTGGGATCGCCCTTTTATGTGCGCTCGTGGATGGAAATGAACGCCAACCTCTT
TGCAGCCCTCAAGCTGGAAAAGATAGGCATGTTCATCCTGCTGACCATGGTGGTGCTTATTGGTTCTTTCTCCATTGTGA
CGTCTCTTGTCATGCTGGTGATGGAAAAAACACGCGACATCGCCATCATGATGTCCATGGGGGCCACACGCGGCATGATA
CGCCGCATCTTCATGTTCCAGGGCAGCATCATCGGCGTTATCGGTACGCTGCTGGGCTATGTGCTCGGCCTTACAGTGGG
CTGGCTGCTCAAGCGCTACCAGTTCATCAAGCTGCCTGAAAACGTGTATACTCTCGACCACCTGCCCATCAGCATCACCC
TCAGCGATGTGCTCATCGTGGGGGCCAGCGCCATGCTGCTGTGCTTTCTGGCCACACTTTACCCGGCCCGCCAGGCGGCC
CGCCTTGAACCGGCGGAAGCCCTGCGCTACGAGTAG

Upstream 100 bases:

>100_bases
CGCCTTTATTGCGTCCATGTGGGGAGTTCTGCCACCGGGAAACCGGCGGCAGGAGCATTTTCTAAAAAATATCTTGAATA
TCCTGCCAAGCTGGGCCAAT

Downstream 100 bases:

>100_bases
CCATGTCTGCACTCTACAAATTTTCCGATGTGAACAAAATTTTTTCCGCACCCGGGGAAAATCTTGAAATTCTCAAAGAT
ATCAGCCTGGTTGTGAACGA

Product: lipoprotein releasing system, transmembrane protein, LolC/E family

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 411; Mature: 410

Protein sequence:

>411_residues
MPQMSFELFVALRYLFSRRKQTFIYIISLMSILGVALGVGALVVVLGVYNGMTTDMRDKILGANSHAIVMSYLPSAFEND
DGLLERIRSIKGVTGATPFVYTEVMLSTANGVKGVVLRGIDPESGPRVLSMLRQMRSGSAADLQKEGAPGLIIGEELAKR
LGLAVGSRVNLLSPSGQKTASGYAPRIRPFEVVGVFKTGMFEYDSSLAFVHLSAARDVLGLPEKYLSGVELTVNDLFKAD
QISSRVATELGSPFYVRSWMEMNANLFAALKLEKIGMFILLTMVVLIGSFSIVTSLVMLVMEKTRDIAIMMSMGATRGMI
RRIFMFQGSIIGVIGTLLGYVLGLTVGWLLKRYQFIKLPENVYTLDHLPISITLSDVLIVGASAMLLCFLATLYPARQAA
RLEPAEALRYE

Sequences:

>Translated_411_residues
MPQMSFELFVALRYLFSRRKQTFIYIISLMSILGVALGVGALVVVLGVYNGMTTDMRDKILGANSHAIVMSYLPSAFEND
DGLLERIRSIKGVTGATPFVYTEVMLSTANGVKGVVLRGIDPESGPRVLSMLRQMRSGSAADLQKEGAPGLIIGEELAKR
LGLAVGSRVNLLSPSGQKTASGYAPRIRPFEVVGVFKTGMFEYDSSLAFVHLSAARDVLGLPEKYLSGVELTVNDLFKAD
QISSRVATELGSPFYVRSWMEMNANLFAALKLEKIGMFILLTMVVLIGSFSIVTSLVMLVMEKTRDIAIMMSMGATRGMI
RRIFMFQGSIIGVIGTLLGYVLGLTVGWLLKRYQFIKLPENVYTLDHLPISITLSDVLIVGASAMLLCFLATLYPARQAA
RLEPAEALRYE
>Mature_410_residues
PQMSFELFVALRYLFSRRKQTFIYIISLMSILGVALGVGALVVVLGVYNGMTTDMRDKILGANSHAIVMSYLPSAFENDD
GLLERIRSIKGVTGATPFVYTEVMLSTANGVKGVVLRGIDPESGPRVLSMLRQMRSGSAADLQKEGAPGLIIGEELAKRL
GLAVGSRVNLLSPSGQKTASGYAPRIRPFEVVGVFKTGMFEYDSSLAFVHLSAARDVLGLPEKYLSGVELTVNDLFKADQ
ISSRVATELGSPFYVRSWMEMNANLFAALKLEKIGMFILLTMVVLIGSFSIVTSLVMLVMEKTRDIAIMMSMGATRGMIR
RIFMFQGSIIGVIGTLLGYVLGLTVGWLLKRYQFIKLPENVYTLDHLPISITLSDVLIVGASAMLLCFLATLYPARQAAR
LEPAEALRYE

Specific function: Part of an ATP-dependent transport system responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and

COG id: COG4591

COG function: function code M; ABC-type transport system, involved in lipoprotein release, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787360, Length=407, Percent_Identity=34.1523341523341, Blast_Score=175, Evalue=5e-45,
Organism=Escherichia coli, GI1787362, Length=415, Percent_Identity=27.9518072289157, Blast_Score=170, Evalue=2e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003838
- InterPro:   IPR011925 [H]

Pfam domain/function: PF02687 FtsX [H]

EC number: NA

Molecular weight: Translated: 44941; Mature: 44810

Theoretical pI: Translated: 9.70; Mature: 9.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQMSFELFVALRYLFSRRKQTFIYIISLMSILGVALGVGALVVVLGVYNGMTTDMRDKI
CCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
LGANSHAIVMSYLPSAFENDDGLLERIRSIKGVTGATPFVYTEVMLSTANGVKGVVLRGI
CCCCCCCHHHHHCCHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCEEEEECC
DPESGPRVLSMLRQMRSGSAADLQKEGAPGLIIGEELAKRLGLAVGSRVNLLSPSGQKTA
CCCCCHHHHHHHHHHHCCCCCCHHHCCCCCEEEHHHHHHHHHHHHCCCEEEECCCCCCCC
SGYAPRIRPFEVVGVFKTGMFEYDSSLAFVHLSAARDVLGLPEKYLSGVELTVNDLFKAD
CCCCCCCCCEEEEEHHHHCCHHCCCCEEEEEEHHHHHHHCCCHHHHCCCEEEHHHHHHHH
QISSRVATELGSPFYVRSWMEMNANLFAALKLEKIGMFILLTMVVLIGSFSIVTSLVMLV
HHHHHHHHHHCCCHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
MEKTRDIAIMMSMGATRGMIRRIFMFQGSIIGVIGTLLGYVLGLTVGWLLKRYQFIKLPE
HHHCCCEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCC
NVYTLDHLPISITLSDVLIVGASAMLLCFLATLYPARQAARLEPAEALRYE
CEEEECCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCC
>Mature Secondary Structure 
PQMSFELFVALRYLFSRRKQTFIYIISLMSILGVALGVGALVVVLGVYNGMTTDMRDKI
CCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
LGANSHAIVMSYLPSAFENDDGLLERIRSIKGVTGATPFVYTEVMLSTANGVKGVVLRGI
CCCCCCCHHHHHCCHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCEEEEECC
DPESGPRVLSMLRQMRSGSAADLQKEGAPGLIIGEELAKRLGLAVGSRVNLLSPSGQKTA
CCCCCHHHHHHHHHHHCCCCCCHHHCCCCCEEEHHHHHHHHHHHHCCCEEEECCCCCCCC
SGYAPRIRPFEVVGVFKTGMFEYDSSLAFVHLSAARDVLGLPEKYLSGVELTVNDLFKAD
CCCCCCCCCEEEEEHHHHCCHHCCCCEEEEEEHHHHHHHCCCHHHHCCCEEEHHHHHHHH
QISSRVATELGSPFYVRSWMEMNANLFAALKLEKIGMFILLTMVVLIGSFSIVTSLVMLV
HHHHHHHHHHCCCHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
MEKTRDIAIMMSMGATRGMIRRIFMFQGSIIGVIGTLLGYVLGLTVGWLLKRYQFIKLPE
HHHCCCEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCC
NVYTLDHLPISITLSDVLIVGASAMLLCFLATLYPARQAARLEPAEALRYE
CEEEECCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]