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The map label for this gene is lytC [H]

Identifier: 220903884

GI number: 220903884

Start: 735085

End: 737511

Strand: Reverse

Name: lytC [H]

Synonym: Ddes_0609

Alternate gene names: 220903884

Gene position: 737511-735085 (Counterclockwise)

Preceding gene: 220903885

Following gene: 220903883

Centisome position: 25.67

GC content: 62.22

Gene sequence:

>2427_bases
GTGGCCCGCAAAGCAAAAAGCCCCCGACCCCAGCCCTCGACCAGAAGCGGTCTCAGGCGGCTTGCGCCTCCCCTGGCCTT
TTTGCTGGCCCTTTGCCTGCTGGTGGTCTGCTTTTACGATACGGGCTACACCTCCCTGCCTCCCACAGCCAAACGCTACG
ATACCGCCAAGGCGGGCATTGAAAGCCTGCGCATGGATGCCAAGCGCTCGGGCCAGCGCGAGCCGTGGGAAAAGCTGGCC
GCAGAATTCCGTGCAATCTATGATGCTGACCCCGGCTGGCCCAATCGGCCCGCCGCCCTCTTCCGCGCTGCGGAAAGCCT
TGAAGAACTCGCCCGCCGCTCCTTTGCCAAAGCCGATGCCCGCAAGGCCATCGAATGCTACGAATCCGTTGCCCTGCGCC
ATGCAGACAGCCGCCTTGCCGACGATGCGCTGTTTCACGCCGCCAAGCTTCGCGCCGCGTGGCTTAAAGACGACAAGGGC
GCGCTGGAACTGATCGGGCGGATCAAAAGCCAGTACCCCAAGGGCGACATGCTGCCCGAGGCTCTGGCGCTGGAAAAGAC
CCTGCTGGCCTCCGCGCAGGGGCGCACCGCGCCGGAAGCCCGCCAGGTGGCAGTGGCTGAAAACAAGGCTGCCGTTGAAG
ACCAGCCGGCCCCGGCTGCACAAGGCGGCAATTCCCCTGCCGCAAACGCTGCCCCCTCCGCAGCACAGGTCGCCGCTGCC
ACTCCCGGCCTTGCGGCGGCCTTGGCGGCTCCTCTGCCGCAAAACCAGCTTCTGCCGCGCTACCGCAAAGCCAAGGCTGA
TATGGAGGCCTTGCGCGCCGACAAGGTGCGTTCCTGCTGGCGGCAGCCGTGGGAAGAGCTGGCCGCAGAATTTTTGCGTA
TCTATCAGAGCCGTAAAAACTGGGCCATTTCGCCTGGCGCGCTCTTTCGCGCGGCTGCAAGCCAGGAAGCGCTGGCGGAC
TGCTCGCACCTGCCTGCCGAGTACAGGCAAGCCCGCGACCTGTACCTCAGCCTGGCCCAGGAATTTCCCAAAAGCGCCCT
GGCTGACGATGCATTTCTGCGCGCGGCCATCATTGATGCCGACCGGCTGAACCAGACTGCAGAAGCCCTGGAACTGCTGG
ACGCCATCGCCACACTCTATTCTCACGGCGACATGCTGCCCCAGGCCAAAGATATGCGCGCGCGCCTCACAGGGCAGTCC
GGCGCAGCCCAGGCAGGCAAGGCAGACCCTACTCCGCCCGCAGCGGTTTCACCTGAAGTACATATGCTCTCGTGGAACTC
CCTGAGCAAAAACGCTGTCGAAATCGTGCTTGAGCTGTCCTCTCCGGCCCGCTACAACGCAAAACTTGTGGAAGGGAAAA
AAGGCGCTCCATCCAGCCTGTATATCGAGCTGGAAAATGCTTCGGTCGTAAAGGATGTCCGCCAGGGCGTGACCATCAAG
GGCAGCCTGTTGCAGTCGGTACGCGTGCGTGACCGCAAGGGCGGCGGCGCGGTCATGCAGTTCAGCTTCAGGGATGTGCG
ACGCTTTGACACCCAGGTGGAAAGCAACCCGTGCCGCATCGTCTTGCGCGTGGCTGCGGGCAACACCCCCCTGCCTCCGC
GCAAGGCATCCGGCGCGGCCTTTGCCGAGCAGGGCAAACCTGCGCCGACCCGTGAAACCCCCTTGCCGGACTCCCGCCAG
GTCAACGATATGGCCCGTCAGCTCGGCCTGACTCTGCGCACGGTCTTCATTGATGCAGGACACGGCGGACGCGATCCCGG
AACCAATCATAACGGCATTCTCGAACGTGCCATCACCCTGGACGTGGCCCTGACCCTGGGGCGCCTCCTGCAGGCCAACG
GTGTGGACGTAGTGTACAGCCGCACCAGGGATACAGGCCTTTCACTGCGGGAGCGGACAACCAGAGCCAATGCCGCCGGG
GCGGACATCTTTGTGTCCATTCATGTCAATGCCAATGAAGACCCCTCCGTAAACGGCTTTGAAACTTACTACCTTGACCT
GGCAAGCAACAGCGAGGCCGCCCGGGTGGCCGCCCTTGAAAACTCTGGCAGCGACCATCGCCTGGGCGACATGCAGAAAA
TGCTGGCCGATGTTATGCTCAATGCCAGAGTTGACGAATCACGCAGGCTTGCACAGGATATTCAGCGACTTAGCATGTTC
CGCCTGAAAAAACGAGAGTATGCCGTCCGCAACAACGGGGTCAAGTCTGCGCCGTTTCACGTACTGCTCGGTGCACAAAT
GCCCGCTGTGCTGGTGGAACTTGGCTATTGCACCCATGCCGCCGAAGCCCGCAATCTCGCCAATGCCAAATATCGTCTTG
CACTGGCCGAGGGACTGGCTGAAGGCATACTTGCATACAAAGACAGACTGCTTAAAAGGCGGACTGCCCAGAATTCCTTG
ACGCCCGAAAGCGCCGATGCTATGTGA

Upstream 100 bases:

>100_bases
TCTGAATTACCTGCCCCACAAGGGCTATAAGGAAATTTTCACGCGCCGTGCCATGTCATAAGCTTGACGGACGCGCCGCA
AGGACAAGCAAGGAGTCTCC

Downstream 100 bases:

>100_bases
TGCAGGGATTTCAAATGTATGCCGTGCTGTCGTATCAGCAAAAATAAAGCCCAGTTACACTGGCGCGGCAAGGTCCGGTC
CCGGCTTGTGCAGCACATGG

Product: N-acetylmuramoyl-L-alanine amidase

Products: NA

Alternate protein names: Cell wall hydrolase; Cell wall-associated polypeptide CWBP49; CWBP49; Major autolysin [H]

Number of amino acids: Translated: 808; Mature: 807

Protein sequence:

>808_residues
MARKAKSPRPQPSTRSGLRRLAPPLAFLLALCLLVVCFYDTGYTSLPPTAKRYDTAKAGIESLRMDAKRSGQREPWEKLA
AEFRAIYDADPGWPNRPAALFRAAESLEELARRSFAKADARKAIECYESVALRHADSRLADDALFHAAKLRAAWLKDDKG
ALELIGRIKSQYPKGDMLPEALALEKTLLASAQGRTAPEARQVAVAENKAAVEDQPAPAAQGGNSPAANAAPSAAQVAAA
TPGLAAALAAPLPQNQLLPRYRKAKADMEALRADKVRSCWRQPWEELAAEFLRIYQSRKNWAISPGALFRAAASQEALAD
CSHLPAEYRQARDLYLSLAQEFPKSALADDAFLRAAIIDADRLNQTAEALELLDAIATLYSHGDMLPQAKDMRARLTGQS
GAAQAGKADPTPPAAVSPEVHMLSWNSLSKNAVEIVLELSSPARYNAKLVEGKKGAPSSLYIELENASVVKDVRQGVTIK
GSLLQSVRVRDRKGGGAVMQFSFRDVRRFDTQVESNPCRIVLRVAAGNTPLPPRKASGAAFAEQGKPAPTRETPLPDSRQ
VNDMARQLGLTLRTVFIDAGHGGRDPGTNHNGILERAITLDVALTLGRLLQANGVDVVYSRTRDTGLSLRERTTRANAAG
ADIFVSIHVNANEDPSVNGFETYYLDLASNSEAARVAALENSGSDHRLGDMQKMLADVMLNARVDESRRLAQDIQRLSMF
RLKKREYAVRNNGVKSAPFHVLLGAQMPAVLVELGYCTHAAEARNLANAKYRLALAEGLAEGILAYKDRLLKRRTAQNSL
TPESADAM

Sequences:

>Translated_808_residues
MARKAKSPRPQPSTRSGLRRLAPPLAFLLALCLLVVCFYDTGYTSLPPTAKRYDTAKAGIESLRMDAKRSGQREPWEKLA
AEFRAIYDADPGWPNRPAALFRAAESLEELARRSFAKADARKAIECYESVALRHADSRLADDALFHAAKLRAAWLKDDKG
ALELIGRIKSQYPKGDMLPEALALEKTLLASAQGRTAPEARQVAVAENKAAVEDQPAPAAQGGNSPAANAAPSAAQVAAA
TPGLAAALAAPLPQNQLLPRYRKAKADMEALRADKVRSCWRQPWEELAAEFLRIYQSRKNWAISPGALFRAAASQEALAD
CSHLPAEYRQARDLYLSLAQEFPKSALADDAFLRAAIIDADRLNQTAEALELLDAIATLYSHGDMLPQAKDMRARLTGQS
GAAQAGKADPTPPAAVSPEVHMLSWNSLSKNAVEIVLELSSPARYNAKLVEGKKGAPSSLYIELENASVVKDVRQGVTIK
GSLLQSVRVRDRKGGGAVMQFSFRDVRRFDTQVESNPCRIVLRVAAGNTPLPPRKASGAAFAEQGKPAPTRETPLPDSRQ
VNDMARQLGLTLRTVFIDAGHGGRDPGTNHNGILERAITLDVALTLGRLLQANGVDVVYSRTRDTGLSLRERTTRANAAG
ADIFVSIHVNANEDPSVNGFETYYLDLASNSEAARVAALENSGSDHRLGDMQKMLADVMLNARVDESRRLAQDIQRLSMF
RLKKREYAVRNNGVKSAPFHVLLGAQMPAVLVELGYCTHAAEARNLANAKYRLALAEGLAEGILAYKDRLLKRRTAQNSL
TPESADAM
>Mature_807_residues
ARKAKSPRPQPSTRSGLRRLAPPLAFLLALCLLVVCFYDTGYTSLPPTAKRYDTAKAGIESLRMDAKRSGQREPWEKLAA
EFRAIYDADPGWPNRPAALFRAAESLEELARRSFAKADARKAIECYESVALRHADSRLADDALFHAAKLRAAWLKDDKGA
LELIGRIKSQYPKGDMLPEALALEKTLLASAQGRTAPEARQVAVAENKAAVEDQPAPAAQGGNSPAANAAPSAAQVAAAT
PGLAAALAAPLPQNQLLPRYRKAKADMEALRADKVRSCWRQPWEELAAEFLRIYQSRKNWAISPGALFRAAASQEALADC
SHLPAEYRQARDLYLSLAQEFPKSALADDAFLRAAIIDADRLNQTAEALELLDAIATLYSHGDMLPQAKDMRARLTGQSG
AAQAGKADPTPPAAVSPEVHMLSWNSLSKNAVEIVLELSSPARYNAKLVEGKKGAPSSLYIELENASVVKDVRQGVTIKG
SLLQSVRVRDRKGGGAVMQFSFRDVRRFDTQVESNPCRIVLRVAAGNTPLPPRKASGAAFAEQGKPAPTRETPLPDSRQV
NDMARQLGLTLRTVFIDAGHGGRDPGTNHNGILERAITLDVALTLGRLLQANGVDVVYSRTRDTGLSLRERTTRANAAGA
DIFVSIHVNANEDPSVNGFETYYLDLASNSEAARVAALENSGSDHRLGDMQKMLADVMLNARVDESRRLAQDIQRLSMFR
LKKREYAVRNNGVKSAPFHVLLGAQMPAVLVELGYCTHAAEARNLANAKYRLALAEGLAEGILAYKDRLLKRRTAQNSLT
PESADAM

Specific function: Autolysins are involved in some important biological processes such as cell separation, cell-wall turnover, competence for genetic transformation, formation of the flagella - in particular of its basal body - and sporulation. Has a high affinity for teich

COG id: COG0860

COG function: function code M; N-acetylmuramoyl-L-alanine amidase

Gene ontology:

Cell location: Secreted, cell wall [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family [H]

Homologues:

Organism=Escherichia coli, GI1788776, Length=230, Percent_Identity=30.4347826086957, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI87082163, Length=223, Percent_Identity=27.8026905829596, Blast_Score=76, Evalue=9e-15,
Organism=Escherichia coli, GI1790611, Length=225, Percent_Identity=30.2222222222222, Blast_Score=73, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007253
- InterPro:   IPR002508 [H]

Pfam domain/function: PF01520 Amidase_3; PF04122 CW_binding_2 [H]

EC number: =3.5.1.28 [H]

Molecular weight: Translated: 87693; Mature: 87561

Theoretical pI: Translated: 9.81; Mature: 9.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARKAKSPRPQPSTRSGLRRLAPPLAFLLALCLLVVCFYDTGYTSLPPTAKRYDTAKAGI
CCCCCCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
ESLRMDAKRSGQREPWEKLAAEFRAIYDADPGWPNRPAALFRAAESLEELARRSFAKADA
HHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
RKAIECYESVALRHADSRLADDALFHAAKLRAAWLKDDKGALELIGRIKSQYPKGDMLPE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCHH
ALALEKTLLASAQGRTAPEARQVAVAENKAAVEDQPAPAAQGGNSPAANAAPSAAQVAAA
HHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHC
TPGLAAALAAPLPQNQLLPRYRKAKADMEALRADKVRSCWRQPWEELAAEFLRIYQSRKN
CCCHHHHHHCCCCCHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
WAISPGALFRAAASQEALADCSHLPAEYRQARDLYLSLAQEFPKSALADDAFLRAAIIDA
CCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCH
DRLNQTAEALELLDAIATLYSHGDMLPQAKDMRARLTGQSGAAQAGKADPTPPAAVSPEV
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCE
HMLSWNSLSKNAVEIVLELSSPARYNAKLVEGKKGAPSSLYIELENASVVKDVRQGVTIK
EEEECCCCCCCEEEEEEECCCCCCCCCEEECCCCCCCCEEEEEECCCHHHHHHHCCCEEH
GSLLQSVRVRDRKGGGAVMQFSFRDVRRFDTQVESNPCRIVLRVAAGNTPLPPRKASGAA
HHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCC
FAEQGKPAPTRETPLPDSRQVNDMARQLGLTLRTVFIDAGHGGRDPGTNHNGILERAITL
HHHCCCCCCCCCCCCCCCHHHHHHHHHHCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHH
DVALTLGRLLQANGVDVVYSRTRDTGLSLRERTTRANAAGADIFVSIHVNANEDPSVNGF
HHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCC
ETYYLDLASNSEAARVAALENSGSDHRLGDMQKMLADVMLNARVDESRRLAQDIQRLSMF
EEEEEEECCCCCHHEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
RLKKREYAVRNNGVKSAPFHVLLGAQMPAVLVELGYCTHAAEARNLANAKYRLALAEGLA
HHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
EGILAYKDRLLKRRTAQNSLTPESADAM
HHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
ARKAKSPRPQPSTRSGLRRLAPPLAFLLALCLLVVCFYDTGYTSLPPTAKRYDTAKAGI
CCCCCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
ESLRMDAKRSGQREPWEKLAAEFRAIYDADPGWPNRPAALFRAAESLEELARRSFAKADA
HHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
RKAIECYESVALRHADSRLADDALFHAAKLRAAWLKDDKGALELIGRIKSQYPKGDMLPE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCHH
ALALEKTLLASAQGRTAPEARQVAVAENKAAVEDQPAPAAQGGNSPAANAAPSAAQVAAA
HHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHC
TPGLAAALAAPLPQNQLLPRYRKAKADMEALRADKVRSCWRQPWEELAAEFLRIYQSRKN
CCCHHHHHHCCCCCHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
WAISPGALFRAAASQEALADCSHLPAEYRQARDLYLSLAQEFPKSALADDAFLRAAIIDA
CCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCH
DRLNQTAEALELLDAIATLYSHGDMLPQAKDMRARLTGQSGAAQAGKADPTPPAAVSPEV
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCE
HMLSWNSLSKNAVEIVLELSSPARYNAKLVEGKKGAPSSLYIELENASVVKDVRQGVTIK
EEEECCCCCCCEEEEEEECCCCCCCCCEEECCCCCCCCEEEEEECCCHHHHHHHCCCEEH
GSLLQSVRVRDRKGGGAVMQFSFRDVRRFDTQVESNPCRIVLRVAAGNTPLPPRKASGAA
HHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCC
FAEQGKPAPTRETPLPDSRQVNDMARQLGLTLRTVFIDAGHGGRDPGTNHNGILERAITL
HHHCCCCCCCCCCCCCCCHHHHHHHHHHCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHH
DVALTLGRLLQANGVDVVYSRTRDTGLSLRERTTRANAAGADIFVSIHVNANEDPSVNGF
HHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCC
ETYYLDLASNSEAARVAALENSGSDHRLGDMQKMLADVMLNARVDESRRLAQDIQRLSMF
EEEEEEECCCCCHHEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
RLKKREYAVRNNGVKSAPFHVLLGAQMPAVLVELGYCTHAAEARNLANAKYRLALAEGLA
HHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
EGILAYKDRLLKRRTAQNSLTPESADAM
HHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1357079; 1682302; 9384377 [H]