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The map label for this gene is hmeD [H]

Identifier: 220903728

GI number: 220903728

Start: 543495

End: 545138

Strand: Reverse

Name: hmeD [H]

Synonym: Ddes_0450

Alternate gene names: 220903728

Gene position: 545138-543495 (Counterclockwise)

Preceding gene: 220903729

Following gene: 220903727

Centisome position: 18.97

GC content: 58.7

Gene sequence:

>1644_bases
ATGGCAAAATTACCTACACCGCAAATGCTTGTCGCCAGCCGTCCGGACTTTCCGGCCGAAGACTGGCTTGACGTCAAGCC
GGAGTTCACGCCGGGCAGTTTTTGCTATCCGGCCAAAAAAGAAACCATGGAACTGCTGCACATGCCCAATCCCCATGAGT
GGGATCCGGCCGCAGAAGACTGGAATCTGCCCGAAAACTGGGAAGAAATCCTGTGCGACGCCTTTGCCGACAGGCTTGAG
AAGCACCGCTCGCTCAAGCTCTTTATGGACATCTGTGTGCGTTGCGGCGCCTGTGCCGACAAGTGCCACTTCTTCCTCGG
CACCAACGACCCCAAGAACATGCCCGTGCTGCGCGCCGAGCTTCTGCGCTCGCTCTACCGCCGCGATTACACCATGCTGG
GCAAGCTTCTTGGCAAAAAGGTCGGCGCCCGCGGCTGGGACATGTCCGTTGTCAAGGAACTGTACTACTACGCTTACCAG
TGCACCGAGTGCCGCCGCTGTTCGCTCTTCTGCCCTTACGGCATCGACACGGCTGAAATCACCGCCATCGTGCGCGAACT
GATGCACGAGGTAGGCCTTGGCACGCACTGGATCATGGACCCGGTGAAAAACTGCAGCTTCACGGGCAACCACCTGGGCA
TCCAGCCCCACTCCTTCGTGGAAATTGTGGAAATGCTGGCCGATGACTGCGAAACCATCACCGGCATCCGCCCCAAAACG
CCCTTCAACGAAAAGGGCCGGGAAATCCTGTTCATCACGCCCTCGGGTGACGTGTTTGCCGACCCCGGCATCTACACCTT
CATGGGCTACCTCATGCTCTTCCACGAGCTTGACCTTGACTACACCTTCTCGACCTATGCTTCTGAAGGCGGCAACTTCG
GTTCCTTCACCTCCTTCAACATGGCCAAGAAGCTCAACGCCAAGATGTATGCCGAAGCCGAGCGTCTGGGTTCCAAGTGG
ATTCTGGGCGGCGAATGCGGCCACATGTGGCGCGTGATCAACCAGTACATGGATACCTACAACGGCCCGTCGCCGGCTAA
TATGGAAATCCCCGTGTCGCCCATCACGGGTACGGTGTTCAAAAACGCCGCCTCCACCAAGATGGTGCATATTGCGGAAT
TTACGGCCGACCTGATTCACCACAACAAGCTGAATCTGGATCCCAGCCGTAACGACCATATCATCACCACCTTCCATGAC
AGCTGCAACCCCGCACGCGCCATGGGTCTGCTGGATGAACCGCGCTACGTGCTGAACGCCGTGTGCAACAACTTCCACGA
AATGCCCGAAAACACCATCCGCGAGCAAACCTTCTGCTGCGGCGCCGGTTCGGGCCTGAACACCGAAGAAATCATGGAAC
TGCGCATGCGCGCCGGTATGCCCCGCGGCAATGCCCTGCGTTTTGTGCAAGAAAAATACGGCGTCAACCACATGGCCTGC
GTGTGCGCCATTGACCGCGCCACCCTGCCCCCGCTTGCCAACTACTGGGCGCCCGGCGTCAATGTGAGCGGGCTGCATGA
ACTGGTGGGCAACGCCCTTGTCATGAAGGGCGAGTGCAAGCGTACCATGGACCTGCGCCAGGAAGATCTGCCCAACGTGG
CGGATGATGAGGATGCGCCCGAAGCGCAGGGGGAGGGCCAATAA

Upstream 100 bases:

>100_bases
CTACGCCGAGTACGAGGATACCTACCGCGAAGCCATGGCTGAAGCCGGGCTGCCGCTGGAAAAGCAACCCGAAAAGGCCG
CCGAGTAAGGAGTCTTCATC

Downstream 100 bases:

>100_bases
ATGTATAACGCCAAAGCAGTTATCGTCGGAATCGTCATCTTTGTGGCCCTGTTTACCTCCCCTTTCTGGTTGAGCATGAT
GGGGCAGGACTATAAGAGCA

Product: reductase, iron-sulfur binding subunit

Products: NA

Alternate protein names: Hme subunit D [H]

Number of amino acids: Translated: 547; Mature: 546

Protein sequence:

>547_residues
MAKLPTPQMLVASRPDFPAEDWLDVKPEFTPGSFCYPAKKETMELLHMPNPHEWDPAAEDWNLPENWEEILCDAFADRLE
KHRSLKLFMDICVRCGACADKCHFFLGTNDPKNMPVLRAELLRSLYRRDYTMLGKLLGKKVGARGWDMSVVKELYYYAYQ
CTECRRCSLFCPYGIDTAEITAIVRELMHEVGLGTHWIMDPVKNCSFTGNHLGIQPHSFVEIVEMLADDCETITGIRPKT
PFNEKGREILFITPSGDVFADPGIYTFMGYLMLFHELDLDYTFSTYASEGGNFGSFTSFNMAKKLNAKMYAEAERLGSKW
ILGGECGHMWRVINQYMDTYNGPSPANMEIPVSPITGTVFKNAASTKMVHIAEFTADLIHHNKLNLDPSRNDHIITTFHD
SCNPARAMGLLDEPRYVLNAVCNNFHEMPENTIREQTFCCGAGSGLNTEEIMELRMRAGMPRGNALRFVQEKYGVNHMAC
VCAIDRATLPPLANYWAPGVNVSGLHELVGNALVMKGECKRTMDLRQEDLPNVADDEDAPEAQGEGQ

Sequences:

>Translated_547_residues
MAKLPTPQMLVASRPDFPAEDWLDVKPEFTPGSFCYPAKKETMELLHMPNPHEWDPAAEDWNLPENWEEILCDAFADRLE
KHRSLKLFMDICVRCGACADKCHFFLGTNDPKNMPVLRAELLRSLYRRDYTMLGKLLGKKVGARGWDMSVVKELYYYAYQ
CTECRRCSLFCPYGIDTAEITAIVRELMHEVGLGTHWIMDPVKNCSFTGNHLGIQPHSFVEIVEMLADDCETITGIRPKT
PFNEKGREILFITPSGDVFADPGIYTFMGYLMLFHELDLDYTFSTYASEGGNFGSFTSFNMAKKLNAKMYAEAERLGSKW
ILGGECGHMWRVINQYMDTYNGPSPANMEIPVSPITGTVFKNAASTKMVHIAEFTADLIHHNKLNLDPSRNDHIITTFHD
SCNPARAMGLLDEPRYVLNAVCNNFHEMPENTIREQTFCCGAGSGLNTEEIMELRMRAGMPRGNALRFVQEKYGVNHMAC
VCAIDRATLPPLANYWAPGVNVSGLHELVGNALVMKGECKRTMDLRQEDLPNVADDEDAPEAQGEGQ
>Mature_546_residues
AKLPTPQMLVASRPDFPAEDWLDVKPEFTPGSFCYPAKKETMELLHMPNPHEWDPAAEDWNLPENWEEILCDAFADRLEK
HRSLKLFMDICVRCGACADKCHFFLGTNDPKNMPVLRAELLRSLYRRDYTMLGKLLGKKVGARGWDMSVVKELYYYAYQC
TECRRCSLFCPYGIDTAEITAIVRELMHEVGLGTHWIMDPVKNCSFTGNHLGIQPHSFVEIVEMLADDCETITGIRPKTP
FNEKGREILFITPSGDVFADPGIYTFMGYLMLFHELDLDYTFSTYASEGGNFGSFTSFNMAKKLNAKMYAEAERLGSKWI
LGGECGHMWRVINQYMDTYNGPSPANMEIPVSPITGTVFKNAASTKMVHIAEFTADLIHHNKLNLDPSRNDHIITTFHDS
CNPARAMGLLDEPRYVLNAVCNNFHEMPENTIREQTFCCGAGSGLNTEEIMELRMRAGMPRGNALRFVQEKYGVNHMACV
CAIDRATLPPLANYWAPGVNVSGLHELVGNALVMKGECKRTMDLRQEDLPNVADDEDAPEAQGEGQ

Specific function: Has menaquinol-oxidizing activity. The hmeC and hmeD subunits may together mediate electron transfer from menaquinol to an unidentified electron acceptor on the cytoplasmic side of the membrane [H]

COG id: COG0247

COG function: function code C; Fe-S oxidoreductase

Gene ontology:

Cell location: Membrane; Peripheral membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012285
- InterPro:   IPR009051 [H]

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 61686; Mature: 61555

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.7 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
8.6 %Cys+Met (Translated Protein)
3.7 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
8.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKLPTPQMLVASRPDFPAEDWLDVKPEFTPGSFCYPAKKETMELLHMPNPHEWDPAAED
CCCCCCCCHHEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCC
WNLPENWEEILCDAFADRLEKHRSLKLFMDICVRCGACADKCHFFLGTNDPKNMPVLRAE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCEEEECCCCCCCCCHHHHH
LLRSLYRRDYTMLGKLLGKKVGARGWDMSVVKELYYYAYQCTECRRCSLFCPYGIDTAEI
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCEECCCCCCHHHH
TAIVRELMHEVGLGTHWIMDPVKNCSFTGNHLGIQPHSFVEIVEMLADDCETITGIRPKT
HHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCC
PFNEKGREILFITPSGDVFADPGIYTFMGYLMLFHELDLDYTFSTYASEGGNFGSFTSFN
CCCCCCCEEEEECCCCCCEECCCHHHHHHHHHHHHHHCCCEEEHHHHCCCCCCCCCCHHH
MAKKLNAKMYAEAERLGSKWILGGECGHMWRVINQYMDTYNGPSPANMEIPVSPITGTVF
HHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCHHHH
KNAASTKMVHIAEFTADLIHHNKLNLDPSRNDHIITTFHDSCNPARAMGLLDEPRYVLNA
HCCCCCCEEHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCHHHHHCCCCCCHHHHHH
VCNNFHEMPENTIREQTFCCGAGSGLNTEEIMELRMRAGMPRGNALRFVQEKYGVNHMAC
HHHHHHHCCHHHHHHHHEEECCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCEEE
VCAIDRATLPPLANYWAPGVNVSGLHELVGNALVMKGECKRTMDLRQEDLPNVADDEDAP
EEEECCCCCCCHHHHCCCCCCHHHHHHHHCCEEEECCCHHHHHHHHHHHCCCCCCCCCCC
EAQGEGQ
CCCCCCC
>Mature Secondary Structure 
AKLPTPQMLVASRPDFPAEDWLDVKPEFTPGSFCYPAKKETMELLHMPNPHEWDPAAED
CCCCCCCHHEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCC
WNLPENWEEILCDAFADRLEKHRSLKLFMDICVRCGACADKCHFFLGTNDPKNMPVLRAE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCEEEECCCCCCCCCHHHHH
LLRSLYRRDYTMLGKLLGKKVGARGWDMSVVKELYYYAYQCTECRRCSLFCPYGIDTAEI
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCEECCCCCCHHHH
TAIVRELMHEVGLGTHWIMDPVKNCSFTGNHLGIQPHSFVEIVEMLADDCETITGIRPKT
HHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCC
PFNEKGREILFITPSGDVFADPGIYTFMGYLMLFHELDLDYTFSTYASEGGNFGSFTSFN
CCCCCCCEEEEECCCCCCEECCCHHHHHHHHHHHHHHCCCEEEHHHHCCCCCCCCCCHHH
MAKKLNAKMYAEAERLGSKWILGGECGHMWRVINQYMDTYNGPSPANMEIPVSPITGTVF
HHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCHHHH
KNAASTKMVHIAEFTADLIHHNKLNLDPSRNDHIITTFHDSCNPARAMGLLDEPRYVLNA
HCCCCCCEEHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCHHHHHCCCCCCHHHHHH
VCNNFHEMPENTIREQTFCCGAGSGLNTEEIMELRMRAGMPRGNALRFVQEKYGVNHMAC
HHHHHHHCCHHHHHHHHEEECCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCEEE
VCAIDRATLPPLANYWAPGVNVSGLHELVGNALVMKGECKRTMDLRQEDLPNVADDEDAP
EEEECCCCCCCHHHHCCCCCCHHHHHHHHCCEEEECCCHHHHHHHHHHHCCCCCCCCCCC
EAQGEGQ
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA