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The map label for this gene is cobC [C]

Identifier: 220903630

GI number: 220903630

Start: 428010

End: 429227

Strand: Reverse

Name: cobC [C]

Synonym: Ddes_0350

Alternate gene names: 220903630

Gene position: 429227-428010 (Counterclockwise)

Preceding gene: 220903632

Following gene: 220903629

Centisome position: 14.94

GC content: 57.39

Gene sequence:

>1218_bases
ATGCAAAAACTTTATGTAGCCATGGTCGGCCTGCCCGCCAGAGGAAAATCCACTCTGGCAAAACGCATCCGTGACGGGCT
GCTGGCCGAGGGCATTCAGGCCAGACTGTTCAATAACGGCGACATGCGCCGTGCGCTTATGGGCGCGGAATCCACAAATC
CGGATTTTTACAATCCCGCCAACGAATCGGGCCGCGAAGCACGCGAGATGATCTGCCGCCGGAATATGGAACTTGCCCGG
ACATGGCTGGCCGCCGAAGGCGAGGTGGCAATTCTGGACGCCACCAACGTAAGCCGCGCACGACGTATTCTTATTGAAAA
AACGCTTACCGACCATCCTGTGCTGTTTGTGGAATGTGTCAATGAAGACCAACTGCTCCTCAAGGCATGCATACGCCGCA
AGGCCACCCTGCCGGAATACGCCGCCTACAGCGAAGATGAAGCCCTGCAAAGCTTTATGAAGCGCATAAGCTATTATGAG
GCCATTTATGAGCCATTGGAAGAGGAAAAATTCTGGCTCTGCGTAGACTCCACCGCCAACCGCATTCTGGGCGAGCGCCC
TTGCGAAGGCTCGCCCTATTATCCTGCCATACGCGAAATCGTGGTCAGCGCCTGGGTTCACTGTCTGTATCTTGCGCGGC
ACGGCCAGACGGAATTCAACGTGCGCGGGCGCATCGGCGGCGACCCGCCCCTGACTGCCAGAGGGCGCAGCCAGGCCAAG
GCCCTGGCACGGCACATGCGCCACAAGGACATAAACTGGGTCTTTACCTCAACCCGCCTGCGTTCGCACGAAACCGCCAC
GCCGCTGCTGGCGGGACACCCCGGCGCTCATGTCATGGCCTTCAAGGAATTTGACGAGATATGGGCCGGCGACTGCGAAG
GTATGCTGTACAGCGAAATCCGCGCAAAAATGCCCGGAGTGACCGCCGGGCGCAATGCCAGCAAGTACACATACGCCTAT
CCCAATGGCGAAAGCTACGCCATGCTGCGCGAGCGCGTGCAGCGCGGACTGCGGCGCGCCCTGTTTCTTGCCGGCGACAC
CCCGCTTGTGATTGTGGGACATCAGGCTGTCAACCGGGTACTGCTTTCCCTTTTCCTGCAGCAGCGCAGCGAAGACGTAC
CCTATGTCTACATACCGCAAAATCAGTATTATCATATAAGCATGACTCCGCGACGCAAGGTTTTTGAACGCATTCCCTAT
CAGGAAGAAATTTTTTAA

Upstream 100 bases:

>100_bases
CCCAGAAGACCGATAACTTTCATACTATGCTCCTTTCCGGGTATTGGCACACCCGCTTTTATTTCATGATAATTTATCTT
ACTCTGGCAATGGAGGGCGT

Downstream 100 bases:

>100_bases
CGGTTTTGCCCTTGCGTCCCTAACAATAAGCTTTACTCTTTTTGCGCGAAACGGTATTAGCCTGCGTGCCAAGCCACTTT
CCCATGTCCCGTCAGGGGCA

Product: phosphoglycerate mutase

Products: NA

Alternate protein names: Phosphoglycerate Mutase Family Protein; Fructose-2 6-Bisphosphatase; Alpha-Ribazole-5-P Phosphatase; Alpha-Ribazole Phosphatase; 6-Phosphofructo-2-Kinase/Fructose-2 6-Biphosphatase; Phosphoglycerate Mutase Protein; Phosphoglycerate Mutase Domain Protein; 6-Phosphofructo-2-Kinase/Fructose-2 6- Biphosphatase; Phosphoglycerate Mutase GpmB; Fructose-2 6-Bisphosphate 2-Phosphatase; 6-Phosphofructo-2-Kinase

Number of amino acids: Translated: 405; Mature: 405

Protein sequence:

>405_residues
MQKLYVAMVGLPARGKSTLAKRIRDGLLAEGIQARLFNNGDMRRALMGAESTNPDFYNPANESGREAREMICRRNMELAR
TWLAAEGEVAILDATNVSRARRILIEKTLTDHPVLFVECVNEDQLLLKACIRRKATLPEYAAYSEDEALQSFMKRISYYE
AIYEPLEEEKFWLCVDSTANRILGERPCEGSPYYPAIREIVVSAWVHCLYLARHGQTEFNVRGRIGGDPPLTARGRSQAK
ALARHMRHKDINWVFTSTRLRSHETATPLLAGHPGAHVMAFKEFDEIWAGDCEGMLYSEIRAKMPGVTAGRNASKYTYAY
PNGESYAMLRERVQRGLRRALFLAGDTPLVIVGHQAVNRVLLSLFLQQRSEDVPYVYIPQNQYYHISMTPRRKVFERIPY
QEEIF

Sequences:

>Translated_405_residues
MQKLYVAMVGLPARGKSTLAKRIRDGLLAEGIQARLFNNGDMRRALMGAESTNPDFYNPANESGREAREMICRRNMELAR
TWLAAEGEVAILDATNVSRARRILIEKTLTDHPVLFVECVNEDQLLLKACIRRKATLPEYAAYSEDEALQSFMKRISYYE
AIYEPLEEEKFWLCVDSTANRILGERPCEGSPYYPAIREIVVSAWVHCLYLARHGQTEFNVRGRIGGDPPLTARGRSQAK
ALARHMRHKDINWVFTSTRLRSHETATPLLAGHPGAHVMAFKEFDEIWAGDCEGMLYSEIRAKMPGVTAGRNASKYTYAY
PNGESYAMLRERVQRGLRRALFLAGDTPLVIVGHQAVNRVLLSLFLQQRSEDVPYVYIPQNQYYHISMTPRRKVFERIPY
QEEIF
>Mature_405_residues
MQKLYVAMVGLPARGKSTLAKRIRDGLLAEGIQARLFNNGDMRRALMGAESTNPDFYNPANESGREAREMICRRNMELAR
TWLAAEGEVAILDATNVSRARRILIEKTLTDHPVLFVECVNEDQLLLKACIRRKATLPEYAAYSEDEALQSFMKRISYYE
AIYEPLEEEKFWLCVDSTANRILGERPCEGSPYYPAIREIVVSAWVHCLYLARHGQTEFNVRGRIGGDPPLTARGRSQAK
ALARHMRHKDINWVFTSTRLRSHETATPLLAGHPGAHVMAFKEFDEIWAGDCEGMLYSEIRAKMPGVTAGRNASKYTYAY
PNGESYAMLRERVQRGLRRALFLAGDTPLVIVGHQAVNRVLLSLFLQQRSEDVPYVYIPQNQYYHISMTPRRKVFERIPY
QEEIF

Specific function: Converts N1-(5-Phospho-Alpha-D-Ribosyl)-5,6- Dimethylbenzimidazole Into N1-Alpha-D-Ribosyl-5,6- Dimethylbenzimidazole; Involved In The Assembly Of The Nucleotide Loop Of Cobalamin. [C]

COG id: COG0406

COG function: function code G; Fructose-2,6-bisphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI224282149, Length=385, Percent_Identity=33.5064935064935, Blast_Score=189, Evalue=4e-48,
Organism=Homo sapiens, GI4758900, Length=385, Percent_Identity=33.5064935064935, Blast_Score=189, Evalue=4e-48,
Organism=Homo sapiens, GI118582286, Length=384, Percent_Identity=33.59375, Blast_Score=189, Evalue=5e-48,
Organism=Homo sapiens, GI4758902, Length=384, Percent_Identity=34.1145833333333, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI64762445, Length=393, Percent_Identity=31.5521628498728, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI64762406, Length=393, Percent_Identity=31.5521628498728, Blast_Score=184, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI71993390, Length=407, Percent_Identity=34.3980343980344, Blast_Score=193, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI17510917, Length=407, Percent_Identity=34.3980343980344, Blast_Score=193, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI25145314, Length=404, Percent_Identity=32.4257425742574, Blast_Score=183, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6322306, Length=400, Percent_Identity=30.75, Blast_Score=162, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6322084, Length=408, Percent_Identity=29.656862745098, Blast_Score=130, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6323377, Length=425, Percent_Identity=23.0588235294118, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24643264, Length=399, Percent_Identity=31.077694235589, Blast_Score=182, Evalue=3e-46,
Organism=Drosophila melanogaster, GI24643254, Length=399, Percent_Identity=31.077694235589, Blast_Score=182, Evalue=3e-46,
Organism=Drosophila melanogaster, GI24643260, Length=399, Percent_Identity=31.077694235589, Blast_Score=182, Evalue=3e-46,
Organism=Drosophila melanogaster, GI24643258, Length=399, Percent_Identity=31.077694235589, Blast_Score=182, Evalue=3e-46,
Organism=Drosophila melanogaster, GI24643256, Length=399, Percent_Identity=31.077694235589, Blast_Score=182, Evalue=3e-46,
Organism=Drosophila melanogaster, GI24643262, Length=399, Percent_Identity=31.077694235589, Blast_Score=182, Evalue=3e-46,
Organism=Drosophila melanogaster, GI24643252, Length=399, Percent_Identity=31.077694235589, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI17137706, Length=399, Percent_Identity=31.077694235589, Blast_Score=180, Evalue=2e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 3.1.3.73 [C]

Molecular weight: Translated: 46287; Mature: 46287

Theoretical pI: Translated: 8.90; Mature: 8.90

Prosite motif: PS00175 PG_MUTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKLYVAMVGLPARGKSTLAKRIRDGLLAEGIQARLFNNGDMRRALMGAESTNPDFYNPA
CCCEEEEEECCCCCCHHHHHHHHHHHHHHCCHHHHCCCCCCHHHHHHCCCCCCCCCCCCC
NESGREAREMICRRNMELARTWLAAEGEVAILDATNVSRARRILIEKTLTDHPVLFVECV
CCCHHHHHHHHHHCCHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHCCCCCEEEEEEC
NEDQLLLKACIRRKATLPEYAAYSEDEALQSFMKRISYYEAIYEPLEEEKFWLCVDSTAN
CCCHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHH
RILGERPCEGSPYYPAIREIVVSAWVHCLYLARHGQTEFNVRGRIGGDPPLTARGRSQAK
HHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHH
ALARHMRHKDINWVFTSTRLRSHETATPLLAGHPGAHVMAFKEFDEIWAGDCEGMLYSEI
HHHHHHHCCCCCEEEECCHHCCCCCCCCEEECCCCCEEEEHHHHHHHHCCCCCCHHHHHH
RAKMPGVTAGRNASKYTYAYPNGESYAMLRERVQRGLRRALFLAGDTPLVIVGHQAVNRV
HHHCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHEEEECCCCEEEECHHHHHHH
LLSLFLQQRSEDVPYVYIPQNQYYHISMTPRRKVFERIPYQEEIF
HHHHHHHHHCCCCCEEEECCCCEEEEEECHHHHHHHHCCCHHCCC
>Mature Secondary Structure
MQKLYVAMVGLPARGKSTLAKRIRDGLLAEGIQARLFNNGDMRRALMGAESTNPDFYNPA
CCCEEEEEECCCCCCHHHHHHHHHHHHHHCCHHHHCCCCCCHHHHHHCCCCCCCCCCCCC
NESGREAREMICRRNMELARTWLAAEGEVAILDATNVSRARRILIEKTLTDHPVLFVECV
CCCHHHHHHHHHHCCHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHCCCCCEEEEEEC
NEDQLLLKACIRRKATLPEYAAYSEDEALQSFMKRISYYEAIYEPLEEEKFWLCVDSTAN
CCCHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHH
RILGERPCEGSPYYPAIREIVVSAWVHCLYLARHGQTEFNVRGRIGGDPPLTARGRSQAK
HHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHH
ALARHMRHKDINWVFTSTRLRSHETATPLLAGHPGAHVMAFKEFDEIWAGDCEGMLYSEI
HHHHHHHCCCCCEEEECCHHCCCCCCCCEEECCCCCEEEEHHHHHHHHCCCCCCHHHHHH
RAKMPGVTAGRNASKYTYAYPNGESYAMLRERVQRGLRRALFLAGDTPLVIVGHQAVNRV
HHHCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHEEEECCCCEEEECHHHHHHH
LLSLFLQQRSEDVPYVYIPQNQYYHISMTPRRKVFERIPYQEEIF
HHHHHHHHHCCCCCEEEECCCCEEEEEECHHHHHHHHCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA