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The map label for this gene is grdC [H]

Identifier: 220903401

GI number: 220903401

Start: 148840

End: 150375

Strand: Direct

Name: grdC [H]

Synonym: Ddes_0115

Alternate gene names: 220903401

Gene position: 148840-150375 (Clockwise)

Preceding gene: 220903400

Following gene: 220903402

Centisome position: 5.18

GC content: 61.78

Gene sequence:

>1536_bases
ATGAAAACTGTTGGCATCAAGGCCGCGGCGTACTGCCTCAACTTTGCGCCGGAACTGGCCCTGCATCATGGCGGCACACC
GGCACAGGAGCGCCGCGCCAAGCCCGATTCCGAATTCCTGCGCGAACTGCCCAAGCACGCGCAAACCTTTGAGCAGGCGG
CATCTTACGCGCCCAACAAAACCTATGTGGGCGCCATGAGCGTGGACGAACTGGCCGCAGCCCCCGCACCCTGGATAGAT
AATCTCGGCGAGCCGCAGCGCTTCGGCAAGTTTGGCGAAATCATGCCCGAGGATGAATTCATCGGGCTTATGGATATCTG
CGATGTTTTTGACCTCATCTGGCTTGAAGAAGGCTTTGCCACGGCCGTGGCCGCCAGGCTGGCCCAAAATCCTGTCATGG
GTGAAAAACAGATGGCCCGTCTTGAAAAGGGCAGGCCCGAGGCCGAACTTCTTGCGGCCATTGAAAAGCACCACGCCCTG
CCCCTGTATTTTGCAGGCAAGGTGGTGGGCTGCTGCCGCCGCGCCCATGACACCGATGAAAACCTCGAAGCCGGGATCAT
GCTGGAAAACCTTGCCAGCAAGGCCAGCGCCGTGCTTTGCCTGCTGCACCTGATCAAGAATGCGGGCATGGCTCCGGCAG
ATGTGGATTTTGTGGTGGAATGCTCGGAAGAAGCCGTGGGCGACGCCATGCAGCGCGGCGGCGGCAATATGGCCAAGGCC
GTTGCCGAAATAGCCGAATGCGTCAATGCCAGCGGGTTTGACGTGCGCGGCTTCTGCGCAGCGCCCGTGGCGGCCATGAT
CACGGCGGCGGGTATGGTTGCCAGCGGCGTGCGGCCCAATGTGGTGGTCATCAGCGGCGGCTCTGTGCCCAAGCTGTATA
TGAACGCCCGCGACCATATCAAAAAGGGCGTTGTTCCGCTTGAGAACTGCGTGGGCAGCTTTGCCCTGCTGCTGGTTCCC
GATGACGGGCAGACACCTGTCATGCGGCTTGAAGGCATCGGCAAGCATACGGTGGGAGCCGGGGCTTCGCCCCAGGCCAT
CACAACGGCCCTGACCTTTGACCCGCTGTCCCGCGTTGGTCTCAAGCTGACTGACGTGGACAAGTACGCCCCGGAACTGC
ACAACGCTGAAATCACCCTGCCCGCGGGCGCGGGCAACGTGCCCGAAGCCAACTACAAGATGATCGCGGCCCTGGCTGTC
ATGAAGGGGCAGATCGAGCGCGCCGATATCCAGAAGTTTGTGGACGAGCGCGGCATGCCGGGCTTTGCGCACACCCAGGG
GCATATCCCTTCGGGCGTTCCCTATGTGGGCCACGCCCTTGAGGCCCTGAAAGAAGGGCGCATCAGGCGGGCCATGATCA
TCGGCAAGGGCAGCCTCTTCCTGGGTCGCCTGACCAATCTGGCTGACGGTGTTTCCTTTATTATGGAAGCACCGGGAAGC
GCCCCTGCGGCGCAGGATGTCAGCCAGGCGGATGTGACGGAAATGCTGCTCGGCACTCTGGGCGATCTGGCGGCCAATCT
GCAAAAGGGCCGGTAG

Upstream 100 bases:

>100_bases
GGCCTGCGCCTTGCCGTGGAGCAGACACCGGCAGGCCCCCCTGCCGTTAAGCAACTCTTTCAAGTGACAGCGCTCTGTAA
TGACGCTGGAGGATAGCAGC

Downstream 100 bases:

>100_bases
AGGAGGGGCTATGGCTAGTCAAAATGACAAGCGCGCCATCCTCGGCAAGGCTCTTGAAGACCTGGTGACGCGGGCGCGCA
GCGGGCGCGAGCCGTGCCGC

Product: betaine reductase

Products: NA

Alternate protein names: Protein PC beta [H]

Number of amino acids: Translated: 511; Mature: 511

Protein sequence:

>511_residues
MKTVGIKAAAYCLNFAPELALHHGGTPAQERRAKPDSEFLRELPKHAQTFEQAASYAPNKTYVGAMSVDELAAAPAPWID
NLGEPQRFGKFGEIMPEDEFIGLMDICDVFDLIWLEEGFATAVAARLAQNPVMGEKQMARLEKGRPEAELLAAIEKHHAL
PLYFAGKVVGCCRRAHDTDENLEAGIMLENLASKASAVLCLLHLIKNAGMAPADVDFVVECSEEAVGDAMQRGGGNMAKA
VAEIAECVNASGFDVRGFCAAPVAAMITAAGMVASGVRPNVVVISGGSVPKLYMNARDHIKKGVVPLENCVGSFALLLVP
DDGQTPVMRLEGIGKHTVGAGASPQAITTALTFDPLSRVGLKLTDVDKYAPELHNAEITLPAGAGNVPEANYKMIAALAV
MKGQIERADIQKFVDERGMPGFAHTQGHIPSGVPYVGHALEALKEGRIRRAMIIGKGSLFLGRLTNLADGVSFIMEAPGS
APAAQDVSQADVTEMLLGTLGDLAANLQKGR

Sequences:

>Translated_511_residues
MKTVGIKAAAYCLNFAPELALHHGGTPAQERRAKPDSEFLRELPKHAQTFEQAASYAPNKTYVGAMSVDELAAAPAPWID
NLGEPQRFGKFGEIMPEDEFIGLMDICDVFDLIWLEEGFATAVAARLAQNPVMGEKQMARLEKGRPEAELLAAIEKHHAL
PLYFAGKVVGCCRRAHDTDENLEAGIMLENLASKASAVLCLLHLIKNAGMAPADVDFVVECSEEAVGDAMQRGGGNMAKA
VAEIAECVNASGFDVRGFCAAPVAAMITAAGMVASGVRPNVVVISGGSVPKLYMNARDHIKKGVVPLENCVGSFALLLVP
DDGQTPVMRLEGIGKHTVGAGASPQAITTALTFDPLSRVGLKLTDVDKYAPELHNAEITLPAGAGNVPEANYKMIAALAV
MKGQIERADIQKFVDERGMPGFAHTQGHIPSGVPYVGHALEALKEGRIRRAMIIGKGSLFLGRLTNLADGVSFIMEAPGS
APAAQDVSQADVTEMLLGTLGDLAANLQKGR
>Mature_511_residues
MKTVGIKAAAYCLNFAPELALHHGGTPAQERRAKPDSEFLRELPKHAQTFEQAASYAPNKTYVGAMSVDELAAAPAPWID
NLGEPQRFGKFGEIMPEDEFIGLMDICDVFDLIWLEEGFATAVAARLAQNPVMGEKQMARLEKGRPEAELLAAIEKHHAL
PLYFAGKVVGCCRRAHDTDENLEAGIMLENLASKASAVLCLLHLIKNAGMAPADVDFVVECSEEAVGDAMQRGGGNMAKA
VAEIAECVNASGFDVRGFCAAPVAAMITAAGMVASGVRPNVVVISGGSVPKLYMNARDHIKKGVVPLENCVGSFALLLVP
DDGQTPVMRLEGIGKHTVGAGASPQAITTALTFDPLSRVGLKLTDVDKYAPELHNAEITLPAGAGNVPEANYKMIAALAV
MKGQIERADIQKFVDERGMPGFAHTQGHIPSGVPYVGHALEALKEGRIRRAMIIGKGSLFLGRLTNLADGVSFIMEAPGS
APAAQDVSQADVTEMLLGTLGDLAANLQKGR

Specific function: In the first step of glycine, betaine and sarcosine reductases, the substrate is bound to component PB via a Schiff base intermediate. Then the PB-activated substrate is nucleophilically attacked by the selenol anion of component PA to transform it to a c

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013751
- InterPro:   IPR017236
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF08545 ACP_syn_III [H]

EC number: =1.21.4.2; =1.21.4.3; =1.21.4.4 [H]

Molecular weight: Translated: 54067; Mature: 54067

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTVGIKAAAYCLNFAPELALHHGGTPAQERRAKPDSEFLRELPKHAQTFEQAASYAPNK
CCCCCHHHHHHHHHHCHHHHHHCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
TYVGAMSVDELAAAPAPWIDNLGEPQRFGKFGEIMPEDEFIGLMDICDVFDLIWLEEGFA
EEEECCCHHHHHCCCCCHHHCCCCHHHHCCCCCCCCCCHHEHHHHHHHHHHHHHHHHHHH
TAVAARLAQNPVMGEKQMARLEKGRPEAELLAAIEKHHALPLYFAGKVVGCCRRAHDTDE
HHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCC
NLEAGIMLENLASKASAVLCLLHLIKNAGMAPADVDFVVECSEEAVGDAMQRGGGNMAKA
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHEEECCHHHHHHHHHHCCCHHHHH
VAEIAECVNASGFDVRGFCAAPVAAMITAAGMVASGVRPNVVVISGGSVPKLYMNARDHI
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHCHHHHH
KKGVVPLENCVGSFALLLVPDDGQTPVMRLEGIGKHTVGAGASPQAITTALTFDPLSRVG
HHCCCCHHHHHCCEEEEEECCCCCCCCHHCCCCCCCCCCCCCCCHHEEEEEECCCHHHHC
LKLTDVDKYAPELHNAEITLPAGAGNVPEANYKMIAALAVMKGQIERADIQKFVDERGMP
CEEECHHHHCHHHCCCEEEECCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCC
GFAHTQGHIPSGVPYVGHALEALKEGRIRRAMIIGKGSLFLGRLTNLADGVSFIMEAPGS
CCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCC
APAAQDVSQADVTEMLLGTLGDLAANLQKGR
CCCHHCCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKTVGIKAAAYCLNFAPELALHHGGTPAQERRAKPDSEFLRELPKHAQTFEQAASYAPNK
CCCCCHHHHHHHHHHCHHHHHHCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
TYVGAMSVDELAAAPAPWIDNLGEPQRFGKFGEIMPEDEFIGLMDICDVFDLIWLEEGFA
EEEECCCHHHHHCCCCCHHHCCCCHHHHCCCCCCCCCCHHEHHHHHHHHHHHHHHHHHHH
TAVAARLAQNPVMGEKQMARLEKGRPEAELLAAIEKHHALPLYFAGKVVGCCRRAHDTDE
HHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCC
NLEAGIMLENLASKASAVLCLLHLIKNAGMAPADVDFVVECSEEAVGDAMQRGGGNMAKA
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHEEECCHHHHHHHHHHCCCHHHHH
VAEIAECVNASGFDVRGFCAAPVAAMITAAGMVASGVRPNVVVISGGSVPKLYMNARDHI
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHCHHHHH
KKGVVPLENCVGSFALLLVPDDGQTPVMRLEGIGKHTVGAGASPQAITTALTFDPLSRVG
HHCCCCHHHHHCCEEEEEECCCCCCCCHHCCCCCCCCCCCCCCCHHEEEEEECCCHHHHC
LKLTDVDKYAPELHNAEITLPAGAGNVPEANYKMIAALAVMKGQIERADIQKFVDERGMP
CEEECHHHHCHHHCCCEEEECCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCC
GFAHTQGHIPSGVPYVGHALEALKEGRIRRAMIIGKGSLFLGRLTNLADGVSFIMEAPGS
CCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCC
APAAQDVSQADVTEMLLGTLGDLAANLQKGR
CCCHHCCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8223622; 1587286 [H]